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Items: 1 to 50 of 74

1.

4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell derived intestinal organoids.

Schöneberg J, Dambournet D, Liu TL, Forster R, Hockemeyer D, Betzig E, Drubin DG.

Mol Biol Cell. 2018 Sep 6:mbcE18060375. doi: 10.1091/mbc.E18-06-0375. [Epub ahead of print]

PMID:
30188768
2.

Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG.

Elife. 2018 Jun 19;7. pii: e37131. doi: 10.7554/eLife.37131.

3.

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E.

Science. 2018 Apr 20;360(6386). pii: eaaq1392. doi: 10.1126/science.aaq1392.

PMID:
29674564
4.

Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.

Fritz-Laylin LK, Riel-Mehan M, Chen BC, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E, Mullins RD.

Elife. 2017 Sep 26;6. pii: e26990. doi: 10.7554/eLife.26990.

5.

Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.

Hong J, Murugesan S, Betzig E, Hammer JA.

PLoS One. 2017 Aug 17;12(8):e0183174. doi: 10.1371/journal.pone.0183174. eCollection 2017.

6.

Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.

Fritzsche M, Fernandes RA, Chang VT, Colin-York H, Clausen MP, Felce JH, Galiani S, Erlenkämper C, Santos AM, Heddleston JM, Pedroza-Pacheco I, Waithe D, de la Serna JB, Lagerholm BC, Liu TL, Chew TL, Betzig E, Davis SJ, Eggeling C.

Sci Adv. 2017 Jun 21;3(6):e1603032. doi: 10.1126/sciadv.1603032. eCollection 2017 Jun.

7.

Applying systems-level spectral imaging and analysis to reveal the organelle interactome.

Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J.

Nature. 2017 Jun 1;546(7656):162-167. doi: 10.1038/nature22369. Epub 2017 May 24.

8.

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF.

Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118.

PMID:
28495700
9.

Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.

Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J.

Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639.

10.

Self-organizing actin patterns shape membrane architecture but not cell mechanics.

Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig E, Eggeling C.

Nat Commun. 2017 Feb 13;8:14347. doi: 10.1038/ncomms14347.

11.

Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.

Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM, Betzig E, Hammer JA.

Nat Cell Biol. 2017 Feb;19(2):85-93. doi: 10.1038/ncb3463. Epub 2017 Jan 23.

12.

A plasma membrane template for macropinocytic cups.

Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR.

Elife. 2016 Dec 13;5. pii: e20085. doi: 10.7554/eLife.20085.

13.

Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.

Hayer A, Shao L, Chung M, Joubert LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T.

Nat Cell Biol. 2016 Dec;18(12):1311-1323. doi: 10.1038/ncb3438. Epub 2016 Nov 14.

PMID:
27842057
14.

Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.

Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T.

Mol Biol Cell. 2016 Nov 7;27(22):3418-3435. Epub 2016 Aug 17.

15.

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.

Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E, Hammer JA.

J Cell Biol. 2016 Nov 7;215(3):383-399. Epub 2016 Oct 31.

16.

V-1 regulates capping protein activity in vivo.

Jung G, Alexander CJ, Wu XS, Piszczek G, Chen BC, Betzig E, Hammer JA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6610-E6619. Epub 2016 Oct 10.

17.

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.

Nixon-Abell J, Obara CJ, Weigel AV, Li D, Legant WR, Xu CS, Pasolli HA, Harvey K, Hess HF, Betzig E, Blackstone C, Lippincott-Schwartz J.

Science. 2016 Oct 28;354(6311). pii: aaf3928. Epub 2016 Oct 27.

PMID:
27789813
18.

Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy.

Zhang X, Zhang M, Li D, He W, Peng J, Betzig E, Xu P.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10364-9. doi: 10.1073/pnas.1611038113. Epub 2016 Aug 25.

19.

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription.

Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z.

Elife. 2016 Aug 3;5. pii: e17056. doi: 10.7554/eLife.17056.

20.

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

Imhof S, Fragoso C, Hemphill A, von Schubert C, Li D, Legant W, Betzig E, Roditi I.

F1000Res. 2016 Apr 14;5:682. doi: 10.12688/f1000research.8249.1. eCollection 2016.

21.

Response to Comment on "Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics".

Li D, Betzig E.

Science. 2016 Apr 29;352(6285):527. doi: 10.1126/science.aad8396. Epub 2016 Apr 28.

22.

High-density three-dimensional localization microscopy across large volumes.

Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E.

Nat Methods. 2016 Apr;13(4):359-65. doi: 10.1038/nmeth.3797. Epub 2016 Mar 7.

23.

Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus.

Yamashita N, Morita M, Legant WR, Chen BC, Betzig E, Yokota H, Mimori-Kiyosue Y.

J Biomed Opt. 2015 Oct;20(10):101206. doi: 10.1117/1.JBO.20.10.101206.

PMID:
26527322
24.

Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline.

Xie J, Wooten M, Tran V, Chen BC, Pozmanter C, Simbolon C, Betzig E, Chen X.

Cell. 2015 Nov 5;163(4):920-33. doi: 10.1016/j.cell.2015.10.002. Epub 2015 Oct 29.

25.

ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.

Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA 3rd, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E.

Science. 2015 Aug 28;349(6251):aab3500. doi: 10.1126/science.aab3500.

26.

Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen.

Thievessen I, Fakhri N, Steinwachs J, Kraus V, McIsaac RS, Gao L, Chen BC, Baird MA, Davidson MW, Betzig E, Oldenbourg R, Waterman CM, Fabry B.

FASEB J. 2015 Nov;29(11):4555-67. doi: 10.1096/fj.14-268235. Epub 2015 Jul 20.

27.

Single Molecules, Cells, and Super-Resolution Optics (Nobel Lecture).

Betzig E.

Angew Chem Int Ed Engl. 2015 Jul 6;54(28):8034-53. doi: 10.1002/anie.201501003. Epub 2015 Jun 18. Review.

PMID:
26087684
28.

Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue.

Wang K, Sun W, Richie CT, Harvey BK, Betzig E, Ji N.

Nat Commun. 2015 Jun 15;6:7276. doi: 10.1038/ncomms8276.

29.

Imaging live-cell dynamics and structure at the single-molecule level.

Liu Z, Lavis LD, Betzig E.

Mol Cell. 2015 May 21;58(4):644-59. doi: 10.1016/j.molcel.2015.02.033. Review.

30.

Actin depletion initiates events leading to granule secretion at the immunological synapse.

Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM.

Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013.

31.

Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells.

Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T.

Mol Biol Cell. 2015 Jun 1;26(11):2044-53. doi: 10.1091/mbc.E15-01-0055. Epub 2015 Apr 7.

32.

Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.

Billington N, Beach JR, Heissler SM, Remmert K, Guzik-Lendrum S, Nagy A, Takagi Y, Shao L, Li D, Yang Y, Zhang Y, Barzik M, Betzig E, Hammer JA 3rd, Sellers JR.

Curr Biol. 2015 Mar 30;25(7):942-8. doi: 10.1016/j.cub.2015.02.012. Epub 2015 Mar 5.

33.

Nonmuscle Myosin II Isoforms Coassemble in Living Cells.

Beach JR, Shao L, Remmert K, Li D, Betzig E, Hammer JA 3rd.

Curr Biol. 2015 Feb 2;25(3):402. doi: 10.1016/j.cub.2015.01.028. Epub 2015 Feb 2. No abstract available.

34.

3D imaging of Sox2 enhancer clusters in embryonic stem cells.

Liu Z, Legant WR, Chen BC, Li L, Grimm JB, Lavis LD, Betzig E, Tjian R.

Elife. 2014 Dec 24;3:e04236. doi: 10.7554/eLife.04236.

35.

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.

Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G.

Elife. 2014 Dec 23;3:e04591. doi: 10.7554/eLife.04591.

36.

Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.

Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E.

Science. 2014 Oct 24;346(6208):1257998. doi: 10.1126/science.1257998. Epub 2014 Oct 23.

37.

Nonmuscle myosin II isoforms coassemble in living cells.

Beach JR, Shao L, Remmert K, Li D, Betzig E, Hammer JA 3rd.

Curr Biol. 2014 May 19;24(10):1160-6. doi: 10.1016/j.cub.2014.03.071. Epub 2014 May 8. Erratum in: Curr Biol. 2015 Feb 2;25(3):402. Curr Biol. 2015 Feb 2;25(3):402.

38.

Rapid adaptive optical recovery of optimal resolution over large volumes.

Wang K, Milkie DE, Saxena A, Engerer P, Misgeld T, Bronner ME, Mumm J, Betzig E.

Nat Methods. 2014 Jun;11(6):625-8. doi: 10.1038/nmeth.2925. Epub 2014 Apr 13.

39.

3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy.

Gao L, Shao L, Chen BC, Betzig E.

Nat Protoc. 2014 May;9(5):1083-101. doi: 10.1038/nprot.2014.087. Epub 2014 Apr 10.

PMID:
24722406
40.

A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells.

Burnette DT, Shao L, Ott C, Pasapera AM, Fischer RS, Baird MA, Der Loughian C, Delanoe-Ayari H, Paszek MJ, Davidson MW, Betzig E, Lippincott-Schwartz J.

J Cell Biol. 2014 Apr 14;205(1):83-96. doi: 10.1083/jcb.201311104. Epub 2014 Apr 7.

41.

Single-molecule dynamics of enhanceosome assembly in embryonic stem cells.

Chen J, Zhang Z, Li L, Chen BC, Revyakin A, Hajj B, Legant W, Dahan M, Lionnet T, Betzig E, Tjian R, Liu Z.

Cell. 2014 Mar 13;156(6):1274-1285. doi: 10.1016/j.cell.2014.01.062.

42.

Fast structural responses of gap junction membrane domains to AB5 toxins.

Majoul IV, Gao L, Betzig E, Onichtchouk D, Butkevich E, Kozlov Y, Bukauskas F, Bennett MV, Lippincott-Schwartz J, Duden R.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4125-33. doi: 10.1073/pnas.1315850110. Epub 2013 Oct 16.

43.

Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes.

Grimm JB, Sung AJ, Legant WR, Hulamm P, Matlosz SM, Betzig E, Lavis LD.

ACS Chem Biol. 2013;8(6):1303-10. doi: 10.1021/cb4000822. Epub 2013 Apr 24.

44.

A localized Wnt signal orients asymmetric stem cell division in vitro.

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R.

Science. 2013 Mar 22;339(6126):1445-8. doi: 10.1126/science.1231077. Erratum in: Science. 2013 May 24;340(6135):924.

45.

Photoactivated Localization Microscopy (PALM) of adhesion complexes.

Shroff H, White H, Betzig E.

Curr Protoc Cell Biol. 2013 Mar;Chapter 4:Unit4.21. doi: 10.1002/0471143030.cb0421s58.

46.

Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions.

Legant WR, Choi CK, Miller JS, Shao L, Gao L, Betzig E, Chen CS.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):881-6. doi: 10.1073/pnas.1207997110. Epub 2012 Dec 31.

47.

Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens.

Gao L, Shao L, Higgins CD, Poulton JS, Peifer M, Davidson MW, Wu X, Goldstein B, Betzig E.

Cell. 2012 Dec 7;151(6):1370-85. doi: 10.1016/j.cell.2012.10.008.

48.

Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos.

Giurumescu CA, Kang S, Planchon TA, Betzig E, Bloomekatz J, Yelon D, Cosman P, Chisholm AD.

Development. 2012 Nov;139(22):4271-9. doi: 10.1242/dev.086256. Epub 2012 Oct 10.

49.

Triggering a cell shape change by exploiting preexisting actomyosin contractions.

Roh-Johnson M, Shemer G, Higgins CD, McClellan JH, Werts AD, Tulu US, Gao L, Betzig E, Kiehart DP, Goldstein B.

Science. 2012 Mar 9;335(6073):1232-5. doi: 10.1126/science.1217869. Epub 2012 Feb 9.

50.

Characterization and adaptive optical correction of aberrations during in vivo imaging in the mouse cortex.

Ji N, Sato TR, Betzig E.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):22-7. doi: 10.1073/pnas.1109202108. Epub 2011 Dec 21.

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