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Items: 30


Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K.

Cell Rep. 2018 Aug 7;24(6):1425-1433. doi: 10.1016/j.celrep.2018.07.027.


Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.


Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K.

J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6.


Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective.

Kumar A, Suryadevara N, Hill TM, Bezbradica JS, Van Kaer L, Joyce S.

Front Immunol. 2017 Dec 22;8:1858. doi: 10.3389/fimmu.2017.01858. eCollection 2017. Review.


NF-κB Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death.

Kumar A, Gordy LE, Bezbradica JS, Stanic AK, Hill TM, Boothby MR, Van Kaer L, Joyce S.

Sci Rep. 2017 Nov 15;7(1):15594. doi: 10.1038/s41598-017-15461-y.


Zebrafish earns its stripes for in vivo ASC speck dynamics.

Bezbradica JS, Schroder K.

J Cell Biol. 2017 Sep 4;216(9):2615-2618. doi: 10.1083/jcb.201708002. Epub 2017 Aug 15.


Characterization and Functional Analysis of Mouse Semi-invariant Natural T Cells.

Kumar A, Bezbradica JS, Stanic AK, Joyce S.

Curr Protoc Immunol. 2017 Apr 3;117:14.13.1-14.13.55. doi: 10.1002/cpim.22.


The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists.

Chen KW, Bezbradica JS, Groß CJ, Wall AA, Sweet MJ, Stow JL, Schroder K.

Eur J Immunol. 2016 Apr;46(4):1004-10. doi: 10.1002/eji.201545943. Epub 2016 Feb 1.


Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals.

Bezbradica JS, Coll RC, Schroder K.

Cell Mol Immunol. 2017 Jan;14(1):118-126. doi: 10.1038/cmi.2016.11. Epub 2016 Mar 21.


Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.

Spencer CT, Bezbradica JS, Ramos MG, Arico CD, Conant SB, Gilchuk P, Gray JJ, Zheng M, Niu X, Hildebrand W, Link AJ, Joyce S.

Proteomics Clin Appl. 2015 Dec;9(11-12):1035-52. doi: 10.1002/prca.201500106.


Signaling pathways activated by a protease allergen in basophils.

Rosenstein RK, Bezbradica JS, Yu S, Medzhitov R.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4963-71. doi: 10.1073/pnas.1418959111. Epub 2014 Nov 4.


TRAF6 is a nexus for TLR-STAT1 crosstalk.

Bezbradica JS, Schroder K.

Immunol Cell Biol. 2014 Oct;92(9):737-8. doi: 10.1038/icb.2014.71. Epub 2014 Aug 12. No abstract available.


A role for the ITAM signaling module in specifying cytokine-receptor functions.

Bezbradica JS, Rosenstein RK, DeMarco RA, Brodsky I, Medzhitov R.

Nat Immunol. 2014 Apr;15(4):333-42. doi: 10.1038/ni.2845. Epub 2014 Mar 9.


Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.

Paduraru C, Bezbradica JS, Kunte A, Kelly R, Shayman JA, Veerapen N, Cox LR, Besra GS, Cresswell P.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5097-102. doi: 10.1073/pnas.1302923110. Epub 2013 Mar 14.


Role of ITAM signaling module in signal integration.

Bezbradica JS, Medzhitov R.

Curr Opin Immunol. 2012 Feb;24(1):58-66. doi: 10.1016/j.coi.2011.12.010. Epub 2012 Jan 11. Review.


IL-15 regulates homeostasis and terminal maturation of NKT cells.

Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S.

J Immunol. 2011 Dec 15;187(12):6335-45. doi: 10.4049/jimmunol.1003965. Epub 2011 Nov 14.


Integration of cytokine and heterologous receptor signaling pathways.

Bezbradica JS, Medzhitov R.

Nat Immunol. 2009 Apr;10(4):333-9. doi: 10.1038/ni.1713. Epub 2009 Mar 19. Review. Erratum in: Nat Immunol. 2009 Jun;10(6):665.


Characterization and functional analysis of mouse invariant natural T (iNKT) cells.

Bezbradica JS, Stanic AK, Joyce S.

Curr Protoc Immunol. 2006 Jul;Chapter 14:Unit 14.13. doi: 10.1002/0471142735.im1413s73.


IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.

Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S, Hunter CA.

Int Immunol. 2008 Jun;20(6):739-52. doi: 10.1093/intimm/dxn032. Epub 2008 Mar 28.


A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence.

Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP.

Cell Host Microbe. 2007 Apr 19;1(2):109-19.


NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway.

Horng T, Bezbradica JS, Medzhitov R.

Nat Immunol. 2007 Dec;8(12):1345-52. Epub 2007 Oct 21.


Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.

Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S.

Immunity. 2006 Sep;25(3):487-97. Epub 2006 Aug 31.


Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.

Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S.

J Immunol. 2005 Apr 15;174(8):4696-705.


Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.

Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5114-9. Epub 2005 Mar 25.


Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids.

Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L.

J Immunol. 2004 Sep 15;173(6):3693-706.


Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis.

Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J, Sudo K, Hatano-Yokoe Y, Bezbradica JS, Joyce S, Abo T, Iwakura Y, Suzuki K, Yamagoe S.

J Immunol. 2004 Jul 1;173(1):579-85.


Natural killer T cells accelerate atherogenesis in mice.

Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Tanaka S, Bezbradica JS, Nakayama T, Taniguchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoé K.

Blood. 2004 Oct 1;104(7):2051-9. Epub 2004 Apr 27.


Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.

Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S.

J Immunol. 2004 Apr 15;172(8):4667-71.


NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes.

Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S.

J Immunol. 2004 Feb 15;172(4):2265-73.


Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].

Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S.

J Immunol. 2003 Nov 1;171(9):4539-51. Erratum in: J Immunol. 2004 Jan 1;172(1):717.

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