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Carboxylic acid derivatives of amlexanox display enhanced potency towards TBK1 and IKK¤Á and reveal mechanisms for selective inhibition.

Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJ.

Mol Pharmacol. 2018 Aug 6. pii: mol.118.112185. doi: 10.1124/mol.118.112185. [Epub ahead of print]


Navigating the conformational landscape of G protein-coupled receptor kinases during allosteric activation.

Yao XQ, Cato MC, Labudde E, Beyett TS, Tesmer JJG, Grant BJ.

J Biol Chem. 2017 Sep 29;292(39):16032-16043. doi: 10.1074/jbc.M117.807461. Epub 2017 Aug 14.


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