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Items: 1 to 50 of 127

1.

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.

Fajgenbaum DC, Langan RA, Japp AS, Partridge HL, Pierson SK, Singh A, Arenas DJ, Ruth JR, Nabel CS, Stone K, Okumura M, Schwarer A, Jose FF, Hamerschlak N, Wertheim GB, Jordan MB, Cohen AD, Krymskaya V, Rubenstein A, Betts MR, Kambayashi T, van Rhee F, Uldrick TS.

J Clin Invest. 2019 Aug 13;130. pii: 126091. doi: 10.1172/JCI126091.

2.

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals.

Klicznik MM, Morawski PA, Höllbacher B, Varkhande SR, Motley SJ, Kuri-Cervantes L, Goodwin E, Rosenblum MD, Long SA, Brachtl G, Duhen T, Betts MR, Campbell DJ, Gratz IK.

Sci Immunol. 2019 Jul 5;4(37). pii: eaav8995. doi: 10.1126/sciimmunol.aav8995.

PMID:
31278120
3.

T follicular helper cells in human efferent lymph retain lymphoid characteristics.

Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ.

J Clin Invest. 2019 Jul 2;129(8):3185-3200. doi: 10.1172/JCI125628. eCollection 2019 Jul 2.

4.

Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B.

Chang KM, Traum D, Park JJ, Ho S, Ojiro K, Wong DK, Wahed AS, Terrault NA, Khalili M, Sterling RK, Janssen HLA, Shuhart MC, Lau DT, Roberts LR, Johnson GS, Kaplan DE, Betts MR, Lee WM, Lok ASF; Hepatitis B Research Network (HBRN).

PLoS Pathog. 2019 Apr 18;15(4):e1007715. doi: 10.1371/journal.ppat.1007715. eCollection 2019 Apr.

5.

Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model.

Brody IB, Calcedo R, Connell MJ, Carnathan DG, Nason M, Lawson BO, Nega MT, Boyd S, Qin Q, Vanderford TH, Wilson JM, Wilson JM, Silvestri G, Betts MR.

Pathog Immun. 2019 Jan 29;4(1):1-20. doi: 10.20411/pai.v4i1.241. eCollection 2019.

6.

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver.

Greig JA, Calcedo R, Kuri-Cervantes L, Nordin JML, Albrecht J, Bote E, Goode T, Chroscinski EA, Bell P, Richman LK, Betts MR, Wilson JM.

Mol Ther Methods Clin Dev. 2018 Dec 5;11:191-201. doi: 10.1016/j.omtm.2018.10.012. eCollection 2018 Dec 14.

7.

Everything in its right place: resident memory CD8+ T cell immunosurveillance of HIV infection.

Buggert M, Japp AS, Betts MR.

Curr Opin HIV AIDS. 2019 Mar;14(2):93-99. doi: 10.1097/COH.0000000000000523.

PMID:
30520744
8.

The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool.

Dias J, Boulouis C, Gorin JB, van den Biggelaar RHGA, Lal KG, Gibbs A, Loh L, Gulam MY, Sia WR, Bari S, Hwang WYK, Nixon DF, Nguyen S, Betts MR, Buggert M, Eller MA, Broliden K, Tjernlund A, Sandberg JK, Leeansyah E.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11513-E11522. doi: 10.1073/pnas.1812273115. Epub 2018 Nov 15.

9.

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue.

Steblyanko M, Anikeeva N, Buggert M, Betts MR, Sykulev Y.

J Vis Exp. 2018 Jul 30;(137). doi: 10.3791/58143.

10.

Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.

Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.

Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526. doi: 10.1126/sciimmunol.aar4526.

11.

Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH.

J Exp Med. 2018 Jun 4;215(6):1531-1542. doi: 10.1084/jem.20171940. Epub 2018 May 16.

12.

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.

Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ.

Sci Transl Med. 2018 Apr 18;10(437). pii: eaar6759. doi: 10.1126/scitranslmed.aar6759.

13.

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.

PLoS Pathog. 2018 Apr 13;14(4):e1006973. doi: 10.1371/journal.ppat.1006973. eCollection 2018 Apr.

14.

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes.

Wendel BS, Del Alcazar D, He C, Del Río-Estrada PM, Aiamkitsumrit B, Ablanedo-Terrazas Y, Hernandez SM, Ma KY, Betts MR, Pulido L, Huang J, Gimotty PA, Reyes-Terán G, Jiang N, Su LF.

Sci Immunol. 2018 Apr 6;3(22). pii: eaan8884. doi: 10.1126/sciimmunol.aan8884.

15.

Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.

Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR, Prlic M.

JCI Insight. 2018 Apr 5;3(7). pii: 98487. doi: 10.1172/jci.insight.98487. eCollection 2018 Apr 5.

16.

Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.

Noyan K, Nguyen S, Betts MR, Sönnerborg A, Buggert M.

Front Immunol. 2018 Jan 22;9:19. doi: 10.3389/fimmu.2018.00019. eCollection 2018.

17.

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

Reuter MA, Del Rio Estrada PM, Buggert M, Petrovas C, Ferrando-Martinez S, Nguyen S, Sada Japp A, Ablanedo-Terrazas Y, Rivero-Arrieta A, Kuri-Cervantes L, Gunzelman HM, Gostick E, Price DA, Koup RA, Naji A, Canaday DH, Reyes-Terán G, Betts MR.

Cell Rep. 2017 Dec 19;21(12):3458-3470. doi: 10.1016/j.celrep.2017.11.075.

18.

T-bet-expressing B cells during HIV and HCV infections.

Knox JJ, Kaplan DE, Betts MR.

Cell Immunol. 2017 Nov;321:26-34. doi: 10.1016/j.cellimm.2017.04.012. Epub 2017 Jul 11. Review.

19.

T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response.

Knox JJ, Buggert M, Kardava L, Seaton KE, Eller MA, Canaday DH, Robb ML, Ostrowski MA, Deeks SG, Slifka MK, Tomaras GD, Moir S, Moody MA, Betts MR.

JCI Insight. 2017 Apr 20;2(8). pii: 92943. doi: 10.1172/jci.insight.92943. eCollection 2017 Apr 20.

20.

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.

Calcedo R, Somanathan S, Qin Q, Betts MR, Rech AJ, Vonderheide RH, Mueller C, Flotte TR, Wilson JM.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1655-1659. doi: 10.1073/pnas.1617726114. Epub 2017 Jan 30.

21.

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.

22.

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, Betts MR, Buggert M, Karlsson AC.

Sci Rep. 2017 Jan 13;7:40354. doi: 10.1038/srep40354.

23.

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.

Roberts ER, Carnathan DG, Li H, Shaw GM, Silvestri G, Betts MR.

PLoS Pathog. 2016 Dec 30;12(12):e1006135. doi: 10.1371/journal.ppat.1006135. eCollection 2016 Dec.

24.

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection.

Buggert M, Frederiksen J, Lund O, Betts MR, Biague A, Nielsen M, Tauriainen J, Norrgren H, Medstrand P, Karlsson AC, Jansson M; SWEGUB CORE group.

AIDS. 2016 Oct 23;30(16):2415-2426.

25.

Corrigendum: Characterization of T-bet and Eomes in Peripheral Human Immune Cells.

Knox JJ, Cosma GL, Betts MR, McLane LM.

Front Immunol. 2016 Sep 8;7:337. doi: 10.3389/fimmu.2016.00337. eCollection 2016.

26.

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

Demers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, Li CK, Eller LA, Rono K, Maganga L, Nitayaphan S, Kibuuka H, Routy JP, Slifka MK, Haynes BF, McMichael AJ, Bernard NF, Robb ML, Betts MR.

PLoS Pathog. 2016 Aug 3;12(8):e1005805. doi: 10.1371/journal.ppat.1005805. eCollection 2016 Aug.

27.

Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders.

Yadav A, Betts MR, Collman RG.

J Neurovirol. 2016 Oct;22(5):584-596. Epub 2016 Mar 28.

28.

Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.

Swanstrom AE, Haggarty B, Jordan APO, Romano J, Leslie GJ, Aye PP, Marx PA, Lackner AA, Del Prete GQ, Robinson JE, Betts MR, Montefiori DC, LaBranche CC, Hoxie JA.

J Virol. 2016 Apr 29;90(10):4966-4980. doi: 10.1128/JVI.02851-15. Print 2016 May 15.

29.

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.

Eller MA, Goonetilleke N, Tassaneetrithep B, Eller LA, Costanzo MC, Johnson S, Betts MR, Krebs SJ, Slike BM, Nitayaphan S, Rono K, Tovanabutra S, Maganga L, Kibuuka H, Jagodzinski L, Peel S, Rolland M, Marovich MA, Kim JH, Michael NL, Robb ML, Streeck H.

J Virol. 2016 Mar 28;90(8):4005-4016. doi: 10.1128/JVI.02785-15. Print 2016 Apr.

30.

CD4 T-cell cytokine correlates of diagnostic tests for latent tuberculous infection in HIV-1-infected subjects.

Van Epps P, Sridaran S, Aung H, Wilson BM, Burant CJ, Nserko M, Mayanja-Kizza H, Betts MR, Toossi Z, Canaday DH.

Int J Tuberc Lung Dis. 2015 Aug;19(8):927-35. doi: 10.5588/ijtld.14.0896.

PMID:
26162359
31.

CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection.

Canaday DH, Sridaran S, Van Epps P, Aung H, Burant CJ, Nsereko M, Mayanja-Kizza H, Betts MR, Toossi Z.

Tuberculosis (Edinb). 2015 Jul;95(4):470-5. doi: 10.1016/j.tube.2014.12.008. Epub 2015 Jan 7.

32.

Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.

Kutzler MA, Wise MC, Hutnick NA, Moldoveanu Z, Hunter M, Reuter M, Yuan S, Yan J, Ginsberg A, Sylvester A, Pahar B, Carnathan D, Kathuria N, Khan AS, Montefiori D, Sardesai NY, Betts MR, Mestecky J, Marx P, Weiner DB.

Mucosal Immunol. 2016 Jan;9(1):13-23. doi: 10.1038/mi.2015.31. Epub 2015 May 6.

33.

Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.

Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR.

J Infect Dis. 2015 Nov 1;212(9):1376-86. doi: 10.1093/infdis/jiv226. Epub 2015 Apr 15.

34.

Age-related differences in polyfunctional T cell responses.

Van Epps P, Banks R, Aung H, Betts MR, Canaday DH.

Immun Ageing. 2014 Oct 23;11:14. doi: 10.1186/1742-4933-11-14. eCollection 2014.

35.

Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.

Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ.

J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29.

36.

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson MA, Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg A, Koup RA, Betts MR, Karlsson AC.

PLoS Pathog. 2014 Jul 17;10(7):e1004251. doi: 10.1371/journal.ppat.1004251. eCollection 2014 Jul.

37.

Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.

Christian DA, Koshy AA, Reuter MA, Betts MR, Boothroyd JC, Hunter CA.

Infect Immun. 2014 Oct;82(10):4056-67. doi: 10.1128/IAI.01643-14. Epub 2014 Jul 14.

38.

Characterization of T-bet and eomes in peripheral human immune cells.

Knox JJ, Cosma GL, Betts MR, McLane LM.

Front Immunol. 2014 May 14;5:217. doi: 10.3389/fimmu.2014.00217. eCollection 2014. Erratum in: Front Immunol. 2016;7:337.

39.

Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector.

Bukh I, Calcedo R, Roy S, Carnathan DG, Grant R, Qin Q, Boyd S, Ratcliffe SJ, Veeder CL, Bellamy SL, Betts MR, Wilson JM.

J Virol. 2014 Aug;88(15):8468-78. doi: 10.1128/JVI.03850-13. Epub 2014 May 14.

40.

Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.

Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, Koshy AA, Wagage S, Reuter MA, Sibley LD, Betts MR, Hunter CA.

PLoS Pathog. 2014 Apr 10;10(4):e1004047. doi: 10.1371/journal.ppat.1004047. eCollection 2014 Apr.

41.

Commentary on Shapiro: clinical development of candidate HIV vaccines: different problems for different vaccines.

Hope TJ, Betts MR.

AIDS Res Hum Retroviruses. 2014 Apr;30(4):330. doi: 10.1089/AID.2014.0047. No abstract available.

42.

Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

Manuel SL, Sehgal M, Connolly J, Makedonas G, Khan ZK, Gardner J, Betts MR, Jain P.

J Clin Immunol. 2013 Oct;33(7):1223-39. doi: 10.1007/s10875-013-9918-x. Epub 2013 Jul 26.

43.

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis.

Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P.

PLoS Pathog. 2013;9(7):e1003504. doi: 10.1371/journal.ppat.1003504. Epub 2013 Jul 18.

44.

CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis.

Demers KR, Reuter MA, Betts MR.

Immunol Rev. 2013 Jul;254(1):190-206. doi: 10.1111/imr.12069. Review.

45.

An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1.

Manuel SL, Sehgal M, Khan ZK, Goedert JJ, Betts MR, Jain P.

AIDS Res Hum Retroviruses. 2013 Sep;29(9):1273-85. doi: 10.1089/AID.2013.0054. Epub 2013 Jul 19.

46.

CD40L expression permits CD8+ T cells to execute immunologic helper functions.

Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, Jürchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A.

Blood. 2013 Jul 18;122(3):405-12. doi: 10.1182/blood-2013-02-483586. Epub 2013 May 29.

47.

Differential localization of T-bet and Eomes in CD8 T cell memory populations.

McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR.

J Immunol. 2013 Apr 1;190(7):3207-15. doi: 10.4049/jimmunol.1201556. Epub 2013 Mar 1.

48.

The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age.

Lelic A, Verschoor CP, Ventresca M, Parsons R, Evelegh C, Bowdish D, Betts MR, Loeb MB, Bramson JL.

PLoS Pathog. 2012;8(12):e1003076. doi: 10.1371/journal.ppat.1003076. Epub 2012 Dec 13.

49.

DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells.

Reuter MA, Yuan S, Marx PA, Kutzler MA, Weiner DB, Betts MR.

Hum Vaccin Immunother. 2012 Nov 1;8(11):1648-53. doi: 10.4161/hv.22247. Epub 2012 Oct 30.

50.

Cytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccines.

Reuter MA, Pombo C, Betts MR.

Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):181-91. doi: 10.1016/j.cytogfr.2012.05.005. Epub 2012 Jun 27. Review.

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