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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.

Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M.

Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28.


Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.

Kato N, March S, Bhatia SN, Marti M.

Methods Mol Biol. 2018;1787:41-52. doi: 10.1007/978-1-4939-7847-2_3.


A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19.


In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN.

Cell Host Microbe. 2018 Mar 14;23(3):395-406.e4. doi: 10.1016/j.chom.2018.01.002. Epub 2018 Feb 22.


Personalized RNA Medicine for Pancreatic Cancer.

Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ.

Clin Cancer Res. 2018 Apr 1;24(7):1734-1747. doi: 10.1158/1078-0432.CCR-17-2733. Epub 2018 Jan 12.


Engineered Livers for Infectious Diseases.

Gural N, Mancio-Silva L, He J, Bhatia SN.

Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(2):131-144. doi: 10.1016/j.jcmgh.2017.11.005. eCollection 2018. Review.


Depolarization signatures map gold nanorods within biological tissue.

Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE.

Nat Photonics. 2017;11:583-588. doi: 10.1038/nphoton.2017.128. Epub 2017 Jul 31.


A robust cell culture system supporting the complete life cycle of hepatitis B virus.

Michailidis E, Pabon J, Xiang K, Park P, Ramanan V, Hoffmann HH, Schneider WM, Bhatia SN, de Jong YP, Shlomai A, Rice CM.

Sci Rep. 2017 Nov 30;7(1):16616. doi: 10.1038/s41598-017-16882-5.


Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas.

Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM.

Sci Rep. 2017 Oct 10;7(1):12922. doi: 10.1038/s41598-017-13032-9.


Ultrasensitive tumour-penetrating nanosensors of protease activity.

Kwon EJ, Dudani JS, Bhatia SN.

Nat Biomed Eng. 2017;1. pii: 0054. doi: 10.1038/s41551-017-0054. Epub 2017 Apr 10.


Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R.

Science. 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043.


In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.

Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaah5505. doi: 10.1126/scitranslmed.aah5505.


Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.

Kwon EJ, Skalak M, Bertucci A, Braun G, Ricci F, Ruoslahti E, Sailor MJ, Bhatia SN.

Adv Mater. 2017 Sep;29(35). doi: 10.1002/adma.201701527. Epub 2017 Jul 12.


Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.

Ng S, March S, Galstian A, Gural N, Stevens KR, Mota MM, Bhatia SN.

Sci Rep. 2017 Mar 31;7:45424. doi: 10.1038/srep45424.


Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL.

Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7.


Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes.

Lo JH, Kwon EJ, Zhang AQ, Singhal P, Bhatia SN.

Bioconjug Chem. 2016 Oct 19;27(10):2323-2331. Epub 2016 Sep 16.


High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.

Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN.

J Biomol Screen. 2016 Oct;21(9):897-911. doi: 10.1177/1087057116660277. Epub 2016 Aug 4.


Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Schuerle S, Dudani JS, Christiansen MG, Anikeeva P, Bhatia SN.

Nano Lett. 2016 Oct 12;16(10):6303-6310. Epub 2016 Sep 13.


Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Joo J, Kwon EJ, Kang J, Skalak M, Anglin EJ, Mann AP, Ruoslahti E, Bhatia SN, Sailor MJ.

Nanoscale Horiz. 2016 Sep 1;1(5):407-414. doi: 10.1039/C6NH00082G. Epub 2016 Jun 14.


Host AMPK Is a Modulator of Plasmodium Liver Infection.

Ruivo MTG, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L.

Cell Rep. 2016 Sep 6;16(10):2539-2545. doi: 10.1016/j.celrep.2016.08.001. Epub 2016 Aug 25.


Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Jain PK, Ramanan V, Schepers AG, Dalvie NS, Panda A, Fleming HE, Bhatia SN.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12440-4. doi: 10.1002/anie.201606123. Epub 2016 Aug 24.


Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT.

Int J Parasitol. 2016 Oct;46(11):679-83. doi: 10.1016/j.ijpara.2016.06.003. Epub 2016 Jul 25.


Synchronized cycles of bacterial lysis for in vivo delivery.

Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J.

Nature. 2016 Aug 4;536(7614):81-85. doi: 10.1038/nature18930. Epub 2016 Jul 20.


Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

Kwon EJ, Skalak M, Lo Bu R, Bhatia SN.

ACS Nano. 2016 Aug 23;10(8):7926-33. doi: 10.1021/acsnano.6b03858. Epub 2016 Jul 21.


Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She ZG, Ruoslahti E, Bhatia SN, Sailor MJ.

Adv Mater. 2016 Sep;28(36):7962-7969. doi: 10.1002/adma.201600634. Epub 2016 Jul 6.


Extracellular matrix in oral squamous cell carcinoma: Friend or foe?

Patankar SR, Wankhedkar DP, Tripathi NS, Bhatia SN, Sridharan G.

Indian J Dent Res. 2016 Mar-Apr;27(2):184-9. doi: 10.4103/0970-9290.183125.


Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

Dudani JS, Buss CG, Akana RTK, Kwong GA, Bhatia SN.

Adv Funct Mater. 2016 May 3;26(17):2919-2928. doi: 10.1002/adfm.201505142. Epub 2016 Mar 22.


Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.


Association between days to complete inpatient discharge summaries with all-payer hospital readmissions in Maryland.

Hoyer EH, Odonkor CA, Bhatia SN, Leung C, Deutschendorf A, Brotman DJ.

J Hosp Med. 2016 Jun;11(6):393-400. doi: 10.1002/jhm.2556. Epub 2016 Feb 23.


Extracellular matrix microarrays to study inductive signaling for endoderm specification.

Malta DFB, Reticker-Flynn NE, da Silva CL, Cabral JMS, Fleming HE, Zaret KS, Bhatia SN, Underhill GH.

Acta Biomater. 2016 Apr 1;34:30-40. doi: 10.1016/j.actbio.2016.02.014. Epub 2016 Feb 12.


Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Logan DJ, Shan J, Bhatia SN, Carpenter AE.

Methods. 2016 Mar 1;96:6-11. doi: 10.1016/j.ymeth.2015.12.002. Epub 2015 Dec 11.


Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Kwon EJ, Lo JH, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14460-6. doi: 10.1073/pnas.1508522112. Epub 2015 Nov 23. Review.


Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN.

Nat Protoc. 2015 Dec;10(12):2027-53. doi: 10.1038/nprot.2015.128. Epub 2015 Nov 19.


Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

Dudani JS, Jain PK, Kwong GA, Stevens KR, Bhatia SN.

ACS Nano. 2015 Dec 22;9(12):11708-17. doi: 10.1021/acsnano.5b05946. Epub 2015 Nov 13.


Mathematical framework for activity-based cancer biomarkers.

Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat SM, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12627-32. doi: 10.1073/pnas.1506925112. Epub 2015 Sep 28.


A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.


Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN.

Cancer Res. 2015 Aug 15;75(16):3255-67. doi: 10.1158/0008-5472.CAN-15-0325. Epub 2015 Jun 29.


CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.

Ramanan V, Shlomai A, Cox DB, Schwartz RE, Michailidis E, Bhatta A, Scott DA, Zhang F, Rice CM, Bhatia SN.

Sci Rep. 2015 Jun 2;5:10833. doi: 10.1038/srep10833.


Programmable probiotics for detection of cancer in urine.

Danino T, Prindle A, Kwong GA, Skalak M, Li H, Allen K, Hasty J, Bhatia SN.

Sci Transl Med. 2015 May 27;7(289):289ra84. doi: 10.1126/scitranslmed.aaa3519.


New Methods in Tissue Engineering: Improved Models for Viral Infection.

Ramanan V, Scull MA, Sheahan TP, Rice CM, Bhatia SN.

Annu Rev Virol. 2014 Nov;1:475-499. doi: 10.1146/annurev-virology-031413-085437.


Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.

Stevens KR, Miller JS, Blakely BL, Chen CS, Bhatia SN.

J Biomed Mater Res A. 2015 Oct;103(10):3331-8. doi: 10.1002/jbm.a.35478. Epub 2015 Apr 30.


Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro.

Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN.

Stem Cell Reports. 2015 Mar 10;4(3):348-59. doi: 10.1016/j.stemcr.2015.01.002. Epub 2015 Feb 7.


Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection.

Itoe MA, Sampaio JL, Cabal GG, Real E, Zuzarte-Luis V, March S, Bhatia SN, Frischknecht F, Thiele C, Shevchenko A, Mota MM.

Cell Host Microbe. 2014 Dec 10;16(6):778-86. doi: 10.1016/j.chom.2014.11.006.


Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.

Reticker-Flynn NE, Bhatia SN.

Cancer Discov. 2015 Feb;5(2):168-81. doi: 10.1158/2159-8290.CD-13-0760. Epub 2014 Nov 24.


In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.

Hanson KK, March S, Ng S, Bhatia SN, Mota MM.

Eukaryot Cell. 2015 Jan;14(1):96-103. doi: 10.1128/EC.00166-14. Epub 2014 Nov 21.


Patterning vascular networks in vivo for tissue engineering applications.

Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS.

Tissue Eng Part C Methods. 2015 May;21(5):509-17. doi: 10.1089/ten.TEC.2014.0258. Epub 2015 Feb 18.


Drug-induced amplification of nanoparticle targeting to tumors.

Lin KY, Kwon EJ, Lo JH, Bhatia SN.

Nano Today. 2014 Oct;9(5):550-559. doi: 10.1016/j.nantod.2014.09.001. Epub 2014 Sep 23.


Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.

Ghosh D, Bagley AF, Na YJ, Birrer MJ, Bhatia SN, Belcher AM.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13948-53. doi: 10.1073/pnas.1400821111. Epub 2014 Sep 11.


Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

Warren AD, Gaylord ST, Ngan KC, Dumont Milutinovic M, Kwong GA, Bhatia SN, Walt DR.

J Am Chem Soc. 2014 Oct 1;136(39):13709-14. doi: 10.1021/ja505676h. Epub 2014 Sep 23.


Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.

Lin KY, Lo JH, Consul N, Kwong GA, Bhatia SN.

ACS Nano. 2014 Sep 23;8(9):8776-85. doi: 10.1021/nn501129q. Epub 2014 Aug 19.

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