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Items: 14


DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas.

Liu C, Fennell LJ, Bettington ML, Walker NI, Dwine J, Leggett BA, Whitehall VLJ.

Clin Epigenetics. 2019 Jun 14;11(1):90. doi: 10.1186/s13148-019-0691-4.


CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.

Mittal D, Lepletier A, Madore J, Aguilera AR, Stannard K, Blake SJ, Whitehall VLJ, Liu C, Bettington ML, Takeda K, Long GV, Scolyer RA, Lan R, Siemers N, Korman A, Teng MWL, Johnston RJ, Dougall WC, Smyth MJ.

Cancer Immunol Res. 2019 Apr;7(4):559-571. doi: 10.1158/2326-6066.CIR-18-0637. Epub 2019 Mar 20.


CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young Patients.

Liu C, Bettington ML, Walker NI, Dwine J, Hartel GF, Leggett BA, Whitehall VLJ.

Gastroenterology. 2018 Nov;155(5):1362-1365.e2. doi: 10.1053/j.gastro.2018.07.012. Epub 2018 Oct 4.


Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.

Lannagan TRM, Lee YK, Wang T, Roper J, Bettington ML, Fennell L, Vrbanac L, Jonavicius L, Somashekar R, Gieniec K, Yang M, Ng JQ, Suzuki N, Ichinose M, Wright JA, Kobayashi H, Putoczki TL, Hayakawa Y, Leedham SJ, Abud HE, Yilmaz ÖH, Marker J, Klebe S, Wirapati P, Mukherjee S, Tejpar S, Leggett BA, Whitehall VLJ, Worthley DL, Woods SL.

Gut. 2019 Apr;68(4):684-692. doi: 10.1136/gutjnl-2017-315920. Epub 2018 Apr 17.


Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry.

Liu C, Walker NI, Leggett BA, Whitehall VL, Bettington ML, Rosty C.

Mod Pathol. 2017 Dec;30(12):1728-1738. doi: 10.1038/modpathol.2017.92. Epub 2017 Jul 28.


Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis.

Brown IS, Miller G, Bettington ML, Rosty C.

Virchows Arch. 2017 May;470(5):597. doi: 10.1007/s00428-017-2132-0. Epub 2017 Apr 19. No abstract available.


GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features.

Liu C, McKeone DM, Walker NI, Bettington ML, Leggett BA, Whitehall VLJ.

Histopathology. 2017 Jun;70(7):1079-1088. doi: 10.1111/his.13180. Epub 2017 Mar 22.


Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis.

Brown IS, Miller GC, Bettington ML, Rosty C.

Virchows Arch. 2016 Nov;469(5):515-522. Epub 2016 Sep 3.


RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.

Bond CE, McKeone DM, Kalimutho M, Bettington ML, Pearson SA, Dumenil TD, Wockner LF, Burge M, Leggett BA, Whitehall VL.

Oncotarget. 2016 Oct 25;7(43):70589-70600. doi: 10.18632/oncotarget.12130.


Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases.

Brown IS, Bettington ML, Bettington A, Miller G, Rosty C.

J Clin Pathol. 2016 Apr;69(4):292-9. doi: 10.1136/jclinpath-2015-203203. Epub 2015 Sep 30.


Traditional serrated adenoma: an update.

Bettington ML, Chetty R.

Hum Pathol. 2015 Jul;46(7):933-8. doi: 10.1016/j.humpath.2015.04.002. Epub 2015 Apr 20. Review.


Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups.

Bond CE, Bettington ML, Pearson SA, McKeone DM, Leggett BA, Whitehall VL.

BMC Cancer. 2015 Jan 23;15:20. doi: 10.1186/s12885-015-1011-9.


Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype.

Whitehall VL, Dumenil TD, McKeone DM, Bond CE, Bettington ML, Buttenshaw RL, Bowdler L, Montgomery GW, Wockner LF, Leggett BA.

Epigenetics. 2014 Nov;9(11):1454-60. doi: 10.4161/15592294.2014.971624.


A clinicopathological and molecular analysis of 200 traditional serrated adenomas.

Bettington ML, Walker NI, Rosty C, Brown IS, Clouston AD, McKeone DM, Pearson SA, Klein K, Leggett BA, Whitehall VL.

Mod Pathol. 2015 Mar;28(3):414-27. doi: 10.1038/modpathol.2014.122. Epub 2014 Sep 12.

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