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Items: 1 to 50 of 104

1.

Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.

Heroes E, Van der Hoeven G, Choy MS, Garcia JDP, Ferreira M, Nys M, Derua R, Beullens M, Ulens C, Peti W, Van Meervelt L, Page R, Bollen M.

Structure. 2019 Mar 5;27(3):507-518.e5. doi: 10.1016/j.str.2018.12.002. Epub 2019 Jan 17.

PMID:
30661852
2.

Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JTM, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2018 Nov 30;38(6). pii: BSR-20150194_COR. doi: 10.1042/BSR-20150194_COR. Print 2018 Dec 21. No abstract available.

3.

A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions.

Wu D, De Wever V, Derua R, Winkler C, Beullens M, Van Eynde A, Bollen M.

J Biol Chem. 2018 Sep 28;293(39):15152-15162. doi: 10.1074/jbc.RA118.004132. Epub 2018 Aug 16.

PMID:
30115685
4.

Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics.

Ferreira M, Beullens M, Bollen M, Van Eynde A.

Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):16-30. doi: 10.1016/j.bbamcr.2018.07.019. Epub 2018 Jul 26.

PMID:
30056088
5.

Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.

Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M.

J Cell Sci. 2018 Jul 9;131(13). pii: jcs214932. doi: 10.1242/jcs.214932.

6.

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint.

Qian J, García-Gimeno MA, Beullens M, Manzione MG, Van der Hoeven G, Igual JC, Heredia M, Sanz P, Gelens L, Bollen M.

Mol Cell. 2017 Nov 16;68(4):715-730.e5. doi: 10.1016/j.molcel.2017.10.011. Epub 2017 Nov 9.

7.

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

Kig C, Beullens M, Beke L, Van Eynde A, Linders JT, Brehmer D, Bollen M.

J Biol Chem. 2017 Aug 4;292(31):12786. doi: 10.1074/jbc.A113.471433. No abstract available.

8.

Split-BioID: a proximity biotinylation assay for dimerization-dependent protein interactions.

De Munter S, Görnemann J, Derua R, Lesage B, Qian J, Heroes E, Waelkens E, Van Eynde A, Beullens M, Bollen M.

FEBS Lett. 2017 Jan;591(2):415-424. doi: 10.1002/1873-3468.12548. Epub 2017 Jan 12.

9.

The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.

Rambout X, Detiffe C, Bruyr J, Mariavelle E, Cherkaoui M, Brohée S, Demoitié P, Lebrun M, Soin R, Lesage B, Guedri K, Beullens M, Bollen M, Farazi TA, Kettmann R, Struman I, Hill DE, Vidal M, Kruys V, Simonis N, Twizere JC, Dequiedt F.

Nat Struct Mol Biol. 2016 Jul;23(7):663-72. doi: 10.1038/nsmb.3243. Epub 2016 Jun 6.

10.

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Vandenberk L, Garg AD, Verschuere T, Koks C, Belmans J, Beullens M, Agostinis P, De Vleeschouwer S, Van Gool SW.

Oncoimmunology. 2015 Sep 11;5(2):e1083669. eCollection 2016 Feb.

11.

Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

Quan XJ, Yuan L, Tiberi L, Claeys A, De Geest N, Yan J, van der Kant R, Xie WR, Klisch TJ, Shymkowitz J, Rousseau F, Bollen M, Beullens M, Zoghbi HY, Vanderhaeghen P, Hassan BA.

Cell. 2016 Jan 28;164(3):460-75. doi: 10.1016/j.cell.2015.12.048.

12.

Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch.

Qian J, Beullens M, Huang J, De Munter S, Lesage B, Bollen M.

Nat Commun. 2015 Dec 17;6:10215. doi: 10.1038/ncomms10215.

13.

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth.

Winkler C, De Munter S, Van Dessel N, Lesage B, Heroes E, Boens S, Beullens M, Van Eynde A, Bollen M.

J Cell Sci. 2015 Dec 15;128(24):4526-37. doi: 10.1242/jcs.175588. Epub 2015 Nov 5.

14.

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2015 Oct 2;35(6). pii: e00267. doi: 10.1042/BSR20150194. Erratum in: Biosci Rep. 2018 Nov 30;38(6):.

15.

Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.

Verheyen T, Görnemann J, Verbinnen I, Boens S, Beullens M, Van Eynde A, Bollen M.

Nucleic Acids Res. 2015 Jul 13;43(12):5771-84. doi: 10.1093/nar/gkv500. Epub 2015 May 18.

16.

Metals in the active site of native protein phosphatase-1.

Heroes E, Rip J, Beullens M, Van Meervelt L, De Gendt S, Bollen M.

J Inorg Biochem. 2015 Aug;149:1-5. doi: 10.1016/j.jinorgbio.2015.03.012. Epub 2015 Mar 31.

PMID:
25890482
17.

MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I.

Clin Transl Med. 2015 Mar 7;4:11. doi: 10.1186/s40169-014-0045-y. eCollection 2015.

18.

Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H.

EMBO J. 2014 Nov 18;33(22):2704-20. doi: 10.15252/embj.201489054. Epub 2014 Oct 8.

19.

Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer.

Litovkin K, Joniau S, Lerut E, Laenen A, Gevaert O, Spahn M, Kneitz B, Isebaert S, Haustermans K, Beullens M, Van Eynde A, Bollen M.

J Cancer Res Clin Oncol. 2014 Nov;140(11):1849-61. doi: 10.1007/s00432-014-1738-8. Epub 2014 Jun 18.

PMID:
24938434
20.

Chemical activators of protein phosphatase-1 induce calcium release inside intact cells.

Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M.

Chem Biol. 2013 Sep 19;20(9):1179-86. doi: 10.1016/j.chembiol.2013.07.008. Epub 2013 Aug 22.

21.

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

Lobbestael E, Zhao J, Rudenko IN, Beylina A, Gao F, Wetter J, Beullens M, Bollen M, Cookson MR, Baekelandt V, Nichols RJ, Taymans JM.

Biochem J. 2013 Nov 15;456(1):119-28. doi: 10.1042/BJ20121772.

22.

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

Kig C, Beullens M, Beke L, Van Eynde A, Linders JT, Brehmer D, Bollen M.

J Biol Chem. 2013 Aug 16;288(33):24200-12. doi: 10.1074/jbc.M113.471433. Epub 2013 Jul 8. Retraction in: J Biol Chem. 2017 Aug 4;292(31):12786.

23.

Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.

Qian J, Beullens M, Lesage B, Bollen M.

Curr Biol. 2013 Jun 17;23(12):1136-43. doi: 10.1016/j.cub.2013.05.017. Epub 2013 Jun 6.

24.

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I.

Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358.

25.

NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes.

Minnebo N, Görnemann J, O'Connell N, Van Dessel N, Derua R, Vermunt MW, Page R, Beullens M, Peti W, Van Eynde A, Bollen M.

Nucleic Acids Res. 2013 Jan;41(2):842-54. doi: 10.1093/nar/gks1255. Epub 2012 Dec 13.

26.

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.

Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S.

Retrovirology. 2012 Nov 9;9:94. doi: 10.1186/1742-4690-9-94.

27.

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway.

Garcia-Haro L, Garcia-Gimeno MA, Neumann D, Beullens M, Bollen M, Sanz P.

FEBS Lett. 2012 Nov 30;586(23):4241-7. doi: 10.1016/j.febslet.2012.10.032. Epub 2012 Oct 29.

28.

Development of a peptide that selectively activates protein phosphatase-1 in living cells.

Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M.

Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9. doi: 10.1002/anie.201204308. Epub 2012 Sep 7. No abstract available.

29.

The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.

O'Connell N, Nichols SR, Heroes E, Beullens M, Bollen M, Peti W, Page R.

Structure. 2012 Oct 10;20(10):1746-56. doi: 10.1016/j.str.2012.08.003. Epub 2012 Aug 30.

30.

A role for PP1/NIPP1 in steering migration of human cancer cells.

Martin-Granados C, Prescott AR, Van Dessel N, Van Eynde A, Arocena M, Klaska IP, Görnemann J, Beullens M, Bollen M, Forrester JV, McCaig CD.

PLoS One. 2012;7(7):e40769. doi: 10.1371/journal.pone.0040769. Epub 2012 Jul 16.

31.

The PP1 binding code: a molecular-lego strategy that governs specificity.

Heroes E, Lesage B, Görnemann J, Beullens M, Van Meervelt L, Bollen M.

FEBS J. 2013 Jan;280(2):584-95. doi: 10.1111/j.1742-4658.2012.08547.x. Epub 2012 Mar 21. Review.

32.

The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

Barber MA, Hendrickx A, Beullens M, Ceulemans H, Oxley D, Thelen S, Thelen M, Bollen M, Welch HC.

Biochem J. 2012 Apr 1;443(1):173-83. doi: 10.1042/BJ20112078.

PMID:
22242915
33.

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

Bultot L, Guigas B, Von Wilamowitz-Moellendorff A, Maisin L, Vertommen D, Hussain N, Beullens M, Guinovart JJ, Foretz M, Viollet B, Sakamoto K, Hue L, Rider MH.

Biochem J. 2012 Apr 1;443(1):193-203. doi: 10.1042/BJ20112026.

PMID:
22233421
34.

C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1.

Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S.

Nucleic Acids Res. 2012 May;40(9):4025-39. doi: 10.1093/nar/gkr1289. Epub 2011 Dec 30.

35.

Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

Ammosova T, Obukhov Y, Kotelkin A, Breuer D, Beullens M, Gordeuk VR, Bollen M, Nekhai S.

PLoS One. 2011 Apr 21;6(4):e18985. doi: 10.1371/journal.pone.0018985.

36.

PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting.

Qian J, Lesage B, Beullens M, Van Eynde A, Bollen M.

Curr Biol. 2011 May 10;21(9):766-73. doi: 10.1016/j.cub.2011.03.047. Epub 2011 Apr 21.

37.

Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA.

Zhang Z, Kelemen O, van Santen MA, Yelton SM, Wendlandt AE, Sviripa VM, Bollen M, Beullens M, Urlaub H, Lührmann R, Watt DS, Stamm S.

J Biol Chem. 2011 Mar 25;286(12):10126-36. doi: 10.1074/jbc.M110.183970. Epub 2011 Jan 10.

38.

Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription.

Ammosova T, Yedavalli VR, Niu X, Jerebtsova M, Van Eynde A, Beullens M, Bollen M, Jeang KT, Nekhai S.

J Biol Chem. 2011 Feb 4;286(5):3798-804. doi: 10.1074/jbc.M110.196493. Epub 2010 Nov 22.

39.

The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells.

Garcia-Haro L, Garcia-Gimeno MA, Neumann D, Beullens M, Bollen M, Sanz P.

FASEB J. 2010 Dec;24(12):5080-91. doi: 10.1096/fj.10-166306. Epub 2010 Aug 19.

PMID:
20724523
40.

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets.

Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, Shima H, Van Eynde A, Bollen M.

Nucleic Acids Res. 2010 Nov;38(21):7500-12. doi: 10.1093/nar/gkq643. Epub 2010 Jul 29.

41.

Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.

Tapia VE, Nicolaescu E, McDonald CB, Musi V, Oka T, Inayoshi Y, Satteson AC, Mazack V, Humbert J, Gaffney CJ, Beullens M, Schwartz CE, Landgraf C, Volkmer R, Pastore A, Farooq A, Bollen M, Sudol M.

J Biol Chem. 2010 Jun 18;285(25):19391-401. doi: 10.1074/jbc.M109.084525. Epub 2010 Apr 21.

42.

The extended PP1 toolkit: designed to create specificity.

Bollen M, Peti W, Ragusa MJ, Beullens M.

Trends Biochem Sci. 2010 Aug;35(8):450-8. doi: 10.1016/j.tibs.2010.03.002. Epub 2010 May 1. Review.

43.

Protein phosphatase 1 regulates the histone code for long-term memory.

Koshibu K, Gräff J, Beullens M, Heitz FD, Berchtold D, Russig H, Farinelli M, Bollen M, Mansuy IM.

J Neurosci. 2009 Oct 14;29(41):13079-89. doi: 10.1523/JNEUROSCI.3610-09.2009.

44.

Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).

Huang X, Beullens M, Zhang J, Zhou Y, Nicolaescu E, Lesage B, Hu Q, Wu J, Bollen M, Shi Y.

J Biol Chem. 2009 Sep 11;284(37):25375-87. doi: 10.1074/jbc.M109.024828. Epub 2009 Jul 10.

45.

Docking motif-guided mapping of the interactome of protein phosphatase-1.

Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M.

Chem Biol. 2009 Apr 24;16(4):365-71. doi: 10.1016/j.chembiol.2009.02.012.

46.

Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155).

Tanuma N, Kim SE, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H.

J Biol Chem. 2008 Dec 19;283(51):35805-14. doi: 10.1074/jbc.M805468200. Epub 2008 Oct 8.

47.

Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases.

Nicolaescu E, Beullens M, Lesage B, Keppens S, Himpens B, Bollen M.

Eur J Cell Biol. 2008 Oct;87(10):817-29. doi: 10.1016/j.ejcb.2008.05.001. Epub 2008 Jul 2.

PMID:
18599155
48.

Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms.

Van Herpe T, De Brabanter J, Beullens M, De Moor B, Van den Berghe G.

Crit Care. 2008;12(1):R24. doi: 10.1186/cc6800. Epub 2008 Feb 26.

49.

Testing for recombinant erythropoietin.

Delanghe JR, Bollen M, Beullens M.

Am J Hematol. 2008 Mar;83(3):237-41.

50.

The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing.

Nuytten M, Beke L, Van Eynde A, Ceulemans H, Beullens M, Van Hummelen P, Fuks F, Bollen M.

Oncogene. 2008 Feb 28;27(10):1449-60. Epub 2007 Sep 3.

PMID:
17724462

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