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An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice.

Castillo PA, Nonnecke EB, Ossorio DT, Tran MTN, Goley SM, Lönnerdal B, Underwood MA, Bevins CL.

Sci Rep. 2019 Sep 11;9(1):13115. doi: 10.1038/s41598-019-49471-9.


Bacterial Colonization of the Hospitalized Newborn: Competition Between Staphylococcus aureus and Staphylococcus epidermidis.

Lee DC, Kananurak A, Tran MT, Connolly PA, Polage CR, Iwase T, Bevins CL, Underwood MA.

Pediatr Infect Dis J. 2019 Jul;38(7):682-686. doi: 10.1097/INF.0000000000002285.


T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium.

Ramirez VT, Godinez DR, Brust-Mascher I, Nonnecke EB, Castillo PA, Gardner MB, Tu D, Sladek JA, Miller EN, Lebrilla CB, Bevins CL, Gareau MG, Reardon C.

PLoS Pathog. 2019 Apr 11;15(4):e1007719. doi: 10.1371/journal.ppat.1007719. eCollection 2019 Apr.


Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.

Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W.

Immunity. 2018 Jun 19;48(6):1233-1244.e6. doi: 10.1016/j.immuni.2018.04.014. Epub 2018 May 29.


Human β-Defensin 2 in Primary Sclerosing Cholangitis.

Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL.

Clin Transl Gastroenterol. 2017 Mar 16;8(3):e80. doi: 10.1038/ctg.2017.8.


The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR.

Nguyen TT, Kläsener K, Zürn C, Castillo PA, Brust-Mascher I, Imai DM, Bevins CL, Reardon C, Reth M, Baumgarth N.

Nat Immunol. 2017 Mar;18(3):321-333. doi: 10.1038/ni.3677. Epub 2017 Jan 30.


Amyloid formation: functional friend or fearful foe?

Bergman P, Roan NR, Römling U, Bevins CL, Münch J.

J Intern Med. 2016 Aug;280(2):139-52. doi: 10.1111/joim.12479. Epub 2016 May 6. Review.


Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human α-Defensin Peptide.

Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM.

Chem Sci. 2016 Mar 1;7(3):1738-1752. doi: 10.1039/C5SC04194E. Epub 2015 Dec 10.


What's one phosphate between friends (and foe)?

Bevins CL, Bäumler AJ.

Cell Host Microbe. 2015 Jan 14;17(1):1-3. doi: 10.1016/j.chom.2014.12.011.


Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene.

Ottolini B, Hornsby MJ, Abujaber R, MacArthur JA, Badge RM, Schwarzacher T, Albertson DG, Bevins CL, Solnick JV, Hollox EJ.

Genome Biol Evol. 2014 Oct 27;6(11):3025-38. doi: 10.1093/gbe/evu236.


Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota.

Underwood MA, Arriola J, Gerber CW, Kaveti A, Kalanetra KM, Kananurak A, Bevins CL, Mills DA, Dvorak B.

Pediatr Res. 2014 Oct;76(4):326-33. doi: 10.1038/pr.2014.102. Epub 2014 Jul 7.


Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.

Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO.

PLoS One. 2014 May 27;9(5):e98269. doi: 10.1371/journal.pone.0098269. eCollection 2014.


Innate immune functions of α-defensins in the small intestine.

Bevins CL.

Dig Dis. 2013;31(3-4):299-304. doi: 10.1159/000354681. Epub 2013 Nov 14. Review.


Dysbiosis--a consequence of Paneth cell dysfunction.

Salzman NH, Bevins CL.

Semin Immunol. 2013 Nov 30;25(5):334-41. doi: 10.1016/j.smim.2013.09.006. Epub 2013 Nov 14. Review.


Salmonella uses energy taxis to benefit from intestinal inflammation.

Rivera-Chávez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins CL, Tsolis RM, Harshey R, Adams LG, Bäumler AJ.

PLoS Pathog. 2013;9(4):e1003267. doi: 10.1371/journal.ppat.1003267. Epub 2013 Apr 18.


Extensive in vivo human milk peptidomics reveals specific proteolysis yielding protective antimicrobial peptides.

Dallas DC, Guerrero A, Khaldi N, Castillo PA, Martin WF, Smilowitz JT, Bevins CL, Barile D, German JB, Lebrilla CB.

J Proteome Res. 2013 May 3;12(5):2295-304. doi: 10.1021/pr400212z. Epub 2013 Apr 24.


Paneth cells: maestros of the small intestinal crypts.

Clevers HC, Bevins CL.

Annu Rev Physiol. 2013;75:289-311. doi: 10.1146/annurev-physiol-030212-183744. Review.


Paneth cells: targets of friendly fire.

McSorley SJ, Bevins CL.

Nat Immunol. 2013 Feb;14(2):114-6. doi: 10.1038/ni.2519. No abstract available.


Routine habitat change: a source of unrecognized transient alteration of intestinal microbiota in laboratory mice.

Ma BW, Bokulich NA, Castillo PA, Kananurak A, Underwood MA, Mills DA, Bevins CL.

PLoS One. 2012;7(10):e47416. doi: 10.1371/journal.pone.0047416. Epub 2012 Oct 17.


Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection.

Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW.

BMC Complement Altern Med. 2012 Jun 29;12:84. doi: 10.1186/1472-6882-12-84.


Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.

Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL.

Science. 2012 Jul 27;337(6093):477-81. doi: 10.1126/science.1218831. Epub 2012 Jun 21.


Multifunctional glycoprotein DEFB126--a curious story of defensin-clad spermatozoa.

Tollner TL, Bevins CL, Cherr GN.

Nat Rev Urol. 2012 Jun 19;9(7):365-75. doi: 10.1038/nrurol.2012.109. Review.


Meeting report: a symposium on the evolution of common molecular pathways underlying innate immunity.

Gardner MB, Baumgarth N, Fell A, McSorley SJ, Solnick JV, Bevins CL.

Microbes Infect. 2012 Aug;14(9):667-71. doi: 10.1016/j.micinf.2012.04.001. Epub 2012 Apr 23.


A combination of secondhand cigarette smoke and Chlamydia pneumoniae accelerates atherosclerosis.

Zhao X, Bu DX, Hayfron K, Pinkerton KE, Bevins CL, Lichtman A, Wiedeman J.

Atherosclerosis. 2012 May;222(1):59-66. doi: 10.1016/j.atherosclerosis.2012.02.005. Epub 2012 Feb 17.


Antimicrobial peptides: agents of border protection for companion animals.

Leonard BC, Affolter VK, Bevins CL.

Vet Dermatol. 2012 Jun;23(3):177-e36. doi: 10.1111/j.1365-3164.2012.01037.x. Epub 2012 Mar 12. Review.


Human alpha defensin 5 expression in the human kidney and urinary tract.

Spencer JD, Hains DS, Porter E, Bevins CL, DiRosario J, Becknell B, Wang H, Schwaderer AL.

PLoS One. 2012;7(2):e31712. doi: 10.1371/journal.pone.0031712. Epub 2012 Feb 16.


Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses.

Underwood MA, Kananurak A, Coursodon CF, Adkins-Reick CK, Chu H, Bennett SH, Wehkamp J, Castillo PA, Leonard BC, Tancredi DJ, Sherman MP, Dvorak B, Bevins CL.

Pediatr Res. 2012 May;71(5):546-51. doi: 10.1038/pr.2012.11. Epub 2012 Feb 9.


Activity, expression and genetic variation of canine β-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.

Leonard BC, Marks SL, Outerbridge CA, Affolter VK, Kananurak A, Young A, Moore PF, Bannasch DL, Bevins CL.

J Innate Immun. 2012;4(3):248-59. doi: 10.1159/000334566. Epub 2012 Jan 19.


Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.

Teltschik Z, Wiest R, Beisner J, Nuding S, Hofmann C, Schoelmerich J, Bevins CL, Stange EF, Wehkamp J.

Hepatology. 2012 Apr;55(4):1154-63. doi: 10.1002/hep.24789. Epub 2012 Feb 15.


The potter's wheel: the host's role in sculpting its microbiota.

Bevins CL, Salzman NH.

Cell Mol Life Sci. 2011 Nov;68(22):3675-85. doi: 10.1007/s00018-011-0830-3. Epub 2011 Oct 4. Review.


A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.

Tollner TL, Venners SA, Hollox EJ, Yudin AI, Liu X, Tang G, Xing H, Kays RJ, Lau T, Overstreet JW, Xu X, Bevins CL, Cherr GN.

Sci Transl Med. 2011 Jul 20;3(92):92ra65. doi: 10.1126/scitranslmed.3002289. Erratum in: Sci Transl Med. 2011 Aug 3;(94):94er5. Sci Transl Med. 2014 May 14;6(236):236er3.


Expression and activity of a novel cathelicidin from domestic cats.

Leonard BC, Chu H, Johns JL, Gallo RL, Moore PF, Marks SL, Bevins CL.

PLoS One. 2011 Apr 12;6(4):e18756. doi: 10.1371/journal.pone.0018756.


Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis.

Bevins CL, Salzman NH.

Nat Rev Microbiol. 2011 May;9(5):356-68. doi: 10.1038/nrmicro2546. Epub 2011 Mar 22. Review.


Gut inflammation provides a respiratory electron acceptor for Salmonella.

Winter SE, Thiennimitr P, Winter MG, Butler BP, Huseby DL, Crawford RW, Russell JM, Bevins CL, Adams LG, Tsolis RM, Roth JR, Bäumler AJ.

Nature. 2010 Sep 23;467(7314):426-9. doi: 10.1038/nature09415.


Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial.

Dhaliwal W, Shawa T, Khanam M, Jagatiya P, Simuyandi M, Ndulo N, Bevins CL, Sanderson IR, Kelly P.

J Infect Dis. 2010 Sep 15;202(6):971-8. doi: 10.1086/655903.


Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum.

Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44. doi: 10.1073/pnas.1003363107. Epub 2010 Aug 2.


Defensin-barbed innate immunity: clinical associations in the pediatric population.

Underwood MA, Bevins CL.

Pediatrics. 2010 Jun;125(6):1237-47. doi: 10.1542/peds.2009-3289. Epub 2010 May 17. Review.


A sweet target for innate immunity.

Liu FT, Bevins CL.

Nat Med. 2010 Mar;16(3):263-4. doi: 10.1038/nm0310-263. No abstract available.


The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells.

Untersmayr E, Bises G, Starkl P, Bevins CL, Scheiner O, Boltz-Nitulescu G, Wrba F, Jensen-Jarolim E.

PLoS One. 2010 Feb 2;5(2):e9023. doi: 10.1371/journal.pone.0009023.


Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut.

Wolfs TG, Derikx JP, Hodin CM, Vanderlocht J, Driessen A, de Bruïne AP, Bevins CL, Lasitschka F, Gassler N, van Gemert WG, Buurman WA.

Inflamm Bowel Dis. 2010 Jan;16(1):68-75. doi: 10.1002/ibd.20995.


Enteric defensins are essential regulators of intestinal microbial ecology.

Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA.

Nat Immunol. 2010 Jan;11(1):76-83. doi: 10.1038/ni.1825. Epub 2009 Oct 22.


Life in the inflamed intestine, Salmonella style.

Santos RL, Raffatellu M, Bevins CL, Adams LG, Tükel C, Tsolis RM, Bäumler AJ.

Trends Microbiol. 2009 Nov;17(11):498-506. doi: 10.1016/j.tim.2009.08.008. Epub 2009 Oct 12. Review.


Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.

Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ.

Cell Host Microbe. 2009 May 8;5(5):476-86. doi: 10.1016/j.chom.2009.03.011.


Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype.

Bevins CL, Stange EF, Wehkamp J.

Gut. 2009 Jun;58(6):882-3; discussion 883-4. No abstract available.


Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection.

Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins CL, Rüssmann H, Monack DM, Adams LG, Bäumler AJ.

Infect Immun. 2009 May;77(5):1904-16. doi: 10.1128/IAI.01341-08. Epub 2009 Feb 23.


Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.

Koslowski MJ, Kübler I, Chamaillard M, Schaeffeler E, Reinisch W, Wang G, Beisner J, Teml A, Peyrin-Biroulet L, Winter S, Herrlinger KR, Rutgeerts P, Vermeire S, Cooney R, Fellermann K, Jewell D, Bevins CL, Schwab M, Stange EF, Wehkamp J.

PLoS One. 2009;4(2):e4496. doi: 10.1371/journal.pone.0004496. Epub 2009 Feb 16.


A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids.

Underwood MA, Salzman NH, Bennett SH, Barman M, Mills DA, Marcobal A, Tancredi DJ, Bevins CL, Sherman MP.

J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):216-25. doi: 10.1097/MPG.0b013e31818de195.


Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.

Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV.

J Biol Chem. 2009 Feb 20;284(8):4881-8. doi: 10.1074/jbc.M808077200. Epub 2008 Dec 18.


Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine.

Godinez I, Raffatellu M, Chu H, Paixão TA, Haneda T, Santos RL, Bevins CL, Tsolis RM, Bäumler AJ.

Infect Immun. 2009 Jan;77(1):387-98. doi: 10.1128/IAI.00933-08. Epub 2008 Oct 27.


Negative interactions with the microbiota: IBD.

Salzman NH, Bevins CL.

Adv Exp Med Biol. 2008;635:67-78. doi: 10.1007/978-0-387-09550-9_6. Review.


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