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The coming of age of Langerhans cell histiocytosis.

Allen CE, Beverley PCL, Collin M, Diamond EL, Egeler RM, Ginhoux F, Glass C, Minkov M, Rollins BJ, van Halteren A.

Nat Immunol. 2020 Jan;21(1):1-7. doi: 10.1038/s41590-019-0558-z. No abstract available.


Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails.

Verreck FAW, Tchilian EZ, Vervenne RAW, Sombroek CC, Kondova I, Eissen OA, Sommandas V, van der Werff NM, Verschoor E, Braskamp G, Bakker J, Langermans JAM, Heidt PJ, Ottenhoff THM, van Kralingen KW, Thomas AW, Beverley PCL, Kocken CHM.

Tuberculosis (Edinb). 2017 May;104:46-57. doi: 10.1016/ Epub 2017 Feb 20.


Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

Dean GS, Clifford D, Whelan AO, Tchilian EZ, Beverley PC, Salguero FJ, Xing Z, Vordermeier HM, Villarreal-Ramos B.

PLoS One. 2015 Nov 6;10(11):e0142270. doi: 10.1371/journal.pone.0142270. eCollection 2015.


A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Beverley PC, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, Marchi E, O'Hara G, Klenerman P, Koszinowski UH, Tchilian EZ.

J Immunol. 2014 Sep 1;193(5):2306-16. doi: 10.4049/jimmunol.1302523. Epub 2014 Jul 28.


Harnessing local and systemic immunity for vaccines against tuberculosis.

Beverley PC, Sridhar S, Lalvani A, Tchilian EZ.

Mucosal Immunol. 2014 Jan;7(1):20-6. doi: 10.1038/mi.2013.99. Epub 2013 Nov 20. Review.


Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells.

Clutterbuck EA, Lazarus R, Yu LM, Bowman J, Bateman EA, Diggle L, Angus B, Peto TE, Beverley PC, Mant D, Pollard AJ.

J Infect Dis. 2012 May 1;205(9):1408-16. doi: 10.1093/infdis/jis212. Epub 2012 Mar 29.


Simultaneous immunization against tuberculosis.

Tchilian EZ, Ronan EO, de Lara C, Lee LN, Franken KL, Vordermeier MH, Ottenhoff TH, Beverley PC.

PLoS One. 2011;6(11):e27477. doi: 10.1371/journal.pone.0027477. Epub 2011 Nov 16.


CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis.

Lee LN, Ronan EO, de Lara C, Franken KL, Ottenhoff TH, Tchilian EZ, Beverley PC.

Infect Immun. 2011 Aug;79(8):3328-37. doi: 10.1128/IAI.01133-10. Epub 2011 May 31.


A randomized study comparing combined pneumococcal conjugate and polysaccharide vaccination schedules in adults.

Lazarus R, Clutterbuck E, Yu LM, Bowman J, Bateman EA, Diggle L, Angus B, Peto TE, Beverley PC, Mant D, Pollard AJ.

Clin Infect Dis. 2011 Mar 15;52(6):736-42. doi: 10.1093/cid/cir003.


Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A.

Lee LN, Baban D, Ronan EO, Ragoussis J, Beverley PC, Tchilian EZ.

BMC Med Genomics. 2010 Oct 13;3:46. doi: 10.1186/1755-8794-3-46.


Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.

Wallace DL, Masters JE, De Lara CM, Henson SM, Worth A, Zhang Y, Kumar SR, Beverley PC, Akbar AN, Macallan DC.

Immunology. 2011 Jan;132(1):27-38. doi: 10.1111/j.1365-2567.2010.03334.x. Epub 2010 Aug 25.


Nasal associated lymphoid tissue (NALT) contributes little to protection against aerosol challenge with Mycobacterium tuberculosis after immunisation with a recombinant adenoviral vaccine.

Ronan EO, Lee LN, Tchilian EZ, Beverley PC.

Vaccine. 2010 Jul 19;28(32):5179-84. doi: 10.1016/j.vaccine.2010.05.075. Epub 2010 Jun 15.


Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

Davies MN, Bayry J, Tchilian EZ, Vani J, Shaila MS, Forbes EK, Draper SJ, Beverley PC, Tough DF, Flower DR.

PLoS One. 2009 Nov 30;4(11):e8084. doi: 10.1371/journal.pone.0008084.


Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection.

Ronan EO, Lee LN, Beverley PC, Tchilian EZ.

PLoS One. 2009 Dec 9;4(12):e8235. doi: 10.1371/journal.pone.0008235.


Immune memory: the basics and how to trigger an efficient long-term immune memory.

Beverley PC.

J Comp Pathol. 2010 Jan;142 Suppl 1:S91-5. doi: 10.1016/j.jcpa.2009.09.008. Epub 2009 Nov 7. Review.


Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose.

Macallan DC, Asquith B, Zhang Y, de Lara C, Ghattas H, Defoiche J, Beverley PC.

Nat Protoc. 2009;4(9):1313-27. doi: 10.1038/nprot.2009.117. Epub 2009 Aug 20.


Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines.

Pollard AJ, Perrett KP, Beverley PC.

Nat Rev Immunol. 2009 Mar;9(3):213-20. doi: 10.1038/nri2494. Review.


Foot-and-mouth disease virus can induce a specific and rapid CD4+ T-cell-independent neutralizing and isotype class-switched antibody response in naïve cattle.

Juleff N, Windsor M, Lefevre EA, Gubbins S, Hamblin P, Reid E, McLaughlin K, Beverley PC, Morrison IW, Charleston B.

J Virol. 2009 Apr;83(8):3626-36. doi: 10.1128/JVI.02613-08. Epub 2009 Jan 28.


Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

Ben-Smith A, Gorak-Stolinska P, Floyd S, Weir RE, Lalor MK, Mvula H, Crampin AC, Wallace D, Beverley PC, Fine PE, Dockrell HM.

BMC Infect Dis. 2008 Oct 15;8:139. doi: 10.1186/1471-2334-8-139.


Lessons for tuberculosis vaccines from respiratory virus infection.

Beverley PC, Tchilian EZ.

Expert Rev Vaccines. 2008 Oct;7(8):1165-72. doi: 10.1586/14760584.7.8.1165. Review.


In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.

Bayry J, Tchilian EZ, Davies MN, Forbes EK, Draper SJ, Kaveri SV, Hill AV, Kazatchkine MD, Beverley PC, Flower DR, Tough DF.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6. doi: 10.1073/pnas.0803453105. Epub 2008 Jul 11.


Primer: making sense of T-cell memory.

Beverley PC.

Nat Clin Pract Rheumatol. 2008 Jan;4(1):43-9. doi: 10.1038/ncprheum0671. Review.


Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory B-cell and antibody responses to immunization with a pneumococcal conjugate vaccine.

Clutterbuck EA, Oh S, Hamaluba M, Westcar S, Beverley PC, Pollard AJ.

Clin Vaccine Immunol. 2008 Feb;15(2):182-93. Epub 2007 Nov 21.


In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection.

Asquith B, Zhang Y, Mosley AJ, de Lara CM, Wallace DL, Worth A, Kaftantzi L, Meekings K, Griffin GE, Tanaka Y, Tough DF, Beverley PC, Taylor GP, Macallan DC, Bangham CR.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8035-40. Epub 2007 May 1.


In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.

Zhang Y, Wallace DL, de Lara CM, Ghattas H, Asquith B, Worth A, Griffin GE, Taylor GP, Tough DF, Beverley PC, Macallan DC.

Immunology. 2007 Jun;121(2):258-65. Epub 2007 Mar 7.


Unusual case presentations associated with the CD45 C77G polymorphism.

Tchilian EZ, Gil J, Navarro ML, Fernandez-Cruz E, Chapel H, Misbah S, Ferry B, Renz H, Schwinzer R, Beverley PC.

Clin Exp Immunol. 2006 Dec;146(3):448-54.


Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length.

Wallace DL, Bérard M, Soares MV, Oldham J, Cook JE, Akbar AN, Tough DF, Beverley PC.

Immunology. 2006 Oct;119(2):243-53.


Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.

Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, Masters JE, Rustin MH, Taams LS, Beverley PC, Macallan DC, Akbar AN.

J Clin Invest. 2006 Sep;116(9):2423-33. Erratum in: J Clin Invest. 2006 Oct;116(10):2829-30.


CD45 is required for type I IFN production by dendritic cells.

Montoya M, Dawes R, Reid D, Lee LN, Piercy J, Borrow P, Tchilian EZ, Beverley PC.

Eur J Immunol. 2006 Aug;36(8):2150-8.


CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.

Piercy J, Petrova S, Tchilian EZ, Beverley PC.

Immunology. 2006 Jun;118(2):250-6.


CD45 regulates apoptosis in peripheral T lymphocytes.

Liu Z, Dawes R, Petrova S, Beverley PC, Tchilian EZ.

Int Immunol. 2006 Jun;18(6):959-66. Epub 2006 Apr 18.


Geographical distribution and disease associations of the CD45 exon 6 138G variant.

Ward V, Hennig BJ, Hirai K, Tahara H, Tamori A, Dawes R, Saito M, Bangham C, Stephens H, Goldfeld AE, Kunachiwa W, Leetrakool N, Hopkin J, Dunstan S, Hill A, Bodmer W, Beverley PC, Tchilian EZ.

Immunogenetics. 2006 Apr;58(2-3):235-9. Epub 2006 Mar 15.


Combinations of CD45 isoforms are crucial for immune function and disease.

Dawes R, Petrova S, Liu Z, Wraith D, Beverley PC, Tchilian EZ.

J Immunol. 2006 Mar 15;176(6):3417-25.


Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.

Dawes R, Hennig B, Irving W, Petrova S, Boxall S, Ward V, Wallace D, Macallan DC, Thursz M, Hill A, Bodmer W, Beverley PC, Tchilian EZ.

J Med Genet. 2006 Aug;43(8):678-84. Epub 2006 Feb 27.


Altered CD45 expression and disease.

Tchilian EZ, Beverley PC.

Trends Immunol. 2006 Mar;27(3):146-53. Epub 2006 Jan 18. Review.


The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

Bennett AR, Gorak-Stolinska P, Ben-Smith A, Floyd S, de Lara CM, Weir RE, Lalor MK, Makamo K, Msiska GK, Crampin AC, Fine PE, Dockrell HM, Beverley PC.

Vaccine. 2006 Mar 24;24(14):2617-26. Epub 2005 Dec 27.


The Nikolas Symposia and histiocytosis.

Beverley PC, Egeler RM, Arceci RJ, Pritchard J.

Nat Rev Cancer. 2005 Jun;5(6):488-94. doi: 10.1038/nrc1632.


B-cell kinetics in humans: rapid turnover of peripheral blood memory cells.

Macallan DC, Wallace DL, Zhang Y, Ghattas H, Asquith B, de Lara C, Worth A, Panayiotakopoulos G, Griffin GE, Tough DF, Beverley PC.

Blood. 2005 May 1;105(9):3633-40. Epub 2005 Jan 11.


Kinetics and clonality of immunological memory in humans.

Beverley PC.

Semin Immunol. 2004 Oct;16(5):315-21. Review.


Will telomere erosion lead to a loss of T-cell memory?

Akbar AN, Beverley PC, Salmon M.

Nat Rev Immunol. 2004 Sep;4(9):737-43. doi: 10.1038/nri1440.


Disease associations and altered immune function in CD45 138G variant carriers.

Boxall S, Stanton T, Hirai K, Ward V, Yasui T, Tahara H, Tamori A, Nishiguchi S, Shiomi S, Ishiko O, Inaba M, Nishizawa Y, Dawes R, Bodmer W, Beverley PC, Tchilian EZ.

Hum Mol Genet. 2004 Oct 15;13(20):2377-84. Epub 2004 Aug 27.


Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.

Tchilian EZ, Dawes R, Hyland L, Montoya M, Le Bon A, Borrow P, Hou S, Tough D, Beverley PC.

Int Immunol. 2004 Sep;16(9):1323-32. Epub 2004 Aug 9.


Direct measurement of T cell subset kinetics in vivo in elderly men and women.

Wallace DL, Zhang Y, Ghattas H, Worth A, Irvine A, Bennett AR, Griffin GE, Beverley PC, Tough DF, Macallan DC.

J Immunol. 2004 Aug 1;173(3):1787-94.


Rapid turnover of effector-memory CD4(+) T cells in healthy humans.

Macallan DC, Wallace D, Zhang Y, De Lara C, Worth AT, Ghattas H, Griffin GE, Beverley PC, Tough DF.

J Exp Med. 2004 Jul 19;200(2):255-60. Epub 2004 Jul 12.


Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo.

Reed JR, Vukmanovic-Stejic M, Fletcher JM, Soares MV, Cook JE, Orteu CH, Jackson SE, Birch KE, Foster GR, Salmon M, Beverley PC, Rustin MH, Akbar AN.

J Exp Med. 2004 May 17;199(10):1433-43.


CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans.

Stanton T, Boxall S, Bennett A, Kaleebu P, Watera C, Whitworth J, French N, Dawes R, Hill AV, Bodmer W, Beverley PC, Tchilian EZ.

Immunogenetics. 2004 May;56(2):107-10. Epub 2004 Apr 1. Review.


Rapid turnover of T cells in acute infectious mononucleosis.

Macallan DC, Wallace DL, Irvine AJ, Asquith B, Worth A, Ghattas H, Zhang Y, Griffin GE, Tough DF, Beverley PC.

Eur J Immunol. 2003 Oct;33(10):2655-65.


Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection.

Soares MV, Plunkett FJ, Verbeke CS, Cook JE, Faint JM, Belaramani LL, Fletcher JM, Hammerschmitt N, Rustin M, Bergler W, Beverley PC, Salmon M, Akbar AN.

Blood. 2004 Jan 1;103(1):162-7. Epub 2003 Sep 11.


Measurement and modeling of human T cell kinetics.

Macallan DC, Asquith B, Irvine AJ, Wallace DL, Worth A, Ghattas H, Zhang Y, Griffin GE, Tough DF, Beverley PC.

Eur J Immunol. 2003 Aug;33(8):2316-26. Erratum in: Eur J Immunol. 2003 Oct;33(10):2947.

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