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Items: 1 to 50 of 272

1.

De novo protein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography.

Botha S, Baitan D, Jungnickel KEJ, Oberthür D, Schmidt C, Stern S, Wiedorn MO, Perbandt M, Chapman HN, Betzel C.

IUCrJ. 2018 Aug 8;5(Pt 5):524-530. doi: 10.1107/S2052252518009223. eCollection 2018 Sep 1.

2.

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering.

Baitan D, Schubert R, Meyer A, Dierks K, Perbandt M, Betzel C.

J Vis Exp. 2018 Aug 14;(138). doi: 10.3791/57070.

PMID:
30175998
3.

The conserved hypothetical protein Tb427.10.13790 is required for cytokinesis in Trypanosoma brucei.

Mudogo CN, Werner SF, Mogk S, Betzel C, Duszenko M.

Acta Trop. 2018 Aug 25;188:34-40. doi: 10.1016/j.actatropica.2018.08.029. [Epub ahead of print]

PMID:
30153427
4.

Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution.

Ahmad MS, Rasheed S, Falke S, Khaliq B, Perbandt M, Choudhary MI, Markiewicz WT, Barciszewski J, Betzel C.

Med Chem. 2018 May 23. doi: 10.2174/1573406414666180524095946. [Epub ahead of print]

PMID:
29792147
5.

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography.

Gicquel Y, Schubert R, Kapis S, Bourenkov G, Schneider T, Perbandt M, Betzel C, Chapman HN, Heymann M.

J Vis Exp. 2018 Apr 24;(134). doi: 10.3791/57133.

6.

Crystal structure of pyrimidine-nucleoside phosphorylase from Bacillus subtilis in complex with imidazole and sulfate.

Balaev VV, Prokofev II, Gabdoulkhakov AG, Betzel C, Lashkov AA.

Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):193-197. doi: 10.1107/S2053230X18002935. Epub 2018 Mar 22.

PMID:
29633966
7.

Thrombin-like enzymes from snake venom: Structural characterization and mechanism of action.

Ullah A, Masood R, Ali I, Ullah K, Ali H, Akbar H, Betzel C.

Int J Biol Macromol. 2018 Jul 15;114:788-811. doi: 10.1016/j.ijbiomac.2018.03.164. Epub 2018 Mar 28. Review.

PMID:
29604354
8.

Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12.

Falke S, Dierks K, Blanchet C, Graewert M, Cipriani F, Meijers R, Svergun D, Betzel C.

J Synchrotron Radiat. 2018 Mar 1;25(Pt 2):361-372. doi: 10.1107/S1600577517017568. Epub 2018 Feb 13.

PMID:
29488914
9.

Highly affine and selective aptamers against cholera toxin as capture elements in magnetic bead-based sandwich ELAA.

Frohnmeyer E, Frisch F, Falke S, Betzel C, Fischer M.

J Biotechnol. 2018 Mar 10;269:35-42. doi: 10.1016/j.jbiotec.2018.01.012. Epub 2018 Feb 3.

PMID:
29408200
10.

Spider's venom phospholipases D: A structural review.

Masood R, Ullah K, Ali H, Ali I, Betzel C, Ullah A.

Int J Biol Macromol. 2018 Feb;107(Pt A):1054-1065. doi: 10.1016/j.ijbiomac.2017.09.081. Epub 2017 Sep 23. Review.

PMID:
28951301
11.

Protein Profile Analysis of Two Australian Snake Venoms by One- Dimensional Gel Electrophoresis and MS/MS Experiments.

Georgieva D, Hildebrand D, Simas R, Coronado MA, Kwiatkowski M, Schlüter H, Arni R, Spencer P, Betzel C.

Curr Med Chem. 2017;24(17):1892-1908. doi: 10.2174/0929867324666170601073148.

PMID:
28571558
12.

A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution.

Schubert R, Kapis S, Gicquel Y, Bourenkov G, Schneider TR, Heymann M, Betzel C, Perbandt M.

IUCrJ. 2016 Oct 26;3(Pt 6):393-401. eCollection 2016 Nov 1.

13.

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.

Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M.

PLoS Pathog. 2016 Jun 14;12(6):e1005660. doi: 10.1371/journal.ppat.1005660. eCollection 2016 Jun.

14.

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein.

Fernández-García Y, Reguera J, Busch C, Witte G, Sánchez-Ramos O, Betzel C, Cusack S, Günther S, Reindl S.

PLoS Pathog. 2016 Jun 14;12(6):e1005635. doi: 10.1371/journal.ppat.1005635. eCollection 2016 Jun.

15.

Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus.

Liu J, Falke S, Drobot B, Oberthuer D, Kikhney A, Guenther T, Fahmy K, Svergun D, Betzel C, Raff J.

Eur Biophys J. 2017 Jan;46(1):77-89. doi: 10.1007/s00249-016-1139-9. Epub 2016 Jun 6.

PMID:
27270294
16.

MOLECULAR MODEL OF CYTOTOXIN-1 FROM NAJA MOSSAMBICA MOSSAMBICA VENOM IN COMPLEX WITH CHYMOTRYPSIN.

Munawar A, Akrem A, Hussain A, Spencer P, Betzel C.

Theor Biol Forum. 2015;108(1-2):89-99.

PMID:
27167912
17.

Two variants of the major serine protease inhibitor from the sea anemone Stichodactyla helianthus, expressed in Pichia pastoris.

García-Fernández R, Ziegelmüller P, González L, Mansur M, Machado Y, Redecke L, Hahn U, Betzel C, Chávez Mde L.

Protein Expr Purif. 2016 Jul;123:42-50. doi: 10.1016/j.pep.2016.03.003. Epub 2016 Mar 16.

PMID:
26993255
18.

Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.

Drebes J, Künz M, Windshügel B, Kikhney AG, Müller IB, Eberle RJ, Oberthür D, Cang H, Svergun DI, Perbandt M, Betzel C, Wrenger C.

Sci Rep. 2016 Mar 10;6:22871. doi: 10.1038/srep22871.

19.

Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine.

Balaev VV, Lashkov AA, Gabdulkhakov AG, Dontsova MV, Seregina TA, Mironov AS, Betzel C, Mikhailov AM.

Acta Crystallogr F Struct Biol Commun. 2016 Mar;72(Pt 3):224-33. doi: 10.1107/S2053230X1600162X. Epub 2016 Feb 19.

20.

Real-time investigation of dynamic protein crystallization in living cells.

Schönherr R, Klinge M, Rudolph JM, Fita K, Rehders D, Lübber F, Schneegans S, Majoul IV, Duszenko M, Betzel C, Brandariz-Nuñez A, Martinez-Costas J, Duden R, Redecke L.

Struct Dyn. 2015 May 22;2(4):041712. doi: 10.1063/1.4921591. eCollection 2015 Jul.

21.

Electronic damage in S atoms in a native protein crystal induced by an intense X-ray free-electron laser pulse.

Galli L, Son SK, Klinge M, Bajt S, Barty A, Bean R, Betzel C, Beyerlein KR, Caleman C, Doak RB, Duszenko M, Fleckenstein H, Gati C, Hunt B, Kirian RA, Liang M, Nanao MH, Nass K, Oberthür D, Redecke L, Shoeman R, Stellato F, Yoon CH, White TA, Yefanov O, Spence J, Chapman HN.

Struct Dyn. 2015 Apr 29;2(4):041703. doi: 10.1063/1.4919398. eCollection 2015 Jul.

22.

Isolation and characterization of Bradykinin potentiating peptides from Agkistrodon bilineatus venom.

Munawar A, Zahid A, Negm A, Akrem A, Spencer P, Betzel C.

Proteome Sci. 2016 Jan 14;14:1. doi: 10.1186/s12953-016-0090-0. eCollection 2016.

23.

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.

Falker C, Hartmann A, Guett I, Dohler F, Altmeppen H, Betzel C, Schubert R, Thurm D, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M.

J Neurochem. 2016 Apr;137(1):88-100. doi: 10.1111/jnc.13514. Epub 2016 Mar 2.

24.

Proteomic analysis of the rare Uracoan rattlesnake Crotalus vegrandis venom: Evidence of a broad arsenal of toxins.

Viala VL, Hildebrand D, Fucase TM, Sciani JM, Prezotto-Neto JP, Riedner M, Sanches L, Nishimura PJ, Oguiura N, Pimenta DC, Schlüter H, Betzel C, Arni RK, Spencer PJ.

Toxicon. 2015 Dec 1;107(Pt B):234-51. doi: 10.1016/j.toxicon.2015.09.023. Epub 2015 Sep 25.

25.

Biophysical and enzymatic properties of aminoglycoside adenylyltransferase AadA6 from Pseudomonas aeruginosa.

Papadovasilaki M, Oberthür D, Gessmann R, Sarrou I, Betzel C, Scoulica E, Petratos K.

Biochem Biophys Rep. 2015 Sep 18;4:152-157. doi: 10.1016/j.bbrep.2015.09.011. eCollection 2015 Dec.

26.

In vivo protein crystallization in combination with highly brilliant radiation sources offers novel opportunities for the structural analysis of post-translationally modified eukaryotic proteins.

Duszenko M, Redecke L, Mudogo CN, Sommer BP, Mogk S, Oberthuer D, Betzel C.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):929-37. doi: 10.1107/S2053230X15011450. Epub 2015 Jul 29. Review.

27.

Introduction to selected articles from the 15th ICCBM.

Einspahr H, Kuta Smatanova I, Betzel C, Mesters J.

Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):805. doi: 10.1107/S2053230X15012534. Epub 2015 Jun 30. No abstract available.

28.

Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants.

Viala VL, Hildebrand D, Trusch M, Fucase TM, Sciani JM, Pimenta DC, Arni RK, Schlüter H, Betzel C, Mirtschin P, Dunstan N, Spencer PJ.

Toxicon. 2015 Dec 1;107(Pt B):252-65. doi: 10.1016/j.toxicon.2015.06.005. Epub 2015 Jun 14.

29.

High resolution structures of Plasmodium falciparum GST complexes provide novel insights into the dimer-tetramer transition and a novel ligand-binding site.

Perbandt M, Eberle R, Fischer-Riepe L, Cang H, Liebau E, Betzel C.

J Struct Biol. 2015 Sep;191(3):365-75. doi: 10.1016/j.jsb.2015.06.008. Epub 2015 Jun 10.

PMID:
26072058
30.

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.

Oberthür D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C.

Nat Commun. 2015 Apr 22;6:6923. doi: 10.1038/ncomms7923.

31.

Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme.

García-Fernández R, Perbandt M, Rehders D, Ziegelmüller P, Piganeau N, Hahn U, Betzel C, Chávez Mde L, Redecke L.

J Biol Chem. 2015 May 29;290(22):14154-65. doi: 10.1074/jbc.M115.647586. Epub 2015 Apr 15.

32.

Latest methods of fluorescence-based protein crystal identification.

Meyer A, Betzel C, Pusey M.

Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):121-31. doi: 10.1107/S2053230X15000114. Epub 2015 Jan 28. Review.

33.

Systematic analysis of protein-detergent complexes applying dynamic light scattering to optimize solutions for crystallization trials.

Meyer A, Dierks K, Hussein R, Brillet K, Brognaro H, Betzel C.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):75-81. doi: 10.1107/S2053230X14027149. Epub 2015 Jan 1.

34.

Isolation, identification and functional profile of excretory-secretory peptides from Onchocerca ochengi.

Eberle R, Brattig NW, Trusch M, Schlüter H, Achukwi MD, Eisenbarth A, Renz A, Liebau E, Perbandt M, Betzel C.

Acta Trop. 2015 Feb;142:156-66. doi: 10.1016/j.actatropica.2014.11.015. Epub 2014 Dec 3.

PMID:
25479441
35.

Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality.

Guo YZ, Sun LH, Oberthuer D, Zhang CY, Shi JY, Di JL, Zhang BL, Cao HL, Liu YM, Li J, Wang Q, Huang HH, Liu J, Schulz JM, Zhang QY, Zhao JL, Betzel C, He JH, Yin DC.

Sci Rep. 2014 Dec 4;4:7308. doi: 10.1038/srep07308.

36.

Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica.

Faisal Tarique K, Arif Abdul Rehman S, Betzel C, Gourinath S.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3023-33. doi: 10.1107/S1399004714021245. Epub 2014 Oct 29.

PMID:
25372691
37.

Pseudechis guttatus venom proteome: Insights into evolution and toxin clustering.

Viala VL, Hildebrand D, Trusch M, Arni RK, Pimenta DC, Schlüter H, Betzel C, Spencer PJ.

J Proteomics. 2014 Oct 14;110:32-44. doi: 10.1016/j.jprot.2014.07.030. Epub 2014 Aug 7.

PMID:
25108201
38.

Room-temperature macromolecular serial crystallography using synchrotron radiation.

Stellato F, Oberthür D, Liang M, Bean R, Gati C, Yefanov O, Barty A, Burkhardt A, Fischer P, Galli L, Kirian RA, Meyer J, Panneerselvam S, Yoon CH, Chervinskii F, Speller E, White TA, Betzel C, Meents A, Chapman HN.

IUCrJ. 2014 May 30;1(Pt 4):204-12. doi: 10.1107/S2052252514010070. eCollection 2014 Jul 1.

39.

Serial crystallography on in vivo grown microcrystals using synchrotron radiation.

Gati C, Bourenkov G, Klinge M, Rehders D, Stellato F, Oberthür D, Yefanov O, Sommer BP, Mogk S, Duszenko M, Betzel C, Schneider TR, Chapman HN, Redecke L.

IUCrJ. 2014 Feb 10;1(Pt 2):87-94. doi: 10.1107/S2052252513033939. eCollection 2014 Mar 1.

40.

Preliminary crystallographic analysis of a cruciferin protein from seeds of Moringa oleifera.

Akrem A, Yousef N, Begum A, Negm A, Meyer A, Perbandt M, Buck F, Betzel C.

Protein J. 2014 Jun;33(3):253-7. doi: 10.1007/s10930-014-9558-x.

PMID:
24705831
41.

Elapid snake venom analyses show the specificity of the peptide composition at the level of genera Naja and Notechis.

Munawar A, Trusch M, Georgieva D, Hildebrand D, Kwiatkowski M, Behnken H, Harder S, Arni R, Spencer P, Schlüter H, Betzel C.

Toxins (Basel). 2014 Feb 28;6(3):850-68. doi: 10.3390/toxins6030850.

42.

Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil.

Prokofev II, Lashkov AA, Gabdulkhakov AG, Dontsova MV, Seregina TA, Mironov AS, Betzel C, Mikhailov AM.

Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):60-3. doi: 10.1107/S2053230X13031877. Epub 2013 Dec 24.

43.

Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases.

Begum A, Drebes J, Kikhney A, Müller IB, Perbandt M, Svergun D, Wrenger C, Betzel C.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2320-9. doi: 10.1107/S0907444913021550. Epub 2013 Nov 19.

PMID:
24311574
44.

MRSA infections: from classical treatment to suicide drugs.

Drebes J, Künz M, Pereira CA, Betzel C, Wrenger C.

Curr Med Chem. 2014;21(15):1809-19. Review.

PMID:
24251575
45.

Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion.

Elmallah MI, Borgmeyer U, Betzel C, Redecke L.

Prion. 2013 Sep-Oct;7(5):404-11. doi: 10.4161/pri.26745. Epub 2013 Oct 9.

46.

Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.

Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1958-64. doi: 10.1107/S0907444913018003. Epub 2013 Sep 20.

47.

Modeling of oxidized PTH (oxPTH) and non-oxidized PTH (n-oxPTH) receptor binding and relationship of oxidized to non-oxidized PTH in children with chronic renal failure, adult patients on hemodialysis and kidney transplant recipients.

Hocher B, Oberthür D, Slowinski T, Querfeld U, Schaefer F, Doyon A, Tepel M, Roth HJ, Grön HJ, Reichetzeder C, Betzel C, Armbruster FP.

Kidney Blood Press Res. 2013;37(4-5):240-51. doi: 10.1159/000350149. Epub 2013 Jul 14.

48.

Production, purification and characterization of recombinant, full-length human claudin-1.

Bonander N, Jamshad M, Oberthür D, Clare M, Barwell J, Hu K, Farquhar MJ, Stamataki Z, Harris HJ, Dierks K, Dafforn TR, Betzel C, McKeating JA, Bill RM.

PLoS One. 2013 May 21;8(5):e64517. doi: 10.1371/journal.pone.0064517. Print 2013.

49.

Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.

Redecke L, Nass K, DePonte DP, White TA, Rehders D, Barty A, Stellato F, Liang M, Barends TRM, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Aquila A, Arnlund D, Bajt S, Barth T, Bogan MJ, Caleman C, Chao TC, Doak RB, Fleckenstein H, Frank M, Fromme R, Galli L, Grotjohann I, Hunter MS, Johansson LC, Kassemeyer S, Katona G, Kirian RA, Koopmann R, Kupitz C, Lomb L, Martin AV, Mogk S, Neutze R, Shoeman RL, Steinbrener J, Timneanu N, Wang D, Weierstall U, Zatsepin NA, Spence JCH, Fromme P, Schlichting I, Duszenko M, Betzel C, Chapman HN.

Science. 2013 Jan 11;339(6116):227-230. doi: 10.1126/science.1229663. Epub 2012 Nov 29.

50.

Expression, purification, crystallization and preliminary X-ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine.

Lashkov AA, Gabdulkhakov AG, Prokofev II, Seregina TA, Sotnichenko SE, Lyashenko AV, Shtil AA, Mironov AS, Betzel C, Mikhailov AM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1394-7. doi: 10.1107/S1744309112041401. Epub 2012 Oct 30.

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