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Items: 1 to 50 of 423

1.

Corrigendum to "Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight" [Neurobiol. Aging 33 (2012) 831.e21-831.e31].

Amtul Z, Uhrig M, Wang L, Rozmahel RF, Beyreuther K.

Neurobiol Aging. 2018 Feb;62:247. doi: 10.1016/j.neurobiolaging.2017.12.007. No abstract available.

PMID:
29277188
2.

A presenilin 1 mutation in the first case of Alzheimer's disease: revisited.

Rupp C, Beyreuther K, Maurer K, Kins S.

Alzheimers Dement. 2014 Nov;10(6):869-72. doi: 10.1016/j.jalz.2014.06.005. Epub 2014 Aug 15.

PMID:
25130656
3.

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.

Amtul Z, Uhrig M, Wang L, Rozmahel RF, Beyreuther K.

Neurobiol Aging. 2012 Apr;33(4):831.e21-31. doi: 10.1016/j.neurobiolaging.2011.07.014. Epub 2011 Sep 13. Erratum in: Neurobiol Aging. 2018 Feb;62:247.

PMID:
21920632
4.

Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids.

Amtul Z, Uhrig M, Beyreuther K.

J Neurosci Res. 2011 Nov;89(11):1795-801. doi: 10.1002/jnr.22706. Epub 2011 Jul 11.

PMID:
21748777
5.

Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.

Amtul Z, Uhrig M, Rozmahel RF, Beyreuther K.

J Biol Chem. 2011 Feb 25;286(8):6100-7. doi: 10.1074/jbc.M110.183608. Epub 2010 Oct 22.

6.

Phospholipids and a phospholipid-rich diet alter the in vitro amyloid-beta peptide levels and amyloid-beta 42/40 ratios.

Amtul Z, Uhrig M, Supino R, Beyreuther K.

Neurosci Lett. 2010 Sep 6;481(2):73-7. doi: 10.1016/j.neulet.2010.06.046. Epub 2010 Jun 19.

PMID:
20600609
7.

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.

Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S.

J Neurosci. 2009 Nov 18;29(46):14534-44. doi: 10.1523/JNEUROSCI.1546-09.2009.

8.

Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.

Lv J, Jia H, Jiang Y, Ruan Y, Liu Z, Yue W, Beyreuther K, Tu P, Zhang D.

Acta Physiol (Oxf). 2009 Aug;196(4):419-25. doi: 10.1111/j.1748-1716.2009.01961.x. Epub 2009 Feb 5.

PMID:
19208093
9.

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.

Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K.

EMBO Rep. 2008 Nov;9(11):1134-40. doi: 10.1038/embor.2008.188. Epub 2008 Oct 3.

10.

Crystal structure of the human Fe65-PTB1 domain.

Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K.

J Biol Chem. 2008 Aug 22;283(34):23113-20. doi: 10.1074/jbc.M800861200. Epub 2008 Jun 11.

11.

Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.

Wun KS, Miles LA, Crespi GA, Wycherley K, Ascher DB, Barnham KJ, Cappai R, Beyreuther K, Masters CL, Parker MW, McKinstry WJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):438-41. doi: 10.1107/S1744309108011718. Epub 2008 Apr 30.

12.

Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain.

Radzimanowski J, Beyreuther K, Sinning I, Wild K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):409-12. doi: 10.1107/S1744309108009524. Epub 2008 Apr 24.

13.

Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain.

Radzimanowski J, Ravaud S, Beyreuther K, Sinning I, Wild K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):382-5. doi: 10.1107/S174430910800835X. Epub 2008 Apr 5.

14.

Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels.

Grimm MO, Grimm HS, Tomic I, Beyreuther K, Hartmann T, Bergmann C.

J Biol Chem. 2008 Apr 25;283(17):11302-11. doi: 10.1074/jbc.M801520200. Epub 2008 Feb 28.

15.

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.

Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW.

J Mol Biol. 2008 Mar 14;377(1):181-92. doi: 10.1016/j.jmb.2007.12.036. Epub 2008 Jan 30.

PMID:
18237744
16.

beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment.

Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S.

J Neurosci Res. 2007 Sep;85(12):2580-90.

PMID:
17335075
17.

Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.

Rusu P, Jansen A, Soba P, Kirsch J, Löwer A, Merdes G, Kuan YH, Jung A, Beyreuther K, Kjaerulff O, Kins S.

Eur J Neurosci. 2007 Feb;25(4):1079-86.

PMID:
17331204
18.

PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.

Kuan YH, Gruebl T, Soba P, Eggert S, Nesic I, Back S, Kirsch J, Beyreuther K, Kins S.

J Biol Chem. 2006 Dec 29;281(52):40114-23. Epub 2006 Oct 18.

19.

Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.

Kins S, Lauther N, Szodorai A, Beyreuther K.

Neurodegener Dis. 2006;3(4-5):218-26. Review.

20.

Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway.

Masters CL, Beyreuther K.

Brain. 2006 Nov;129(Pt 11):2823-39. Epub 2006 Sep 29. Review.

PMID:
17012295
21.

Consensus meeting: monosodium glutamate - an update.

Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, Kempski O, Stehle P, Steinhart H, Walker R.

Eur J Clin Nutr. 2007 Mar;61(3):304-13. Epub 2006 Sep 6. Review. Erratum in: Eur J Clin Nutr. 2007 Jul;61(7):928.

PMID:
16957679
22.

GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons.

Liu Z, Ruan Y, Yue W, Zhu Z, Hartmann T, Beyreuther K, Zhang D.

Neurosci Lett. 2006 Oct 16;407(1):59-63. Epub 2006 Sep 1.

PMID:
16949204
23.

Pathways to the discovery of the Abeta amyloid of Alzheimer's disease.

Masters CL, Beyreuther K.

J Alzheimers Dis. 2006;9(3 Suppl):155-61.

PMID:
16914854
24.

Amyloid precursor protein regulates differentiation of human neural stem cells.

Kwak YD, Brannen CL, Qu T, Kim HM, Dong X, Soba P, Majumdar A, Kaplan A, Beyreuther K, Sugaya K.

Stem Cells Dev. 2006 Jun;15(3):381-9.

PMID:
16846375
25.

Teasing out the tangles.

Kins S, Beyreuther K.

Nat Med. 2006 Jul;12(7):764-5; discussion 765. No abstract available.

PMID:
16829938
26.

Delineating common molecular mechanisms in Alzheimer's and prion diseases.

Barnham KJ, Cappai R, Beyreuther K, Masters CL, Hill AF.

Trends Biochem Sci. 2006 Aug;31(8):465-72. Epub 2006 Jul 3. Review.

PMID:
16820299
27.

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.

Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P.

Neurobiol Dis. 2005 Nov;20(2):303-13.

PMID:
16242637
28.

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K.

EMBO J. 2005 Oct 19;24(20):3624-34. Epub 2005 Sep 29. Erratum in: EMBO J. 2006 Feb 8;25(3):653.

29.

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.

Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R.

EMBO J. 2004 Oct 13;23(20):4082-95. Epub 2004 Sep 23.

30.

Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.

Jia H, Jiang Y, Ruan Y, Zhang Y, Ma X, Zhang J, Beyreuther K, Tu P, Zhang D.

Neurosci Lett. 2004 Aug 26;367(1):123-8.

PMID:
15308312
31.

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.

Barnham KJ, Haeffner F, Ciccotosto GD, Curtain CC, Tew D, Mavros C, Beyreuther K, Carrington D, Masters CL, Cherny RA, Cappai R, Bush AI.

FASEB J. 2004 Sep;18(12):1427-9. Epub 2004 Jul 1.

PMID:
15231727
32.

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease.

George AJ, Holsinger RM, McLean CA, Laughton KM, Beyreuther K, Evin G, Masters CL, Li QX.

Neurobiol Dis. 2004 Jun;16(1):124-32.

PMID:
15207269
33.

Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.

Loewer A, Soba P, Beyreuther K, Paro R, Merdes G.

EMBO Rep. 2004 Apr;5(4):405-11.

34.

GM1 ganglioside regulates the proteolysis of amyloid precursor protein.

Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D.

Mol Psychiatry. 2004 Oct;9(10):946-52.

PMID:
15052275
35.
36.

Iron inhibits neurotoxicity induced by trace copper and biological reductants.

White AR, Barnham KJ, Huang X, Voltakis I, Beyreuther K, Masters CL, Cherny RA, Bush AI, Cappai R.

J Biol Inorg Chem. 2004 Apr;9(3):269-80. Epub 2004 Feb 3.

PMID:
14758525
37.

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, Davis S, Beyreuther K, Tanzi RE, Masters CL.

Arch Neurol. 2003 Dec;60(12):1685-91. Erratum in: Arch Neurol. 2004 May;61(5):776.

PMID:
14676042
38.

The LPS receptor (CD14) links innate immunity with Alzheimer's disease.

Fassbender K, Walter S, Kühl S, Landmann R, Ishii K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, Brechtel K, Walter J, Multhaup G, Penke B, Adachi Y, Hartmann T, Beyreuther K.

FASEB J. 2004 Jan;18(1):203-5. Epub 2003 Nov 3.

PMID:
14597556
39.

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.

Schmechel A, Zentgraf H, Scheuermann S, Fritz G, Pipkorn R, Reed J, Beyreuther K, Bayer TA, Multhaup G.

J Biol Chem. 2003 Sep 12;278(37):35317-24. Epub 2003 Jul 1.

40.

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.

Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C.

Neurobiol Dis. 2003 Mar;12(2):110-20.

PMID:
12667466
41.

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.

White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R.

Brain Res. 2003 Mar 21;966(2):231-44.

PMID:
12618346
42.

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.

Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R.

J Biol Chem. 2003 May 9;278(19):17401-7. Epub 2003 Feb 28.

44.

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

Grimm HS, Beher D, Lichtenthaler SF, Shearman MS, Beyreuther K, Hartmann T.

J Biol Chem. 2003 Apr 11;278(15):13077-85. Epub 2003 Jan 29.

45.

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.

Sernee MF, Evin G, Culvenor JG, Villadangos JA, Beyreuther K, Masters CL, Cappai R.

Eur J Biochem. 2003 Feb;270(3):495-506.

46.

Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein.

Khalil Z, Poliviou H, Maynard CJ, Beyreuther K, Masters CL, Li QX.

J Alzheimers Dis. 2002 Dec;4(6):467-78.

PMID:
12515898
47.

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.

Grziwa B, Grimm MO, Masters CL, Beyreuther K, Hartmann T, Lichtenthaler SF.

J Biol Chem. 2003 Feb 28;278(9):6803-8. Epub 2002 Nov 25.

48.

Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.

Li QX, Campbell BC, McLean CA, Thyagarajan D, Gai WP, Kapsa RM, Beyreuther K, Masters CL, Culvenor JG.

J Alzheimers Dis. 2002 Aug;4(4):309-15.

PMID:
12446933
49.

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

Maynard CJ, Cappai R, Volitakis I, Cherny RA, White AR, Beyreuther K, Masters CL, Bush AI, Li QX.

J Biol Chem. 2002 Nov 22;277(47):44670-6. Epub 2002 Sep 4.

50.

Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease.

Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, Beyreuther K, Masters CL, Nurcombe V.

J Alzheimers Dis. 1999 Nov;1(4-5):275-85.

PMID:
12214125

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