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Items: 40

1.

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.

Du J, Yan L, Torres R, Gong X, Bian H, Marugán C, Boehnke K, Baquero C, Hui YH, Chapman SC, Yang Y, Zeng Y, Bogner SM, Foreman RT, Capen A, Donoho GP, Van Horn RD, Barnard DS, Dempsey JA, Beckmann RP, Marshall MS, Chio LC, Qian Y, Webster YW, Aggarwal A, Chu S, Bhattachar S, Stancato LF, Dowless MS, Iversen PW, Manro JR, Walgren JL, Halstead BW, Dieter MZ, Martinez R, Bhagwat SV, Kreklau EL, Lallena MJ, Ye XS, Patel BKR, Reinhard C, Plowman GD, Barda DA, Henry JR, Buchanan SG, Campbell RM.

Mol Cancer Ther. 2019 Dec;18(12):2207-2219. doi: 10.1158/1535-7163.MCT-18-0529. Epub 2019 Sep 17.

PMID:
31530649
2.

High-altitude pulmonary oedema: Newer treatment modalities for an age-old problem.

Yanamandra U, Sharma M, Katoch D, Yanamandra S, Bhattachar SA, Gupta A, Patyal S, Grewal R, Kumar S, Nair V.

Indian J Med Res. 2019 Jun;149(6):778-782. doi: 10.4103/ijmr.IJMR_1981_17.

3.

Is it time to revise the acclimatization schedule at high altitude? Evidence from a field trial in Western Himalayas.

Sikri G, Kotwal A, Singh SP, Bhattachar S, Bhatia SS, Dutt M, Srinath N.

Med J Armed Forces India. 2019 Jul;75(3):251-258. doi: 10.1016/j.mjafi.2018.01.001. Epub 2018 Aug 14.

PMID:
31388226
4.

Anthropometric evaluation of school-going native highlanders (4-19 years of age) from the Leh-Ladakh region in India.

Yanamandra U, Bhattachar SA, Katoch D, Yanamandra S, Shankar S, Kumari VKL, Ayekappam A, Kumar S, Patyal S, Nair V.

Int J Adolesc Med Health. 2019 May 10. pii: /j/ijamh.ahead-of-print/ijamh-2018-0253/ijamh-2018-0253.xml. doi: 10.1515/ijamh-2018-0253. [Epub ahead of print]

PMID:
31075082
5.

Erythropoietin and ferritin response in native highlanders aged 4-19 years from the Leh-Ladakh region of India.

Yanamandra U, Senee H, Yanamadra S, Das SK, Bhattachar SA, Das R, Kumar S, Malhotra P, Varma S, Varma N, Nair V.

Br J Haematol. 2019 Jan;184(2):263-268. doi: 10.1111/bjh.15553. Epub 2018 Nov 26.

PMID:
30474185
6.

Hematological Parameters in Native Highlanders of Ladakh Aged 4-19 Years.

Yanamandra U, Bhattachar SA, Das SK, Yanamandra S, Kumari VKL, Ayekappam A, Kumar S, Malhotra P, Varma S, Varma N, Nair V.

Indian J Hematol Blood Transfus. 2018 Oct;34(4):731-738. doi: 10.1007/s12288-018-0967-4. Epub 2018 May 12.

7.

Relative Bioavailability Risk Assessment: A Systematic Approach to Assessing In Vivo Risk Associated With CM&C-Related Changes.

Aburub A, Sperry DC, Bhattachar S, Lobo E, Ding X, Rose JP.

J Pharm Sci. 2019 Jan;108(1):8-17. doi: 10.1016/j.xphs.2018.07.012. Epub 2018 Jul 25.

PMID:
30053554
8.

Comparison of Optic Nerve Sheath Diameter between both eyes: A Bedside Ultrasonography Approach.

Yanamandra U, Gupta A, Bhattachar SA, Yanamandra S, Das SK, Patyal S, Grewal R, Nair V.

Indian J Crit Care Med. 2018 Mar;22(3):150-153. doi: 10.4103/ijccm.IJCCM_498_17.

9.

In response to HMOX1 microsatellite polymorphism by Cao et al.

Sikri G, Bhattachar S.

Wilderness Environ Med. 2018 Jun;29(2):278. doi: 10.1016/j.wem.2017.11.008. Epub 2018 Feb 3. No abstract available.

PMID:
29398188
10.

Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration.

Zhao G, Green CF, Hui YH, Prieto L, Shepard R, Dong S, Wang T, Tan B, Gong X, Kays L, Johnson RL, Wu W, Bhattachar S, Del Prado M, Gillig JR, Fernandez MC, Roth KD, Buchanan S, Kuo MS, Geeganage S, Burkholder TP.

Mol Cancer Ther. 2017 Dec;16(12):2677-2688. doi: 10.1158/1535-7163.MCT-16-0674. Epub 2017 Oct 20.

11.

Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates.

Landis MS, Bhattachar S, Yazdanian M, Morrison J.

AAPS PharmSciTech. 2018 Jan;19(1):1-10. doi: 10.1208/s12249-017-0849-3. Epub 2017 Jul 28.

PMID:
28755053
12.

Risk of high altitude pulmonary edema and telomere length.

Sikri G, Bhattachar S.

J Gene Med. 2017 May;19(5). doi: 10.1002/jgm.2953. No abstract available.

PMID:
28544179
13.

Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema".

Sikri G, Bhattachar S.

Mediators Inflamm. 2017;2017:8546027. doi: 10.1155/2017/8546027. Epub 2017 Feb 8. No abstract available.

14.

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Partridge KM, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland A, Gooding K, Harvey A, Hughes NE, Kuklish SL, Luz JG, Manninen PR, McGee JE, Mudra DR, Navarro A, Norman BH, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, Weller JM, York JS, Yu XP.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. doi: 10.1016/j.bmcl.2016.11.011. Epub 2016 Nov 7.

PMID:
28190634
15.

Acute mountain sickness amongst tourists to Lhasa.

Sikri G, Bhattachar S.

Arch Public Health. 2017 Jan 27;75:4. doi: 10.1186/s13690-016-0172-6. eCollection 2017.

16.

In Response to Risk Determinants of Acute Mountain Sickness by Lawrence and Reid.

Sikri G, Bhattachar S, Thapa B.

Wilderness Environ Med. 2017 Mar;28(1):57-58. doi: 10.1016/j.wem.2016.10.005. Epub 2016 Dec 6. No abstract available.

PMID:
27939594
17.

Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial.

Yanamandra U, Nair V, Singh S, Gupta A, Mulajkar D, Yanamandra S, Norgais K, Mukherjee R, Singh V, Bhattachar SA, Patyal S, Grewal R, Chopra B.

High Alt Med Biol. 2016 Dec;17(4):294-299. Epub 2016 Dec 1.

PMID:
27906598
18.

Altitude-induced pulmonary hypertension on one-day rapid ascent of Mount Fuji: incidence and therapeutic effects of sildenafil.

Bhattachar S, Sikri G, Thapa B.

Echocardiography. 2016 Sep;33(9):1441. doi: 10.1111/echo.13301. No abstract available.

PMID:
27677646
19.

Chemokines in High Altitude Pulmonary Edema.

Bhattachar S, Sikri G.

Indian J Clin Biochem. 2016 Oct;31(4):483-4. doi: 10.1007/s12291-016-0581-x. Epub 2016 May 27. No abstract available.

20.

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10.

PMID:
27554445
21.

ROCK2 and MYLK variants and high-altitude pulmonary edema.

Sikri G, Bhattachar S.

Appl Clin Genet. 2016 Aug 2;9:137-9. doi: 10.2147/TACG.S113924. eCollection 2016. No abstract available.

22.

Pulmonary Embolism in Young Natives of High Altitude.

Singhal S, Bhattachar SA, Paliwal V, Malhotra VK, Addya K, Kotwal A.

Heart Views. 2016 Apr-Jun;17(2):62-5. doi: 10.4103/1995-705X.185115.

23.

Acute mountain sickness and duration of pre-exposure to high altitude.

Sikri G, Bhattachar S.

Neuroreport. 2016 Sep 7;27(13):997. doi: 10.1097/WNR.0000000000000640. No abstract available.

PMID:
27483198
25.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP.

J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub 2015 Dec 18.

PMID:
26653180
26.

Is HAPO the exclusive diagnosis of pulmonary oedema at HA?

Singh SP, Chawla A, Bhattachar SA.

Med J Armed Forces India. 2013 Apr;69(2):201. doi: 10.1016/j.mjafi.2013.02.016. No abstract available.

27.
28.

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, Beidler D, Liimatta MB, Smith SE, Dudley DT, Sadagopan N, Bhattachar SN, Kesten SJ, Nomanbhoy TK, Cravatt BF, Ahn K.

ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.

29.

Weak bases and formation of a less soluble lauryl sulfate salt/complex in sodium lauryl sulfate (SLS) containing media.

Bhattachar SN, Risley DS, Werawatganone P, Aburub A.

Int J Pharm. 2011 Jun 30;412(1-2):95-8. doi: 10.1016/j.ijpharm.2011.04.018. Epub 2011 Apr 16.

PMID:
21527324
30.

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.

J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19.

31.

In silico prediction of ionization constants of drugs.

Lee PH, Ayyampalayam SN, Carreira LA, Shalaeva M, Bhattachar S, Coselmon R, Poole S, Gifford E, Lombardo F.

Mol Pharm. 2007 Jul-Aug;4(4):498-512. Epub 2007 Jul 13.

PMID:
17629304
32.

Automated approach to couple solubility with final pH and crystallinity for pharmaceutical discovery compounds.

Seadeek C, Ando H, Bhattachar SN, Heimbach T, Sonnenberg JL, Blackburn AC.

J Pharm Biomed Anal. 2007 Apr 11;43(5):1660-6. Epub 2007 Jan 5.

PMID:
17270379
33.

Solubility: it's not just for physical chemists.

Bhattachar SN, Deschenes LA, Wesley JA.

Drug Discov Today. 2006 Nov;11(21-22):1012-8. Epub 2006 Sep 26. Review.

PMID:
17055411
34.

Solubility measurement of polymorphic compounds via the pH-metric titration technique.

Fioritto AF, Bhattachar SN, Wesley JA.

Int J Pharm. 2007 Feb 7;330(1-2):105-13. Epub 2006 Sep 10.

PMID:
17049191
35.

The road map to oral bioavailability: an industrial perspective.

Thomas VH, Bhattachar S, Hitchingham L, Zocharski P, Naath M, Surendran N, Stoner CL, El-Kattan A.

Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):591-608. Review.

PMID:
16859407
36.

Increased dissolution rate and bioavailability through comicronization with microcrystalline cellulose.

Spence JK, Bhattachar SN, Wesley JA, Martin PJ, Babu SR.

Pharm Dev Technol. 2005;10(4):451-60.

PMID:
16370174
37.

Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery.

Bhattachar SN, Wesley JA, Seadeek C.

J Pharm Biomed Anal. 2006 Apr 11;41(1):152-7. Epub 2005 Dec 20.

PMID:
16364585
38.

Evaluation of the vibratory feeder method for assessment of powder flow properties.

Bhattachar SN, Hedden DB, Olsofsky AM, Qu X, Hsieh WY, Canter KG.

Int J Pharm. 2004 Jan 28;269(2):385-92.

PMID:
14706250
39.

Dissolution behavior of a poorly water soluble compound in the presence of Tween 80.

Chen LR, Wesley JA, Bhattachar S, Ruiz B, Bahash K, Babu SR.

Pharm Res. 2003 May;20(5):797-801.

PMID:
12751636
40.

Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus.

Bhattachar SN, Wesley JA, Fioritto A, Martin PJ, Babu SR.

Int J Pharm. 2002 Apr 2;236(1-2):135-43.

PMID:
11891077

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