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Items: 16


Promiscuous terpene synthases from Prunella vulgaris highlight the importance of substrate and compartment switching in terpene synthase evolution.

Johnson SR, Bhat WW, Sadre R, Miller GP, Garcia AS, Hamberger B.

New Phytol. 2019 Jul;223(1):323-335. doi: 10.1111/nph.15778. Epub 2019 Apr 8.


A chromosomal-scale genome assembly of Tectona grandis reveals the importance of tandem gene duplication and enables discovery of genes in natural product biosynthetic pathways.

Zhao D, Hamilton JP, Bhat WW, Johnson SR, Godden GT, Kinser TJ, Boachon B, Dudareva N, Soltis DE, Soltis PS, Hamberger B, Buell CR.

Gigascience. 2019 Mar 1;8(3). pii: giz005. doi: 10.1093/gigascience/giz005.


A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae).

Johnson SR, Bhat WW, Bibik J, Turmo A, Hamberger B; Evolutionary Mint Genomics Consortium, Hamberger B.

J Biol Chem. 2019 Jan 25;294(4):1349-1362. doi: 10.1074/jbc.RA118.006025. Epub 2018 Nov 29.


Functional Promiscuity of Two Divergent Paralogs of Type III Plant Polyketide Synthases.

Pandith SA, Dhar N, Rana S, Bhat WW, Kushwaha M, Gupta AP, Shah MA, Vishwakarma R, Lattoo SK.

Plant Physiol. 2016 Aug;171(4):2599-619. doi: 10.1104/pp.16.00003. Epub 2016 Jun 7.


A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering.

Dhar N, Razdan S, Rana S, Bhat WW, Vishwakarma R, Lattoo SK.

Front Plant Sci. 2015 Nov 27;6:1031. doi: 10.3389/fpls.2015.01031. eCollection 2015. Review.


Therapeutic effects of R8, a semi-synthetic analogue of Vasicine, on murine model of allergic airway inflammation via STAT6 inhibition.

Rayees S, Mabalirajan U, Bhat WW, Rasool S, Rather RA, Panda L, Satti NK, Lattoo SK, Ghosh B, Singh G.

Int Immunopharmacol. 2015 May;26(1):246-56. doi: 10.1016/j.intimp.2015.03.035. Epub 2015 Apr 8.


Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations.

Rana S, Bhat WW, Dhar N, Pandith SA, Razdan S, Vishwakarma R, Lattoo SK.

BMC Biotechnol. 2014 Nov 23;14:89. doi: 10.1186/s12896-014-0089-5.


A phenylalanine ammonia-lyase ortholog (PkPAL1) from Picrorhiza kurrooa Royle ex. Benth: molecular cloning, promoter analysis and response to biotic and abiotic elicitors.

Bhat WW, Razdan S, Rana S, Dhar N, Wani TA, Qazi P, Vishwakarma R, Lattoo SK.

Gene. 2014 Sep 1;547(2):245-56. doi: 10.1016/j.gene.2014.06.046. Epub 2014 Jun 27.


Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal.

Dhar N, Rana S, Razdan S, Bhat WW, Hussain A, Dhar RS, Vaishnavi S, Hamid A, Vishwakarma R, Lattoo SK.

J Biol Chem. 2014 Jun 13;289(24):17249-67. doi: 10.1074/jbc.M114.571919. Epub 2014 Apr 25.


An inducible NADPH-cytochrome P450 reductase from Picrorhiza kurrooa - an imperative redox partner of cytochrome P450 enzymes.

Bhat WW, Rana S, Dhar N, Razdan S, Pandith SA, Vishwakarma R, Lattoo SK.

Funct Integr Genomics. 2014 Jun;14(2):381-99. doi: 10.1007/s10142-014-0362-7. Epub 2014 Feb 13.


Dynamics of withanolide biosynthesis in relation to temporal expression pattern of metabolic genes in Withania somnifera (L.) Dunal: a comparative study in two morpho-chemovariants.

Dhar N, Rana S, Bhat WW, Razdan S, Pandith SA, Khan S, Dutt P, Dhar RS, Vaishnavi S, Vishwakarma R, Lattoo SK.

Mol Biol Rep. 2013 Dec;40(12):7007-16. doi: 10.1007/s11033-013-2820-z. Epub 2013 Nov 5.


Molecular characterization of UGT94F2 and UGT86C4, two glycosyltransferases from Picrorhiza kurrooa: comparative structural insight and evaluation of substrate recognition.

Bhat WW, Dhar N, Razdan S, Rana S, Mehra R, Nargotra A, Dhar RS, Ashraf N, Vishwakarma R, Lattoo SK.

PLoS One. 2013 Sep 16;8(9):e73804. doi: 10.1371/journal.pone.0073804. eCollection 2013.


Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.

Pathania AS, Joshi A, Kumar S, Guru SK, Bhushan S, Sharma PR, Bhat WW, Saxena AK, Singh J, Shah BA, Andotra SS, Taneja SC, Malik FA, Kumar A.

Apoptosis. 2013 Dec;18(12):1561-73. doi: 10.1007/s10495-013-0889-4.


NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal.

Rana S, Lattoo SK, Dhar N, Razdan S, Bhat WW, Dhar RS, Vishwakarma R.

PLoS One. 2013;8(2):e57068. doi: 10.1371/journal.pone.0057068. Epub 2013 Feb 21.


Molecular characterization and promoter analysis of squalene epoxidase gene from Withania somnifera (L.) Dunal.

Razdan S, Bhat WW, Rana S, Dhar N, Lattoo SK, Dhar RS, Vishwakarma RA.

Mol Biol Rep. 2013 Feb;40(2):905-16. doi: 10.1007/s11033-012-2131-9. Epub 2012 Oct 13.


Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal.

Bhat WW, Lattoo SK, Razdan S, Dhar N, Rana S, Dhar RS, Khan S, Vishwakarma RA.

Gene. 2012 May 10;499(1):25-36. doi: 10.1016/j.gene.2012.03.004. Epub 2012 Mar 9.


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