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Items: 12


Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice.

Christensen J, Litherland K, Faller T, van de Kerkhof E, Natt F, Hunziker J, Boos J, Beuvink I, Bowman K, Baryza J, Beverly M, Vargeese C, Heudi O, Stoeckli M, Krauser J, Swart P.

Drug Metab Dispos. 2014 Mar;42(3):431-40. doi: 10.1124/dmd.113.055434. Epub 2014 Jan 3.


Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides.

Boos JA, Kirk DW, Piccolotto ML, Zuercher W, Gfeller S, Neuner P, Dattler A, Wishart WL, Von Arx F, Beverly M, Christensen J, Litherland K, van de Kerkhof E, Swart PJ, Faller T, Beyerbach A, Morrissey D, Hunziker J, Beuvink I.

Nucleic Acids Res. 2013 Aug;41(15):e145. doi: 10.1093/nar/gkt515. Epub 2013 Jun 13.


A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs.

Beuvink I, Kolb FA, Budach W, Garnier A, Lange J, Natt F, Dengler U, Hall J, Filipowicz W, Weiler J.

Nucleic Acids Res. 2007;35(7):e52. Epub 2007 Mar 13.


ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.

Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE.

J Biol Chem. 2005 Jun 24;280(25):24175-80. Epub 2005 Apr 29.


The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G.

Cell. 2005 Mar 25;120(6):747-59.


Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, Tobler S, Heusser C, O'Reilly T, Stolz B, Marti A, Thomas G, Lane HA.

Cancer Res. 2004 Jan 1;64(1):252-61.


Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.

Wang RA, Vadlamudi RK, Bagheri-Yarmand R, Beuvink I, Hynes NE, Kumar R.

J Cell Biol. 2003 May 12;161(3):583-92. Epub 2003 May 5.


Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling.

Lane HA, Motoyama AB, Beuvink I, Hynes NE.

Ann Oncol. 2001;12 Suppl 1:S21-2. Review.


ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE.

J Biol Chem. 1999 Jun 11;274(24):17209-18.

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