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Items: 1 to 50 of 202

1.

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer.

Gilles ME, Hao L, Brown K, Lim J, Bhatia SN, Slack FJ.

Oncotarget. 2019 Sep 3;10(51):5349-5358. doi: 10.18632/oncotarget.27160. eCollection 2019 Sep 3.

2.

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring.

Loynachan CN, Soleimany AP, Dudani JS, Lin Y, Najer A, Bekdemir A, Chen Q, Bhatia SN, Stevens MM.

Nat Nanotechnol. 2019 Sep;14(9):883-890. doi: 10.1038/s41565-019-0527-6. Epub 2019 Sep 2.

PMID:
31477801
3.

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Camarda G, Jirawatcharadech P, Priestley RS, Saif A, March S, Wong MHL, Leung S, Miller AB, Baker DA, Alano P, Paine MJI, Bhatia SN, O'Neill PM, Ward SA, Biagini GA.

Nat Commun. 2019 Jul 19;10(1):3226. doi: 10.1038/s41467-019-11239-0.

4.

Synthetic and living micropropellers for convection-enhanced nanoparticle transport.

Schuerle S, Soleimany AP, Yeh T, Anand GM, Häberli M, Fleming HE, Mirkhani N, Qiu F, Hauert S, Wang X, Nelson BJ, Bhatia SN.

Sci Adv. 2019 Apr 26;5(4):eaav4803. doi: 10.1126/sciadv.aav4803. eCollection 2019 Apr.

5.

Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.

Werling K, Shaw WR, Itoe MA, Westervelt KA, Marcenac P, Paton DG, Peng D, Singh N, Smidler AL, South A, Deik AA, Mancio-Silva L, Demas AR, March S, Calvo E, Bhatia SN, Clish CB, Catteruccia F.

Cell. 2019 Apr 4;177(2):315-325.e14. doi: 10.1016/j.cell.2019.02.036. Epub 2019 Mar 28.

PMID:
30929905
6.

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

Mancio-Silva L, Fleming HE, Miller AB, Milstein S, Liebow A, Haslett P, Sepp-Lorenzino L, Bhatia SN.

Cell Metab. 2019 Mar 5;29(3):727-735.e3. doi: 10.1016/j.cmet.2019.02.003.

7.

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB.

Cancer Res. 2019 Apr 15;79(8):1952-1966. doi: 10.1158/0008-5472.CAN-18-1604. Epub 2019 Feb 12.

PMID:
30755444
8.

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W.

Gastroenterology. 2019 May;156(6):1788-1804.e13. doi: 10.1053/j.gastro.2019.01.010. Epub 2019 Jan 12.

9.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2019 Jan;25(1):188-189. doi: 10.1038/s41591-018-0315-0.

PMID:
30552419
10.

Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.

Buss CG, Dudani JS, Akana RTK, Fleming HE, Bhatia SN.

EBioMedicine. 2018 Dec;38:248-256. doi: 10.1016/j.ebiom.2018.11.031. Epub 2018 Nov 29.

11.

A Plasmodium berghei sporozoite-based vaccination platform against human malaria.

Mendes AM, Machado M, Gonçalves-Rosa N, Reuling IJ, Foquet L, Marques C, Salman AM, Yang ASP, Moser KA, Dwivedi A, Hermsen CC, Jiménez-Díaz B, Viera S, Santos JM, Albuquerque I, Bhatia SN, Bial J, Angulo-Barturen I, Silva JC, Leroux-Roels G, Janse CJ, Khan SM, Mota MM, Sauerwein RW, Prudêncio M.

NPJ Vaccines. 2018 Aug 24;3:33. doi: 10.1038/s41541-018-0068-2. eCollection 2018.

12.

Classification of prostate cancer using a protease activity nanosensor library.

Dudani JS, Ibrahim M, Kirkpatrick J, Warren AD, Bhatia SN.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8954-8959. doi: 10.1073/pnas.1805337115. Epub 2018 Aug 20.

13.

iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer.

Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN.

Mol Cancer Ther. 2018 Nov;17(11):2377-2388. doi: 10.1158/1535-7163.MCT-17-1090. Epub 2018 Aug 10.

PMID:
30097486
14.

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.

Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M.

Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28.

15.

Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.

Kato N, March S, Bhatia SN, Marti M.

Methods Mol Biol. 2018;1787:41-52. doi: 10.1007/978-1-4939-7847-2_3.

PMID:
29736708
16.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19. Erratum in: Nat Med. 2019 Jan;25(1):188-189.

17.

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN.

Cell Host Microbe. 2018 Mar 14;23(3):395-406.e4. doi: 10.1016/j.chom.2018.01.002. Epub 2018 Feb 22.

18.

Personalized RNA Medicine for Pancreatic Cancer.

Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ.

Clin Cancer Res. 2018 Apr 1;24(7):1734-1747. doi: 10.1158/1078-0432.CCR-17-2733. Epub 2018 Jan 12.

19.

Engineered Livers for Infectious Diseases.

Gural N, Mancio-Silva L, He J, Bhatia SN.

Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(2):131-144. doi: 10.1016/j.jcmgh.2017.11.005. eCollection 2018. Review.

20.

Depolarization signatures map gold nanorods within biological tissue.

Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE.

Nat Photonics. 2017;11:583-588. doi: 10.1038/nphoton.2017.128. Epub 2017 Jul 31.

21.

A robust cell culture system supporting the complete life cycle of hepatitis B virus.

Michailidis E, Pabon J, Xiang K, Park P, Ramanan V, Hoffmann HH, Schneider WM, Bhatia SN, de Jong YP, Shlomai A, Rice CM.

Sci Rep. 2017 Nov 30;7(1):16616. doi: 10.1038/s41598-017-16882-5.

22.

Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas.

Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM.

Sci Rep. 2017 Oct 10;7(1):12922. doi: 10.1038/s41598-017-13032-9.

23.

Ultrasensitive tumour-penetrating nanosensors of protease activity.

Kwon EJ, Dudani JS, Bhatia SN.

Nat Biomed Eng. 2017;1. pii: 0054. doi: 10.1038/s41551-017-0054. Epub 2017 Apr 10.

24.

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R.

Science. 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043.

25.

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.

Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaah5505. doi: 10.1126/scitranslmed.aah5505.

26.

Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.

Kwon EJ, Skalak M, Bertucci A, Braun G, Ricci F, Ruoslahti E, Sailor MJ, Bhatia SN.

Adv Mater. 2017 Sep;29(35). doi: 10.1002/adma.201701527. Epub 2017 Jul 12.

27.

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.

Ng S, March S, Galstian A, Gural N, Stevens KR, Mota MM, Bhatia SN.

Sci Rep. 2017 Mar 31;7:45424. doi: 10.1038/srep45424.

28.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL.

Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7.

29.

Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes.

Lo JH, Kwon EJ, Zhang AQ, Singhal P, Bhatia SN.

Bioconjug Chem. 2016 Oct 19;27(10):2323-2331. Epub 2016 Sep 16.

30.

High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.

Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN.

J Biomol Screen. 2016 Oct;21(9):897-911. doi: 10.1177/1087057116660277. Epub 2016 Aug 4.

31.

Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Schuerle S, Dudani JS, Christiansen MG, Anikeeva P, Bhatia SN.

Nano Lett. 2016 Oct 12;16(10):6303-6310. Epub 2016 Sep 13.

32.

Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Joo J, Kwon EJ, Kang J, Skalak M, Anglin EJ, Mann AP, Ruoslahti E, Bhatia SN, Sailor MJ.

Nanoscale Horiz. 2016 Sep 1;1(5):407-414. doi: 10.1039/C6NH00082G. Epub 2016 Jun 14.

33.

Host AMPK Is a Modulator of Plasmodium Liver Infection.

Ruivo MTG, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L.

Cell Rep. 2016 Sep 6;16(10):2539-2545. doi: 10.1016/j.celrep.2016.08.001. Epub 2016 Aug 25.

34.

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Jain PK, Ramanan V, Schepers AG, Dalvie NS, Panda A, Fleming HE, Bhatia SN.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12440-4. doi: 10.1002/anie.201606123. Epub 2016 Aug 24.

35.

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT.

Int J Parasitol. 2016 Oct;46(11):679-83. doi: 10.1016/j.ijpara.2016.06.003. Epub 2016 Jul 25.

36.

Synchronized cycles of bacterial lysis for in vivo delivery.

Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J.

Nature. 2016 Aug 4;536(7614):81-85. doi: 10.1038/nature18930. Epub 2016 Jul 20.

37.

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

Kwon EJ, Skalak M, Lo Bu R, Bhatia SN.

ACS Nano. 2016 Aug 23;10(8):7926-33. doi: 10.1021/acsnano.6b03858. Epub 2016 Jul 21.

38.

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She ZG, Ruoslahti E, Bhatia SN, Sailor MJ.

Adv Mater. 2016 Sep;28(36):7962-7969. doi: 10.1002/adma.201600634. Epub 2016 Jul 6.

39.

Extracellular matrix in oral squamous cell carcinoma: Friend or foe?

Patankar SR, Wankhedkar DP, Tripathi NS, Bhatia SN, Sridharan G.

Indian J Dent Res. 2016 Mar-Apr;27(2):184-9. doi: 10.4103/0970-9290.183125.

40.

Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

Dudani JS, Buss CG, Akana RTK, Kwong GA, Bhatia SN.

Adv Funct Mater. 2016 May 3;26(17):2919-2928. doi: 10.1002/adfm.201505142. Epub 2016 Mar 22.

41.

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.

42.

Association between days to complete inpatient discharge summaries with all-payer hospital readmissions in Maryland.

Hoyer EH, Odonkor CA, Bhatia SN, Leung C, Deutschendorf A, Brotman DJ.

J Hosp Med. 2016 Jun;11(6):393-400. doi: 10.1002/jhm.2556. Epub 2016 Feb 23.

PMID:
26913814
43.

Extracellular matrix microarrays to study inductive signaling for endoderm specification.

Malta DFB, Reticker-Flynn NE, da Silva CL, Cabral JMS, Fleming HE, Zaret KS, Bhatia SN, Underhill GH.

Acta Biomater. 2016 Apr 1;34:30-40. doi: 10.1016/j.actbio.2016.02.014. Epub 2016 Feb 12.

44.

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Logan DJ, Shan J, Bhatia SN, Carpenter AE.

Methods. 2016 Mar 1;96:6-11. doi: 10.1016/j.ymeth.2015.12.002. Epub 2015 Dec 11.

45.

Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Kwon EJ, Lo JH, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14460-6. doi: 10.1073/pnas.1508522112. Epub 2015 Nov 23. Review.

46.

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN.

Nat Protoc. 2015 Dec;10(12):2027-53. doi: 10.1038/nprot.2015.128. Epub 2015 Nov 19.

47.

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

Dudani JS, Jain PK, Kwong GA, Stevens KR, Bhatia SN.

ACS Nano. 2015 Dec 22;9(12):11708-17. doi: 10.1021/acsnano.5b05946. Epub 2015 Nov 13.

48.

Mathematical framework for activity-based cancer biomarkers.

Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat SM, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12627-32. doi: 10.1073/pnas.1506925112. Epub 2015 Sep 28.

49.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.

50.

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN.

Cancer Res. 2015 Aug 15;75(16):3255-67. doi: 10.1158/0008-5472.CAN-15-0325. Epub 2015 Jun 29.

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