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Items: 1 to 50 of 272

1.

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.

Demeyer A, Skordos I, Driege Y, Kreike M, Hochepied T, Baens M, Staal J, Beyaert R.

Front Immunol. 2019 Aug 14;10:1898. doi: 10.3389/fimmu.2019.01898. eCollection 2019.

2.

MALT1-deletion in T-cells protects against the development of auto-immune arthritis, but causes spontaneous osteoporosis.

Gilis E, Gaublomme D, Staal J, Venken K, Dhaenens M, Lambrecht S, Coudenys J, Decruy T, Schryvers N, Driege Y, Dumas E, Demeyer A, De Muynck A, van Hengel J, Van Hoorebeke L, Deforce D, Beyaert R, Elewaut D.

Arthritis Rheumatol. 2019 Jul 1. doi: 10.1002/art.41029. [Epub ahead of print]

PMID:
31259485
3.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

Dendoncker K, Timmermans S, Vandewalle J, Eggermont M, Lempiäinen J, Paakinaho V, Van Hamme E, Dewaele S, Vandevyver S, Ballegeer M, Souffriau J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Beyaert R, De Bosscher K, Palvimo JJ, Van Montagu M, Libert C.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12942-12951. doi: 10.1073/pnas.1821565116. Epub 2019 Jun 10. Erratum in: Proc Natl Acad Sci U S A. 2019 Jul 22;:.

PMID:
31182584
4.

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site.

Staal J, Alci K, De Schamphelaire W, Vanhoucke M, Beyaert R.

Biotechniques. 2019 Jun;66(6):254-259. doi: 10.2144/btn-2019-0014. Epub 2019 May 24.

5.

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.

Holgado A, Braun H, Van Nuffel E, Detry S, Schuijs MJ, Deswarte K, Vergote K, Haegman M, Baudelet G, Haustraete J, Hammad H, Lambrecht BN, Savvides SN, Afonina IS, Beyaert R.

J Allergy Clin Immunol. 2019 Jul;144(1):204-215. doi: 10.1016/j.jaci.2019.02.028. Epub 2019 Mar 13.

PMID:
30876911
6.

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.

Pauwels AM, Härtlova A, Peltier J, Driege Y, Baudelet G, Brodin P, Trost M, Beyaert R, Hoffmann E.

Mol Cell Proteomics. 2019 May;18(5):909-922. doi: 10.1074/mcp.RA119.001316. Epub 2019 Feb 26.

PMID:
30808727
7.

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties.

Cochet F, Facchini FA, Zaffaroni L, Billod JM, Coelho H, Holgado A, Braun H, Beyaert R, Jerala R, Jimenez-Barbero J, Martin-Santamaria S, Peri F.

Sci Rep. 2019 Jan 29;9(1):919. doi: 10.1038/s41598-018-37421-w.

8.

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells.

Lork M, Staal J, Beyaert R.

Cell Immunol. 2019 Jun;340:103877. doi: 10.1016/j.cellimm.2018.11.001. Epub 2018 Dec 1. Review.

PMID:
30514565
9.

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.

Meloni L, Verstrepen L, Kreike M, Staal J, Driege Y, Afonina IS, Beyaert R.

Molecules. 2018 Nov 30;23(12). pii: E3144. doi: 10.3390/molecules23123144.

10.

A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.

De Bruyne M, Hoste L, Bogaert DJ, Van den Bossche L, Tavernier SJ, Parthoens E, Migaud M, Konopnicki D, Yombi JC, Lambrecht BN, van Daele S, Alves de Medeiros AK, Brochez L, Beyaert R, De Baere E, Puel A, Casanova JL, Goffard JC, Savvides SN, Haerynck F, Staal J, Dullaers M.

Front Immunol. 2018 Oct 31;9:2366. doi: 10.3389/fimmu.2018.02366. eCollection 2018.

11.

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.

Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, Liu S, Yu G, Liu S, Beyaert R, Chang M, Li Q, Cao Y.

JCI Insight. 2018 Oct 18;3(20). pii: 122375. doi: 10.1172/jci.insight.122375.

12.

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation.

Borio A, Holgado A, Garate JA, Beyaert R, Heine H, Zamyatina A.

ChemMedChem. 2018 Nov 6;13(21):2317-2331. doi: 10.1002/cmdc.201800505. Epub 2018 Oct 23.

PMID:
30276970
13.

IL-33 signalling contributes to pollutant-induced allergic airway inflammation.

De Grove KC, Provoost S, Braun H, Blomme EE, Teufelberger AR, Krysko O, Beyaert R, Brusselle GG, Joos GF, Maes T.

Clin Exp Allergy. 2018 Dec;48(12):1665-1675. doi: 10.1111/cea.13261. Epub 2018 Sep 19.

PMID:
30159930
14.

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications.

Staal J, Beyaert R.

Cells. 2018 Aug 29;7(9). pii: E122. doi: 10.3390/cells7090122. Review.

15.

Inhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in Mice.

Kip E, Staal J, Tima HG, Verstrepen L, Romano M, Lemeire K, Suin V, Hamouda A, Baens M, Libert C, Kalai M, Van Gucht S, Beyaert R.

J Virol. 2018 Oct 29;92(22). pii: e00720-18. doi: 10.1128/JVI.00720-18. Print 2018 Nov 15.

16.

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex.

Lembo-Fazio L, Billod JM, Di Lorenzo F, Paciello I, Pallach M, Vaz-Francisco S, Holgado A, Beyaert R, Fresno M, Shimoyama A, Lanzetta R, Fukase K, Gully D, Giraud E, Martín-Santamaría S, Bernardini ML, Silipo A.

Front Immunol. 2018 Aug 14;9:1888. doi: 10.3389/fimmu.2018.01888. eCollection 2018.

17.

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation.

Souffriau J, Eggermont M, Van Ryckeghem S, Van Looveren K, Van Wyngene L, Van Hamme E, Vuylsteke M, Beyaert R, De Bosscher K, Libert C.

Sci Rep. 2018 Aug 27;8(1):12894. doi: 10.1038/s41598-018-31150-w.

18.

Psoriasis Plays a Wild CARD.

Van Nuffel E, Afonina IS, Beyaert R.

J Invest Dermatol. 2018 Sep;138(9):1903-1905. doi: 10.1016/j.jid.2018.05.001.

19.

Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature.

Casillo A, Ziaco M, Lindner B, Parrilli E, Schwudke D, Holgado A, Beyaert R, Lanzetta R, Tutino ML, Corsaro MM.

Extremophiles. 2018 Nov;22(6):955-963. doi: 10.1007/s00792-018-1051-6. Epub 2018 Aug 20.

PMID:
30128707
20.

Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.

Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, Gul IS, Sundararaman S, Gonçalves A, Dhondt I, Pinzón JH, Braeckman BP, Technau U, Saeys Y, van Roy F, Beyaert R.

Front Immunol. 2018 May 24;9:1136. doi: 10.3389/fimmu.2018.01136. eCollection 2018.

21.

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

Adanitsch F, Shi J, Shao F, Beyaert R, Heine H, Zamyatina A.

Chem Sci. 2018 Mar 15;9(16):3957-3963. doi: 10.1039/c7sc05323a. eCollection 2018 Apr 28.

22.

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.

Lork M, Kreike M, Staal J, Beyaert R.

Front Cell Dev Biol. 2018 Apr 10;6:40. doi: 10.3389/fcell.2018.00040. eCollection 2018.

23.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

24.

GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines.

Gul IS, Staal J, Hulpiau P, De Keuckelaere E, Kamm K, Deroo T, Sanders E, Staes K, Driege Y, Saeys Y, Beyaert R, Technau U, Schierwater B, van Roy F.

Genome Biol Evol. 2018 Mar 1;10(3):909-917. doi: 10.1093/gbe/evy040.

25.

How Good Roommates Can Protect against Microbial Sepsis.

Beyaert R, Libert C.

Cell Host Microbe. 2018 Mar 14;23(3):283-285. doi: 10.1016/j.chom.2018.02.007.

26.

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Facchini FA, Zaffaroni L, Minotti A, Rapisarda S, Calabrese V, Forcella M, Fusi P, Airoldi C, Ciaramelli C, Billod JM, Schromm AB, Braun H, Palmer C, Beyaert R, Lapenta F, Jerala R, Pirianov G, Martin-Santamaria S, Peri F.

J Med Chem. 2018 Apr 12;61(7):2895-2909. doi: 10.1021/acs.jmedchem.7b01803. Epub 2018 Mar 12.

27.

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

Borghi A, Haegman M, Fischer R, Carpentier I, Bertrand MJM, Libert C, Afonina IS, Beyaert R.

Biochem Pharmacol. 2018 Jul;153:292-298. doi: 10.1016/j.bcp.2018.01.039. Epub 2018 Jan 31.

PMID:
29378181
28.

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain.

Kip E, Staal J, Verstrepen L, Tima HG, Terryn S, Romano M, Lemeire K, Suin V, Hamouda A, Kalai M, Beyaert R, Van Gucht S.

J Virol. 2018 Mar 28;92(8). pii: e02029-17. doi: 10.1128/JVI.02029-17. Print 2018 Apr 15.

29.

Dichotomous function of IL-33 in health and disease: From biology to clinical implications.

Braun H, Afonina IS, Mueller C, Beyaert R.

Biochem Pharmacol. 2018 Feb;148:238-252. doi: 10.1016/j.bcp.2018.01.010. Epub 2018 Jan 5. Review.

PMID:
29309756
30.

Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1.

Cruz JA, Childs EE, Amatya N, Garg AV, Beyaert R, Kane LP, Aneskievich BJ, Ma A, Gaffen SL.

Immunohorizons. 2017 Sep;1(7):133-141. doi: 10.4049/immunohorizons.1700035.

31.

A20 Restrains Thymic Regulatory T Cell Development.

Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H.

J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25.

32.

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Fischer JC, Otten V, Steiger K, Schmickl M, Slotta-Huspenina J, Beyaert R, van Loo G, Peschel C, Poeck H, Haas T, Spoerl S.

Eur J Immunol. 2017 Nov;47(11):1982-1988. doi: 10.1002/eji.201646911. Epub 2017 Sep 15.

33.

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.

Afonina IS, Zhong Z, Karin M, Beyaert R.

Nat Immunol. 2017 Jul 19;18(8):861-869. doi: 10.1038/ni.3772. Review.

PMID:
28722711
34.

Unusual Lipid A from a Cold-Adapted Bacterium: Detailed Structural Characterization.

Casillo A, Ziaco M, Lindner B, Parrilli E, Schwudke D, Holgado A, Verstrepen L, Sannino F, Beyaert R, Lanzetta R, Tutino ML, Corsaro MM.

Chembiochem. 2017 Sep 19;18(18):1845-1854. doi: 10.1002/cbic.201700287. Epub 2017 Jul 27.

PMID:
28650563
35.

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.

Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, O'Brien C, Provoost S, Hammad H, Gonçalves A, Beyaert R, Declercq W, Vandenabeele P, Krysko DV, Bröker BM, Bachert C, Krysko O.

J Allergy Clin Immunol. 2018 Feb;141(2):549-559.e7. doi: 10.1016/j.jaci.2017.05.004. Epub 2017 May 19.

PMID:
28532656
36.

Abscisic Acid as Pathogen Effector and Immune Regulator.

Lievens L, Pollier J, Goossens A, Beyaert R, Staal J.

Front Plant Sci. 2017 Apr 19;8:587. doi: 10.3389/fpls.2017.00587. eCollection 2017. Review.

37.

Patterns, Receptors, and Signals: Regulation of Phagosome Maturation.

Pauwels AM, Trost M, Beyaert R, Hoffmann E.

Trends Immunol. 2017 Jun;38(6):407-422. doi: 10.1016/j.it.2017.03.006. Epub 2017 Apr 14. Review.

38.

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.

Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN.

Nat Commun. 2017 Apr 3;8:14937. doi: 10.1038/ncomms14937.

39.

CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.

Lork M, Verhelst K, Beyaert R.

Cell Death Differ. 2017 Jul;24(7):1172-1183. doi: 10.1038/cdd.2017.46. Epub 2017 Mar 31. Review.

40.

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

Kip E, Nazé F, Suin V, Vanden Berghe T, Francart A, Lamoral S, Vandenabeele P, Beyaert R, Van Gucht S, Kalai M.

Cell Death Discov. 2017 Mar 6;3:17012. doi: 10.1038/cddiscovery.2017.12. eCollection 2017.

41.

99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study.

Lambert B, Carron P, D'Asseler Y, Bacher K, Van den Bosch F, Elewaut D, Verbruggen G, Beyaert R, Dumolyn C, De Vos F.

EJNMMI Res. 2016 Dec;6(1):88. Epub 2016 Dec 12.

42.

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.

Van Nuffel E, Schmitt A, Afonina IS, Schulze-Osthoff K, Beyaert R, Hailfinger S.

J Invest Dermatol. 2017 Mar;137(3):569-575. doi: 10.1016/j.jid.2016.09.031. Epub 2016 Dec 8. Review.

43.

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

de Kleer IM, Kool M, de Bruijn MJ, Willart M, van Moorleghem J, Schuijs MJ, Plantinga M, Beyaert R, Hams E, Fallon PG, Hammad H, Hendriks RW, Lambrecht BN.

Immunity. 2016 Dec 20;45(6):1285-1298. doi: 10.1016/j.immuni.2016.10.031. Epub 2016 Dec 6.

44.

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

Tima HG, Al Dulayymi JR, Denis O, Lehebel P, Baols KS, Mohammed MO, L'Homme L, Sahb MM, Potemberg G, Legrand S, Lang R, Beyaert R, Piette J, Baird MS, Huygen K, Romano M.

J Innate Immun. 2017;9(2):162-180. doi: 10.1159/000450955. Epub 2016 Nov 18.

45.

Litter decay controlled by temperature, not soil properties, affecting future soil carbon.

Gregorich EG, Janzen H, Ellert BH, Helgason BL, Qian B, Zebarth BJ, Angers DA, Beyaert RP, Drury CF, Duguid SD, May WE, McConkey BG, Dyck MF.

Glob Chang Biol. 2017 Apr;23(4):1725-1734. doi: 10.1111/gcb.13502. Epub 2016 Oct 8.

PMID:
27633488
46.

Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy.

Lork M, Delvaeye M, Gonçalves A, Van Hamme E, Beyaert R.

Methods Mol Biol. 2016;1449:243-50. doi: 10.1007/978-1-4939-3756-1_14.

PMID:
27613040
47.

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

Drennan MB, Govindarajan S, Verheugen E, Coquet JM, Staal J, McGuire C, Taghon T, Leclercq G, Beyaert R, van Loo G, Lambrecht BN, Elewaut D.

J Exp Med. 2016 Sep 19;213(10):1973-81. doi: 10.1084/jem.20151065. Epub 2016 Aug 22.

48.

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis.

De Wilde K, Martens A, Lambrecht S, Jacques P, Drennan MB, Debusschere K, Govindarajan S, Coudenys J, Verheugen E, Windels F, Catrysse L, Lories R, McGonagle D, Beyaert R, van Loo G, Elewaut D.

Ann Rheum Dis. 2017 Mar;76(3):585-592. doi: 10.1136/annrheumdis-2016-209454. Epub 2016 Aug 22.

PMID:
27551052
49.

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.

Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef SA, Mc Guire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R, van Loo G.

Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.

50.

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.

Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y.

Nat Commun. 2016 May 6;7:11385. doi: 10.1038/ncomms11385.

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