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The Hybrid Theory of Stories and Arguments Applied to the Simonshaven Case.

Bex FJ.

Top Cogn Sci. 2019 May 6. doi: 10.1111/tops.12426. [Epub ahead of print]


FOXP1 is a regulator of quiescence in healthy human CD4+ T cells and is constitutively repressed in T cells from patients with lymphoproliferative disorders.

Garaud S, Roufosse F, De Silva P, Gu-Trantien C, Lodewyckx JN, Duvillier H, Dedeurwaerder S, Bizet M, Defrance M, Fuks F, Bex F, Willard-Gallo K.

Eur J Immunol. 2017 Jan;47(1):168-179. doi: 10.1002/eji.201646373. Epub 2016 Nov 30.


Highlights on distinctive structural and functional properties of HTLV Tax proteins.

Romanelli MG, Diani E, Bergamo E, Casoli C, Ciminale V, Bex F, Bertazzoni U.

Front Microbiol. 2013 Sep 9;4:271. doi: 10.3389/fmicb.2013.00271. Review.


Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.

Lodewick J, Sampaio C, Boxus M, Rinaldi AS, Coulonval K, Willems L, Roger PP, Bex F.

Retrovirology. 2013 Jul 23;10:75. doi: 10.1186/1742-4690-10-75.


Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein.

Turci M, Lodewick J, Di Gennaro G, Rinaldi AS, Marin O, Diani E, Sampaio C, Bex F, Bertazzoni U, Romanelli MG.

Retrovirology. 2012 Dec 7;9:102. doi: 10.1186/1742-4690-9-102.


Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.

Murrills RJ, Fukayama S, Boschelli F, Matteo JJ, Owens J, Golas JM, Patel D, Lane G, Liu YB, Carter L, Jussif J, Spaulding V, Wang YD, Boschelli DH, McKew JC, Li XJ, Lockhead S, Milligan C, Kharode YP, Diesl V, Bai Y, Follettie M, Bex FJ, Komm B, Bodine PV.

J Pharmacol Exp Ther. 2012 Mar;340(3):676-87. doi: 10.1124/jpet.111.185793. Epub 2011 Dec 9.


Move or die: the fate of the Tax oncoprotein of HTLV-1.

Lodewick J, Lamsoul I, Bex F.

Viruses. 2011 Jun;3(6):829-57. doi: 10.3390/v3060829. Epub 2011 Jun 15. Review.


Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation.

Avesani F, Romanelli MG, Turci M, Di Gennaro G, Sampaio C, Bidoia C, Bertazzoni U, Bex F.

Virology. 2010 Dec 5;408(1):39-48. doi: 10.1016/j.virol.2010.08.023. Epub 2010 Sep 27.


BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

Keutgens A, Zhang X, Shostak K, Robert I, Olivier S, Vanderplasschen A, Chapelle JP, Viatour P, Merville MP, Bex F, Gothot A, Chariot A.

J Biol Chem. 2010 Aug 13;285(33):25831-40. doi: 10.1074/jbc.M110.112128. Epub 2010 Jun 17.


Effects of HPV-16 E5, E6 and E7 proteins on survival, adhesion, migration and invasion of trophoblastic cells.

Boulenouar S, Weyn C, Van Noppen M, Moussa Ali M, Favre M, Delvenne PO, Bex F, Noël A, Englert Y, Fontaine V.

Carcinogenesis. 2010 Mar;31(3):473-80. doi: 10.1093/carcin/bgp281. Epub 2009 Nov 16.


Hit to lead studies on (hetero)arylpyrimidines--agonists of the canonical Wnt-beta-catenin cellular messaging system.

Gilbert AM, Bursavich MG, Alon N, Bhat BM, Bex FJ, Cain M, Coleburn V, Gironda V, Green P, Hauze DB, Kharode Y, Krishnamurthy G, Kirisits M, Lam HS, Liu YB, Lombardi S, Matteo J, Murrills R, Robinson JA, Selim S, Sharp M, Unwalla R, Varadarajan U, Zhao W, Yaworsky PJ.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):366-70. doi: 10.1016/j.bmcl.2009.10.093. Epub 2009 Oct 25.


(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.

Pelletier JC, Lundquist JT 4th, Gilbert AM, Alon N, Bex FJ, Bhat BM, Bursavich MG, Coleburn VE, Felix LA, Green DM, Green P, Hauze DB, Kharode YP, Lam HS, Lockhead SR, Magolda RL, Matteo JJ, Mehlmann JF, Milligan C, Murrills RJ, Pirrello J, Selim S, Sharp MC, Unwalla RJ, Vera MD, Wrobel JE, Yaworsky P, Bodine PV.

J Med Chem. 2009 Nov 26;52(22):6962-5. doi: 10.1021/jm9014197.


A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV.

J Cell Biochem. 2009 Dec 1;108(5):1066-75. doi: 10.1002/jcb.22335.


Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway.

Lodewick J, Lamsoul I, Polania A, Lebrun S, Burny A, Ratner L, Bex F.

Virology. 2009 Mar 30;386(1):68-78. doi: 10.1016/j.virol.2008.12.043. Epub 2009 Feb 5.


HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.

Turci M, Lodewick J, Righi P, Polania A, Romanelli MG, Bex F, Bertazzoni U.

Virology. 2009 Mar 30;386(1):6-11. doi: 10.1016/j.virol.2009.01.003. Epub 2009 Feb 4.


Parathyroid hormone synergizes with non-cyclic AMP pathways to activate the cyclic AMP response element.

Murrills RJ, Andrews JL, Samuel RL, Coleburn VE, Bhat BM, Bhat RA, Bex FJ, Bodine PV.

J Cell Biochem. 2009 Apr 1;106(5):887-95. doi: 10.1002/jcb.22057.


Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1.

Terme JM, Wencker M, Favre-Bonvin A, Bex F, Gazzolo L, Duc Dodon M, Jalinot P.

J Virol. 2008 Aug;82(16):7913-22. doi: 10.1128/JVI.02414-07. Epub 2008 May 21.


The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.

Mascaux C, Bex F, Martin B, Burny A, Haller A, Paesmans M, Willard-Gallo K, Ninane V, Sculier JP.

Eur Respir J. 2008 Sep;32(3):678-86. doi: 10.1183/09031936.00008408. Epub 2008 May 14.


STAT5 is an ambivalent regulator of neutrophil homeostasis.

Fiévez L, Desmet C, Henry E, Pajak B, Hegenbarth S, Garzé V, Bex F, Jaspar F, Boutet P, Gillet L, Vanderplasschen A, Knolle PA, Leo O, Moser M, Lekeux P, Bureau F.

PLoS One. 2007 Aug 15;2(8):e727.


Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.

Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, Piette J.

J Biol Chem. 2007 Jul 20;282(29):21308-18. Epub 2007 May 30.


Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton.

Legrand-Poels S, Kustermans G, Bex F, Kremmer E, Kufer TA, Piette J.

J Cell Sci. 2007 Apr 1;120(Pt 7):1299-310. Epub 2007 Mar 13.


HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation.

Akl H, Badran BM, Zein NE, Bex F, Sotiriou C, Willard-Gallo KE, Burny A, Martiat P.

Leukemia. 2007 Apr;21(4):788-96. Epub 2007 Feb 8. Erratum in: Leukemia. 2009 Nov;23(11):2187. Zein, N E [corrected to Zein, N El].


Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling.

Bhat BM, Allen KM, Liu W, Graham J, Morales A, Anisowicz A, Lam HS, McCauley C, Coleburn V, Cain M, Fortier E, Bhat RA, Bex FJ, Yaworsky PJ.

Gene. 2007 Apr 15;391(1-2):103-12. Epub 2006 Dec 29.


DNA vaccine encoding endosome-targeted human papillomavirus type 16 E7 protein generates CD4+ T cell-dependent protection.

Brulet JM, Maudoux F, Thomas S, Thielemans K, Burny A, Leo O, Bex F, Hallez S.

Eur J Immunol. 2007 Feb;37(2):376-84.


Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner.

Cardoso F, Durbecq V, Laes JF, Badran B, Lagneaux L, Bex F, Desmedt C, Willard-Gallo K, Ross JS, Burny A, Piccart M, Sotiriou C.

Mol Cancer Ther. 2006 Dec;5(12):3042-51. Epub 2006 Dec 5.


Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains.

Baydoun H, Duc-Dodon M, Lebrun S, Gazzolo L, Bex F.

Gene. 2007 Jan 15;386(1-2):191-201. Epub 2006 Sep 30.


Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1.

Bodine PV, Seestaller-Wehr L, Kharode YP, Bex FJ, Komm BS.

J Cell Physiol. 2007 Feb;210(2):352-7.


Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.

Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Hill AA, Akhter MP, Johnson ML, Recker RR, Komm BS, Bex FJ.

J Biol Chem. 2006 Oct 20;281(42):31720-8. Epub 2006 Aug 14.


Identification of a PTH regulated gene selectively induced in vivo during PTH-mediated bone formation.

Robinson JA, Susulic V, Liu YB, Taylor C, Hardenburg J, Gironda V, Zhao W, Kharode Y, McLarney S, Bai Y, Malone DP, Murrills R, Bex F.

J Cell Biochem. 2006 Aug 1;98(5):1203-20.


The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism.

Adam E, Hansen KK, Astudillo Fernandez O, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD, Jacquet A.

J Biol Chem. 2006 Mar 17;281(11):6910-23. Epub 2005 Nov 17. Erratum in: J Biol Chem. 2007 Feb 16;282(7):5100. Astudillo, Olaya Fernandez [corrected to Astudillo Fernandez, Olaya].


Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F.

Mol Cell Biol. 2005 Dec;25(23):10391-406.


Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors.

Liu PQ, Tan S, Mendel MC, Murrills RJ, Bhat BM, Schlag B, Samuel R, Matteo JJ, de la Rosa R, Howes K, Reik A, Case CC, Bex FJ, Young K, Gregory PD.

J Biomol Screen. 2005 Jun;10(4):304-13.


Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes.

Kress E, Baydoun HH, Bex F, Gazzolo L, Duc Dodon M.

Retrovirology. 2005 Feb 9;2:8.


In vitro and in vivo activities of C-terminally truncated PTH peptides reveal a disconnect between cAMP signaling and functional activity.

Murrills RJ, Matteo JJ, Samuel RL, Andrews JL, Bhat BM, Coleburn VE, Kharode YP, Bex FJ.

Bone. 2004 Dec;35(6):1263-72.


Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma.

Nasr R, El-Sabban ME, Karam JA, Dbaibo G, Kfoury Y, Arnulf B, Lepelletier Y, Bex F, de Thé H, Hermine O, Bazarbachi A.

Oncogene. 2005 Jan 13;24(3):419-30.


Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding.

Chiari E, Lamsoul I, Lodewick J, Chopin C, Bex F, Pique C.

J Virol. 2004 Nov;78(21):11823-32.


Gene activation and gene silencing: a subtle equilibrium.

Quivy V, Calomme C, Dekoninck A, Demonte D, Bex F, Lamsoul I, Vanhulle C, Burny A, Van Lint C.

Cloning Stem Cells. 2004;6(2):140-9. Review.


Bone biomechanical properties in LRP5 mutant mice.

Akhter MP, Wells DJ, Short SJ, Cullen DM, Johnson ML, Haynatzki GR, Babij P, Allen KM, Yaworsky PJ, Bex F, Recker RR.

Bone. 2004 Jul;35(1):162-9.


The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice.

Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, Goad MB, Gaur T, Stein GS, Lian JB, Komm BS.

Mol Endocrinol. 2004 May;18(5):1222-37. Epub 2004 Feb 19.


Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development.

Pouillon V, Hascakova-Bartova R, Pajak B, Adam E, Bex F, Dewaste V, Van Lint C, Leo O, Erneux C, Schurmans S.

Nat Immunol. 2003 Nov;4(11):1136-43. Epub 2003 Sep 28.


Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha.

Adam E, Quivy V, Bex F, Chariot A, Collette Y, Vanhulle C, Schoonbroodt S, Goffin V, Nguyên TL, Gloire G, Carrard G, Friguet B, De Launoit Y, Burny A, Bours V, Piette J, Van Lint C.

Mol Cell Biol. 2003 Sep;23(17):6200-9. Erratum in: Mol Cell Biol. 2004 Aug;24(15):6890.


High bone mass in mice expressing a mutant LRP5 gene.

Babij P, Zhao W, Small C, Kharode Y, Yaworsky PJ, Bouxsein ML, Reddy PS, Bodine PV, Robinson JA, Bhat B, Marzolf J, Moran RA, Bex F.

J Bone Miner Res. 2003 Jun;18(6):960-74.


The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.

Dewaste V, Moreau C, De Smedt F, Bex F, De Smedt H, Wuytack F, Missiaen L, Erneux C.

Biochem J. 2003 Aug 15;374(Pt 1):41-9.


Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells.

Nasr R, Rosenwald A, El-Sabban ME, Arnulf B, Zalloua P, Lepelletier Y, Bex F, Hermine O, Staudt L, de Thé H, Bazarbachi A.

Blood. 2003 Jun 1;101(11):4576-82. Epub 2003 Jan 30.


Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice.

Turgeman G, Zilberman Y, Zhou S, Kelly P, Moutsatsos IK, Kharode YP, Borella LE, Bex FJ, Komm BS, Bodine PV, Gazit D.

J Cell Biochem. 2002;86(3):461-74.


PTH-dependent adenylyl cyclase activation in SaOS-2 cells: passage dependent effects on G protein interactions.

Gao H, Bodine PV, Murrills R, Bex FJ, Bilezikian JP, Morris SA.

J Cell Physiol. 2002 Oct;193(1):10-8.


Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.

Hemelaar J, Bex F, Booth B, Cerundolo V, McMichael A, Daenke S.

J Virol. 2001 Nov;75(22):11106-15.


Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara.

Nilsson C, Mäkitalo B, Berglund P, Bex F, Liljeström P, Sutter G, Erfle V, ten Haaft P, Heeney J, Biberfeld G, Thorstensson R.

Vaccine. 2001 May 14;19(25-26):3526-36.


Glucocorticoids attenuate T cell receptor signaling.

Van Laethem F, Baus E, Smyth LA, Andris F, Bex F, Urbain J, Kioussis D, Leo O.

J Exp Med. 2001 Apr 2;193(7):803-14.


A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.

Heeney JL, Koopman G, Rosenwirth B, Bogers W, van Dijk J, Nieuwenhuis I, Niphuis H, ten Haaft P, Hanke T, Rhodes G, Berglund P, Burny A, Bex F, Sutter G, Liljeström P.

J Med Primatol. 2000 Aug;29(3-4):268-73.


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