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Items: 1 to 50 of 178


The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.

Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC.

Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2336-2346. doi: 10.1167/iovs.18-26459.


Connecting Exosomes and Connexins.

Gemel J, Kilkus J, Dawson G, Beyer EC.

Cancers (Basel). 2019 Apr 4;11(4). pii: E476. doi: 10.3390/cancers11040476.


Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.

Jara O, Minogue PJ, Berthoud VM, Beyer EC.

Exp Eye Res. 2018 Oct;175:192-198. doi: 10.1016/j.exer.2018.06.015. Epub 2018 Jun 18.


Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.

Gao J, Minogue PJ, Beyer EC, Mathias RT, Berthoud VM.

Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C492-C503. doi: 10.1152/ajpcell.00277.2017. Epub 2018 Jan 3.


Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Leybaert L, Lampe PD, Dhein S, Kwak BR, Ferdinandy P, Beyer EC, Laird DW, Naus CC, Green CR, Schulz R.

Pharmacol Rev. 2017 Oct;69(4):396-478. doi: 10.1124/pr.115.012062. Review.


Characterization of a variant of gap junction protein α8 identified in a family with hereditary cataract.

Kuo DS, Sokol JT, Minogue PJ, Berthoud VM, Slavotinek AM, Beyer EC, Gould DB.

PLoS One. 2017 Aug 21;12(8):e0183438. doi: 10.1371/journal.pone.0183438. eCollection 2017.


Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice.

Minogue PJ, Gao J, Zoltoski RK, Novak LA, Mathias RT, Beyer EC, Berthoud VM.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4366–4374. doi: 10.1167/iovs.17-21684. Erratum in: Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4799.


Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry.

Zhong G, Akoum N, Appadurai DA, Hayrapetyan V, Ahmed O, Martinez AD, Beyer EC, Moreno AP.

Front Physiol. 2017 May 29;8:346. doi: 10.3389/fphys.2017.00346. eCollection 2017.


Gap junction gene and protein families: Connexins, innexins, and pannexins.

Beyer EC, Berthoud VM.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):5-8. doi: 10.1016/j.bbamem.2017.05.016. Epub 2017 May 27. Review.


Gap junction structure: unraveled, but not fully revealed.

Beyer EC, Berthoud VM.

F1000Res. 2017 Apr 26;6:568. doi: 10.12688/f1000research.10490.1. eCollection 2017. Review.


Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.

Lapping-Carr G, Khalyfa A, Rangel S, Darlington W, Beyer EC, Peddinti R, Cunningham JM, Gozal D.

Pediatr Pulmonol. 2017 Nov;52(11):1478-1485. doi: 10.1002/ppul.23698. Epub 2017 May 9.


Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.

Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC.

BMC Cell Biol. 2017 Jan 17;18(Suppl 1):7. doi: 10.1186/s12860-016-0117-5.


The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.

Berthoud VM, Minogue PJ, Lambert PA, Snabb JI, Beyer EC.

J Biol Chem. 2016 Aug 19;291(34):17569-78. doi: 10.1074/jbc.M115.707950. Epub 2016 Jun 17.


Connexin23 deletion does not affect lens transparency.

Berthoud VM, Minogue PJ, Snabb JI, Dzhashiashvili Y, Novak LA, Zoltoski RK, Popko B, Beyer EC.

Exp Eye Res. 2016 May;146:283-8. doi: 10.1016/j.exer.2016.03.025. Epub 2016 Mar 31.


The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family.

Senthil Kumar G, Dinesh Kumar K, Minogue PJ, Berthoud VM, Kannan R, Beyer EC, Santhiya ST.

Open Access J Ophthalmol. 2016;1(1). pii: 106. Epub 2016 Jul 28.


Are these connexins compatible and does it matter?

Beyer EC.

Channels (Austin). 2015;9(2):63-4. doi: 10.1080/19336950.2015.1030186. No abstract available.


The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.

Tong JJ, Minogue PJ, Kobeszko M, Beyer EC, Berthoud VM, Ebihara L.

J Membr Biol. 2015 Feb;248(1):145-55. doi: 10.1007/s00232-014-9752-y. Epub 2014 Nov 18.


Connexin40 abnormalities and atrial fibrillation in the human heart.

Gemel J, Levy AE, Simon AR, Bennett KB, Ai X, Akhter S, Beyer EC.

J Mol Cell Cardiol. 2014 Nov;76:159-68. doi: 10.1016/j.yjmcc.2014.08.021. Epub 2014 Sep 6.


Connexin46fs380 causes progressive cataracts.

Berthoud VM, Minogue PJ, Yu H, Snabb JI, Beyer EC.

Invest Ophthalmol Vis Sci. 2014 Aug 7;55(10):6639-48. doi: 10.1167/iovs.14-15012.


Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.

Gemel J, Simon AR, Patel D, Xu Q, Matiukas A, Veenstra RD, Beyer EC.

J Mol Cell Cardiol. 2014 Sep;74:330-9. doi: 10.1016/j.yjmcc.2014.06.010. Epub 2014 Jun 25.


Gap junction protein connexin43 exacerbates lung vascular permeability.

O'Donnell JJ 3rd, Birukova AA, Beyer EC, Birukov KG.

PLoS One. 2014 Jun 26;9(6):e100931. doi: 10.1371/journal.pone.0100931. eCollection 2014.


Connexin hemichannels in the lens.

Beyer EC, Berthoud VM.

Front Physiol. 2014 Feb 11;5:20. doi: 10.3389/fphys.2014.00020. eCollection 2014. Review.


Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.

Patel D, Gemel J, Xu Q, Simon AR, Lin X, Matiukas A, Beyer EC, Veenstra RD.

FEBS Lett. 2014 Apr 17;588(8):1458-64. doi: 10.1016/j.febslet.2014.01.010. Epub 2014 Jan 20.


Roles and regulation of lens epithelial cell connexins.

Berthoud VM, Minogue PJ, Osmolak P, Snabb JI, Beyer EC.

FEBS Lett. 2014 Apr 17;588(8):1297-303. doi: 10.1016/j.febslet.2013.12.024. Epub 2014 Jan 14. Review.


c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.

Rutledge CA, Ng FS, Sulkin MS, Greener ID, Sergeyenko AM, Liu H, Gemel J, Beyer EC, Sovari AA, Efimov IR, Dudley SC.

J Am Coll Cardiol. 2014 Mar 11;63(9):928-34. doi: 10.1016/j.jacc.2013.10.081. Epub 2014 Jan 8.


Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.

Berthoud VM, Minogue PJ, Yu H, Schroeder R, Snabb JI, Beyer EC.

Invest Ophthalmol Vis Sci. 2013 Nov 19;54(12):7614-22. doi: 10.1167/iovs.13-13188.


Interfering amino terminal peptides and functional implications for heteromeric gap junction formation.

Beyer EC, Lin X, Veenstra RD.

Front Pharmacol. 2013 May 21;4:67. doi: 10.3389/fphar.2013.00067. eCollection 2013.


A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.

Minogue PJ, Beyer EC, Berthoud VM.

J Biol Chem. 2013 Jul 12;288(28):20427-34. doi: 10.1074/jbc.M113.452847. Epub 2013 May 17.


Connexin mutants and cataracts.

Beyer EC, Ebihara L, Berthoud VM.

Front Pharmacol. 2013 Apr 15;4:43. doi: 10.3389/fphar.2013.00043. eCollection 2013.


c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.

Yan J, Kong W, Zhang Q, Beyer EC, Walcott G, Fast VG, Ai X.

Cardiovasc Res. 2013 Mar 1;97(3):589-97. doi: 10.1093/cvr/cvs366. Epub 2012 Dec 14.


An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.

Senthil Kumar G, Kyle JW, Minogue PJ, Dinesh Kumar K, Vasantha K, Berthoud VM, Beyer EC, Santhiya ST.

Exp Eye Res. 2013 May;110:136-41. doi: 10.1016/j.exer.2012.10.010. Epub 2012 Oct 29.


Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.

Jara O, Acuña R, García IE, Maripillán J, Figueroa V, Sáez JC, Araya-Secchi R, Lagos CF, Pérez-Acle T, Berthoud VM, Beyer EC, Martínez AD.

Mol Biol Cell. 2012 Sep;23(17):3299-311. Epub 2012 Jul 11.


Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer.

Gemel J, Nelson TK, Burt JM, Beyer EC.

J Membr Biol. 2012 Jun;245(5-6):231-41. doi: 10.1007/s00232-012-9444-4. Epub 2012 Jun 23.


Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.

Smith TD, Mohankumar A, Minogue PJ, Beyer EC, Berthoud VM, Koval M.

J Membr Biol. 2012 Jun;245(5-6):221-30. doi: 10.1007/s00232-012-9443-5. Epub 2012 Jun 22.


Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.

Beyer EC, Lipkind GM, Kyle JW, Berthoud VM.

Biochim Biophys Acta. 2012 Aug;1818(8):1823-30. doi: 10.1016/j.bbamem.2011.10.011. Epub 2011 Oct 20. Review.


Autophagy: a pathway that contributes to connexin degradation.

Lichtenstein A, Minogue PJ, Beyer EC, Berthoud VM.

J Cell Sci. 2011 Mar 15;124(Pt 6):910-20. doi: 10.1242/jcs.073072.


Different domains are critical for oligomerization compatibility of different connexins.

Martínez AD, Maripillán J, Acuña R, Minogue PJ, Berthoud VM, Beyer EC.

Biochem J. 2011 May 15;436(1):35-43. doi: 10.1042/BJ20110008.


Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.

Tong JJ, Minogue PJ, Guo W, Chen TL, Beyer EC, Berthoud VM, Ebihara L.

Am J Physiol Cell Physiol. 2011 May;300(5):C1055-64. doi: 10.1152/ajpcell.00384.2010. Epub 2011 Jan 12.


The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.

Graw J, Schmidt W, Minogue PJ, Rodriguez J, Tong JJ, Klopp N, Illig T, Ebihara L, Berthoud VM, Beyer EC.

Mol Vis. 2009 Sep 14;15:1881-5.


A mutant connexin50 with enhanced hemichannel function leads to cell death.

Minogue PJ, Tong JJ, Arora A, Russell-Eggitt I, Hunt DM, Moore AT, Ebihara L, Beyer EC, Berthoud VM.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5837-45. doi: 10.1167/iovs.09-3759. Epub 2009 Aug 13.


Connexin40 and connexin43 determine gating properties of atrial gap junction channels.

Lin X, Gemel J, Glass A, Zemlin CW, Beyer EC, Veenstra RD.

J Mol Cell Cardiol. 2010 Jan;48(1):238-45. doi: 10.1016/j.yjmcc.2009.05.014. Epub 2009 May 30.


The N terminus of connexin37 contains an alpha-helix that is required for channel function.

Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC.

J Biol Chem. 2009 Jul 24;284(30):20418-27. doi: 10.1074/jbc.M109.016907. Epub 2009 May 28.


The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum.

Lichtenstein A, Gaietta GM, Deerinck TJ, Crum J, Sosinsky GE, Beyer EC, Berthoud VM.

Exp Eye Res. 2009 Mar;88(3):600-9. doi: 10.1016/j.exer.2008.11.024. Epub 2008 Dec 6.


Oxidative stress, lens gap junctions, and cataracts.

Berthoud VM, Beyer EC.

Antioxid Redox Signal. 2009 Feb;11(2):339-53. doi: 10.1089/ars.2008.2119. Review.


An intact connexin N-terminus is required for function but not gap junction formation.

Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC.

J Cell Sci. 2008 Aug 15;121(Pt 16):2744-50. doi: 10.1242/jcs.032482. Epub 2008 Jul 29.


Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.

Thomas BC, Minogue PJ, Valiunas V, Kanaporis G, Brink PR, Berthoud VM, Beyer EC.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2549-56. doi: 10.1167/iovs.07-1658. Epub 2008 Mar 7.


Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.

Gemel J, Lin X, Collins R, Veenstra RD, Beyer EC.

Biochem Biophys Res Commun. 2008 May 2;369(2):388-94. doi: 10.1016/j.bbrc.2008.02.040. Epub 2008 Feb 20.


A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.

Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT.

J Med Genet. 2008 Mar;45(3):155-60. Epub 2007 Nov 15.


Transgenic overexpression of connexin50 induces cataracts.

Chung J, Berthoud VM, Novak L, Zoltoski R, Heilbrunn B, Minogue PJ, Liu X, Ebihara L, Kuszak J, Beyer EC.

Exp Eye Res. 2007 Mar;84(3):513-28. Epub 2007 Jan 10.

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