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Items: 10


Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus.

Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters JM, Schmidt N, Pelton JG, Gross CA, Meiler J, DeGrado WF.

J Am Chem Soc. 2018 Jun 20;140(24):7471-7485. doi: 10.1021/jacs.7b09670. Epub 2018 Jun 9.


Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel.

Xu Y, Bhate MP, McDermott AE.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8788-8793. doi: 10.1073/pnas.1701330114. Epub 2017 Aug 2.


Signal transduction in histidine kinases: insights from new structures.

Bhate MP, Molnar KS, Goulian M, DeGrado WF.

Structure. 2015 Jun 2;23(6):981-94. doi: 10.1016/j.str.2015.04.002. Epub 2015 May 14. Review.


De novo design of a transmembrane Zn²⁺-transporting four-helix bundle.

Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF.

Science. 2014 Dec 19;346(6216):1520-4. doi: 10.1126/science.1261172.


Transmembrane allosteric coupling of the gates in a potassium channel.

Wylie BJ, Bhate MP, McDermott AE.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):185-90. doi: 10.1073/pnas.1319577110. Epub 2013 Dec 16.


Preparation of uniformly isotope labeled KcsA for solid state NMR: expression, purification, reconstitution into liposomes and functional assay.

Bhate MP, Wylie BJ, Thompson A, Tian L, Nimigean C, McDermott AE.

Protein Expr Purif. 2013 Oct;91(2):119-24. doi: 10.1016/j.pep.2013.07.013. Epub 2013 Aug 1.


Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.

Yamada T, Bhate MP, Strange K.

Biophys J. 2013 May 7;104(9):1893-904. doi: 10.1016/j.bpj.2013.03.026.


Protonation state of E71 in KcsA and its role for channel collapse and inactivation.

Bhate MP, McDermott AE.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15265-70. Epub 2012 Aug 31.


Conformational dynamics in the selectivity filter of KcsA in response to potassium ion concentration.

Bhate MP, Wylie BJ, Tian L, McDermott AE.

J Mol Biol. 2010 Aug 13;401(2):155-66. doi: 10.1016/j.jmb.2010.06.031. Epub 2010 Jun 19.


Solvation and hydrogen bonding in alanine- and glycine-containing dipeptides probed using solution- and solid-state NMR spectroscopy.

Bhate MP, Woodard JC, Mehta MA.

J Am Chem Soc. 2009 Jul 15;131(27):9579-89. doi: 10.1021/ja902917s.


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