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Items: 1 to 50 of 112

1.

Switch hitter: Bcl11b in T cells and ILC2s.

Harly C, Bhandoola A.

J Exp Med. 2020 Jan 6;217(1). pii: e20191739. doi: 10.1084/jem.20191739.

PMID:
31828302
2.

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.

Ghaedi M, Shen ZY, Orangi M, Martinez-Gonzalez I, Wei L, Lu X, Das A, Heravi-Moussavi A, Marra MA, Bhandoola A, Takei F.

J Exp Med. 2020 Mar 2;217(3). pii: e20182293. doi: 10.1084/jem.20182293.

PMID:
31816636
3.

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth.

Cowan JE, Malin J, Zhao Y, Seedhom MO, Harly C, Ohigashi I, Kelly M, Takahama Y, Yewdell JW, Cam M, Bhandoola A.

Nat Commun. 2019 Dec 2;10(1):5498. doi: 10.1038/s41467-019-13465-y.

4.

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y.

Science. 2019 Oct 25;366(6464). pii: eaax6624. doi: 10.1126/science.aax6624.

PMID:
31649166
5.

Response to Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells".

Larsen BM, Cowan JE, Bhandoola A.

J Immunol. 2019 Nov 1;203(9):2355-2356. doi: 10.4049/jimmunol.1901011. No abstract available.

PMID:
31636133
6.

Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development.

Abramowitz LK, Harly C, Das A, Bhandoola A, Hanover JA.

Sci Rep. 2019 Aug 29;9(1):12569. doi: 10.1038/s41598-019-48991-8.

7.

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis.

Bosticardo M, Yamazaki Y, Cowan J, Giardino G, Corsino C, Scalia G, Prencipe R, Ruffner M, Hill DA, Sakovich I, Yemialyanava I, Tam JS, Padem N, Elder ME, Sleasman JW, Perez E, Niebur H, Seroogy CM, Sharapova S, Gebbia J, Kleiner GI, Peake J, Abbott JK, Gelfand EW, Crestani E, Biggs C, Butte MJ, Hartog N, Hayward A, Chen K, Heimall J, Seeborg F, Bartnikas LM, Cooper MA, Pignata C, Bhandoola A, Notarangelo LD.

Am J Hum Genet. 2019 Sep 5;105(3):549-561. doi: 10.1016/j.ajhg.2019.07.014. Epub 2019 Aug 22.

PMID:
31447097
8.

The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage.

Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A.

Nat Immunol. 2019 Sep;20(9):1150-1160. doi: 10.1038/s41590-019-0445-7. Epub 2019 Jul 29.

9.

Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells.

Larsen BM, Cowan JE, Wang Y, Tanaka Y, Zhao Y, Voisin B, Constantinides MG, Nagao K, Belkaid Y, Awasthi P, Takahama Y, Bhandoola A.

J Immunol. 2019 Aug 1;203(3):686-695. doi: 10.4049/jimmunol.1801540. Epub 2019 Jun 26.

PMID:
31243087
10.

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion.

Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415. doi: 10.1073/pnas.1905675116. Epub 2019 May 31. Erratum in: Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19761.

11.

The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months.

Richardson LA, Schmid SL, Bhandoola A, Harly C, Hedenström A, Laub MT, Mace GM, Sengupta P, Stock AM, Read AF, Malik HS, Estelle M, Lowell S, Kimmelman J.

PLoS Biol. 2019 Feb 27;17(2):e3000180. doi: 10.1371/journal.pbio.3000180. eCollection 2019 Feb. No abstract available.

12.

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity.

Gautam S, Fioravanti J, Zhu W, Le Gall JB, Brohawn P, Lacey NE, Hu J, Hocker JD, Hawk NV, Kapoor V, Telford WG, Gurusamy D, Yu Z, Bhandoola A, Xue HH, Roychoudhuri R, Higgs BW, Restifo NP, Bender TP, Ji Y, Gattinoni L.

Nat Immunol. 2019 Mar;20(3):337-349. doi: 10.1038/s41590-018-0311-z. Epub 2019 Feb 18.

13.

Cutting Edge: Core Binding Factor β Is Required for Group 2 Innate Lymphoid Cell Activation.

Shen X, Liang M, Chen X, Pasha MA, D'Souza SS, Hidde K, Howard J, Sultana DA, Fung ITH, Ye L, Pan J, Liu G, Drake JR, Drake LA, Zhu J, Bhandoola A, Yang Q.

J Immunol. 2019 Mar 15;202(6):1669-1673. doi: 10.4049/jimmunol.1800852. Epub 2019 Feb 6.

PMID:
30728212
14.

Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.

Hsu AP, Donkó A, Arrington ME, Swamydas M, Fink D, Das A, Escobedo O, Bonagura V, Szabolcs P, Steinberg HN, Bergerson J, Skoskiewicz A, Makhija M, Davis J, Foruraghi L, Palmer C, Fuleihan RL, Church JA, Bhandoola A, Lionakis MS, Campbell S, Leto TL, Kuhns DB, Holland SM.

Blood. 2019 May 2;133(18):1977-1988. doi: 10.1182/blood-2018-11-886028. Epub 2019 Feb 5.

PMID:
30723080
15.

Neighbors help neighbors control urban mosquitoes.

Johnson BJ, Brosch D, Christiansen A, Wells E, Wells M, Bhandoola AF, Milne A, Garrison S, Fonseca DM.

Sci Rep. 2018 Oct 25;8(1):15797. doi: 10.1038/s41598-018-34161-9.

16.

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.

Johnson JL, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, Pear WS, Bhandoola A, Wherry EJ, Vahedi G.

Immunity. 2018 Feb 20;48(2):243-257.e10. doi: 10.1016/j.immuni.2018.01.012.

17.

Lineage specification in innate lymphocytes.

Das A, Harly C, Yang Q, Bhandoola A.

Cytokine Growth Factor Rev. 2018 Aug;42:20-26. doi: 10.1016/j.cytogfr.2018.01.005. Epub 2018 Jan 12. Review.

18.

Development and differentiation of early innate lymphoid progenitors.

Harly C, Cam M, Kaye J, Bhandoola A.

J Exp Med. 2018 Jan 2;215(1):249-262. doi: 10.1084/jem.20170832. Epub 2017 Nov 28.

19.

A novel role for p53 in self-tolerance.

Larsen BM, Bhandoola A.

Blood. 2017 Jul 27;130(4):388-389. doi: 10.1182/blood-2017-06-789115. No abstract available.

20.

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar BR.

JCI Insight. 2017 May 18;2(10). pii: 92056. doi: 10.1172/jci.insight.92056. eCollection 2017 May 18.

21.

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells.

Zhang K, Xu X, Pasha MA, Siebel CW, Costello A, Haczku A, MacNamara K, Liang T, Zhu J, Bhandoola A, Maillard I, Yang Q.

J Immunol. 2017 Mar 1;198(5):1798-1803. doi: 10.4049/jimmunol.1601421. Epub 2017 Jan 23.

22.

CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions.

Nish SA, Zens KD, Kratchmarov R, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Bhandoola A, Xue HH, Farber DL, Reiner SL.

J Exp Med. 2017 Jan;214(1):39-47. doi: 10.1084/jem.20161046. Epub 2016 Dec 6.

23.

CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination.

Lin WW, Nish SA, Yen B, Chen YH, Adams WC, Kratchmarov R, Rothman NJ, Bhandoola A, Xue HH, Reiner SL.

Cell Rep. 2016 Nov 8;17(7):1773-1782. doi: 10.1016/j.celrep.2016.10.032.

24.

Progress on thymic function from Maui.

Cowan J, Bhandoola A.

Nat Immunol. 2016 Sep 20;17(10):1129-32. doi: 10.1038/ni.3555.

PMID:
27648536
25.

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, Hubbard C, Armstrong SA, Nussenzweig A, Fernandez-Capetillo O.

Sci Signal. 2016 Sep 13;9(445):ra91. doi: 10.1126/scisignal.aad8243.

26.

Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71.

Brugnera E, Bhandoola A, Cibotti R, Yu Q, Guinter TI, Yamashita Y, Sharrow SO, Singer A.

J Immunol. 2016 Mar 1;196(5):1985-97. No abstract available.

27.

The development of adult innate lymphoid cells.

Yang Q, Bhandoola A.

Curr Opin Immunol. 2016 Apr;39:114-20. doi: 10.1016/j.coi.2016.01.006. Epub 2016 Feb 9. Review.

28.

A doppelgänger of T cell development.

Harly C, Bhandoola A.

Cell Cycle. 2016;15(4):479-80. doi: 10.1080/15384101.2015.1125244. No abstract available.

29.

Editorial: Ephs, ephrins, and early T cell development.

Bryson JL, Bhandoola A.

J Leukoc Biol. 2015 Dec;98(6):877-9. doi: 10.1189/jlb.1CE0315-132R. No abstract available.

PMID:
26628637
30.

Intrathymic Injection.

Manna S, Bhandoola A.

Methods Mol Biol. 2016;1323:203-9. doi: 10.1007/978-1-4939-2809-5_17.

PMID:
26294410
31.

Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice.

Yang Q, Ge MQ, Kokalari B, Redai IG, Wang X, Kemeny DM, Bhandoola A, Haczku A.

J Allergy Clin Immunol. 2016 Feb;137(2):571-8. doi: 10.1016/j.jaci.2015.06.037. Epub 2015 Aug 15.

32.

TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.

Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, Wang H, Wang X, Yu S, Zhou X, Cam M, Xue HH, Bhandoola A.

Nat Immunol. 2015 Oct;16(10):1044-50. doi: 10.1038/ni.3248. Epub 2015 Aug 17.

33.

Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells.

Califano D, Cho JJ, Uddin MN, Lorentsen KJ, Yang Q, Bhandoola A, Li H, Avram D.

Immunity. 2015 Aug 18;43(2):354-68. doi: 10.1016/j.immuni.2015.07.005. Epub 2015 Jul 28.

34.

Transcriptional regulation of innate and adaptive lymphocyte lineages.

De Obaldia ME, Bhandoola A.

Annu Rev Immunol. 2015;33:607-42. doi: 10.1146/annurev-immunol-032414-112032. Epub 2015 Feb 4. Review.

PMID:
25665079
35.

The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development.

Rupp LJ, Brady BL, Carpenter AC, De Obaldia ME, Bhandoola A, Bosselut R, Muljo SA, Bassing CH.

J Immunol. 2014 Oct 15;193(8):4032-42. doi: 10.4049/jimmunol.1401359. Epub 2014 Sep 12.

36.

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.

Zhang SL, Wang X, Manna S, Zlotoff DA, Bryson JL, Blazar BR, Bhandoola A.

Blood. 2014 Jul 10;124(2):296-304. doi: 10.1182/blood-2014-01-552794. Epub 2014 May 29.

37.

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.

Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y.

Science. 2014 Jan 24;343(6169):432-7. doi: 10.1126/science.1247606.

38.

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.

De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A.

Nat Immunol. 2013 Dec;14(12):1277-84. doi: 10.1038/ni.2760. Epub 2013 Nov 3.

39.

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells.

Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D.

J Exp Med. 2013 Aug 26;210(9):1823-37. doi: 10.1084/jem.20122332. Epub 2013 Aug 19.

40.

Deconstructing development.

Harly C, Wherry EJ, Bhandoola A.

Nat Immunol. 2013 Jun;14(6):529-31. doi: 10.1038/ni.2613. No abstract available.

PMID:
23685815
41.

Trafficking to the thymus.

Zhang SL, Bhandoola A.

Curr Top Microbiol Immunol. 2014;373:87-111. doi: 10.1007/82_2013_324. Review.

PMID:
23624945
42.

T cell factor 1 is required for group 2 innate lymphoid cell generation.

Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A.

Immunity. 2013 Apr 18;38(4):694-704. doi: 10.1016/j.immuni.2012.12.003.

43.

Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus.

De Obaldia ME, Bell JJ, Bhandoola A.

Blood. 2013 Jan 3;121(1):64-71. doi: 10.1182/blood-2012-08-451773. Epub 2012 Nov 14.

44.

Decoding HSC heterogeneity.

Yang Q, Bhandoola A.

Blood. 2012 May 24;119(21):4819-20. doi: 10.1182/blood-2012-03-417238. No abstract available.

PMID:
22627594
45.

Immunology. Rebuilding the thymus.

Bhandoola A, Artis D.

Science. 2012 Apr 6;336(6077):40-1. doi: 10.1126/science.1221677. No abstract available.

PMID:
22491841
46.

Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.

Sultana DA, Zhang SL, Todd SP, Bhandoola A.

J Immunol. 2012 May 1;188(9):4385-93. doi: 10.4049/jimmunol.1101116. Epub 2012 Mar 28.

47.

Losing TREC with age.

Zhang SL, Bhandoola A.

Immunity. 2012 Feb 24;36(2):163-5. doi: 10.1016/j.immuni.2012.02.005.

48.

Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.

Chen MJ, Li Y, De Obaldia ME, Yang Q, Yzaguirre AD, Yamada-Inagawa T, Vink CS, Bhandoola A, Dzierzak E, Speck NA.

Cell Stem Cell. 2011 Dec 2;9(6):541-52. doi: 10.1016/j.stem.2011.10.003. Erratum in: Cell Stem Cell. 2012 Mar 2;10(3):345-6.

49.

Cutting edge: Natural helper cells derive from lymphoid progenitors.

Yang Q, Saenz SA, Zlotoff DA, Artis D, Bhandoola A.

J Immunol. 2011 Dec 1;187(11):5505-9. doi: 10.4049/jimmunol.1102039. Epub 2011 Oct 24.

50.

A critical role for TCF-1 in T-lineage specification and differentiation.

Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A.

Nature. 2011 Aug 3;476(7358):63-8. doi: 10.1038/nature10279.

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