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Items: 1 to 50 of 150


Presynaptic endoplasmic reticulum and neurotransmission.

Bezprozvanny I, Kavalali ET.

Cell Calcium. 2020 Jan;85:102133. doi: 10.1016/j.ceca.2019.102133. Epub 2019 Nov 27.


Calcium hypothesis of neurodegeneration - An update.

Bezprozvanny I.

Biochem Biophys Res Commun. 2019 Dec 17;520(4):667-669. doi: 10.1016/j.bbrc.2019.10.016. No abstract available.


Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution.

Chakraborty T, Driscoll MK, Jeffery E, Murphy MM, Roudot P, Chang BJ, Vora S, Wong WM, Nielson CD, Zhang H, Zhemkov V, Hiremath C, De La Cruz ED, Yi Y, Bezprozvanny I, Zhao H, Tomer R, Heintzmann R, Meeks JP, Marciano DK, Morrison SJ, Danuser G, Dean KM, Fiolka R.

Nat Methods. 2019 Nov;16(11):1109-1113. doi: 10.1038/s41592-019-0615-4. Epub 2019 Oct 31.


Mutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability.

Ryskamp DA, Zhemkov V, Bezprozvanny I.

Front Neurosci. 2019 Sep 19;13:1012. doi: 10.3389/fnins.2019.01012. eCollection 2019.


Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases.

Ryskamp DA, Korban S, Zhemkov V, Kraskovskaya N, Bezprozvanny I.

Front Neurosci. 2019 Aug 28;13:862. doi: 10.3389/fnins.2019.00862. eCollection 2019. Review.


Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2.

Egorova PA, Bezprozvanny IB.

Neurotherapeutics. 2019 Oct;16(4):1050-1073. doi: 10.1007/s13311-019-00777-6. Review.


Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease.

Chernyuk D, Zernov N, Kabirova M, Bezprozvanny I, Popugaeva E.

Neuroscience. 2019 Jul 1;410:118-127. doi: 10.1016/j.neuroscience.2019.04.043. Epub 2019 May 2.


Amyloid β perturbs elevated heme flux induced with neuronal development.

Vidal C, Daescu K, Fitzgerald KE, Starokadomska A, Bezprozvanny I, Zhang L.

Alzheimers Dement (N Y). 2019 Jan 22;5:27-37. doi: 10.1016/j.trci.2018.12.003. eCollection 2019.


Derivatives of Piperazines as Potential Therapeutic Agents for Alzheimer's Disease.

Popugaeva E, Chernyuk D, Zhang H, Postnikova TY, Pats K, Fedorova E, Poroikov V, Zaitsev AV, Bezprozvanny I.

Mol Pharmacol. 2019 Apr;95(4):337-348. doi: 10.1124/mol.118.114348. Epub 2019 Jan 29.


Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Ryskamp D, Wu L, Wu J, Kim D, Rammes G, Geva M, Hayden M, Bezprozvanny I.

Neurobiol Dis. 2019 Apr;124:489-504. doi: 10.1016/j.nbd.2018.12.022. Epub 2018 Dec 27.


Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology.

Pchitskaya EI, Zhemkov VA, Bezprozvanny IB.

Biochemistry (Mosc). 2018 Sep;83(9):1068-1074. doi: 10.1134/S0006297918090080. Review.


Reactions of Cyclometalated Platinum(II) [Pt(NC)(PR3)Cl] Complexes with Imidazole and Imidazole-Containing Biomolecules: Fine-Tuning of Reactivity and Photophysical Properties via Ligand Design.

Solomatina AI, Chelushkin PS, Abakumova TO, Zhemkov VA, Kim M, Bezprozvanny I, Gurzhiy VV, Melnikov AS, Anufrikov YA, Koshevoy IO, Su SH, Chou PT, Tunik SP.

Inorg Chem. 2019 Jan 7;58(1):204-217. doi: 10.1021/acs.inorgchem.8b02204. Epub 2018 Oct 30.


Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.

Popugaeva E, Pchitskaya E, Bezprozvanny I.

Antioxid Redox Signal. 2018 Oct 20;29(12):1176-1188. doi: 10.1089/ars.2018.7506. Epub 2018 Aug 3. Review.


In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model.

Egorova PA, Gavrilova AV, Bezprozvanny IB.

Cerebellum. 2018 Oct;17(5):590-600. doi: 10.1007/s12311-018-0951-4.


Pin1 mediates Aβ42-induced dendritic spine loss.

Stallings NR, O'Neal MA, Hu J, Kavalali ET, Bezprozvanny I, Malter JS.

Sci Signal. 2018 Mar 20;11(522). pii: eaap8734. doi: 10.1126/scisignal.aap8734.


Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease.

Wu J, Ryskamp D, Birnbaumer L, Bezprozvanny I.

J Huntingtons Dis. 2018;7(1):35-50. doi: 10.3233/JHD-170266.


STIM proteins as regulators of neuronal store-operated calcium influx.

Popugaeva E, Bezprozvanny I.

Neurodegener Dis Manag. 2018 Feb;8(1):5-7. doi: 10.2217/nmt-2017-0053. Epub 2018 Jan 3. Review. No abstract available.


Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders.

Egorova PA, Bezprozvanny IB.

FEBS J. 2018 Oct;285(19):3547-3565. doi: 10.1111/febs.14366. Epub 2018 Jan 12. Review.


Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.

Pchitskaya E, Kraskovskaya N, Chernyuk D, Popugaeva E, Zhang H, Vlasova O, Bezprozvanny I.

Sci Rep. 2017 Dec 15;7(1):17625. doi: 10.1038/s41598-017-17762-8.


Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease.

Bol'shakova AV, Kraskovskaya NA, Gainullina AN, Kukanova EO, Vlasova OL, Bezprozvanny IB.

Bull Exp Biol Med. 2017 Dec;164(2):252-258. doi: 10.1007/s10517-017-3968-7. Epub 2017 Nov 25.


Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

Grigorenko AP, Moliaka YK, Plotnikova OV, Smirnov A, Nikishina VA, Goltsov AY, Gusev F, Andreeva TV, Nelson O, Bezprozvanny I, Rogaev EI.

Oncotarget. 2017 May 30;8(47):82006-82026. doi: 10.18632/oncotarget.18299. eCollection 2017 Oct 10.


Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.

Pchitskaya E, Popugaeva E, Bezprozvanny I.

Cell Calcium. 2018 Mar;70:87-94. doi: 10.1016/j.ceca.2017.06.008. Epub 2017 Jun 30. Review.


Misery loves company - shared features of neurodegenerative disorders.

Bezprozvanny I, Sorgato MC, Carafoli E.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):979-980. doi: 10.1016/j.bbrc.2017.01.099. No abstract available.


Neurons from skin mimic brain holes.

Bezprozvanny I, Kiselev SL.

Oncotarget. 2017 Feb 7;8(6):8997-8998. doi: 10.18632/oncotarget.13709. No abstract available.


Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.

Zhang H, Sun S, Wu L, Pchitskaya E, Zakharova O, Fon Tacer K, Bezprozvanny I.

J Neurosci. 2016 Nov 23;36(47):11837-11850.


The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I.

Neurobiol Dis. 2017 Jan;97(Pt A):46-59. doi: 10.1016/j.nbd.2016.10.006. Epub 2016 Nov 3.


Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Popugaeva E, Pchitskaya E, Bezprozvanny I.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):998-1004. doi: 10.1016/j.bbrc.2016.09.053. Epub 2016 Sep 15. Review.


The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.

Zhemkov VA, Kulminskaya AA, Bezprozvanny IB, Kim M.

FEBS Open Bio. 2016 Feb 18;6(3):168-78. doi: 10.1002/2211-5463.12029. eCollection 2016 Mar.


In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.

Egorova PA, Zakharova OA, Vlasova OL, Bezprozvanny IB.

J Neurophysiol. 2016 Jun 1;115(6):2840-51. doi: 10.1152/jn.00913.2015. Epub 2016 Mar 16.


Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.

Wu J, Ryskamp DA, Liang X, Egorova P, Zakharova O, Hung G, Bezprozvanny I.

J Neurosci. 2016 Jan 6;36(1):125-41. doi: 10.1523/JNEUROSCI.1038-15.2016.


AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease.

Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R.

Neurodegener Dis. 2016;16(1-2):95-110.


Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.

Popugaeva E, Vlasova OL, Bezprozvanny I.

Neurodegener Dis Manag. 2015 Oct;5(5):395-8. doi: 10.2217/nmt.15.36. Epub 2015 Oct 19. Review.


Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling.

Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber KM, Wu JI.

Mol Cell Biol. 2015 Oct 12;36(1):70-83. doi: 10.1128/MCB.00534-15. Print 2016 Jan 1.


Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.

Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I.

J Neurosci. 2015 Sep 30;35(39):13275-86. doi: 10.1523/JNEUROSCI.1034-15.2015.


STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.

Popugaeva E, Pchitskaya E, Speshilova A, Alexandrov S, Zhang H, Vlasova O, Bezprozvanny I.

Mol Neurodegener. 2015 Aug 15;10:37. doi: 10.1186/s13024-015-0034-7.


Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Egorova P, Popugaeva E, Bezprozvanny I.

Semin Cell Dev Biol. 2015 Apr;40:127-33. doi: 10.1016/j.semcdb.2015.03.010. Epub 2015 Apr 4. Review.


Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease.

Zhang H, Liu J, Sun S, Pchitskaya E, Popugaeva E, Bezprozvanny I.

J Alzheimers Dis. 2015;45(2):561-80. doi: 10.3233/JAD-142427.


An automated and quantitative method to evaluate progression of striatal pathology in Huntington's disease transgenic mice.

Liang X, Wu J, Egorova P, Bezprozvanny I.

J Huntingtons Dis. 2014;3(4):343-350. doi: 10.3233/JHD-140128.


Commentary on "Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice".

Popugaeva E, Bezprozvanny I.

Front Cell Neurosci. 2014 Oct 28;8:351. doi: 10.3389/fncel.2014.00351. eCollection 2014. No abstract available.


Simplified method to perform CLARITY imaging.

Poguzhelskaya E, Artamonov D, Bolshakova A, Vlasova O, Bezprozvanny I.

Mol Neurodegener. 2014 May 26;9:19. doi: 10.1186/1750-1326-9-19.


Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

Sun S, Zhang H, Liu J, Popugaeva E, Xu NJ, Feske S, White CL 3rd, Bezprozvanny I.

Neuron. 2014 Apr 2;82(1):79-93. doi: 10.1016/j.neuron.2014.02.019.


The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.

Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, Bezprozvanny I.

Channels (Austin). 2014;8(3):230-42.


Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

Fedorenko OA, Popugaeva E, Enomoto M, Stathopulos PB, Ikura M, Bezprozvanny I.

Eur J Pharmacol. 2014 Sep 15;739:39-48. doi: 10.1016/j.ejphar.2013.10.074. Epub 2013 Dec 1. Review.


Reconstitution of endoplasmic reticulum InsP3 receptors into black lipid membranes.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.prot073106. doi: 10.1101/pdb.prot073106.


Preparation of microsomes to study Ca2+ channels.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.prot073098. doi: 10.1101/pdb.prot073098.


Bilayer measurement of endoplasmic reticulum Ca2+ channels.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.top066225. doi: 10.1101/pdb.top066225.


Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?

Popugaeva E, Bezprozvanny I.

Neurodegener Dis. 2014;13(2-3):139-41. doi: 10.1159/000354778. Epub 2013 Sep 24.


Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease.

Popugaeva E, Bezprozvanny I.

Front Mol Neurosci. 2013 Sep 18;6:29. doi: 10.3389/fnmol.2013.00029. eCollection 2013.


Presenilins and calcium signaling-systems biology to the rescue.

Bezprozvanny I.

Sci Signal. 2013 Jul 9;6(283):pe24. doi: 10.1126/scisignal.2004296. Review.


The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration.

Bezprozvanny I, Hiesinger PR.

Mol Neurodegener. 2013 Jul 8;8:23. doi: 10.1186/1750-1326-8-23. Review.

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