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Items: 38


PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.

de Semir D, Bezrookove V, Nosrati M, Dar AA, Wu C, Shen J, Rieken C, Venkatasubramanian M, Miller JR 3rd, Desprez PY, McAllister S, Soroceanu L, Debs RJ, Salomonis N, Schadendorf D, Cleaver JE, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5766-E5775. doi: 10.1073/pnas.1804779115. Epub 2018 Jun 4.


Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.

Bezrookove V, Nosrati M, Miller JR 3rd, De Semir D, Dar AA, Vosoughi E, Vaquero E, Sucker A, Lazar AJ, Gershenwald JE, Davies MA, Schadendorf D, Kashani-Sabet M.

Clin Cancer Res. 2018 Sep 1;24(17):4119-4125. doi: 10.1158/1078-0432.CCR-18-0791. Epub 2018 May 18.


Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency.

Reid-Bayliss KS, Arron ST, Loeb LA, Bezrookove V, Cleaver JE.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10151-6. doi: 10.1073/pnas.1610020113. Epub 2016 Aug 19.


BPTF transduces MITF-driven prosurvival signals in melanoma cells.

Dar AA, Majid S, Bezrookove V, Phan B, Ursu S, Nosrati M, De Semir D, Sagebiel RW, Miller JR 3rd, Debs R, Cleaver JE, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6254-8. doi: 10.1073/pnas.1606027113. Epub 2016 May 16.


Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.

Phan B, Majid S, Ursu S, de Semir D, Nosrati M, Bezrookove V, Kashani-Sabet M, Dar AA.

Oncotarget. 2016 Apr 12;7(15):19519-30. doi: 10.18632/oncotarget.6961.


Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma.

Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, Cobbs CS.

Cancer Res. 2015 Aug 1;75(15):3065-76. doi: 10.1158/0008-5472.CAN-14-3307.


The role of BPTF in melanoma progression and in response to BRAF-targeted therapy.

Dar AA, Nosrati M, Bezrookove V, de Semir D, Majid S, Thummala S, Sun V, Tong S, Leong SP, Minor D, Billings PR, Soroceanu L, Debs R, Miller JR 3rd, Sagebiel RW, Kashani-Sabet M.

J Natl Cancer Inst. 2015 Feb 23;107(5). pii: djv034. doi: 10.1093/jnci/djv034.


Antitumor activity of miR-1280 in melanoma by regulation of Src.

Sun V, Zhou WB, Nosrati M, Majid S, Thummala S, de Semir D, Bezrookove V, de Feraudy S, Chun L, Schadendorf D, Debs R, Kashani-Sabet M, Dar AA.

Mol Ther. 2015 Jan;23(1):71-8. doi: 10.1038/mt.2014.176. Epub 2014 Sep 8.


Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.

Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13487-92. doi: 10.1073/pnas.1414135111. Epub 2014 Aug 18.


HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation.

Cobbs C, Khan S, Matlaf L, McAllister S, Zider A, Yount G, Rahlin K, Harkins L, Bezrookove V, Singer E, Soroceanu L.

Oncotarget. 2014 Feb 28;5(4):1091-100.


Prognostic impact of PHIP copy number in melanoma: linkage to ulceration.

Bezrookove V, De Semir D, Nosrati M, Tong S, Wu C, Thummala S, Dar AA, Leong SPL, Cleaver JE, Sagebiel RW, Miller JR 3rd, Kashani-Sabet M.

J Invest Dermatol. 2014 Mar;134(3):783-790. doi: 10.1038/jid.2013.369. Epub 2013 Sep 4.


Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor.

Matlaf LA, Harkins LE, Bezrookove V, Cobbs CS, Soroceanu L.

PLoS One. 2013 Jul 5;8(7):e68176. doi: 10.1371/journal.pone.0068176. Print 2013.


Conceptual developments in the causes of Cockayne syndrome.

Cleaver JE, Bezrookove V, Revet I, Huang EJ.

Mech Ageing Dev. 2013 May-Jun;134(5-6):284-90. doi: 10.1016/j.mad.2013.02.005. Epub 2013 Feb 18. Review.


The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.

Dar AA, Majid S, Rittsteuer C, de Semir D, Bezrookove V, Tong S, Nosrati M, Sagebiel R, Miller JR 3rd, Kashani-Sabet M.

J Natl Cancer Inst. 2013 Mar 20;105(6):433-42. doi: 10.1093/jnci/djt003. Epub 2013 Jan 30.


Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.

De Semir D, Nosrati M, Bezrookove V, Dar AA, Federman S, Bienvenu G, Venna S, Rangel J, Climent J, Meyer Tamg├╝ney TM, Thummala S, Tong S, Leong SP, Haqq C, Billings P, Miller JR 3rd, Sagebiel RW, Debs R, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7067-72. doi: 10.1073/pnas.1119949109. Epub 2012 Apr 17.


Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype.

Soroceanu L, Matlaf L, Bezrookove V, Harkins L, Martinez R, Greene M, Soteropoulos P, Cobbs CS.

Cancer Res. 2011 Nov 1;71(21):6643-53. doi: 10.1158/0008-5472.CAN-11-0744. Epub 2011 Sep 7.


Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.

Jalas JR, Vemula S, Bezrookove V, Leboit PE, Simko JP, Bastian BC.

Am J Surg Pathol. 2011 Sep;35(9):1413-8. doi: 10.1097/PAS.0b013e31822280d8.


miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein.

Dar AA, Majid S, de Semir D, Nosrati M, Bezrookove V, Kashani-Sabet M.

J Biol Chem. 2011 May 13;286(19):16606-14. doi: 10.1074/jbc.M111.227611. Epub 2011 Mar 24.


A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.

de Feraudy S, Revet I, Bezrookove V, Feeney L, Cleaver JE.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6870-5. doi: 10.1073/pnas.1002175107. Epub 2010 Mar 29.


PCC and COBRA-FISH a new tool to characterize primary cervical carcinomas: to assess hall-marks and stage specificity.

Darroudi F, Bergs JW, Bezrookove V, Buist MR, Stalpers LJ, Franken NA.

Cancer Lett. 2010 Jan 1;287(1):67-74. doi: 10.1016/j.canlet.2009.05.034. Epub 2009 Jun 23.


Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC.

Nature. 2009 Jan 29;457(7229):599-602. doi: 10.1038/nature07586. Epub 2008 Dec 10.


APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.

Abal M, Obrador-Hevia A, Janssen KP, Casadome L, Menendez M, Carpentier S, Barillot E, Wagner M, Ansorge W, Moeslein G, Fsihi H, Bezrookove V, Reventos J, Louvard D, Capella G, Robine S.

Gastroenterology. 2007 Jun;132(7):2448-58. Epub 2007 Mar 19.


Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS.

Nat Cell Biol. 2006 Oct;8(10):1053-63. Epub 2006 Sep 10. Erratum in: Nat Cell Biol. 2006 Nov;8(11):1309.


Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.

Vries RG, Bezrookove V, Zuijderduijn LM, Kia SK, Houweling A, Oruetxebarria I, Raap AK, Verrijzer CP.

Genes Dev. 2005 Mar 15;19(6):665-70.


Molecular cytogenetic characterization by combined COBRA-FISH and fiber-FISH: application to PER.C6 cells.

Wiegant J, Brouwer K, Bezrookove V, Smits S, Raap AK, Bout A, Tanke HJ.

Biotechniques. 2004 Aug;37(2):188, 190, 192 passim. No abstract available.


A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.

Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C.

Cancer Genet Cytogenet. 2004 Feb;149(1):72-6.


Multiple supernumerary ring chromosomes of different origin in a patient: a clinical report and review of the literature.

Beverstock GC, Bezrookove V, Mollevanger P, van de Kamp JJ, Pearson P, Kouwenberg JM, Rosenberg C.

Am J Med Genet A. 2003 Oct 1;122A(2):168-73. Review.


Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers.

Bezrookove V, Smits R, Moeslein G, Fodde R, Tanke HJ, Raap AK, Darroudi F.

Genes Chromosomes Cancer. 2003 Oct;38(2):177-86.


Identification of RUNX1/AML1 as a classical tumor suppressor gene.

Silva FP, Morolli B, Storlazzi CT, Anelli L, Wessels H, Bezrookove V, Kluin-Nelemans HC, Giphart-Gassler M.

Oncogene. 2003 Jan 30;22(4):538-47.


A 10-Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred.

Wagner A, van der Klift H, Franken P, Wijnen J, Breukel C, Bezrookove V, Smits R, Kinarsky Y, Barrows A, Franklin B, Lynch J, Lynch H, Fodde R.

Genes Chromosomes Cancer. 2002 Sep;35(1):49-57.


Insights into the sites of X ray and neutron induced chromosomal aberrations in human lymphocytes using COBRA-MFISH.

Darroudi F, Bezrookove V, Fomina J, Mesker WE, Wiegant JC, Raap AK, Tanke HJ.

Radiat Prot Dosimetry. 2002;99(1-4):189-92.


Differentially painting human chromosome arms with combined binary ratio-labeling fluorescence in situ hybridization.

Wiegant J, Bezrookove V, Rosenberg C, Tanke HJ, Raap AK, Zhang H, Bittner M, Trent JM, Meltzer P.

Genome Res. 2000 Jun;10(6):861-5.


Individuals with abnormal phenotype and normal G-banding karyotype: improvement and limitations in the diagnosis by the use of 24-colour FISH.

Bezrookove V, Hansson K, van der Burg M, van der Smagt JJ, Hilhorst-Hofstee Y, Wiegant J, Beverstock GC, Raap AK, Tanke H, Breuning MH, Rosenberg C.

Hum Genet. 2000 Apr;106(4):392-8.


Synthesis and purification of horseradish peroxidase-labeled oligonucleotides for tyramide-based fluorescence in situ hybridization.

van Gijlswijk RP, van de Corput MP, Bezrookove V, Wiegant J, Tanke HJ, Raap AK.

Histochem Cell Biol. 2000 Mar;113(3):175-80.


Simultaneous molecular karyotyping and mapping of viral DNA integration sites by 25-color COBRA-FISH.

Szuhai K, Bezrookove V, Wiegant J, Vrolijk J, Dirks RW, Rosenberg C, Raap AK, Tanke HJ.

Genes Chromosomes Cancer. 2000 May;28(1):92-7.


ULS: a versatile method of labeling nucleic acids for FISH based on a monofunctional reaction of cisplatin derivatives with guanine moieties.

Wiegant JC, van Gijlswijk RP, Heetebrij RJ, Bezrookove V, Raap AK, Tanke HJ.

Cytogenet Cell Genet. 1999;87(1-2):47-52.


Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines.

Koopman LA, Szuhai K, van Eendenburg JD, Bezrookove V, Kenter GG, Schuuring E, Tanke H, Fleuren GJ.

Cancer Res. 1999 Nov 1;59(21):5615-24.


New strategy for multi-colour fluorescence in situ hybridisation: COBRA: COmbined Binary RAtio labelling.

Tanke HJ, Wiegant J, van Gijlswijk RP, Bezrookove V, Pattenier H, Heetebrij RJ, Talman EG, Raap AK, Vrolijk J.

Eur J Hum Genet. 1999 Jan;7(1):2-11.

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