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Items: 1 to 50 of 59

1.

Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism.

Zhang H, Basit A, Busch D, Yabut K, Bhatt DK, Drozdzik M, Ostrowski M, Li A, Collins C, Oswald S, Prasad B.

Biochem Pharmacol. 2018 Aug 4;156:32-42. doi: 10.1016/j.bcp.2018.08.003. [Epub ahead of print]

PMID:
30086285
2.

Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy.

Liao MZ, Gao C, Bhatt DK, Prasad B, Mao Q.

Drug Metab Lett. 2018 Jun 25. doi: 10.2174/1872312812666180625122810. [Epub ahead of print]

PMID:
29938623
3.

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice.

Li CY, Dempsey JL, Wang D, Lee S, Weigel KM, Fei Q, Bhatt DK, Prasad B, Raftery D, Gu H, Cui JY.

Drug Metab Dispos. 2018 Aug;46(8):1226-1240. doi: 10.1124/dmd.118.081547. Epub 2018 May 16.

PMID:
29769268
4.

Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.

Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B.

Clin Pharmacol Ther. 2018 May 8. doi: 10.1002/cpt.1109. [Epub ahead of print]

PMID:
29737521
5.

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.

Prasad B, Bhatt DK, Johnson K, Chapa R, Chu X, Salphati L, Xiao G, Lee C, Hop CECA, Mathias A, Lai Y, Liao M, Humphreys WG, Kumer SC, Unadkat JD.

Drug Metab Dispos. 2018 Jul;46(7):943-952. doi: 10.1124/dmd.118.080523. Epub 2018 Apr 25.

PMID:
29695616
6.

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B.

Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30.

PMID:
29602798
7.

Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation.

Liao MZ, Gao C, Phillips BR, Neradugomma NK, Han LW, Bhatt DK, Prasad B, Shen DD, Mao Q.

Drug Metab Dispos. 2018 Feb;46(2):100-108. doi: 10.1124/dmd.117.076745. Epub 2017 Nov 20.

PMID:
29158248
8.

Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers.

Li CY, Lee S, Cade S, Kuo LJ, Schultz IR, Bhatt DK, Prasad B, Bammler TK, Cui JY.

Drug Metab Dispos. 2017 Nov;45(11):1197-1214. doi: 10.1124/dmd.117.077024. Epub 2017 Sep 1.

PMID:
28864748
9.

Critical Issues and Optimized Practices in Quantification of Protein Abundance Level to Determine Interindividual Variability in DMET Proteins by LC-MS/MS Proteomics.

Bhatt DK, Prasad B.

Clin Pharmacol Ther. 2018 Apr;103(4):619-630. doi: 10.1002/cpt.819. Epub 2017 Sep 25. Review.

PMID:
28833066
10.

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.

PMID:
28819071
11.

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Sep;45(9):1044-1048. doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12.

PMID:
28607029
12.

Choroid plexus aquaporin 1 and intracranial pressure are increased in obese rats: towards an idiopathic intracranial hypertension model?

Uldall M, Bhatt DK, Kruuse C, Juhler M, Jansen-Olesen I, Jensen RH.

Int J Obes (Lond). 2017 Jul;41(7):1141-1147. doi: 10.1038/ijo.2017.83. Epub 2017 Mar 27.

PMID:
28344346
13.

The Promises of Quantitative Proteomics in Precision Medicine.

Prasad B, Vrana M, Mehrotra A, Johnson K, Bhatt DK.

J Pharm Sci. 2017 Mar;106(3):738-744. doi: 10.1016/j.xphs.2016.11.017. Epub 2016 Dec 8.

14.

Effect of PGD2 on middle meningeal artery and mRNA expression profile of L-PGD2 synthase and DP receptors in trigeminovascular system and other pain processing structures in rat brain.

Sekeroglu A, Jacobsen JM, Jansen-Olesen I, Gupta S, Sheykhzade M, Olesen J, Bhatt DK.

Pharmacol Rep. 2017 Feb;69(1):50-56. doi: 10.1016/j.pharep.2016.09.015. Epub 2016 Sep 19.

PMID:
27898338
15.

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B.

Drug Metab Dispos. 2017 Feb;45(2):216-223. doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28.

16.

CGRP infusion in unanesthetized rats increases expression of c-Fos in the nucleus tractus solitarius and caudal ventrolateral medulla, but not in the trigeminal nucleus caudalis.

Bhatt DK, Ramachandran R, Christensen SL, Gupta S, Jansen-Olesen I, Olesen J.

Cephalalgia. 2015 Mar;35(3):220-33. doi: 10.1177/0333102414535995. Epub 2014 Jun 3.

PMID:
24895375
17.

PACAP-38 infusion causes sustained vasodilation of the middle meningeal artery in the rat: possible involvement of mast cells.

Bhatt DK, Gupta S, Olesen J, Jansen-Olesen I.

Cephalalgia. 2014 Oct;34(11):877-86. doi: 10.1177/0333102414523846. Epub 2014 Feb 21.

PMID:
24563332
18.

Effect of treatment of cow's urine "Gomutra" and antioxidants in alleviating the lindane-induced oxidative stress in kidney of Swiss mice (Mus musculus).

Nagda G, Bhatt DK.

Mol Biol Rep. 2014;41(4):1967-76. doi: 10.1007/s11033-014-3044-6. Epub 2014 Jan 16.

PMID:
24430296
19.

Effect of pressure blanching on sensory and proximate composition of peanut milk.

Jain P, Yadav DN, Rajput H, Bhatt DK.

J Food Sci Technol. 2013 Jun;50(3):605-8. doi: 10.1007/s13197-011-0373-5. Epub 2011 Apr 19.

20.

mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC.

Bhatt DK, Gupta S, Ploug KB, Jansen-Olesen I, Olesen J.

Neurosci Lett. 2014 Jan 24;559:99-104. doi: 10.1016/j.neulet.2013.11.057. Epub 2013 Dec 7.

PMID:
24321404
21.

Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation.

Ramachandran R, Bhatt DK, Ploug KB, Hay-Schmidt A, Jansen-Olesen I, Gupta S, Olesen J.

Cephalalgia. 2014 Feb;34(2):136-47. doi: 10.1177/0333102413502735. Epub 2013 Sep 2.

PMID:
24000375
22.

NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models.

Bhatt DK, Gupta S, Jansen-Olesen I, Andrews JS, Olesen J.

Cephalalgia. 2013 Jan;33(2):87-100. doi: 10.1177/0333102412466967. Epub 2012 Nov 15.

PMID:
23155193
23.

Modulation of acid phosphatase and lactic dehydrogenase in hexachlorocyclohexane-induced hepatocarcinogenesis in mice.

Bhatt DK, Nagda G.

J Biochem Mol Toxicol. 2012 Nov;26(11):439-44. doi: 10.1002/jbt.21441. Epub 2012 Nov 6.

PMID:
23132770
24.

A naturalistic glyceryl trinitrate infusion migraine model in the rat.

Ramachandran R, Bhatt DK, Ploug KB, Olesen J, Jansen-Olesen I, Hay-Schmidt A, Gupta S.

Cephalalgia. 2012 Jan;32(1):73-84. doi: 10.1177/0333102411430855. Epub 2011 Dec 15.

PMID:
22174360
27.

Inhibition of lindane-induced toxicity using alpha-lipoic acid and vitamin E in the brain of Mus musculus.

Bist R, Misra S, Bhatt DK.

Protoplasma. 2010 Jun;242(1-4):49-53. doi: 10.1007/s00709-010-0121-0. Epub 2010 May 20.

PMID:
20490610
28.

Activation of PAR-2 elicits NO-dependent and CGRP-independent dilation of the dural artery.

Bhatt DK, Ploug KB, Ramachandran R, Olesen J, Gupta S.

Headache. 2010 Jun;50(6):1017-30. doi: 10.1111/j.1526-4610.2010.01679.x. Epub 2010 May 7.

PMID:
20487037
30.

Improvement of the closed cranial window model in rats by intracarotid infusion of signalling molecules implicated in migraine.

Gupta S, Bhatt DK, Boni LJ, Olesen J.

Cephalalgia. 2010 Jan;30(1):27-36. doi: 10.1111/j.1468-2982.2009.01888.x. Erratum in: Cephalalgia. 2010 Jun;30(6):768.

PMID:
19438925
31.

Modulation of tricarboxylic acid cycle dehydrogenases during hepatocarcinogenesis induced by hexachlorocyclohexane in mice.

Bhatt DK, Bano M.

Exp Toxicol Pathol. 2009 Jul;61(4):325-32. doi: 10.1016/j.etp.2008.09.004. Epub 2008 Oct 31.

PMID:
18951770
32.
33.

Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats.

Tikoo K, Bhatt DK, Gaikwad AB, Sharma V, Kabra DG.

FEBS Lett. 2007 May 15;581(10):2027-35. Epub 2007 Apr 24.

34.

PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral.

Italia JL, Bhatt DK, Bhardwaj V, Tikoo K, Kumar MN.

J Control Release. 2007 Jun 4;119(2):197-206. Epub 2007 Feb 14.

PMID:
17399839
35.
36.
37.

Dominant-lethal study of technical-grade hexachlorocyclohexane in Swiss mice.

Lakkad BC, Nigam SK, Karnik AB, Thakore KN, Aravinda Babu K, Bhatt DK, Kashyap SK.

Mutat Res. 1982 Jun;101(4):315-20.

PMID:
6180316
38.

Distribution of 5'-nucleotidase during hepatocarcinogenesis induced by hexachlorocyclohexane in Swiss mice.

Bhatt DK, Nigam SK, Lakkad BC, Aravinda Babu KA, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK.

Indian J Exp Biol. 1981 Dec;19(12):1159-62. No abstract available.

PMID:
6174432
39.

Pattern of glycogen and iron accumulation in early appearing BHC induced liver lesions and liver tumours.

Nigam SK, Babu KA, Bhatt DK, Karnik AB, Thakore KN, Lakkad BC, Kashyap SK, Chatterjee SK.

Indian J Med Res. 1981 Aug;74:289-96. No abstract available.

PMID:
6171515
40.

Distribution of cyclic 3',5'-phosphodiesterase, monoamine oxidase & beta-glucuronidase in liver tumours induced by technical grade hexachlorocyclohexane in inbred swiss mice.

Bhatt DK, Nigam SK, Lakkad BC, Aravinda Babu K, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK.

Indian J Exp Biol. 1981 Jul;19(7):625-9. No abstract available.

PMID:
6171510
41.

Histochemical changes in ATPase distribution during hexachlorocyclohexane induced hepatocarcinogenesis in inbred Swiss mice.

Bhatt DK, Nigam SK, Aravinda Babu K, Lakkad BC, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK.

Indian J Exp Biol. 1981 Jul;19(7):621-4. No abstract available.

PMID:
6171509
42.
43.

Effect of hexachlorocyclohexane on somatic and meiotic divisions in male Swiss mice.

Babu KA, Nigam SK, Lakkad BC, Bhatt DK, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK.

Bull Environ Contam Toxicol. 1981 Apr;26(4):508-12. No abstract available.

PMID:
6165419
45.
46.

Sequential histochemical changes in the distribution of alkaline phosphatase in the hexachlorocyclohexane (HCCH) induced liver tumours in pure inbred Swiss mice.

Bhatt DK, Nigam Sk, Lakkad BC, Babu KA, Karnik AB, Thakore KN, Kashyap SK.

Cell Mol Biol Incl Cyto Enzymol. 1981;27(2-3):231-8. No abstract available.

PMID:
6170435
47.

Experimental studies on insecticides commonly used in India.

Nigam SK, Bhatt DK, Karnik AB, Thakore KN, Aravinda Babu K, Lakkad BC, Kashyap SK, Chatterjee SK.

J Cancer Res Clin Oncol. 1981;99(1-2):143-52.

PMID:
6166613
48.

Early changes in serum protein and liver LDH isoenzymes in mice exposed to technical grade hexachlorocyclohexane (BHC) and their possible relationship to liver tumours.

Thakore KN, Nigam SK, Karnik AB, Lakkad BC, Bhatt DK, Babu KA, Kashyap SK, Chatterjee SK.

Toxicology. 1981;19(1):31-7.

PMID:
6164129
49.

Distribution of ATPase & 5-nucleotidase in deep cerebellar nuclei & layers of cerebellum of the squirrel Funambulus palmarum.

Tewari HB, Bhatt DK.

Indian J Exp Biol. 1980 Oct;18(10):1131-5. No abstract available.

PMID:
6260630
50.

In vitro cytological and cytogenetic effects of an Indian variety of chrysotile asbestos.

Babu KA, Lakkad BC, Nigam SK, Bhatt DK, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK.

Environ Res. 1980 Apr;21(2):416-22. No abstract available.

PMID:
7408813

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