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Items: 1 to 50 of 138


Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.

Popugaeva E, Pchitskaya E, Bezprozvanny I.

Antioxid Redox Signal. 2018 Oct 20;29(12):1176-1188. doi: 10.1089/ars.2018.7506. Epub 2018 Aug 3.


In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model.

Egorova PA, Gavrilova AV, Bezprozvanny IB.

Cerebellum. 2018 Jun 6. doi: 10.1007/s12311-018-0951-4. [Epub ahead of print]


Pin1 mediates Aβ42-induced dendritic spine loss.

Stallings NR, O'Neal MA, Hu J, Kavalali ET, Bezprozvanny I, Malter JS.

Sci Signal. 2018 Mar 20;11(522). pii: eaap8734. doi: 10.1126/scisignal.aap8734.


Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease.

Wu J, Ryskamp D, Birnbaumer L, Bezprozvanny I.

J Huntingtons Dis. 2018;7(1):35-50. doi: 10.3233/JHD-170266.


STIM proteins as regulators of neuronal store-operated calcium influx.

Popugaeva E, Bezprozvanny I.

Neurodegener Dis Manag. 2018 Feb;8(1):5-7. doi: 10.2217/nmt-2017-0053. Epub 2018 Jan 3. No abstract available.


Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders.

Egorova PA, Bezprozvanny IB.

FEBS J. 2018 Oct;285(19):3547-3565. doi: 10.1111/febs.14366. Epub 2018 Jan 12. Review.


Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.

Pchitskaya E, Kraskovskaya N, Chernyuk D, Popugaeva E, Zhang H, Vlasova O, Bezprozvanny I.

Sci Rep. 2017 Dec 15;7(1):17625. doi: 10.1038/s41598-017-17762-8.


Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease.

Bol'shakova AV, Kraskovskaya NA, Gainullina AN, Kukanova EO, Vlasova OL, Bezprozvanny IB.

Bull Exp Biol Med. 2017 Dec;164(2):252-258. doi: 10.1007/s10517-017-3968-7. Epub 2017 Nov 25.


Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

Grigorenko AP, Moliaka YK, Plotnikova OV, Smirnov A, Nikishina VA, Goltsov AY, Gusev F, Andreeva TV, Nelson O, Bezprozvanny I, Rogaev EI.

Oncotarget. 2017 May 30;8(47):82006-82026. doi: 10.18632/oncotarget.18299. eCollection 2017 Oct 10.


Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.

Pchitskaya E, Popugaeva E, Bezprozvanny I.

Cell Calcium. 2018 Mar;70:87-94. doi: 10.1016/j.ceca.2017.06.008. Epub 2017 Jun 30. Review.


Misery loves company - shared features of neurodegenerative disorders.

Bezprozvanny I, Sorgato MC, Carafoli E.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):979-980. doi: 10.1016/j.bbrc.2017.01.099. No abstract available.


Neurons from skin mimic brain holes.

Bezprozvanny I, Kiselev SL.

Oncotarget. 2017 Feb 7;8(6):8997-8998. doi: 10.18632/oncotarget.13709. No abstract available.


Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.

Zhang H, Sun S, Wu L, Pchitskaya E, Zakharova O, Fon Tacer K, Bezprozvanny I.

J Neurosci. 2016 Nov 23;36(47):11837-11850.


The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I.

Neurobiol Dis. 2017 Jan;97(Pt A):46-59. doi: 10.1016/j.nbd.2016.10.006. Epub 2016 Nov 3.


Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Popugaeva E, Pchitskaya E, Bezprozvanny I.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):998-1004. doi: 10.1016/j.bbrc.2016.09.053. Epub 2016 Sep 15. Review.


The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.

Zhemkov VA, Kulminskaya AA, Bezprozvanny IB, Kim M.

FEBS Open Bio. 2016 Feb 18;6(3):168-78. doi: 10.1002/2211-5463.12029. eCollection 2016 Mar.


In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.

Egorova PA, Zakharova OA, Vlasova OL, Bezprozvanny IB.

J Neurophysiol. 2016 Jun 1;115(6):2840-51. doi: 10.1152/jn.00913.2015. Epub 2016 Mar 16.


Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.

Wu J, Ryskamp DA, Liang X, Egorova P, Zakharova O, Hung G, Bezprozvanny I.

J Neurosci. 2016 Jan 6;36(1):125-41. doi: 10.1523/JNEUROSCI.1038-15.2016.


AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease.

Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R.

Neurodegener Dis. 2016;16(1-2):95-110.


Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.

Popugaeva E, Vlasova OL, Bezprozvanny I.

Neurodegener Dis Manag. 2015 Oct;5(5):395-8. doi: 10.2217/nmt.15.36. Epub 2015 Oct 19. Review.


Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling.

Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber KM, Wu JI.

Mol Cell Biol. 2015 Oct 12;36(1):70-83. doi: 10.1128/MCB.00534-15. Print 2016 Jan 1.


Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.

Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I.

J Neurosci. 2015 Sep 30;35(39):13275-86. doi: 10.1523/JNEUROSCI.1034-15.2015.


STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.

Popugaeva E, Pchitskaya E, Speshilova A, Alexandrov S, Zhang H, Vlasova O, Bezprozvanny I.

Mol Neurodegener. 2015 Aug 15;10:37. doi: 10.1186/s13024-015-0034-7.


Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Egorova P, Popugaeva E, Bezprozvanny I.

Semin Cell Dev Biol. 2015 Apr;40:127-33. doi: 10.1016/j.semcdb.2015.03.010. Epub 2015 Apr 4. Review.


Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease.

Zhang H, Liu J, Sun S, Pchitskaya E, Popugaeva E, Bezprozvanny I.

J Alzheimers Dis. 2015;45(2):561-80. doi: 10.3233/JAD-142427.


An automated and quantitative method to evaluate progression of striatal pathology in Huntington's disease transgenic mice.

Liang X, Wu J, Egorova P, Bezprozvanny I.

J Huntingtons Dis. 2014;3(4):343-350. doi: 10.3233/JHD-140128.


Commentary on "Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice".

Popugaeva E, Bezprozvanny I.

Front Cell Neurosci. 2014 Oct 28;8:351. doi: 10.3389/fncel.2014.00351. eCollection 2014. No abstract available.


Simplified method to perform CLARITY imaging.

Poguzhelskaya E, Artamonov D, Bolshakova A, Vlasova O, Bezprozvanny I.

Mol Neurodegener. 2014 May 26;9:19. doi: 10.1186/1750-1326-9-19.


Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

Sun S, Zhang H, Liu J, Popugaeva E, Xu NJ, Feske S, White CL 3rd, Bezprozvanny I.

Neuron. 2014 Apr 2;82(1):79-93. doi: 10.1016/j.neuron.2014.02.019.


The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.

Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, Bezprozvanny I.

Channels (Austin). 2014;8(3):230-42.


Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

Fedorenko OA, Popugaeva E, Enomoto M, Stathopulos PB, Ikura M, Bezprozvanny I.

Eur J Pharmacol. 2014 Sep 15;739:39-48. doi: 10.1016/j.ejphar.2013.10.074. Epub 2013 Dec 1. Review.


Reconstitution of endoplasmic reticulum InsP3 receptors into black lipid membranes.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.prot073106. doi: 10.1101/pdb.prot073106.


Preparation of microsomes to study Ca2+ channels.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.prot073098. doi: 10.1101/pdb.prot073098.


Bilayer measurement of endoplasmic reticulum Ca2+ channels.

Bezprozvanny I.

Cold Spring Harb Protoc. 2013 Nov 1;2013(11). pii: pdb.top066225. doi: 10.1101/pdb.top066225.


Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?

Popugaeva E, Bezprozvanny I.

Neurodegener Dis. 2014;13(2-3):139-41. doi: 10.1159/000354778. Epub 2013 Sep 24.


Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease.

Popugaeva E, Bezprozvanny I.

Front Mol Neurosci. 2013 Sep 18;6:29. doi: 10.3389/fnmol.2013.00029. eCollection 2013.


Presenilins and calcium signaling-systems biology to the rescue.

Bezprozvanny I.

Sci Signal. 2013 Jul 9;6(283):pe24. doi: 10.1126/scisignal.2004296. Review.


The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration.

Bezprozvanny I, Hiesinger PR.

Mol Neurodegener. 2013 Jul 8;8:23. doi: 10.1186/1750-1326-8-23. Review.


Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.

Luo Y, Vali S, Sun S, Chen X, Liang X, Drozhzhina T, Popugaeva E, Bezprozvanny I.

ACS Chem Neurosci. 2013 Jun 19;4(6):952-62. doi: 10.1021/cn400011f. Epub 2013 Mar 7.


Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.

Kasumu AW, Hougaard C, Rode F, Jacobsen TA, Sabatier JM, Eriksen BL, Strøbæk D, Liang X, Egorova P, Vorontsova D, Christophersen P, Rønn LC, Bezprozvanny I.

Chem Biol. 2012 Oct 26;19(10):1340-53. doi: 10.1016/j.chembiol.2012.07.013.


Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice.

Kasumu AW, Liang X, Egorova P, Vorontsova D, Bezprozvanny I.

J Neurosci. 2012 Sep 12;32(37):12786-96. doi: 10.1523/JNEUROSCI.1643-12.2012.


Presenilins: a novel link between intracellular calcium signaling and lysosomal function?

Bezprozvanny I.

J Cell Biol. 2012 Jul 9;198(1):7-10. doi: 10.1083/jcb.201206003.


Response to Shilling et al. (10.1074/jbc.M111.300491).

Bezprozvanny I, Supnet C, Sun S, Zhang H, De Strooper B.

J Biol Chem. 2012 Jun 8;287(24):20469; author reply 20470. doi: 10.1074/jbc.L112.356790. No abstract available.


The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A.

J Biol Chem. 2012 Jan 20;287(4):2544-57. doi: 10.1074/jbc.M111.275354. Epub 2011 Nov 28.


Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.

Chen X, Wu J, Lvovskaya S, Herndon E, Supnet C, Bezprozvanny I.

Mol Neurodegener. 2011 Nov 25;6:81. doi: 10.1186/1750-1326-6-81.


Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.

Chen X, Wu J, Luo Y, Liang X, Supnet C, Kim MW, Lotz GP, Yang G, Muchowski PJ, Kodadek T, Bezprozvanny I.

Chem Biol. 2011 Sep 23;18(9):1113-25. doi: 10.1016/j.chembiol.2011.06.010.


Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.

Supnet C, Bezprozvanny I.

Sci China Life Sci. 2011 Aug;54(8):744-51. doi: 10.1007/s11427-011-4201-y. Epub 2011 Jul 24. Review.


Delay in I(min) channel activation induced by dissociation of Homer proteins in A431 cells.

Shalygin AV, Ryazantseva MA, Glushankova LN, Bezprozvanny IB, Mozhayeva GN, Kaznacheyeva EV.

Dokl Biol Sci. 2011 May-Jun;438:131-4. doi: 10.1134/S0012496611030033. Epub 2011 Jul 5. No abstract available.


Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.

Wu J, Shih HP, Vigont V, Hrdlicka L, Diggins L, Singh C, Mahoney M, Chesworth R, Shapiro G, Zimina O, Chen X, Wu Q, Glushankova L, Ahlijanian M, Koenig G, Mozhayeva GN, Kaznacheyeva E, Bezprozvanny I.

Chem Biol. 2011 Jun 24;18(6):777-93. doi: 10.1016/j.chembiol.2011.04.012.

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