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Items: 43


Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer.

Song H, Zeng J, Roychoudhury S, Biswas P, Mohapatra B, Ray S, Dowlatshahi K, Wang J, Band V, Talmon G, Bhakat KK.

Mol Cancer Ther. 2019 Oct 1. pii: molcanther.0600.2019. doi: 10.1158/1535-7163.MCT-19-0600. [Epub ahead of print]


Biochemical and Cellular Assays to Assess the Effects of Acetylation on Base Excision Repair Enzymes.

Roychoudhury S, Pramanik S, Harris HL, Bhakat KK.

Methods Mol Biol. 2019;1983:191-206. doi: 10.1007/978-1-4939-9434-2_11.


Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.

Sengupta S, Yang C, Hegde ML, Hegde PM, Mitra J, Pandey A, Dutta A, Datarwala AT, Bhakat KK, Mitra S.

DNA Repair (Amst). 2018 Jun - Jul;66-67:1-10. doi: 10.1016/j.dnarep.2018.04.001. Epub 2018 Apr 17.


Suppression of STAT3 NH2 -terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de-repression by microRNA-21.

Ray S, Coulter DW, Gray SD, Sughroue JA, Roychoudhury S, McIntyre EM, Chaturvedi NK, Bhakat KK, Joshi SS, McGuire TR, Sharp JG.

Mol Carcinog. 2018 Apr;57(4):536-548. doi: 10.1002/mc.22778. Epub 2018 Jan 25.


The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression.

Nath S, Roychoudhury S, Kling MJ, Song H, Biswas P, Shukla A, Band H, Joshi S, Bhakat KK.

Cell Signal. 2017 Nov;39:18-31. doi: 10.1016/j.cellsig.2017.07.019. Epub 2017 Jul 25.


Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.

Roychoudhury S, Nath S, Song H, Hegde ML, Bellot LJ, Mantha AK, Sengupta S, Ray S, Natarajan A, Bhakat KK.

Mol Cell Biol. 2017 Mar 1;37(6). pii: e00401-16. doi: 10.1128/MCB.00401-16. Print 2017 Mar 15.


Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.

Sengupta S, Mantha AK, Song H, Roychoudhury S, Nath S, Ray S, Bhakat KK.

Oncotarget. 2016 Nov 15;7(46):75197-75209. doi: 10.18632/oncotarget.12113.


Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.

Bhakat KK, Sengupta S, Adeniyi VF, Roychoudhury S, Nath S, Bellot LJ, Feng D, Mantha AK, Sinha M, Qiu S, Luxon BA.

Oncotarget. 2016 Apr 19;7(16):22590-604. doi: 10.18632/oncotarget.8026.


Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression.

Sengupta S, Mitra S, Bhakat KK.

PLoS One. 2013 Jul 16;8(7):e68467. doi: 10.1371/journal.pone.0068467. Print 2013.


Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.

Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G.

Mol Biol Cell. 2012 Oct;23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23.


Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex.

Sengupta S, Chattopadhyay R, Mantha AK, Mitra S, Bhakat KK.

J Hypertens. 2012 May;30(5):917-25. doi: 10.1097/HJH.0b013e3283525124.


Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S, Szczesny B.

Mech Ageing Dev. 2012 Apr;133(4):157-68. doi: 10.1016/j.mad.2012.01.005. Epub 2012 Jan 31. Review.


Preferential repair of oxidized base damage in the transcribed genes of mammalian cells.

Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK.

J Biol Chem. 2011 Feb 25;286(8):6006-16. doi: 10.1074/jbc.M110.198796. Epub 2010 Dec 17.


Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.

Ray S, Lee C, Hou T, Bhakat KK, Brasier AR.

Mol Endocrinol. 2010 Feb;24(2):391-401. doi: 10.1210/me.2009-0319. Epub 2009 Dec 23.


Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis.

Konduri SD, Ticku J, Bobustuc GC, Sutphin RM, Colon J, Isley B, Bhakat KK, Srivenugopal KS, Baker CH.

Clin Cancer Res. 2009 Oct 1;15(19):6087-95. doi: 10.1158/1078-0432.CCR-09-0887. Epub 2009 Sep 29. Erratum in: Clin Cancer Res. 2010 Jan 1;16(1):369. Kalkunte, Srivenugopal S [corrected to Srivenugopal, Kalkunte S].


Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.

Bhattacharyya A, Chattopadhyay R, Burnette BR, Cross JV, Mitra S, Ernst PB, Bhakat KK, Crowe SE.

Gastroenterology. 2009 Jun;136(7):2258-69. doi: 10.1053/j.gastro.2009.02.014.


Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK.

Mol Cell Biol. 2008 Dec;28(23):7066-80. doi: 10.1128/MCB.00244-08. Epub 2008 Sep 22.


Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

Bhakat KK, Mantha AK, Mitra S.

Antioxid Redox Signal. 2009 Mar;11(3):621-38. doi: 10.1089/ARS.2008.2198. Review.


Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.

Mantha AK, Oezguen N, Bhakat KK, Izumi T, Braun W, Mitra S.

J Mol Biol. 2008 May 23;379(1):28-37. doi: 10.1016/j.jmb.2008.03.052. Epub 2008 Apr 3.


APE1/Ref-1 regulates PTEN expression mediated by Egr-1.

Fantini D, Vascotto C, Deganuto M, Bivi N, Gustincich S, Marcon G, Quadrifoglio F, Damante G, Bhakat KK, Mitra S, Tell G.

Free Radic Res. 2008 Jan;42(1):20-9. doi: 10.1080/10715760701765616.


Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.

Zaky A, Busso C, Izumi T, Chattopadhyay R, Bassiouny A, Mitra S, Bhakat KK.

Nucleic Acids Res. 2008 Mar;36(5):1555-66. doi: 10.1093/nar/gkm1173. Epub 2008 Jan 21.


Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.

Dou H, Theriot CA, Das A, Hegde ML, Matsumoto Y, Boldogh I, Hazra TK, Bhakat KK, Mitra S.

J Biol Chem. 2008 Feb 8;283(6):3130-40. Epub 2007 Nov 21.


Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.

Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C.

J Biol Chem. 2007 Nov 23;282(47):33994-4002. Epub 2007 Oct 1.


Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.

Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK.

J Biol Chem. 2007 Sep 28;282(39):28474-84. Epub 2007 Aug 7.


Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

Mitra S, Izumi T, Boldogh I, Bhakat KK, Chattopadhyay R, Szczesny B.

DNA Repair (Amst). 2007 Apr 1;6(4):461-9. Epub 2006 Dec 12.


Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.

Bhakat KK, Mokkapati SK, Boldogh I, Hazra TK, Mitra S.

Mol Cell Biol. 2006 Mar;26(5):1654-65.


Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species.

Das A, Hazra TK, Boldogh I, Mitra S, Bhakat KK.

J Biol Chem. 2005 Oct 21;280(42):35272-80. Epub 2005 Aug 22.


Two essential but distinct functions of the mammalian abasic endonuclease.

Izumi T, Brown DB, Naidu CV, Bhakat KK, Macinnes MA, Saito H, Chen DJ, Mitra S.

Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5739-43. Epub 2005 Apr 11.


Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution.

Szczesny B, Bhakat KK, Mitra S, Boldogh I.

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):755-65.


Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.

Bhakat KK, Hazra TK, Mitra S.

Nucleic Acids Res. 2004 Jun 2;32(10):3033-9. Print 2004.


Acetylation of human AP-endonuclease 1, a critical enzyme in DNA repair and transcription regulation.

Bhakat KK, Yang SH, Mitra S.

Methods Enzymol. 2003;371:292-300. No abstract available.


Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S.

EMBO J. 2003 Dec 1;22(23):6299-309.


Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.

Boldogh I, Roy G, Lee MS, Bacsi A, Hazra TK, Bhakat KK, Das GC, Mitra S.

Toxicology. 2003 Nov 15;193(1-2):137-52.


Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage.

Izumi T, Wiederhold LR, Roy G, Roy R, Jaiswal A, Bhakat KK, Mitra S, Hazra TK.

Toxicology. 2003 Nov 15;193(1-2):43-65. Review.


Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea.

Shimada Y, Nishimura M, Kakinuma S, Ogiu T, Fujimoto H, Kubo A, Nagai J, Kobayash K, Tano K, Yoshinaga S, Bhakat KK.

Int J Radiat Biol. 2003 Jun;79(6):423-30.


Multifaceted resistance of gliomas to temozolomide.

Bocangel DB, Finkelstein S, Schold SC, Bhakat KK, Mitra S, Kokkinakis DM.

Clin Cancer Res. 2002 Aug;8(8):2725-34.


Choreography of oxidative damage repair in mammalian genomes.

Mitra S, Izumi T, Boldogh I, Bhakat KK, Hill JW, Hazra TK.

Free Radic Biol Med. 2002 Jul 1;33(1):15-28. Review.


The mutK gene of Vibrio cholerae: a new gene involved in DNA mismatch repair.

Bhakat KK, Sudarshana SM, Das J.

J Bacteriol. 1999 Feb;181(3):879-83.

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