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Molecular characterization and safety assessment of biofortified provitamin A rice.

Oliva N, Florida Cueto-Reaño M, Trijatmiko KR, Samia M, Welsch R, Schaub P, Beyer P, Mackenzie D, Boncodin R, Reinke R, Slamet-Loedin I, Mallikarjuna Swamy BP.

Sci Rep. 2020 Jan 28;10(1):1376. doi: 10.1038/s41598-020-57669-5.


Ground-state charge-transfer interactions in donor:acceptor pairs of organic semiconductors - a spectroscopic study of two representative systems.

Duva G, Beyer P, Scholz R, Belova V, Opitz A, Hinderhofer A, Gerlach A, Schreiber F.

Phys Chem Chem Phys. 2019 Aug 21;21(31):17190-17199. doi: 10.1039/c9cp02939g. Epub 2019 Jul 31.


Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters.

Wang J, Cary BP, Beyer PD, Gellman SH, Weix DJ.

Angew Chem Int Ed Engl. 2019 Aug 26;58(35):12081-12085. doi: 10.1002/anie.201906000. Epub 2019 Jul 30.


Electron transport pathways in isolated chromoplasts from Narcissus pseudonarcissus L.

Grabsztunowicz M, Mulo P, Baymann F, Mutoh R, Kurisu G, Sétif P, Beyer P, Krieger-Liszkay A.

Plant J. 2019 Jul;99(2):245-256. doi: 10.1111/tpj.14319. Epub 2019 May 7.


Template-Free Orientation Selection of Rod-Like Molecular Semiconductors in Polycrystalline Films.

Duva G, Mann A, Pithan L, Beyer P, Hagenlocher J, Gerlach A, Hinderhofer A, Schreiber F.

J Phys Chem Lett. 2019 Mar 7;10(5):1031-1036. doi: 10.1021/acs.jpclett.9b00304. Epub 2019 Feb 20.


Construction of a fusion enzyme for astaxanthin formation and its characterisation in microbial and plant hosts: A new tool for engineering ketocarotenoids.

Nogueira M, Enfissi EMA, Welsch R, Beyer P, Zurbriggen MD, Fraser PD.

Metab Eng. 2019 Mar;52:243-252. doi: 10.1016/j.ymben.2018.12.006. Epub 2018 Dec 20.


Validation of an Autoclave Procedure for Sterilization of Mouse (Mus musculus) Carcasses.

Pils MC, Kränzler K, Beyer P, Heise U, Pasche B, Riedesel H.

J Am Assoc Lab Anim Sci. 2019 Jan 1;58(1):87-91. doi: 10.30802/AALAS-JAALAS-18-000020. Epub 2018 Nov 6.


Analysis of the clinical antibacterial and antituberculosis pipeline.

Theuretzbacher U, Gottwalt S, Beyer P, Butler M, Czaplewski L, Lienhardt C, Moja L, Paul M, Paulin S, Rex JH, Silver LL, Spigelman M, Thwaites GE, Paccaud JP, Harbarth S.

Lancet Infect Dis. 2019 Feb;19(2):e40-e50. doi: 10.1016/S1473-3099(18)30513-9. Epub 2018 Oct 15. Review.


Molecular structure of the substrate-induced thin-film phase of tetracene.

Pithan L, Nabok D, Cocchi C, Beyer P, Duva G, Simbrunner J, Rawle J, Nicklin C, Schäfer P, Draxl C, Schreiber F, Kowarik S.

J Chem Phys. 2018 Oct 14;149(14):144701. doi: 10.1063/1.5043379.


Enzyme Fusion Removes Competition for Geranylgeranyl Diphosphate in Carotenogenesis.

Camagna M, Grundmann A, Bär C, Koschmieder J, Beyer P, Welsch R.

Plant Physiol. 2019 Mar;179(3):1013-1027. doi: 10.1104/pp.18.01026. Epub 2018 Oct 11.


The drugs don't work: WHO's role in advancing new antibiotics.

Beyer P, Moorthy V, Paulin S, Hill SR, Sprenger M, Garner S, Simão M, Guerra R, Magrini N, Swaminathan S.

Lancet. 2018 Jul 28;392(10144):264-266. doi: 10.1016/S0140-6736(18)31570-8. No abstract available.


Synthetic Biology Makes Polymer Materials Count.

Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W.

Adv Mater. 2018 May;30(21):e1800472. doi: 10.1002/adma.201800472. Epub 2018 Mar 30.


Plant-type phytoene desaturase: Functional evaluation of structural implications.

Koschmieder J, Fehling-Kaschek M, Schaub P, Ghisla S, Brausemann A, Timmer J, Beyer P.

PLoS One. 2017 Nov 27;12(11):e0187628. doi: 10.1371/journal.pone.0187628. eCollection 2017.


Corrigendum: Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2017 Nov 2;68(18):5249. doi: 10.1093/jxb/erx347. No abstract available.


Nonenzymatic β-Carotene Degradation in Provitamin A-Biofortified Crop Plants.

Schaub P, Wüst F, Koschmieder J, Yu Q, Virk P, Tohme J, Beyer P.

J Agric Food Chem. 2017 Aug 9;65(31):6588-6598. doi: 10.1021/acs.jafc.7b01693. Epub 2017 Jul 28.


Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation.

Brausemann A, Gemmecker S, Koschmieder J, Ghisla S, Beyer P, Einsle O.

Structure. 2017 Aug 1;25(8):1222-1232.e3. doi: 10.1016/j.str.2017.06.002. Epub 2017 Jun 29.


Evidence for Anisotropic Electronic Coupling of Charge Transfer States in Weakly Interacting Organic Semiconductor Mixtures.

Belova V, Beyer P, Meister E, Linderl T, Halbich MU, Gerhard M, Schmidt S, Zechel T, Meisel T, Generalov AV, Anselmo AS, Scholz R, Konovalov O, Gerlach A, Koch M, Hinderhofer A, Opitz A, Brütting W, Schreiber F.

J Am Chem Soc. 2017 Jun 28;139(25):8474-8486. doi: 10.1021/jacs.7b01622. Epub 2017 Jun 15.


Insights into the formation of carlactone from in-depth analysis of the CCD8-catalyzed reactions.

Bruno M, Vermathen M, Alder A, Wüst F, Schaub P, van der Steen R, Beyer P, Ghisla S, Al-Babili S.

FEBS Lett. 2017 Mar;591(5):792-800. doi: 10.1002/1873-3468.12593. Epub 2017 Mar 9.


Diffusion and nucleation in multilayer growth of PTCDI-C8 studied with in situ X-ray growth oscillations and real-time small angle X-ray scattering.

Zykov A, Bommel S, Wolf C, Pithan L, Weber C, Beyer P, Santoro G, Rabe JP, Kowarik S.

J Chem Phys. 2017 Feb 7;146(5):052803. doi: 10.1063/1.4961460.


Strongly enhanced Raman scattering of Cu-phthalocyanine sandwiched between graphene and Au(111).

Lin WI, Gholami MF, Beyer P, Severin N, Shao F, Zenobi R, Rabe JP.

Chem Commun (Camb). 2017 Jan 5;53(4):724-727. doi: 10.1039/c6cc08672a.


Direct Photoalignment and Optical Patterning of Molecular Thin Films.

Pithan L, Beyer P, Bogula L, Zykov A, Schäfer P, Rawle J, Nicklin C, Opitz A, Kowarik S.

Adv Mater. 2017 Feb;29(6). doi: 10.1002/adma.201604382. Epub 2016 Dec 1.


StrigoQuant: A genetically encoded biosensor for quantifying strigolactone activity and specificity.

Samodelov SL, Beyer HM, Guo X, Augustin M, Jia KP, Baz L, Ebenhöh O, Beyer P, Weber W, Al-Babili S, Zurbriggen MD.

Sci Adv. 2016 Nov 4;2(11):e1601266. eCollection 2016 Nov.


Enzymatic study on AtCCD4 and AtCCD7 and their potential to form acyclic regulatory metabolites.

Bruno M, Koschmieder J, Wuest F, Schaub P, Fehling-Kaschek M, Timmer J, Beyer P, Al-Babili S.

J Exp Bot. 2016 Nov;67(21):5993-6005. Epub 2016 Oct 6. Erratum in: J Exp Bot. 2017 Nov 2;68(18):5249.


Carotenogenesis Is Regulated by 5'UTR-Mediated Translation of Phytoene Synthase Splice Variants.

Álvarez D, Voß B, Maass D, Wüst F, Schaub P, Beyer P, Welsch R.

Plant Physiol. 2016 Dec;172(4):2314-2326. Epub 2016 Oct 11.


Prices, Costs, and Affordability of New Medicines for Hepatitis C in 30 Countries: An Economic Analysis.

Iyengar S, Tay-Teo K, Vogler S, Beyer P, Wiktor S, de Joncheere K, Hill S.

PLoS Med. 2016 May 31;13(5):e1002032. doi: 10.1371/journal.pmed.1002032. eCollection 2016 May.


Geographically Sourcing Cocaine's Origin - Delineation of the Nineteen Major Coca Growing Regions in South America.

Mallette JR, Casale JF, Jordan J, Morello DR, Beyer PM.

Sci Rep. 2016 Mar 23;6:23520. doi: 10.1038/srep23520.


Regional Disparities in Diabetes Care for Pediatric Patients with Type 1 Diabetes. A Cross-sectional DPV Multicenter Analysis of 24,928 German Children and Adolescents.

Bohn B, Rosenbauer J, Icks A, Vogel C, Beyer P, Rütschle H, Hermann U, Holterhus PM, Wagner V, von Sengbusch S, Fink K, Holl RW; DPV initiative.

Exp Clin Endocrinol Diabetes. 2016 Feb;124(2):111-9. doi: 10.1055/s-0042-101159. Epub 2016 Feb 19.


Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis.

Gemmecker S, Schaub P, Koschmieder J, Brausemann A, Drepper F, Rodriguez-Franco M, Ghisla S, Warscheid B, Einsle O, Beyer P.

PLoS One. 2015 Jul 6;10(7):e0131717. doi: 10.1371/journal.pone.0131717. eCollection 2015.


Tissue-Specific Apocarotenoid Glycosylation Contributes to Carotenoid Homeostasis in Arabidopsis Leaves.

Lätari K, Wüst F, Hübner M, Schaub P, Beisel KG, Matsubara S, Beyer P, Welsch R.

Plant Physiol. 2015 Aug;168(4):1550-62. doi: 10.1104/pp.15.00243. Epub 2015 Jul 1.


Hospital admission for diabetic ketoacidosis or severe hypoglycemia in 31,330 young patients with type 1 diabetes.

Karges B, Rosenbauer J, Holterhus PM, Beyer P, Seithe H, Vogel C, Böckmann A, Peters D, Müther S, Neu A, Holl RW; DPV Initiative.

Eur J Endocrinol. 2015 Sep;173(3):341-50. doi: 10.1530/EJE-15-0129. Epub 2015 Jun 18.


The potato carotenoid cleavage dioxygenase 4 catalyzes a single cleavage of β-ionone ring-containing carotenes and non-epoxidated xanthophylls.

Bruno M, Beyer P, Al-Babili S.

Arch Biochem Biophys. 2015 Apr 15;572:126-133. doi: 10.1016/ Epub 2015 Feb 19.


Simplification of antiviral hepatitis C virus therapy to support expanded access in resource-limited settings.

Ford N, Swan T, Beyer P, Hirnschall G, Easterbrook P, Wiktor S.

J Hepatol. 2014 Nov;61(1 Suppl):S132-8. doi: 10.1016/j.jhep.2014.09.019. Epub 2014 Nov 3. Review.


Lattice matching as the determining factor for molecular tilt and multilayer growth mode of the nanographene hexa-peri-hexabenzocoronene.

Beyer P, Breuer T, Ndiaye S, Zykov A, Viertel A, Gensler M, Rabe JP, Hecht S, Witte G, Kowarik S.

ACS Appl Mater Interfaces. 2014 Dec 10;6(23):21484-93. doi: 10.1021/am506465b. Epub 2014 Nov 24.


Controlling the growth mode of para-sexiphenyl (6P) on ZnO by partial fluorination.

Sparenberg M, Zykov A, Beyer P, Pithan L, Weber C, Garmshausen Y, Carlà F, Hecht S, Blumstengel S, Henneberger F, Kowarik S.

Phys Chem Chem Phys. 2014 Dec 21;16(47):26084-93. doi: 10.1039/c4cp04048a. Epub 2014 Oct 31.


Insights from the cold transcriptome of Physcomitrella patens: global specialization pattern of conserved transcriptional regulators and identification of orphan genes involved in cold acclimation.

Beike AK, Lang D, Zimmer AD, Wüst F, Trautmann D, Wiedemann G, Beyer P, Decker EL, Reski R.

New Phytol. 2015 Jan;205(2):869-81. doi: 10.1111/nph.13004. Epub 2014 Sep 10.


Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis.

Frusciante S, Diretto G, Bruno M, Ferrante P, Pietrella M, Prado-Cabrero A, Rubio-Moraga A, Beyer P, Gomez-Gomez L, Al-Babili S, Giuliano G.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12246-51. doi: 10.1073/pnas.1404629111. Epub 2014 Aug 5.


In vitro analysis of the plastid terminal oxidase in photosynthetic electron transport.

Feilke K, Yu Q, Beyer P, Sétif P, Krieger-Liszkay A.

Biochim Biophys Acta. 2014 Oct;1837(10):1684-90. doi: 10.1016/j.bbabio.2014.07.016. Epub 2014 Aug 1.


Tomato carotenoid cleavage dioxygenases 1A and 1B: Relaxed double bond specificity leads to a plenitude of dialdehydes, mono-apocarotenoids and isoprenoid volatiles.

Ilg A, Bruno M, Beyer P, Al-Babili S.

FEBS Open Bio. 2014 Jun 25;4:584-93. doi: 10.1016/j.fob.2014.06.005. eCollection 2014.


Diagnosis, therapy and control of diabetes mellitus in children and adolescents.

Neu A, Beyer P, Bürger-Büsing J, Danne T, Etspüler J, Heidtmann B, Holl RW, Karges B, Kiess W, Knerr I, Kordonouri O, Lange K, Lepler R, Marg W, Näke A, Petersen M, Podeswik A, Stachow R, von Sengbusch S, Wagner V, Ziegler R, Holterhus PM; German Diabetes Association.

Exp Clin Endocrinol Diabetes. 2014 Jul;122(7):425-34. doi: 10.1055/s-0034-1366384. Epub 2014 Jul 11. No abstract available.


Carotene Hydroxylase Activity Determines the Levels of Both α-Carotene and Total Carotenoids in Orange Carrots.

Arango J, Jourdan M, Geoffriau E, Beyer P, Welsch R.

Plant Cell. 2014 May;26(5):2223-2233. Epub 2014 May 23.


Functional and molecular characterization of plastid terminal oxidase from rice (Oryza sativa).

Yu Q, Feilke K, Krieger-Liszkay A, Beyer P.

Biochim Biophys Acta. 2014 Aug;1837(8):1284-92. doi: 10.1016/j.bbabio.2014.04.007. Epub 2014 Apr 26.


On the substrate- and stereospecificity of the plant carotenoid cleavage dioxygenase 7.

Bruno M, Hofmann M, Vermathen M, Alder A, Beyer P, Al-Babili S.

FEBS Lett. 2014 May 2;588(9):1802-7. doi: 10.1016/j.febslet.2014.03.041. Epub 2014 Mar 28.


Effect of constitutive expression of bacterial phytoene desaturase CRTI on photosynthetic electron transport in Arabidopsis thaliana.

Galzerano D, Feilke K, Schaub P, Beyer P, Krieger-Liszkay A.

Biochim Biophys Acta. 2014 Mar;1837(3):345-53. doi: 10.1016/j.bbabio.2013.12.010. Epub 2013 Dec 27.


Direct diabetes-related costs in young patients with early-onset, long-lasting type 1 diabetes.

Bächle C, Icks A, Straßburger K, Flechtner-Mors M, Hungele A, Beyer P, Placzek K, Hermann U, Schumacher A, Freff M, Stahl-Pehe A, Holl RW, Rosenbauer J; DPV Initiative and the German BMBF Competence Network Diabetes Mellitus.

PLoS One. 2013 Aug 13;8(8):e70567. doi: 10.1371/journal.pone.0070567. eCollection 2013.


Lipoatrophy is associated with an increased risk of Hashimoto's thyroiditis and coeliac disease in female patients with type 1 diabetes.

Salgin B, Meissner T, Beyer P, Haberland H, Borkenstein M, Fussenegger J, Brand U, Hauffa BP, Hungele A, Holl RW.

Horm Res Paediatr. 2013;79(6):368-72. doi: 10.1159/000351708. Epub 2013 Jun 19.


The ORF slr0091 of Synechocystis sp. PCC6803 encodes a high-light induced aldehyde dehydrogenase converting apocarotenals and alkanals.

Trautmann D, Beyer P, Al-Babili S.

FEBS J. 2013 Aug;280(15):3685-96. doi: 10.1111/febs.12361. Epub 2013 Jul 5.


Policy coherence for improved medical innovation and access.

Mirza Z, Krattiger A, Taubman A, Bartels HG, Beyer P, Kampf R, Watal J.

Bull World Health Organ. 2013 May 1;91(5):315-315A. doi: 10.2471/BLT.13.122705. No abstract available.


Reaction specificities of the ε-ionone-forming lycopene cyclase from rice (Oryza sativa) elucidated in vitro.

Yu Q, Beyer P.

FEBS Lett. 2012 Sep 21;586(19):3415-20. doi: 10.1016/j.febslet.2012.07.060. Epub 2012 Jul 31.


On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.

Schaub P, Yu Q, Gemmecker S, Poussin-Courmontagne P, Mailliot J, McEwen AG, Ghisla S, Al-Babili S, Cavarelli J, Beyer P.

PLoS One. 2012;7(6):e39550. doi: 10.1371/journal.pone.0039550. Epub 2012 Jun 22.


Frequency and cost of diabetic ketoacidosis in Germany--study in 12,001 paediatric patients.

Icks A, Strassburger K, Baechle C, Rosenbauer J, Giani G, Beyer P, Holl RW.

Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):58-9. doi: 10.1055/s-0032-1312639. Epub 2012 Jun 11.


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