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Items: 1 to 50 of 62

1.

Phase 2 Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes.

Santini V, Valcárcel D, Platzbecker U, Komrokji RS, Cleverly A, Lahn MM, Janssen J, Zhao Y, Chiang A, Giagounidis A, Guba SC, Sridharan A, Gueorguieva I, Girvan A, da Silva Ferreira M, Bhagat TD, Pradhan K, Steidl U, Will B, Verma A.

Clin Cancer Res. 2019 Sep 3. pii: clincanres.1338.2019. doi: 10.1158/1078-0432.CCR-19-1338. [Epub ahead of print]

PMID:
31481511
2.

Prevalence of Oral Habits of Schoolchildren in the Mixed Dentition in Dharan, Nepal.

Agrawal S, Dali M, Bhagat T, Koirala B, Shrestha S, Niraula SR.

J Dent Child (Chic). 2019 May 15;86(2):88-92.

PMID:
31395113
3.

Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks.

Sundaravel S, Kuo WL, Jeong JJ, Choudhary GS, Gordon-Mitchell S, Liu H, Bhagat TD, McGraw KL, Gurbuxani S, List AF, Verma A, Wickrema A.

Clin Cancer Res. 2019 Sep 15;25(18):5638-5649. doi: 10.1158/1078-0432.CCR-19-0924. Epub 2019 Jul 15.

PMID:
31308061
4.

Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions.

Bowler TG, Pradhan K, Kong Y, Bartenstein M, Morrone KA, Sridharan A, Kessel RM, Shastri A, Giricz O, Bhagat TD, Gordon-Mitchell S, Rohanizadegan M, Hooda L, Datt I, Przychodzen BP, Parmar S, Maqbool S, Maciejewski JP, Steidl U, Greally JM, Verma A.

Leuk Lymphoma. 2019 Jul 10:1-6. doi: 10.1080/10428194.2019.1630620. [Epub ahead of print]

PMID:
31288594
5.

Amelogenesis Imperfecta: A Case Series from the Community.

Singh A, Agrawal SK, Shrestha A, Bhagat T.

JNMA J Nepal Med Assoc. 2018 Nov-Dec;56(214):977-979.

PMID:
31065148
6.

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.

Smith MA, Choudhary GS, Pellagatti A, Choi K, Bolanos LC, Bhagat TD, Gordon-Mitchell S, Von Ahrens D, Pradhan K, Steeples V, Kim S, Steidl U, Walter M, Fraser IDC, Kulkarni A, Salomonis N, Komurov K, Boultwood J, Verma A, Starczynowski DT.

Nat Cell Biol. 2019 May;21(5):640-650. doi: 10.1038/s41556-019-0314-5. Epub 2019 Apr 22.

7.

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.

Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A.

Cancer Discov. 2019 Jun;9(6):778-795. doi: 10.1158/2159-8290.CD-18-1138. Epub 2019 Apr 3.

PMID:
30944118
8.

Fluoride Level in Drinking Water Sources of Eastern Nepal.

Singh A, Shrestha A, Bhagat T.

J Nepal Health Res Counc. 2019 Jan 28;16(41):414-418.

PMID:
30739932
9.

Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.

Shenoy N, Bhagat TD, Cheville J, Lohse C, Bhattacharyya S, Tischer A, Machha V, Gordon-Mitchell S, Choudhary G, Wong LF, Gross L, Ressigue E, Leibovich B, Boorjian SA, Steidl U, Wu X, Pradhan K, Gartrell B, Agarwal B, Pagliaro L, Suzuki M, Greally JM, Rakheja D, Thompson RH, Susztak K, Witzig T, Zou Y, Verma A.

J Clin Invest. 2019 Mar 4;130:1612-1625. doi: 10.1172/JCI98747. eCollection 2019 Mar 4.

10.

Effectiveness of Herbal Mouthwash among Visually Impaired Residential School Students.

Dahal S, Shrestha A, Bhagat T.

JNMA J Nepal Med Assoc. 2018 Jul-Aug;56(212):728-734.

PMID:
30387458
11.

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S, Lopez R, Pradhan K, Giricz O, Ravipati G, Wong LF, Cole S, Bhagat TD, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan VJ, Wickrema A, Ye BH, Frank DA, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod AR, Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B, Verma A.

J Clin Invest. 2018 Dec 3;128(12):5479-5488. doi: 10.1172/JCI120156. Epub 2018 Nov 5.

12.

Translation and validation of the Nepalese version of the Geriatric Oral Health Assessment Index.

Agrawal SK, Shrestha A, Bhagat T.

Gerodontology. 2019 Mar;36(1):30-35. doi: 10.1111/ger.12373. Epub 2018 Sep 19.

PMID:
30230596
13.

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.

Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M.

Blood. 2018 Oct 4;132(14):1507-1518. doi: 10.1182/blood-2018-01-824607. Epub 2018 Aug 13.

14.

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

Giricz O, Mo Y, Dahlman KB, Cotto-Rios XM, Vardabasso C, Nguyen H, Matusow B, Bartenstein M, Polishchuk V, Johnson DB, Bhagat TD, Shellooe R, Burton E, Tsai J, Zhang C, Habets G, Greally JM, Yu Y, Kenny PA, Fields GB, Pradhan K, Stanley ER, Bernstein E, Bollag G, Gavathiotis E, West BL, Sosman JA, Verma AK.

JCI Insight. 2018 Jul 26;3(14). pii: 120422. doi: 10.1172/jci.insight.120422. eCollection 2018 Jul 26.

15.

Fournier's gangrene: a rare manifestation of Chikungunya fever.

Goel A, Gupta S, Agarwal A, Shiwach N, Chawda V, Bhagat TS.

Trop Doct. 2018 Jan;48(1):36-37. doi: 10.1177/0049475517699542. Epub 2017 Mar 20. No abstract available.

PMID:
29316869
16.

Evaluation of Dental Caries Among Preschool Children in Kathmandu-Using Significant Caries Index.

Limbu S, Dikshit P, Bhagat T.

JNMA J Nepal Med Assoc. 2017 Jul-Sep;56(207):341-5.

PMID:
29255317
17.

Innovative Economical Surgical Suture Board.

Gupta S, Goel A, Agarwal A, Gupta AK, Bhagat TS.

Indian J Surg. 2017 Dec;79(6):576-577. doi: 10.1007/s12262-017-1686-z. Epub 2017 Sep 14.

18.

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.

Bhattacharyya S, Pradhan K, Campbell N, Mazdo J, Vasantkumar A, Maqbool S, Bhagat TD, Gupta S, Suzuki M, Yu Y, Greally JM, Steidl U, Bradner J, Dawlaty M, Godley L, Maitra A, Verma A.

Genome Res. 2017 Nov;27(11):1830-1842. doi: 10.1101/gr.222794.117. Epub 2017 Oct 6.

19.

Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells.

Shenoy N, Bhagat T, Nieves E, Stenson M, Lawson J, Choudhary GS, Habermann T, Nowakowski G, Singh R, Wu X, Verma A, Witzig TE.

Blood Cancer J. 2017 Jul 21;7(7):e587. doi: 10.1038/bcj.2017.65.

20.

Rehabilitation of Nose following Chemical Burn Using CAD/CAM Made Substructure for Implant Retained Nasal Prosthesis: A Clinical Report.

Chaturvedi S, Bhagat T, Verma AK, Gurumurthy V, Ali M, Vadhwani P, Chaturvedi M.

Case Rep Dent. 2017;2017:2784606. doi: 10.1155/2017/2784606. Epub 2017 Jun 18.

21.

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.

Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A.

Cancer Res. 2017 Sep 15;77(18):4846-4857. doi: 10.1158/0008-5472.CAN-17-0282. Epub 2017 Jul 6.

22.
23.

The role of stromal cancer-associated fibroblasts in pancreatic cancer.

von Ahrens D, Bhagat TD, Nagrath D, Maitra A, Verma A.

J Hematol Oncol. 2017 Mar 28;10(1):76. doi: 10.1186/s13045-017-0448-5. Review.

24.

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.

Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K.

J Biol Chem. 2017 Jan 20;292(3):837-846. doi: 10.1074/jbc.M116.745208. Epub 2016 Dec 1.

25.

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.

Bachegowda L, Morrone K, Winski SL, Mantzaris I, Bartenstein M, Ramachandra N, Giricz O, Sukrithan V, Nwankwo G, Shahnaz S, Bhagat T, Bhattacharyya S, Assal A, Shastri A, Gordon-Mitchell S, Pellagatti A, Boultwood J, Schinke C, Yu Y, Guha C, Rizzi J, Garrus J, Brown S, Wollenberg L, Hogeland G, Wright D, Munson M, Rodriguez M, Gross S, Chantry D, Zou Y, Platanias L, Burgess LE, Pradhan K, Steidl U, Verma A.

Cancer Res. 2016 Aug 15;76(16):4841-4849. doi: 10.1158/0008-5472.CAN-15-3062. Epub 2016 Jun 10.

26.

In vitro Assessment of Clasps of Cobalt-Chromium and Nickel-titanium Alloys in Removable Prosthesis.

Kola MZ, Raghav D, Kumar P, Alqahtani F, Murayshed MS, Bhagat TV.

J Contemp Dent Pract. 2016 Mar 1;17(3):253-7.

PMID:
27207207
27.

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.

Sundaravel S, Duggan R, Bhagat T, Ebenezer DL, Liu H, Yu Y, Bartenstein M, Unnikrishnan M, Karmakar S, Liu TC, Torregroza I, Quenon T, Anastasi J, McGraw KL, Pellagatti A, Boultwood J, Yajnik V, Artz A, Le Beau MM, Steidl U, List AF, Evans T, Verma A, Wickrema A.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6359-68. doi: 10.1073/pnas.1516394112. Epub 2015 Nov 2.

28.

Telescopic Partial Dentures-Concealed Technology.

Bhagat TV, Walke AN.

J Int Oral Health. 2015 Sep;7(9):143-7. Review.

29.

Central role of ULK1 in type I interferon signaling.

Saleiro D, Mehrotra S, Kroczynska B, Beauchamp EM, Lisowski P, Majchrzak-Kita B, Bhagat TD, Stein BL, McMahon B, Altman JK, Kosciuczuk EM, Baker DP, Jie C, Jafari N, Thompson CB, Levine RL, Fish EN, Verma AK, Platanias LC.

Cell Rep. 2015 Apr 28;11(4):605-17. doi: 10.1016/j.celrep.2015.03.056. Epub 2015 Apr 16.

30.

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.

Schinke C, Giricz O, Li W, Shastri A, Gordon S, Barreyro L, Bhagat T, Bhattacharyya S, Ramachandra N, Bartenstein M, Pellagatti A, Boultwood J, Wickrema A, Yu Y, Will B, Wei S, Steidl U, Verma A.

Blood. 2015 May 14;125(20):3144-52. doi: 10.1182/blood-2015-01-621631. Epub 2015 Mar 25. Erratum in: Blood. 2015 Jul 16;126(3):425. Barreryo, Laura [corrected to Barreyro, Laura].

31.

Systemic inflammatory response syndrome and platelet count ≥250×10(9) are associated with venous thromboembolic disease.

Pate A, Baltazar GA, Labana S, Bhagat T, Kim J, Chendrasekhar A.

Int J Gen Med. 2015 Jan 14;8:37-40. doi: 10.2147/IJGM.S72259. eCollection 2015.

32.

Knowledge of dental interns towards emergency management of avulsed tooth in dental colleges in Nepal.

Limbu S, Dikshit P, Bhagat T, Mehata S.

J Nepal Health Res Counc. 2014 Jan;12(26):1-7.

PMID:
25574976
33.

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21.

Caescu CI, Guo X, Tesfa L, Bhagat TD, Verma A, Zheng D, Stanley ER.

Blood. 2015 Feb 19;125(8):e1-13. doi: 10.1182/blood-2014-10-608000. Epub 2015 Jan 8.

34.

Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival.

Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S, Izquierdo MC, Park AS, Giricz O, Vallumsetla N, Gundabolu K, Ware K, Bhagat TD, Suzuki M, Pullman J, Liu XS, Greally JM, Susztak K, Verma A.

Clin Cancer Res. 2014 Aug 15;20(16):4349-60. doi: 10.1158/1078-0432.CCR-14-0494. Epub 2014 Jun 10.

35.

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA.

Cell Rep. 2014 Jun 12;7(5):1343-1352. doi: 10.1016/j.celrep.2014.04.040. Epub 2014 May 15.

36.

Eltrombopag can overcome the anti-megakaryopoietic effects of lenalidomide without increasing proliferation of the malignant myelodysplastic syndrome/acute myelogenous leukemia clone.

Tamari R, Schinke C, Bhagat T, Roth M, Braunschweig I, Will B, Steidl U, Verma A.

Leuk Lymphoma. 2014 Dec;55(12):2901-6. doi: 10.3109/10428194.2014.894186. Epub 2014 Mar 20.

PMID:
24650011
37.

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia.

Bartholdy B, Christopeit M, Will B, Mo Y, Barreyro L, Yu Y, Bhagat TD, Okoye-Okafor UC, Todorova TI, Greally JM, Levine RL, Melnick A, Verma A, Steidl U.

J Clin Invest. 2014 Mar;124(3):1158-67.

38.

Successful Elimination of Ascaris lumbricoides from the Gallbladder by Conservative Medical Therapy.

Misra MK, Singh S, Bhagat TS.

Indian J Surg. 2013 Jun;75(Suppl 1):379-81. doi: 10.1007/s12262-012-0527-3. Epub 2012 Aug 16.

39.

High resolution integrative analysis reveals widespread genetic and epigenetic changes after chronic in-vitro acid and bile exposure in Barrett's epithelium cells.

Bajpai M, Kessel R, Bhagat T, Nischal S, Yu Y, Verma A, Das KM.

Genes Chromosomes Cancer. 2013 Dec;52(12):1123-32. doi: 10.1002/gcc.22106. Epub 2013 Oct 3.

PMID:
24123713
40.

Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells.

Yang X, Song JH, Cheng Y, Wu W, Bhagat T, Yu Y, Abraham JM, Ibrahim S, Ravich W, Roland BC, Khashab M, Singh VK, Shin EJ, Yang X, Verma AK, Meltzer SJ, Mori Y.

Gut. 2014 Jun;63(6):881-90. doi: 10.1136/gutjnl-2013-305266. Epub 2013 Sep 2.

41.

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, Bhagat TD, Nischal S, Christopeit M, Parekh S, Steidl U, Godley L, Maitra A, Greally JM, Verma A.

Nucleic Acids Res. 2013 Sep;41(16):e157. doi: 10.1093/nar/gkt601. Epub 2013 Jul 16.

42.

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Will B, Vogler TO, Bartholdy B, Garrett-Bakelman F, Mayer J, Barreyro L, Pandolfi A, Todorova TI, Okoye-Okafor UC, Stanley RF, Bhagat TD, Verma A, Figueroa ME, Melnick A, Roth M, Steidl U.

Nat Immunol. 2013 May;14(5):437-45. doi: 10.1038/ni.2572. Epub 2013 Apr 7.

43.

Role of DNA methylation in the pathogenesis and treatment of myelodysplastic syndromes.

Khan H, Vale C, Bhagat T, Verma A.

Semin Hematol. 2013 Jan;50(1):16-37. doi: 10.1053/j.seminhematol.2013.01.001. Review.

PMID:
23507481
44.

Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis.

Heuck CJ, Mehta J, Bhagat T, Gundabolu K, Yu Y, Khan S, Chrysofakis G, Schinke C, Tariman J, Vickrey E, Pulliam N, Nischal S, Zhou L, Bhattacharyya S, Meagher R, Hu C, Maqbool S, Suzuki M, Parekh S, Reu F, Steidl U, Greally J, Verma A, Singhal SB.

J Immunol. 2013 Mar 15;190(6):2966-75. doi: 10.4049/jimmunol.1202493. Epub 2013 Feb 13.

45.

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling.

Bhagat TD, Zhou L, Sokol L, Kessel R, Caceres G, Gundabolu K, Tamari R, Gordon S, Mantzaris I, Jodlowski T, Yu Y, Jing X, Polineni R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati S, Steidl U, Stein C, Ju W, Liu G, Kenny P, List A, Bitzer M, Verma A.

Blood. 2013 Apr 11;121(15):2875-81. doi: 10.1182/blood-2011-12-397067. Epub 2013 Feb 6.

46.

Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma.

Wu W, Bhagat TD, Yang X, Song JH, Cheng Y, Agarwal R, Abraham JM, Ibrahim S, Bartenstein M, Hussain Z, Suzuki M, Yu Y, Chen W, Eng C, Greally J, Verma A, Meltzer SJ.

Gastroenterology. 2013 May;144(5):956-966.e4. doi: 10.1053/j.gastro.2013.01.019. Epub 2013 Jan 16.

47.

High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis.

Yu Y, Mo Y, Ebenezer D, Bhattacharyya S, Liu H, Sundaravel S, Giricz O, Wontakal S, Cartier J, Caces B, Artz A, Nischal S, Bhagat T, Bathon K, Maqbool S, Gligich O, Suzuki M, Steidl U, Godley L, Skoultchi A, Greally J, Wickrema A, Verma A.

J Biol Chem. 2013 Mar 29;288(13):8805-14. doi: 10.1074/jbc.M112.423756. Epub 2013 Jan 10.

48.

Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms.

Nischal S, Bhattacharyya S, Christopeit M, Yu Y, Zhou L, Bhagat TD, Sohal D, Will B, Mo Y, Suzuki M, Pardanani A, McDevitt M, Maciejewski JP, Melnick AM, Greally JM, Steidl U, Moliterno A, Verma A.

Cancer Res. 2013 Feb 1;73(3):1076-85. doi: 10.1158/0008-5472.CAN-12-0735. Epub 2012 Oct 11.

49.

Mutations in the telomere capping complex in bone marrow failure and related syndromes.

Walne AJ, Bhagat T, Kirwan M, Gitiaux C, Desguerre I, Leonard N, Nogales E, Vulliamy T, Dokal IS.

Haematologica. 2013 Mar;98(3):334-8. doi: 10.3324/haematol.2012.071068. Epub 2012 Aug 16.

50.

Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.

Agarwal A, Polineni R, Hussein Z, Vigoda I, Bhagat TD, Bhattacharyya S, Maitra A, Verma A.

Int J Clin Exp Pathol. 2012;5(5):382-96. Epub 2012 May 23. Review.

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