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Items: 1 to 50 of 186

1.

Reduction in the neuronal surface of post- and pre-synaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer´s disease.

Martín-Belmonte A, Aguado C, Alfaro-Ruíz R, Moreno-Martínez AE, de la Ossa L, Martínez-Hernández J, Buisson A, Früh S, Bettler B, Shigemoto R, Fukazawa Y, Luján R.

Brain Pathol. 2019 Nov 15. doi: 10.1111/bpa.12802. [Epub ahead of print]

PMID:
31729777
2.

GABAB Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet.

Tsunekawa T, Banno R, Yaginuma H, Taki K, Mizoguchi A, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Goto M, Suga H, Bettler B, Arima H.

iScience. 2019 Oct 25;20:337-347. doi: 10.1016/j.isci.2019.09.032. Epub 2019 Sep 26.

3.

Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior.

Winkler M, Biswas S, Berger SM, Küchler M, Preisendörfer L, Choo M, Früh S, Rem PD, Enkel T, Arnold B, Komljenovic D, Sticht C, Goerdt S, Bettler B, von Bohlen Und Halbach O, Bartsch D, Géraud C.

Mol Psychiatry. 2019 Sep 11. doi: 10.1038/s41380-019-0519-9. [Epub ahead of print]

PMID:
31511635
4.

Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction.

Sereikaite V, Fritzius T, Kasaragod VB, Bader N, Maric HM, Schindelin H, Bettler B, Strømgaard K.

J Med Chem. 2019 Oct 10;62(19):8819-8830. doi: 10.1021/acs.jmedchem.9b01087. Epub 2019 Sep 25.

PMID:
31509708
5.

Multiple failures in the lutenising hormone surge generating system in GABAB1KO female mice.

Di Giorgio NP, Bizzozzero Hiriart M, Surkin PN, López PV, Bourguignon NS, Dorfman VB, Bettler B, Libertun C, Lux-Lantos V.

J Neuroendocrinol. 2019 Aug;31(8):e12765. doi: 10.1111/jne.12765. Epub 2019 Jul 15.

PMID:
31269532
6.

The organizing principle of GABAB receptor complexes: Physiological and pharmacological implications.

Fritzius T, Bettler B.

Basic Clin Pharmacol Toxicol. 2019 Apr 29. doi: 10.1111/bcpt.13241. [Epub ahead of print] Review.

PMID:
31033219
7.

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.

Dinamarca MC, Raveh A, Schneider A, Fritzius T, Früh S, Rem PD, Stawarski M, Lalanne T, Turecek R, Choo M, Besseyrias V, Bildl W, Bentrop D, Staufenbiel M, Gassmann M, Fakler B, Schwenk J, Bettler B.

Nat Commun. 2019 Mar 22;10(1):1331. doi: 10.1038/s41467-019-09164-3.

8.

GABAB receptors modulate morphine antinociception: Pharmacological and genetic approaches.

Pedrón VT, Varani AP, Bettler B, Balerio GN.

Pharmacol Biochem Behav. 2019 May;180:11-21. doi: 10.1016/j.pbb.2019.02.015. Epub 2019 Mar 6.

PMID:
30851293
9.

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.

Tomé M, Tchorz J, Gassmann M, Bettler B.

Stem Cell Res. 2019 Mar;35:101390. doi: 10.1016/j.scr.2019.101390. Epub 2019 Feb 7.

10.

Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling.

Vickers ED, Clark C, Osypenko D, Fratzl A, Kochubey O, Bettler B, Schneggenburger R.

Neuron. 2018 Aug 22;99(4):720-735.e6. doi: 10.1016/j.neuron.2018.07.018. Epub 2018 Aug 2.

11.

A tribute to Norman G Bowery.

Bettler B, Crunelli V, Enna SJ.

Neuropharmacology. 2018 Jul 1;136(Pt A):1-2. doi: 10.1016/j.neuropharm.2018.05.022. Epub 2018 May 18. No abstract available.

PMID:
29782875
12.

Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor.

Porcu A, Melis M, Turecek R, Ullrich C, Mocci I, Bettler B, Gessa GL, Castelli MP.

Neuropharmacology. 2018 May 1;133:107-120. doi: 10.1016/j.neuropharm.2018.01.024.

PMID:
29407764
13.

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.

Mariotti L, Losi G, Lia A, Melone M, Chiavegato A, Gómez-Gonzalo M, Sessolo M, Bovetti S, Forli A, Zonta M, Requie LM, Marcon I, Pugliese A, Viollet C, Bettler B, Fellin T, Conti F, Carmignoto G.

Nat Commun. 2018 Jan 8;9(1):82. doi: 10.1038/s41467-017-02642-6.

14.

Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, de la Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y.

Brain Struct Funct. 2018 Apr;223(3):1565-1587. doi: 10.1007/s00429-017-1568-y. Epub 2017 Nov 25.

15.

GABAB receptor subtypes differentially regulate thalamic spindle oscillations.

Ulrich D, Lalanne T, Gassmann M, Bettler B.

Neuropharmacology. 2018 Jul 1;136(Pt A):106-116. doi: 10.1016/j.neuropharm.2017.10.033. Epub 2017 Oct 26.

PMID:
29106983
16.

Corrigendum: Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior.

Edwards NJ, Tejeda HA, Pignatelli M, Zhang S, McDevitt RA, Wu J, Bass CE, Bettler B, Morales M, Bonci A.

Nat Neurosci. 2017 Jul 26;20(8):1189. doi: 10.1038/nn0817-1189c. No abstract available.

PMID:
28745720
17.

Nicotine-induced molecular alterations are modulated by GABAB receptor activity.

Varani AP, Pedrón VT, Aon AJ, Höcht C, Acosta GB, Bettler B, Balerio GN.

Addict Biol. 2018 Jan;23(1):230-246. doi: 10.1111/adb.12506. Epub 2017 Apr 17.

PMID:
28419642
18.

Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes.

Bettler B, Fakler B.

Curr Opin Neurobiol. 2017 Aug;45:16-23. doi: 10.1016/j.conb.2017.02.011. Epub 2017 Mar 7. Review.

PMID:
28282540
19.

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission.

Zapata J, Moretto E, Hannan S, Murru L, Longatti A, Mazza D, Benedetti L, Fossati M, Heise C, Ponzoni L, Valnegri P, Braida D, Sala M, Francolini M, Hildebrand J, Kalscheuer V, Fanelli F, Sala C, Bettler B, Bassani S, Smart TG, Passafaro M.

Nat Commun. 2017 Mar 6;8:14536. doi: 10.1038/ncomms14536.

20.

Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior.

Edwards NJ, Tejeda HA, Pignatelli M, Zhang S, McDevitt RA, Wu J, Bass CE, Bettler B, Morales M, Bonci A.

Nat Neurosci. 2017 Mar;20(3):438-448. doi: 10.1038/nn.4482. Epub 2017 Jan 23. Erratum in: Nat Neurosci. 2017 Jul 26;20(8):1189.

PMID:
28114294
21.

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

Jacobson LH, Hoyer D, Fehlmann D, Bettler B, Kaupmann K, Cryan JF.

Psychopharmacology (Berl). 2017 May;234(9-10):1511-1523. doi: 10.1007/s00213-016-4521-5. Epub 2017 Jan 9.

PMID:
28070618
22.

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks.

Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, Manahan-Vaughan D, Martín ED, Kirchhoff F, Araque A.

Elife. 2016 Dec 24;5. pii: e20362. doi: 10.7554/eLife.20362.

23.

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.

Fritzius T, Turecek R, Seddik R, Kobayashi H, Tiao J, Rem PD, Metz M, Kralikova M, Bouvier M, Gassmann M, Bettler B.

J Neurosci. 2017 Feb 1;37(5):1162-1175. doi: 10.1523/JNEUROSCI.2181-16.2016. Epub 2016 Dec 21.

24.

Organization and functions of mGlu and GABAB receptor complexes.

Pin JP, Bettler B.

Nature. 2016 Dec 1;540(7631):60-68. doi: 10.1038/nature20566. Review.

PMID:
27905440
25.

Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16.

Cathomas F, Sigrist H, Schmid L, Seifritz E, Gassmann M, Bettler B, Pryce CR.

Behav Brain Res. 2017 Jan 15;317:393-400. doi: 10.1016/j.bbr.2016.10.006. Epub 2016 Oct 4.

PMID:
27717812
26.

An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery.

Sailer MH, Sarvepalli D, Brégère C, Fisch U, Guentchev M, Weller M, Guzman R, Bettler B, Ghosh A, Hutter G.

J Vis Exp. 2016 Aug 23;(114). doi: 10.3791/54018.

27.

Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression.

Zhang J, Tan L, Ren Y, Liang J, Lin R, Feng Q, Zhou J, Hu F, Ren J, Wei C, Yu T, Zhuang Y, Bettler B, Wang F, Luo M.

Cell. 2016 Jul 28;166(3):716-728. doi: 10.1016/j.cell.2016.06.026. Epub 2016 Jul 14.

28.

KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons.

Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik Á.

Cereb Cortex. 2017 Mar 1;27(3):2318-2334. doi: 10.1093/cercor/bhw090.

29.

Presynaptic GABAB Receptors Regulate Hippocampal Synapses during Associative Learning in Behaving Mice.

Jurado-Parras MT, Delgado-García JM, Sánchez-Campusano R, Gassmann M, Bettler B, Gruart A.

PLoS One. 2016 Feb 5;11(2):e0148800. doi: 10.1371/journal.pone.0148800. eCollection 2016.

30.

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics.

Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B.

Nat Neurosci. 2016 Feb;19(2):233-42. doi: 10.1038/nn.4198. Epub 2015 Dec 21.

PMID:
26691831
31.

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.

Giachino C, Boulay JL, Ivanek R, Alvarado A, Tostado C, Lugert S, Tchorz J, Coban M, Mariani L, Bettler B, Lathia J, Frank S, Pfister S, Kool M, Taylor V.

Cancer Cell. 2015 Dec 14;28(6):730-742. doi: 10.1016/j.ccell.2015.10.008. Epub 2015 Dec 5.

32.

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

Jacobson LH, Sweeney FF, Kaupmann K, O'Leary OF, Gassmann M, Bettler B, Cryan JF.

Behav Brain Res. 2016 Feb 1;298(Pt B):12-6. doi: 10.1016/j.bbr.2015.10.039. Epub 2015 Oct 27.

PMID:
26518330
33.

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.

Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, Dernick G, Wettstein JG, Iglesias A, Rolink A, Bettler B, Hoener MC.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2049-61. doi: 10.1016/j.euroneuro.2015.08.011. Epub 2015 Aug 20.

PMID:
26372541
34.

GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks.

Vertkin I, Styr B, Slomowitz E, Ofir N, Shapira I, Berner D, Fedorova T, Laviv T, Barak-Broner N, Greitzer-Antes D, Gassmann M, Bettler B, Lotan I, Slutsky I.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3291-9. doi: 10.1073/pnas.1424810112. Epub 2015 Jun 8.

35.

GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper.

Doly S, Shirvani H, Gäta G, Meye FJ, Emerit MB, Enslen H, Achour L, Pardo-Lopez L, Yang SK, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M, Marullo S.

Mol Psychiatry. 2016 Apr;21(4):480-90. doi: 10.1038/mp.2015.72. Epub 2015 Jun 2.

36.

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T.

J Neurosci. 2015 Apr 22;35(16):6452-63. doi: 10.1523/JNEUROSCI.2450-14.2015.

37.

Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.

Cathomas F, Stegen M, Sigrist H, Schmid L, Seifritz E, Gassmann M, Bettler B, Pryce CR.

Transl Psychiatry. 2015 Feb 17;5:e510. doi: 10.1038/tp.2015.8.

38.

GABA blocks pathological but not acute TRPV1 pain signals.

Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J.

Cell. 2015 Feb 12;160(4):759-770. doi: 10.1016/j.cell.2015.01.022.

39.

Mechanisms of fast desensitization of GABA(B) receptor-gated currents.

Raveh A, Turecek R, Bettler B.

Adv Pharmacol. 2015;73:145-65. doi: 10.1016/bs.apha.2014.11.004. Epub 2015 Jan 14.

PMID:
25637440
40.

Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.

Varani AP, Pedrón VT, Machado LM, Antonelli MC, Bettler B, Balerio GN.

Neuropharmacology. 2015 Mar;90:90-101. doi: 10.1016/j.neuropharm.2014.11.013. Epub 2014 Dec 3.

PMID:
25479464
41.

GABAB(1) receptor subunit isoforms differentially regulate stress resilience.

O'Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, El Yacoubi M, Vaugeois JM, Gassmann M, Bettler B, Dinan TG, Cryan JF.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15232-7. doi: 10.1073/pnas.1404090111. Epub 2014 Oct 6.

42.

Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits.

Rajalu M, Fritzius T, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Bettler B.

Neuropharmacology. 2015 Jan;88:145-54. doi: 10.1016/j.neuropharm.2014.08.020. Epub 2014 Sep 6.

43.

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.

Martin CB, Gassmann M, Chevarin C, Hamon M, Rudolph U, Bettler B, Lanfumey L, Mongeau R.

J Neurochem. 2014 Dec;131(5):566-72. doi: 10.1111/jnc.12929. Epub 2014 Sep 4.

44.

GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization.

Adelfinger L, Turecek R, Ivankova K, Jensen AA, Moss SJ, Gassmann M, Bettler B.

Biochem Pharmacol. 2014 Oct 1;91(3):369-79. doi: 10.1016/j.bcp.2014.07.013. Epub 2014 Jul 24.

45.

Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization.

Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Schulte U, Fakler B, Bettler B.

Neuron. 2014 Jun 4;82(5):1032-44. doi: 10.1016/j.neuron.2014.04.015. Epub 2014 May 15.

46.

Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.

Varani AP, Pedrón VT, Bettler B, Balerio GN.

Neuropharmacology. 2014 Jun;81:31-41. doi: 10.1016/j.neuropharm.2014.01.030. Epub 2014 Jan 30.

PMID:
24486711
47.

Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers.

Faroni A, Castelnovo LF, Procacci P, Caffino L, Fumagalli F, Melfi S, Gambarotta G, Bettler B, Wrabetz L, Magnaghi V.

Glia. 2014 Apr;62(4):548-65. doi: 10.1002/glia.22625. Epub 2014 Jan 29.

48.

Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice.

Di Giorgio NP, Semaan SJ, Kim J, López PV, Bettler B, Libertun C, Lux-Lantos VA, Kauffman AS.

Endocrinology. 2014 Mar;155(3):1033-44. doi: 10.1210/en.2013-1573. Epub 2013 Dec 20.

49.

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.

Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, Bettler B, Taylor V.

Development. 2014 Jan;141(1):83-90. doi: 10.1242/dev.102608. Epub 2013 Nov 27.

50.

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.

Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H.

J Neurosci. 2013 Oct 23;33(43):17166-73. doi: 10.1523/JNEUROSCI.0897-13.2013.

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