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Items: 48


Pericentrin-mediated SAS-6 recruitment promotes centriole assembly.

Ito D, Zitouni S, Jana SC, Duarte P, Surkont J, Carvalho-Santos Z, Pereira-Leal JB, Ferreira MG, Bettencourt-Dias M.

Elife. 2019 Jun 11;8. pii: e41418. doi: 10.7554/eLife.41418.


Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome.

de Almeida BP, Vieira AF, Paredes J, Bettencourt-Dias M, Barbosa-Morais NL.

PLoS Comput Biol. 2019 Mar 11;15(3):e1006832. doi: 10.1371/journal.pcbi.1006832. eCollection 2019 Mar.


PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation.

Montenegro Gouveia S, Zitouni S, Kong D, Duarte P, Ferreira Gomes B, Sousa AL, Tranfield EM, Hyman A, Loncarek J, Bettencourt-Dias M.

J Cell Sci. 2018 Nov 9;132(4). pii: jcs219501. doi: 10.1242/jcs.219501.


Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity.

Jana SC, Mendonça S, Machado P, Werner S, Rocha J, Pereira A, Maiato H, Bettencourt-Dias M.

Nat Cell Biol. 2018 Aug;20(8):928-941. doi: 10.1038/s41556-018-0132-1. Epub 2018 Jul 16.


Centrosome Remodelling in Evolution.

Ito D, Bettencourt-Dias M.

Cells. 2018 Jul 6;7(7). pii: E71. doi: 10.3390/cells7070071. Review.


Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.

Lopes CAM, Mesquita M, Cunha AI, Cardoso J, Carapeta S, Laranjeira C, Pinto AE, Pereira-Leal JB, Dias-Pereira A, Bettencourt-Dias M, Chaves P.

J Cell Biol. 2018 Jul 2;217(7):2353-2363. doi: 10.1083/jcb.201711191. Epub 2018 May 8.


Noncanonical Biogenesis of Centrioles and Basal Bodies.

Nabais C, Pereira SG, Bettencourt-Dias M.

Cold Spring Harb Symp Quant Biol. 2017;82:123-135. doi: 10.1101/sqb.2017.82.034694. Epub 2018 Apr 23.


Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation.

Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M.

Nat Commun. 2018 Mar 28;9(1):1258. doi: 10.1038/s41467-018-03641-x.


Building the right centriole for each cell type.

Loncarek J, Bettencourt-Dias M.

J Cell Biol. 2018 Mar 5;217(3):823-835. doi: 10.1083/jcb.201704093. Epub 2017 Dec 28. Review.


Maintaining centrosomes and cilia.

Werner S, Pimenta-Marques A, Bettencourt-Dias M.

J Cell Sci. 2017 Nov 15;130(22):3789-3800. doi: 10.1242/jcs.203505. Review.


Centrosome Assembly: Reconstructing the Core Cartwheel Structure In Vitro.

Marteil G, Dias Louro MA, Bettencourt-Dias M.

Curr Biol. 2017 Jun 19;27(12):R606-R609. doi: 10.1016/j.cub.2017.04.044.


CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression.

Cardoso J, Mesquita M, Dias Pereira A, Bettencourt-Dias M, Chaves P, Pereira-Leal JB.

PLoS One. 2016 Sep 1;11(9):e0161967. doi: 10.1371/journal.pone.0161967. eCollection 2016.


Methods to Study Centrosomes and Cilia in Drosophila.

Jana SC, Mendonça S, Werner S, Bettencourt-Dias M.

Methods Mol Biol. 2016;1454:215-36. doi: 10.1007/978-1-4939-3789-9_14.


Drosophila melanogaster as a model for basal body research.

Jana SC, Bettencourt-Dias M, Durand B, Megraw TL.

Cilia. 2016 Jul 5;5:22. doi: 10.1186/s13630-016-0041-5. eCollection 2016. Review.


A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster.

Pimenta-Marques A, Bento I, Lopes CA, Duarte P, Jana SC, Bettencourt-Dias M.

Science. 2016 Jul 1;353(6294):aaf4866. doi: 10.1126/science.aaf4866. Epub 2016 May 26.


CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis.

Zitouni S, Francia ME, Leal F, Montenegro Gouveia S, Nabais C, Duarte P, Gilberto S, Brito D, Moyer T, Kandels-Lewis S, Ohta M, Kitagawa D, Holland AJ, Karsenti E, Lorca T, Lince-Faria M, Bettencourt-Dias M.

Curr Biol. 2016 May 9;26(9):1127-37. doi: 10.1016/j.cub.2016.03.055. Epub 2016 Apr 21.


Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes.

Borrego-Pinto J, Somogyi K, Karreman MA, König J, Müller-Reichert T, Bettencourt-Dias M, Gönczy P, Schwab Y, Lénárt P.

J Cell Biol. 2016 Mar 28;212(7):815-27. doi: 10.1083/jcb.201510083. Epub 2016 Mar 21.


Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila.

Chen JV, Kao LR, Jana SC, Sivan-Loukianova E, Mendonça S, Cabrera OA, Singh P, Cabernard C, Eberl DF, Bettencourt-Dias M, Megraw TL.

J Cell Biol. 2015 Oct 26;211(2):435-53. doi: 10.1083/jcb.201502032. Epub 2015 Oct 19.


PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space.

Lopes CA, Jana SC, Cunha-Ferreira I, Zitouni S, Bento I, Duarte P, Gilberto S, Freixo F, Guerrero A, Francia M, Lince-Faria M, Carneiro J, Bettencourt-Dias M.

Dev Cell. 2015 Oct 26;35(2):222-35. doi: 10.1016/j.devcel.2015.09.020. Epub 2015 Oct 17.


Polo-like kinases: structural variations lead to multiple functions.

Zitouni S, Nabais C, Jana SC, Guerrero A, Bettencourt-Dias M.

Nat Rev Mol Cell Biol. 2014 Jul;15(7):433-52. doi: 10.1038/nrm3819. Review.


Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution.

Jana SC, Marteil G, Bettencourt-Dias M.

Curr Opin Cell Biol. 2014 Feb;26:96-106. doi: 10.1016/ Epub 2013 Dec 25. Review.


Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.

Cunha-Ferreira I, Bento I, Pimenta-Marques A, Jana SC, Lince-Faria M, Duarte P, Borrego-Pinto J, Gilberto S, Amado T, Brito D, Rodrigues-Martins A, Debski J, Dzhindzhev N, Bettencourt-Dias M.

Curr Biol. 2013 Nov 18;23(22):2245-2254. doi: 10.1016/j.cub.2013.09.037. Epub 2013 Oct 31.


Q&A: Who needs a centrosome?

Bettencourt-Dias M.

BMC Biol. 2013 Apr 11;11:28. doi: 10.1186/1741-7007-11-28. No abstract available.


Polo boxes come out of the crypt: a new view of PLK function and evolution.

Jana SC, Bazan JF, Bettencourt-Dias M.

Structure. 2012 Nov 7;20(11):1801-4. doi: 10.1016/j.str.2012.10.008. Erratum in: Structure. 2012 Dec 5;20(12):2191. Bettencourt Dias, Mónica [corrected to Bettencourt-Dias, Mónica].


BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair.

Carvalho-Santos Z, Machado P, Alvarez-Martins I, Gouveia SM, Jana SC, Duarte P, Amado T, Branco P, Freitas MC, Silva ST, Antony C, Bandeiras TM, Bettencourt-Dias M.

Dev Cell. 2012 Aug 14;23(2):412-24. doi: 10.1016/j.devcel.2012.06.001.


Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.

Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW.

Mol Biol Cell. 2012 May;23(10):1838-45. doi: 10.1091/mbc.E11-12-1043. Epub 2012 Mar 28.


Deconstructing the centriole: structure and number control.

Brito DA, Gouveia SM, Bettencourt-Dias M.

Curr Opin Cell Biol. 2012 Feb;24(1):4-13. doi: 10.1016/ Epub 2012 Feb 8. Review.


A structural road map to unveil basal body composition and assembly.

Jana SC, Machado P, Bettencourt-Dias M.

EMBO J. 2012 Feb 1;31(3):519-21. doi: 10.1038/emboj.2011.474. Epub 2012 Feb 1. No abstract available.


Evolution: Tracing the origins of centrioles, cilia, and flagella.

Carvalho-Santos Z, Azimzadeh J, Pereira-Leal JB, Bettencourt-Dias M.

J Cell Biol. 2011 Jul 25;194(2):165-75. doi: 10.1083/jcb.201011152. Review. Erratum in: J Cell Biol. 2011 Oct 17;195(2):341.


Centrosomes and cilia in human disease.

Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA.

Trends Genet. 2011 Aug;27(8):307-15. doi: 10.1016/j.tig.2011.05.004. Epub 2011 Jun 15. Review.


Asterless is a scaffold for the onset of centriole assembly.

Dzhindzhev NS, Yu QD, Weiskopf K, Tzolovsky G, Cunha-Ferreira I, Riparbelli M, Rodrigues-Martins A, Bettencourt-Dias M, Callaini G, Glover DM.

Nature. 2010 Oct 7;467(7316):714-8. doi: 10.1038/nature09445. Epub 2010 Sep 19.


Mónica Bettencourt-Dias: centered on centrioles. Interview by Ben Short.

Bettencourt-Dias M.

J Cell Biol. 2010 Sep 6;190(5):710-1. doi: 10.1083/jcb.1905pi. No abstract available.


Microscopy methods for the study of centriole biogenesis and function in Drosophila.

Martins AR, Machado P, Callaini G, Bettencourt-Dias M.

Methods Cell Biol. 2010;97:223-42. doi: 10.1016/S0091-679X(10)97013-1. Review.


Stepwise evolution of the centriole-assembly pathway.

Carvalho-Santos Z, Machado P, Branco P, Tavares-Cadete F, Rodrigues-Martins A, Pereira-Leal JB, Bettencourt-Dias M.

J Cell Sci. 2010 May 1;123(Pt 9):1414-26. doi: 10.1242/jcs.064931. Epub 2010 Apr 14.


Centrioles: active players or passengers during mitosis?

Debec A, Sullivan W, Bettencourt-Dias M.

Cell Mol Life Sci. 2010 Jul;67(13):2173-94. doi: 10.1007/s00018-010-0323-9. Epub 2010 Mar 19. Review.


RNAi in Drosophila S2 cells as a tool for studying cell cycle progression.

Bettencourt-Dias M, Goshima G.

Methods Mol Biol. 2009;545:39-62. doi: 10.1007/978-1-60327-993-2_3.


Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells.

Kuriyama R, Bettencourt-Dias M, Hoffmann I, Arnold M, Sandvig L.

J Cell Sci. 2009 Jun 15;122(Pt 12):2014-23. doi: 10.1242/jcs.036715. Epub 2009 May 19.


From zero to many: control of centriole number in development and disease.

Cunha-Ferreira I, Bento I, Bettencourt-Dias M.

Traffic. 2009 May;10(5):482-98. doi: 10.1111/j.1600-0854.2009.00905.x. Review.


SnapShot: centriole biogenesis.

Bettencourt-Dias M, Glover DM.

Cell. 2009 Jan 9;136(1):188-188.e1. doi: 10.1016/j.cell.2008.12.035. No abstract available.


The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

Cunha-Ferreira I, Rodrigues-Martins A, Bento I, Riparbelli M, Zhang W, Laue E, Callaini G, Glover DM, Bettencourt-Dias M.

Curr Biol. 2009 Jan 13;19(1):43-9. doi: 10.1016/j.cub.2008.11.037. Epub 2008 Dec 11.


From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages.

Rodrigues-Martins A, Riparbelli M, Callaini G, Glover DM, Bettencourt-Dias M.

Cell Cycle. 2008 Jan 1;7(1):11-6. Epub 2007 Oct 26.


Double life of centrioles: CP110 in the spotlight.

Bettencourt-Dias M, Carvalho-Santos Z.

Trends Cell Biol. 2008 Jan;18(1):8-11.


DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly.

Rodrigues-Martins A, Bettencourt-Dias M, Riparbelli M, Ferreira C, Ferreira I, Callaini G, Glover DM.

Curr Biol. 2007 Sep 4;17(17):1465-72. Epub 2007 Aug 9.


Centrosome biogenesis and function: centrosomics brings new understanding.

Bettencourt-Dias M, Glover DM.

Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63. Review.


Revisiting the role of the mother centriole in centriole biogenesis.

Rodrigues-Martins A, Riparbelli M, Callaini G, Glover DM, Bettencourt-Dias M.

Science. 2007 May 18;316(5827):1046-50. Epub 2007 Apr 26.


SAK/PLK4 is required for centriole duplication and flagella development.

Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, Riparbelli M, Lehmann L, Gatt MK, Carmo N, Balloux F, Callaini G, Glover DM.

Curr Biol. 2005 Dec 20;15(24):2199-207. Epub 2005 Dec 1.


Genome-wide survey of protein kinases required for cell cycle progression.

Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG, Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, Cooper M, Jones D, Frenz L, Glover DM.

Nature. 2004 Dec 23;432(7020):980-7.


Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.

Bettencourt-Dias M, Mittnacht S, Brockes JP.

J Cell Sci. 2003 Oct 1;116(Pt 19):4001-9. Epub 2003 Aug 19.

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