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Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications.

Hilu KW, Friend SA, Vallanadu V, Brown AM, Hollingsworth LR 4th, Bevan DR.

PLoS One. 2019 Nov 1;14(11):e0222440. doi: 10.1371/journal.pone.0222440. eCollection 2019.


Modelling the effect of the introduction of antenatal screening for group B Streptococcus (GBS) carriage in the UK.

Bevan D, White A, Marshall J, Peckham C.

BMJ Open. 2019 Mar 23;9(3):e024324. doi: 10.1136/bmjopen-2018-024324.


In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery.

Worrell BL, Brown AM, Santos WL, Bevan DR.

J Chem Inf Model. 2019 May 28;59(5):2339-2351. doi: 10.1021/acs.jcim.8b00931. Epub 2019 Mar 19.


Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses.

Mirastschijski U, Dinesh N, Baskaran S, Wedekind D, Gavrilovic J, Murray MY, Bevan D, Kelm S.

Wound Repair Regen. 2019 Jul;27(4):309-323. doi: 10.1111/wrr.12704. Epub 2019 Mar 7.


Curare: from laboratory to law court.

Bevan DR.

Clin Invest Med. 2018 Nov 3;41:17-20. doi: 10.25011/cim.v41i2.31419.


1978: Forty years later.

Bortolussi R, MacLeod S, Bevan D, Angel J.

Clin Invest Med. 2018 Nov 3;41:3-4. doi: 10.25011/cim.v41i2.31404.


HIV-1 Env gp41 Transmembrane Domain Dynamics Are Modulated by Lipid, Water, and Ion Interactions.

Hollingsworth LR 4th, Lemkul JA, Bevan DR, Brown AM.

Biophys J. 2018 Jul 3;115(1):84-94. doi: 10.1016/j.bpj.2018.05.022.


Interplay between metalloproteinases and cell signalling in blood brain barrier integrity.

Pla-Navarro I, Bevan D, Hajihosseini MK, Lee M, Gavrilovic J.

Histol Histopathol. 2018 Dec;33(12):1253-1270. doi: 10.14670/HH-18-003. Epub 2018 May 11. Review.


The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.

Ehara T, Adams CM, Bevan D, Ji N, Meredith EL, Belanger DB, Powers J, Kato M, Solovay C, Liu D, Capparelli M, Bolduc P, Grob JE, Daniels MH, Ferrara L, Yang L, Li B, Towler CS, Stacy RC, Prasanna G, Mogi M.

J Med Chem. 2018 Mar 22;61(6):2552-2570. doi: 10.1021/acs.jmedchem.8b00007. Epub 2018 Mar 2.


Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region.

Hollingsworth LR 4th, Brown AM, Gandour RD, Bevan DR.

PLoS One. 2018 Jan 18;13(1):e0190658. doi: 10.1371/journal.pone.0190658. eCollection 2018.


n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD.

Vauzour D, Rodriguez-Ramiro I, Rushbrook S, Ipharraguerre IR, Bevan D, Davies S, Tejera N, Mena P, de Pascual-Teresa S, Del Rio D, Gavrilovic J, Minihane AM.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):69-78. doi: 10.1016/j.bbadis.2017.10.002. Epub 2017 Oct 3.


Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.

Pasi KJ, Rangarajan S, Georgiev P, Mant T, Creagh MD, Lissitchkov T, Bevan D, Austin S, Hay CR, Hegemann I, Kazmi R, Chowdary P, Gercheva-Kyuchukova L, Mamonov V, Timofeeva M, Soh CH, Garg P, Vaishnaw A, Akinc A, Sørensen B, Ragni MV.

N Engl J Med. 2017 Aug 31;377(9):819-828. doi: 10.1056/NEJMoa1616569. Epub 2017 Jul 10.


Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.

Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL.

J Med Chem. 2017 May 11;60(9):3933-3957. doi: 10.1021/acs.jmedchem.7b00233. Epub 2017 Apr 25.


Natural product-based amyloid inhibitors.

Velander P, Wu L, Henderson F, Zhang S, Bevan DR, Xu B.

Biochem Pharmacol. 2017 Sep 1;139:40-55. doi: 10.1016/j.bcp.2017.04.004. Epub 2017 Apr 6. Review.


Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).

Brown AM, Bevan DR.

Arch Biochem Biophys. 2017 Jan 15;614:1-13. doi: 10.1016/ Epub 2016 Nov 21.


Molecular Dynamics Simulations of Amyloid β-Peptide (1-42): Tetramer Formation and Membrane Interactions.

Brown AM, Bevan DR.

Biophys J. 2016 Sep 6;111(5):937-49. doi: 10.1016/j.bpj.2016.08.001.


Development of a structured undergraduate research experience: Framework and implications.

Brown AM, Lewis SN, Bevan DR.

Biochem Mol Biol Educ. 2016 Sep 10;44(5):463-74. doi: 10.1002/bmb.20975. Epub 2016 Apr 28.


Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.

Cross JB, Zhang J, Yang Q, Mesleh MF, Romero JA, Wang B, Bevan D, Poutsiaka KM, Epie F, Moy T, Daniel A, Shotwell J, Chamberlain B, Carter N, Andersen O, Barker J, Ryan MD, Metcalf CA 3rd, Silverman J, Nguyen K, Lippa B, Dolle RE.

ACS Med Chem Lett. 2016 Feb 16;7(4):374-8. doi: 10.1021/acsmedchemlett.5b00368. eCollection 2016 Apr 14.


Purine salvage in Methanocaldococcus jannaschii: Elucidating the role of a conserved cysteine in adenine deaminase.

Miller DV, Brown AM, Xu H, Bevan DR, White RH.

Proteins. 2016 Jun;84(6):828-40. doi: 10.1002/prot.25033. Epub 2016 Apr 1.


Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.

Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL.

ACS Med Chem Lett. 2016 Feb 2;7(3):229-34. doi: 10.1021/acsmedchemlett.5b00304. eCollection 2016 Mar 10.


Weight loss surgery improves quality of life in pediatric patients with osteogenesis imperfecta.

Zani A, Ford-Adams M, Ratcliff M, Bevan D, Inge TH, Desai A.

Surg Obes Relat Dis. 2017 Jan;13(1):41-44. doi: 10.1016/j.soard.2015.11.029. Epub 2015 Dec 2.


Molecular modeling of the elastomeric properties of repeating units and building blocks of resilin, a disordered elastic protein.

Khandaker MSK, Dudek DM, Beers EP, Dillard DA, Bevan DR.

J Mech Behav Biomed Mater. 2016 Aug;61:110-121. doi: 10.1016/j.jmbbm.2016.01.017. Epub 2016 Jan 25.


Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.

Zhang J, Yang Q, Romero JA, Cross J, Wang B, Poutsiaka KM, Epie F, Bevan D, Wu Y, Moy T, Daniel A, Chamberlain B, Carter N, Shotwell J, Arya A, Kumar V, Silverman J, Nguyen K, Metcalf CA 3rd, Ryan D, Lippa B, Dolle RE.

ACS Med Chem Lett. 2015 Sep 8;6(10):1080-5. doi: 10.1021/acsmedchemlett.5b00266. eCollection 2015 Oct 8.


Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.

Zhang J, Yang Q, Cross JB, Romero JA, Poutsiaka KM, Epie F, Bevan D, Wang B, Zhang Y, Chavan A, Zhang X, Moy T, Daniel A, Nguyen K, Chamberlain B, Carter N, Shotwell J, Silverman J, Metcalf CA 3rd, Ryan D, Lippa B, Dolle RE.

J Med Chem. 2015 Nov 12;58(21):8503-12. doi: 10.1021/acs.jmedchem.5b00961. Epub 2015 Oct 22.


Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A.

Konkle BA, Stasyshyn O, Chowdary P, Bevan DH, Mant T, Shima M, Engl W, Dyck-Jones J, Fuerlinger M, Patrone L, Ewenstein B, Abbuehl B.

Blood. 2015 Aug 27;126(9):1078-85. doi: 10.1182/blood-2015-03-630897. Epub 2015 Jul 8.


Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.

Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR.

PLoS One. 2015 May 8;10(5):e0123984. doi: 10.1371/journal.pone.0123984. eCollection 2015.


Molecular dynamics of the asymmetric dimers of EGFR: simulations on the active and inactive conformations of the kinase domain.

Songtawee N, Bevan DR, Choowongkomon K.

J Mol Graph Model. 2015 May;58:16-29. doi: 10.1016/j.jmgm.2015.03.002. Epub 2015 Mar 14.


Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.

Lewis SN, Garcia Z, Hontecillas R, Bassaganya-Riera J, Bevan DR.

J Comput Aided Mol Des. 2015 May;29(5):421-39. doi: 10.1007/s10822-015-9831-x. Epub 2015 Jan 24.


Long-term safety and efficacy of factor IX gene therapy in hemophilia B.

Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, Della Peruta M, Lheriteau E, Patel N, Raj D, Riddell A, Pie J, Rangarajan S, Bevan D, Recht M, Shen YM, Halka KG, Basner-Tschakarjan E, Mingozzi F, High KA, Allay J, Kay MA, Ng CY, Zhou J, Cancio M, Morton CL, Gray JT, Srivastava D, Nienhuis AW, Davidoff AM.

N Engl J Med. 2014 Nov 20;371(21):1994-2004. doi: 10.1056/NEJMoa1407309.


A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories.

Fisher AK, Freedman BG, Bevan DR, Senger RS.

Comput Struct Biotechnol J. 2014 Sep 3;11(18):91-9. doi: 10.1016/j.csbj.2014.08.010. eCollection 2014 Aug. Review.


Pharmacokinetic and pharmacodynamic properties of plasma-derived vs. recombinant factor IX in patients with hemophilia B: a prospective crossover study.

Alamelu J, Bevan D, Sorensen B, Rangarajan S.

J Thromb Haemost. 2014 Dec;12(12):2044-8. doi: 10.1111/jth.12756. Epub 2014 Nov 11.


A steroid receptor coactivator acts as the DNA-binding partner of the methoprene-tolerant protein in regulating juvenile hormone response genes.

Li M, Liu P, Wiley JD, Ojani R, Bevan DR, Li J, Zhu J.

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):47-58. doi: 10.1016/j.mce.2014.06.021. Epub 2014 Jul 6.


Biophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain.

Capelluto DG, Zhao X, Lucas A, Lemkul JA, Xiao S, Fu X, Sun F, Bevan DR, Finkielstein CV.

Biophys J. 2014 Mar 4;106(5):1101-11. doi: 10.1016/j.bpj.2014.01.032.


Steered molecular dynamics identifies critical residues of the Nodamura virus B2 suppressor of RNAi.

Allen WJ, Wiley MR, Myles KM, Adelman ZN, Bevan DR.

J Mol Model. 2014 Mar;20(3):2092. doi: 10.1007/s00894-014-2092-0. Epub 2014 Feb 19.


Simulations of monomeric amyloid β-peptide (1-40) with varying solution conditions and oxidation state of Met35: implications for aggregation.

Brown AM, Lemkul JA, Schaum N, Bevan DR.

Arch Biochem Biophys. 2014 Mar 1;545:44-52. doi: 10.1016/ Epub 2014 Jan 11.


An in-vitro assessment of tranexamic acid as an adjunct to rFVIII or rFVIIa treatment in haemophilia A.

Rea CJ, Foley JH, Bevan DH, Sørensen B.

Ann Hematol. 2014 Apr;93(4):683-92. doi: 10.1007/s00277-013-1921-z. Epub 2013 Nov 6.


Comparing atomistic molecular mechanics force fields for a difficult target: a case study on the Alzheimer's amyloid β-peptide.

Gerben SR, Lemkul JA, Brown AM, Bevan DR.

J Biomol Struct Dyn. 2014;32(11):1817-32. doi: 10.1080/07391102.2013.838518. Epub 2013 Sep 13.


Management of urinary incontinence in women: summary of updated NICE guidance.

Smith A, Bevan D, Douglas HR, James D.

BMJ. 2013 Sep 10;347:f5170. doi: 10.1136/bmj.f5170. No abstract available. Erratum in: BMJ. 2013;347:f6392.


Aggregation of Alzheimer's amyloid β-peptide in biological membranes: a molecular dynamics study.

Lemkul JA, Bevan DR.

Biochemistry. 2013 Jul 23;52(29):4971-80. doi: 10.1021/bi400562x. Epub 2013 Jul 15.


Congenital and acquired bleeding disorders: the right factor for the right patient.

Bevan DH, Oldenburg J.

Thromb Res. 2012 Dec;130 Suppl 2:S1. doi: 10.1016/S0049-3848(13)00046-7. No abstract available.


A multiple-baseline study of the effects associated with metacognitive therapy in postpartum depression.

Bevan D, Wittkowski A, Wells A.

J Midwifery Womens Health. 2013 Jan-Feb;58(1):69-75. doi: 10.1111/j.1542-2011.2012.00255.x.


The role of the coordination defect (CD) in the structures of anion-deficient, fluorite-related compounds.

Bevan DJ, Martin LL, Martin RL.

Acta Crystallogr B. 2013 Feb;69(Pt 1):17-29. doi: 10.1107/S0108768112051105. Epub 2013 Jan 19.


The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's disease.

Lemkul JA, Bevan DR.

ACS Chem Neurosci. 2012 Nov 21;3(11):845-56. doi: 10.1021/cn300091a. Epub 2012 Aug 27. Review.


Probing the active site chemistry of β-glucosidases along the hydrolysis reaction pathway.

Badieyan S, Bevan DR, Zhang C.

Biochemistry. 2012 Nov 6;51(44):8907-18. doi: 10.1021/bi300675x. Epub 2012 Oct 24.


Properties of β-thioglucoside hydrolases (TGG1 and TGG2) from leaves of Arabidopsis thaliana.

Zhou C, Tokuhisa JG, Bevan DR, Esen A.

Plant Sci. 2012 Aug;191-192:82-92. doi: 10.1016/j.plantsci.2012.02.004. Epub 2012 Feb 16.


Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2.

Lu P, Hontecillas R, Horne WT, Carbo A, Viladomiu M, Pedragosa M, Bevan DR, Lewis SN, Bassaganya-Riera J.

PLoS One. 2012;7(4):e34643. doi: 10.1371/journal.pone.0034643. Epub 2012 Apr 11.


A salt-bridge controlled by ligand binding modulates the hydrolysis reaction in a GH5 endoglucanase.

Badieyan S, Bevan DR, Zhang C.

Protein Eng Des Sel. 2012 May;25(5):223-33. doi: 10.1093/protein/gzs010. Epub 2012 Mar 13.


Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6.

Baker N, Sharpe P, Culley K, Otero M, Bevan D, Newham P, Barker W, Clements KM, Langham CJ, Goldring MB, Gavrilović J.

Arthritis Rheum. 2012 Jul;64(7):2289-99. doi: 10.1002/art.34411.


Using differential reinforcement of low rates to reduce children's requests for teacher attention.

Austin JL, Bevan D.

J Appl Behav Anal. 2011 Fall;44(3):451-61. doi: 10.1901/jaba.2011.44-451.

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