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Items: 1 to 50 of 384

1.

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706. doi: 10.1073/pnas.1809232115. Epub 2018 Aug 27.

PMID:
30150374
2.

B-1a Cell Development in Splenectomized Neonatal Mice.

Pedersen GK, Li X, Khoenkhoen S, Ádori M, Beutler B, Karlsson Hedestam GB.

Front Immunol. 2018 Jul 30;9:1738. doi: 10.3389/fimmu.2018.01738. eCollection 2018.

3.

Gastrointestinal Bleed from Erosive Gastritis and Duodenitis: A Sentinel Event of Invasive Lobular Carcinoma of the Breast and a Diagnostic Dilemma.

Ulanja MB, Taha M, Al-Mashhadani A, Beutler BD, Al-Tekreeti M, Elliot C, Ambika S.

Cureus. 2018 Jun 7;10(6):e2757. doi: 10.7759/cureus.2757.

4.

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.

Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.

Nat Commun. 2018 May 23;9(1):2041. doi: 10.1038/s41467-018-04324-3.

5.

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE.

J Clin Invest. 2018 Mar 1;128(3):1178-1189. doi: 10.1172/JCI97702. Epub 2018 Feb 19.

6.

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.

Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B.

Nat Commun. 2018 Jan 30;9(1):441. doi: 10.1038/s41467-017-02806-4.

7.

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, Choi JH, Dosenovic P, Karlsson MCI, Beutler B, Karlsson Hedestam GB.

J Immunol. 2018 Jan 15;200(2):775-787. doi: 10.4049/jimmunol.1700791. Epub 2017 Dec 8.

PMID:
29222168
8.

Angiokeratoma of the Glans Penis.

Beutler BD, Cohen PR.

Skinmed. 2017 Oct 1;15(5):343-347. eCollection 2017.

PMID:
29139361
9.

Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.

Pollard KM, Escalante GM, Huang H, Haraldsson KM, Hultman P, Christy JM, Pawar RD, Mayeux JM, Gonzalez-Quintial R, Baccala R, Beutler B, Theofilopoulos AN, Kono DH.

J Immunol. 2017 Dec 1;199(11):3739-3747. doi: 10.4049/jimmunol.1700332. Epub 2017 Oct 20.

PMID:
29055005
10.

The ESRP1-GPR137 axis contributes to intestinal pathogenesis.

Mager LF, Koelzer VH, Stuber R, Thoo L, Keller I, Koeck I, Langenegger M, Simillion C, Pfister SP, Faderl M, Genitsch V, Tcymbarevich I, Juillerat P, Li X, Xia Y, Karamitopoulou E, Lyck R, Zlobec I, Hapfelmeier S, Bruggmann R, McCoy KD, Macpherson AJ, Müller C, Beutler B, Krebs P.

Elife. 2017 Oct 4;6. pii: e28366. doi: 10.7554/eLife.28366.

11.

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B.

J Exp Med. 2017 Nov 6;214(11):3263-3277. doi: 10.1084/jem.20161630. Epub 2017 Oct 2.

12.

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.

Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B.

Sci Rep. 2017 Sep 15;7(1):11717. doi: 10.1038/s41598-017-10343-9.

13.

Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12.

14.

Reconstruction of the Mouse Inflammasome System in HEK293T Cells.

Shi H, Murray A, Beutler B.

Bio Protoc. 2016 Nov 5;6(21). pii: e1986. doi: 10.21769/BioProtoc.1986.

15.

Polydactylous Transverse Erythronychia: Report of a Patient with Multiple Horizontal Red Bands Affecting the Fingernails.

Chang C, Beutler BD, Cohen PR.

Dermatol Ther (Heidelb). 2017 Jun;7(2):255-262. doi: 10.1007/s13555-017-0177-2. Epub 2017 Mar 4.

16.

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.

Israel L, Wang Y, Bulek K, Della Mina E, Zhang Z, Pedergnana V, Chrabieh M, Lemmens NA, Sancho-Shimizu V, Descatoire M, Lasseau T, Israelsson E, Lorenzo L, Yun L, Belkadi A, Moran A, Weisman LE, Vandenesch F, Batteux F, Weller S, Levin M, Herberg J, Abhyankar A, Prando C, Itan Y, van Wamel WJB, Picard C, Abel L, Chaussabel D, Li X, Beutler B, Arkwright PD, Casanova JL, Puel A.

Cell. 2017 Feb 23;168(5):789-800.e10. doi: 10.1016/j.cell.2017.01.039.

17.

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30.

18.

Creatine maintains intestinal homeostasis and protects against colitis.

Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, Zhan X, Wang T, Zhan X, Bu CH, Murray AR, Beutler B.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1273-E1281. doi: 10.1073/pnas.1621400114. Epub 2017 Jan 30.

19.

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP.

J Cell Sci. 2017 Mar 1;130(5):868-878. doi: 10.1242/jcs.196436. Epub 2017 Jan 19.

20.

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.

Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, Strasser A, Gray D, Hodgkin PD, Beutler B, Vivier E, Ugolini S, Huntington ND.

J Exp Med. 2017 Feb;214(2):491-510. doi: 10.1084/jem.20160869. Epub 2017 Jan 5.

21.

Innate immunity and the new forward genetics.

Beutler B.

Best Pract Res Clin Haematol. 2016 Dec;29(4):379-387. doi: 10.1016/j.beha.2016.10.018. Epub 2016 Oct 21. Review.

22.

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6418-E6426. Epub 2016 Oct 5.

23.

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O.

Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27.

24.
25.

Intravascular papillary endothelial hyperplasia of the vulva: report of a patient with Masson tumor of the vulva and literature review.

Beutler BD, Cohen PR.

Dermatol Online J. 2016 May 15;22(5). pii: 13030/qt0ss9x4vf. Review.

PMID:
27617519
26.

Finding New Components of the Mammalian Immune System.

Beutler B.

Rambam Maimonides Med J. 2016 Jul 28;7(3). doi: 10.5041/RMMJ.10245.

27.

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.

Wang JQ, Beutler B, Goodnow CC, Horikawa K.

Blood. 2016 Sep 22;128(12):1604-8. doi: 10.1182/blood-2016-03-708065. Epub 2016 Jul 25.

28.

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15. doi: 10.1073/pnas.1607592113. Epub 2016 Jun 14.

30.

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists.

Morin MD, Wang Y, Jones BT, Su L, Surakattula MM, Berger M, Huang H, Beutler EK, Zhang H, Beutler B, Boger DL.

J Med Chem. 2016 May 26;59(10):4812-30. doi: 10.1021/acs.jmedchem.6b00177. Epub 2016 Apr 25.

31.

Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens.

Pedersen GK, Ádori M, Stark JM, Khoenkhoen S, Arnold C, Beutler B, Karlsson Hedestam GB.

Front Immunol. 2016 Mar 1;7:65. doi: 10.3389/fimmu.2016.00065. eCollection 2016.

32.

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.

Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93. doi: 10.1073/pnas.1525639113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 5;113(14 ):E2096.

33.

Localized cutaneous argyria: Report of two patients and literature review.

Beutler BD, Lee RA, Cohen PR.

Dermatol Online J. 2016 Nov 15;22(11). pii: 13030/qt4wm1j7pt. Review.

PMID:
28329568
34.

Pseudocyst of the auricle in patients with movement disorders: report of two patients with ataxia-associated auricular pseudocysts.

Beutler BD, Cohen PR.

Dermatol Pract Concept. 2015 Oct 31;5(4):59-64. doi: 10.5826/dpc.0504a15. eCollection 2015 Oct.

35.

Sarcoma-associated sarcoid reaction: Report of cutaneous sarcoid reaction in a patient with liposarcoma.

Beutler BD, Cohen PR.

World J Clin Cases. 2015 Dec 16;3(12):988-92. doi: 10.12998/wjcc.v3.i12.988.

36.

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.

Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B.

Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7.

37.

Q&A: Chance encounters.

Beutler B, Thaiss CA.

Nature. 2015 Oct 22;526(7574):S59-60. doi: 10.1038/526S59a. No abstract available.

PMID:
26488245
38.

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.

Simon MM, Moresco EM, Bull KR, Kumar S, Mallon AM, Beutler B, Potter PK.

Mamm Genome. 2015 Oct;26(9-10):486-500. doi: 10.1007/s00335-015-9603-x. Epub 2015 Oct 8. Review.

39.

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.

Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ, Beutler B.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5706-14. doi: 10.1073/pnas.1515619112. Epub 2015 Oct 5.

40.

Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.

Beutler BD, Cohen PR.

Dermatol Online J. 2015 Aug 15;21(8). pii: 13030/qt7kb930rf. Review.

PMID:
26437158
41.

Prurigo Pigmentosa: Literature Review.

Beutler BD, Cohen PR, Lee RA.

Am J Clin Dermatol. 2015 Dec;16(6):533-43. doi: 10.1007/s40257-015-0154-4. Review.

PMID:
26334426
42.

Tobacco-associated yellow discoloration of upper lip hair: smoker's mustache.

Beutler BD, Cohen PR.

Dermatol Online J. 2015 May 18;21(5). pii: 13030/qt8ck911z0.

PMID:
26295850
43.

Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5189-98. doi: 10.1073/pnas.1511585112. Epub 2015 Aug 12.

44.

Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses.

Beutler BD, Cohen PR.

Dermatol Pract Concept. 2015 Apr 30;5(2):121-4. doi: 10.5826/dpc.0502a24. eCollection 2015 Apr.

45.

Sarcoidosis in Melanoma Patients: Case Report and Literature Review.

Beutler BD, Cohen PR.

Cancers (Basel). 2015 Jun 15;7(2):1005-21. doi: 10.3390/cancers7020821. Review.

46.

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.

Mager LF, Riether C, Schürch CM, Banz Y, Wasmer MH, Stuber R, Theocharides AP, Li X, Xia Y, Saito H, Nakae S, Baerlocher GM, Manz MG, McCoy KD, Macpherson AJ, Ochsenbein AF, Beutler B, Krebs P.

J Clin Invest. 2015 Jul 1;125(7):2579-91. doi: 10.1172/JCI77347. Epub 2015 May 26.

47.

Helsinki alert of biodiversity and health.

von Hertzen L, Beutler B, Bienenstock J, Blaser M, Cani PD, Eriksson J, Färkkilä M, Haahtela T, Hanski I, Jenmalm MC, Kere J, Knip M, Kontula K, Koskenvuo M, Ling C, Mandrup-Poulsen T, von Mutius E, Mäkelä MJ, Paunio T, Pershagen G, Renz H, Rook G, Saarela M, Vaarala O, Veldhoen M, de Vos WM.

Ann Med. 2015 May;47(3):218-25. doi: 10.3109/07853890.2015.1010226. Epub 2015 Apr 23. Review.

48.

Reticular telangiectatic erythema: case report and literature review.

Beutler BD, Cohen PR.

Dermatol Pract Concept. 2015 Jan 30;5(1):71-5. doi: 10.5826/dpc.0501a16. eCollection 2015 Jan.

49.

Real-time resolution of point mutations that cause phenovariance in mice.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9. doi: 10.1073/pnas.1423216112. Epub 2015 Jan 20.

50.

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.

Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Karlsson Hedestam GB, Chen ZJ, Beutler B.

Science. 2014 Dec 19;346(6216):1486-92. doi: 10.1126/science.346.6216.1486. Retraction in: Science. 2017 Oct 27;358(6362):458.

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