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Items: 1 to 50 of 218


Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker.

Carvalho-de-Souza JL, Bezanilla F.

Nat Commun. 2019 Aug 8;10(1):3584. doi: 10.1038/s41467-019-11545-7.


An atlas of nano-enabled neural interfaces.

Acarón Ledesma H, Li X, Carvalho-de-Souza JL, Wei W, Bezanilla F, Tian B.

Nat Nanotechnol. 2019 Jul;14(7):645-657. doi: 10.1038/s41565-019-0487-x. Epub 2019 Jul 3. Review.


Nongenetic optical neuromodulation with silicon-based materials.

Jiang Y, Parameswaran R, Li X, Carvalho-de-Souza JL, Gao X, Meng L, Bezanilla F, Shepherd GMG, Tian B.

Nat Protoc. 2019 May;14(5):1339-1376. doi: 10.1038/s41596-019-0135-9. Epub 2019 Apr 12.


Continuum Gating Current Models Computed with Consistent Interactions.

Horng TL, Eisenberg RS, Liu C, Bezanilla F.

Biophys J. 2019 Jan 22;116(2):270-282. doi: 10.1016/j.bpj.2018.11.3140. Epub 2018 Dec 14.


Methodological improvements for fluorescence recordings in Xenopus laevis oocytes.

Lee EEL, Bezanilla F.

J Gen Physiol. 2019 Feb 4;151(2):264-272. doi: 10.1085/jgp.201812189. Epub 2019 Jan 3.


Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity.

Carvalho-de-Souza JL, Nag OK, Oh E, Huston AL, Vurgaftman I, Pepperberg DR, Bezanilla F, Delehanty JB.

ACS Chem Neurosci. 2019 Mar 20;10(3):1478-1487. doi: 10.1021/acschemneuro.8b00486. Epub 2019 Jan 15.


Influences: The Cell Physiology Laboratory in Montemar, Chile.

Bezanilla F.

J Gen Physiol. 2018 Nov 5;150(11):1464-1468. doi: 10.1085/jgp.201812157. Epub 2018 Oct 19. No abstract available.


Gating currents.

Bezanilla F.

J Gen Physiol. 2018 Jul 2;150(7):911-932. doi: 10.1085/jgp.201812090. Epub 2018 Jun 25. Review.


Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape.

Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA.

J Gen Physiol. 2018 Jul 2;150(7):1017-1024. doi: 10.1085/jgp.201812075. Epub 2018 Jun 4.


Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET.

Carrasquel-Ursulaez W, Alvarez O, Bezanilla F, Latorre R.

Biophys J. 2018 Jun 5;114(11):2493-2497. doi: 10.1016/j.bpj.2018.04.008. Epub 2018 Apr 26.


Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires.

Parameswaran R, Carvalho-de-Souza JL, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B.

Nat Nanotechnol. 2018 Mar;13(3):260-266. doi: 10.1038/s41565-017-0041-7. Epub 2018 Feb 19.


Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation.

Mathur C, Johnson KR, Tong BA, Miranda P, Srikumar D, Basilio D, Latorre R, Bezanilla F, Holmgren M.

Sci Rep. 2018 Feb 2;8(1):2207. doi: 10.1038/s41598-018-20684-8.


Development of a PET radioligand for potassium channels to image CNS demyelination.

Brugarolas P, Sánchez-Rodríguez JE, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B.

Sci Rep. 2018 Jan 12;8(1):607. doi: 10.1038/s41598-017-18747-3.


Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.

Carvalho-de-Souza JL, Bezanilla F.

J Gen Physiol. 2018 Feb 5;150(2):307-321. doi: 10.1085/jgp.201711882. Epub 2018 Jan 10.


LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b.

Nanazashvili M, Sánchez-Rodríguez JE, Fosque B, Bezanilla F, Sackin H.

Biophys J. 2018 Jan 9;114(1):88-97. doi: 10.1016/j.bpj.2017.10.044.


Optocapacitive Generation of Action Potentials by Microsecond Laser Pulses of Nanojoule Energy.

Carvalho-de-Souza JL, Pinto BI, Pepperberg DR, Bezanilla F.

Biophys J. 2018 Jan 23;114(2):283-288. doi: 10.1016/j.bpj.2017.11.018. Epub 2017 Dec 19.


Roadmap on semiconductor-cell biointerfaces.

Tian B, Xu S, Rogers JA, Cestellos-Blanco S, Yang P, Carvalho-de-Souza JL, Bezanilla F, Liu J, Bao Z, Hjort M, Cao Y, Melosh N, Lanzani G, Benfenati F, Galli G, Gygi F, Kautz R, Gorodetsky AA, Kim SS, Lu TK, Anikeeva P, Cifra M, Krivosudský O, Havelka D, Jiang Y.

Phys Biol. 2018 Mar 9;15(3):031002. doi: 10.1088/1478-3975/aa9f34. Review.


Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin.

Kubota T, Dang B, Carvalho-de-Souza JL, Correa AM, Bezanilla F.

Sci Rep. 2017 Nov 27;7(1):16329. doi: 10.1038/s41598-017-16426-x.


Correspondence: Reply to 'Revisiting the theoretical cell membrane thermal capacitance response'.

Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F.

Nat Commun. 2017 Nov 10;8(1):1432. doi: 10.1038/s41467-017-00436-4. No abstract available.


Corrigendum: Infrared light excites cells by changing their electrical capacitance.

Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F.

Nat Commun. 2017 Nov 10;8:16148. doi: 10.1038/ncomms16148.


Biophysical Characterization of Genetically Encoded Voltage Sensor ASAP1: Dynamic Range Improvement.

Lee EEL, Bezanilla F.

Biophys J. 2017 Nov 21;113(10):2178-2181. doi: 10.1016/j.bpj.2017.10.018. Epub 2017 Nov 3.


Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit.

Kubota T, Correa AM, Bezanilla F.

Sci Rep. 2017 Mar 28;7:45310. doi: 10.1038/srep45310.


Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1857-E1865. doi: 10.1073/pnas.1700453114. Epub 2017 Feb 15.


Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin.

Dang B, Shen R, Kubota T, Mandal K, Bezanilla F, Roux B, Kent SB.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3324-3328. doi: 10.1002/anie.201612398. Epub 2017 Feb 14.


A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor.

Barchad-Avitzur O, Priest MF, Dekel N, Bezanilla F, Parnas H, Ben-Chaim Y.

Biophys J. 2016 Oct 4;111(7):1396-1408. doi: 10.1016/j.bpj.2016.08.035.


Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.

Jiang Y, Carvalho-de-Souza JL, Wong RC, Luo Z, Isheim D, Zuo X, Nicholls AW, Jung IW, Yue J, Liu DJ, Wang Y, De Andrade V, Xiao X, Navrazhnykh L, Weiss DE, Wu X, Seidman DN, Bezanilla F, Tian B.

Nat Mater. 2016 Sep;15(9):1023-30. doi: 10.1038/nmat4673. Epub 2016 Jun 27.


Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin.

Dang B, Kubota T, Mandal K, Correa AM, Bezanilla F, Kent SB.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8639-42. doi: 10.1002/anie.201603420. Epub 2016 May 31.


β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.

Castillo JP, Sánchez-Rodríguez JE, Hyde HC, Zaelzer CA, Aguayo D, Sepúlveda RV, Luk LY, Kent SB, Gonzalez-Nilo FD, Bezanilla F, Latorre R.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3231-9. doi: 10.1073/pnas.1606381113. Epub 2016 May 23.


Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.

Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F.

Nat Commun. 2015 Dec 17;6:10173. doi: 10.1038/ncomms10173.


Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator.

Treger JS, Priest MF, Bezanilla F.

Elife. 2015 Nov 24;4:e10482. doi: 10.7554/eLife.10482.


Resting state of the human proton channel dimer in a lipid bilayer.

Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5926-35. doi: 10.1073/pnas.1515043112. Epub 2015 Oct 6.


Functional Site-Directed Fluorometry.

Priest M, Bezanilla F.

Adv Exp Med Biol. 2015;869:55-76. doi: 10.1007/978-1-4939-2845-3_4. Review.


Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.

Castillo JP, Rui H, Basilio D, Das A, Roux B, Latorre R, Bezanilla F, Holmgren M.

Nat Commun. 2015 Jul 24;6:7622. doi: 10.1038/ncomms8622.


Photosensitivity of neurons enabled by cell-targeted gold nanoparticles.

Carvalho-de-Souza JL, Treger JS, Dang B, Kent SB, Pepperberg DR, Bezanilla F.

Neuron. 2015 Apr 8;86(1):207-17. doi: 10.1016/j.neuron.2015.02.033. Epub 2015 Mar 12.


A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway.

Sánchez-Rodríguez JE, Khalili-Araghi F, Miranda P, Roux B, Holmgren M, Bezanilla F.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1335-1344. doi: 10.1016/j.jmb.2015.01.011. Epub 2015 Jan 28.


Real-time imaging of electrical signals with an infrared FDA-approved dye.

Treger JS, Priest MF, Iezzi R, Bezanilla F.

Biophys J. 2014 Sep 16;107(6):L09-12. doi: 10.1016/j.bpj.2014.07.054.


Probing α-3(10) transitions in a voltage-sensing S4 helix.

Kubota T, Lacroix JJ, Bezanilla F, Correa AM.

Biophys J. 2014 Sep 2;107(5):1117-1128. doi: 10.1016/j.bpj.2014.07.042.


Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin.

Dang B, Kubota T, Correa AM, Bezanilla F, Kent SB.

Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8970-4. doi: 10.1002/anie.201404438. Epub 2014 Jul 2.


Moving gating charges through the gating pore in a Kv channel voltage sensor.

Lacroix JJ, Hyde HC, Campos FV, Bezanilla F.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1950-9. doi: 10.1073/pnas.1406161111. Epub 2014 Apr 29.


Molecular mechanism of Mg2+-dependent gating in CorA.

Dalmas O, Sompornpisut P, Bezanilla F, Perozo E.

Nat Commun. 2014 Apr 2;5:3590. doi: 10.1038/ncomms4590.


A repulsion mechanism explains magnesium permeation and selectivity in CorA.

Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3002-7. doi: 10.1073/pnas.1319054111. Epub 2014 Feb 10.


S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel.

Priest MF, Lacroix JJ, Villalba-Galea CA, Bezanilla F.

Biophys J. 2013 Nov 19;105(10):2312-22. doi: 10.1016/j.bpj.2013.09.053.


The gating charge should not be estimated by fitting a two-state model to a Q-V curve.

Bezanilla F, Villalba-Galea CA.

J Gen Physiol. 2013 Dec;142(6):575-8. doi: 10.1085/jgp.201311056. Epub 2013 Nov 11.


Sensing charges of the Ciona intestinalis voltage-sensing phosphatase.

Villalba-Galea CA, Frezza L, Sandtner W, Bezanilla F.

J Gen Physiol. 2013 Nov;142(5):543-55. doi: 10.1085/jgp.201310993. Epub 2013 Oct 14.


Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.

Lacroix JJ, Campos FV, Frezza L, Bezanilla F.

Neuron. 2013 Aug 21;79(4):651-7. doi: 10.1016/j.neuron.2013.05.036.


Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography.

Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB.

J Am Chem Soc. 2013 Aug 14;135(32):11911-9. doi: 10.1021/ja4046795. Epub 2013 Aug 6.


Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.

Capes DL, Goldschen-Ohm MP, Arcisio-Miranda M, Bezanilla F, Chanda B.

J Gen Physiol. 2013 Aug;142(2):101-12. doi: 10.1085/jgp.201310998. Epub 2013 Jul 15.


Thermal mechanisms of millimeter wave stimulation of excitable cells.

Shapiro MG, Priest MF, Siegel PH, Bezanilla F.

Biophys J. 2013 Jun 18;104(12):2622-8. doi: 10.1016/j.bpj.2013.05.014.


IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits.

Ruscic KJ, Miceli F, Villalba-Galea CA, Dai H, Mishina Y, Bezanilla F, Goldstein SA.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):E559-66. doi: 10.1073/pnas.1222616110. Epub 2013 Jan 28.


Intermediate state trapping of a voltage sensor.

Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F.

J Gen Physiol. 2012 Dec;140(6):635-52. doi: 10.1085/jgp.201210827.

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