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Items: 13

1.

Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (nAChRs).

Strachan JP, Kombo DC, Mazurov A, Heemstra R, Bhatti BS, Akireddy R, Murthy S, Miao L, Jett JE, Speake J, Bencherif M.

Eur J Med Chem. 2014 Oct 30;86:60-74. doi: 10.1016/j.ejmech.2014.08.019. Epub 2014 Aug 7.

PMID:
25147147
2.

Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.

Breining SR, Melvin M, Bhatti BS, Byrd GD, Kiser MN, Hepler CD, Hooker DN, Zhang J, Reynolds LA, Benson LR, Fedorov NB, Sidach SS, Mitchener JP, Lucero LM, Lukas RJ, Whiteaker P, Yohannes D.

J Med Chem. 2012 Nov 26;55(22):9929-45. doi: 10.1021/jm3011299. Epub 2012 Oct 17.

PMID:
23025891
3.

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.

Mazurov AA, Miao L, Bhatti BS, Strachan JP, Akireddy S, Murthy S, Kombo D, Xiao YD, Hammond P, Zhang J, Hauser TA, Jordan KG, Miller CH, Speake JD, Gatto GJ, Yohannes D.

J Med Chem. 2012 Nov 8;55(21):9181-94. doi: 10.1021/jm3006542. Epub 2012 Jul 27.

PMID:
22793665
4.

Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor.

Strachan JP, Farias JJ, Zhang J, Caldwell WS, Bhatti BS.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5089-92. doi: 10.1016/j.bmcl.2012.05.108. Epub 2012 Jun 13.

PMID:
22749278
5.

Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.

Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS.

J Org Chem. 2008 May 2;73(9):3497-507. doi: 10.1021/jo800028q. Epub 2008 Mar 26.

PMID:
18363376
6.

Synthesis of bicyclic tertiary alpha-amino acids.

Strachan JP, Whitaker RC, Miller CH, Bhatti BS.

J Org Chem. 2006 Dec 22;71(26):9909-11.

PMID:
17168622
7.

The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.

Marrero MB, Papke RL, Bhatti BS, Shaw S, Bencherif M.

J Pharmacol Exp Ther. 2004 Apr;309(1):16-27. Epub 2004 Jan 13.

PMID:
14722323
8.

Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples.

Byrd GD, Caldwell WS, Bhatti BS, Ravard A, Crooks PA.

Drug Metabol Drug Interact. 2000;16(4):281-97.

PMID:
11201307
9.
10.

The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.

Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, Fowler K, Reeves L, Lippiello PM.

J Pharmacol Exp Ther. 1998 Mar;284(3):886-94.

PMID:
9495846
12.

Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine.

Caldwell WS, Greene JM, Byrd GD, Chang KM, Uhrig MS, deBethizy JD, Crooks PA, Bhatti BS, Riggs RM.

Chem Res Toxicol. 1992 Mar-Apr;5(2):280-5.

PMID:
1643259
13.

New oligospirostanosides and oligofurostanosides from Asparagus adscendens roots.

Sharma SC, Chand R, Bhatti BS, Sati OP.

Planta Med. 1982 Sep;46(1):48-51.

PMID:
17396940

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