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Items: 1 to 50 of 267

1.

Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour.

Kotini MP, Mäe MA, Belting HG, Betsholtz C, Affolter M.

Vascul Pharmacol. 2018 Nov 10. pii: S1537-1891(18)30194-0. doi: 10.1016/j.vph.2018.11.002. [Epub ahead of print] Review.

PMID:
30423447
2.

Multiple roles of lymphatic vessels in peripheral lymph node development.

Bovay E, Sabine A, Prat-Luri B, Kim S, Son K, Willrodt AH, Olsson C, Halin C, Kiefer F, Betsholtz C, Jeon NL, Luther SA, Petrova TV.

J Exp Med. 2018 Nov 5;215(11):2760-2777. doi: 10.1084/jem.20180217. Epub 2018 Oct 24.

PMID:
30355615
3.

Single-Cell mRNA Sequencing of the Mouse Brain Vasculature.

Vanlandewijck M, Betsholtz C.

Methods Mol Biol. 2018;1846:309-324. doi: 10.1007/978-1-4939-8712-2_21.

PMID:
30242769
4.

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.

He L, Vanlandewijck M, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Segerstolpe Å, Liu J, Gustafsson S, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Sci Data. 2018 Aug 21;5:180160. doi: 10.1038/sdata.2018.160.

5.

Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state.

Mihajlica N, Betsholtz C, Hammarlund-Udenaes M.

Eur J Pharm Sci. 2018 Nov 1;124:182-187. doi: 10.1016/j.ejps.2018.08.009. Epub 2018 Aug 9.

PMID:
30098392
6.

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events.

Honkura N, Richards M, Laviña B, Sáinz-Jaspeado M, Betsholtz C, Claesson-Welsh L.

Nat Commun. 2018 Jul 16;9(1):2746. doi: 10.1038/s41467-018-04929-8.

7.

Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier.

Mihajlica N, Betsholtz C, Hammarlund-Udenaes M.

Eur J Pharm Sci. 2018 Sep 15;122:77-84. doi: 10.1016/j.ejps.2018.06.018. Epub 2018 Jun 20.

PMID:
29933077
8.

Author Correction: A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Nature. 2018 Aug;560(7716):E3. doi: 10.1038/s41586-018-0232-x.

PMID:
29925939
9.

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.

Laviña B, Castro M, Niaudet C, Cruys B, Álvarez-Aznar A, Carmeliet P, Bentley K, Brakebusch C, Betsholtz C, Gaengel K.

Development. 2018 Jul 2;145(13). pii: dev161182. doi: 10.1242/dev.161182.

PMID:
29853619
10.

PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung.

Gouveia L, Betsholtz C, Andrae J.

Development. 2018 Apr 10;145(7). pii: dev161976. doi: 10.1242/dev.161976.

11.

Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures.

Kuppe C, Rohlfs W, Grepl M, Schulte K, Veron D, Elger M, Sanden SK, Saritas T, Andrae J, Betsholtz C, Trautwein C, Hausmann R, Quaggin S, Bachmann S, Kriz W, Tufro A, Floege J, Moeller MJ.

Nephrol Dial Transplant. 2018 Apr 9. doi: 10.1093/ndt/gfy057. [Epub ahead of print]

PMID:
29635428
12.

Global analysis of A-to-I RNA editing reveals association with common disease variants.

Franzén O, Ermel R, Sukhavasi K, Jain R, Jain A, Betsholtz C, Giannarelli C, Kovacic JC, Ruusalepp A, Skogsberg J, Hao K, Schadt EE, Björkegren JLM.

PeerJ. 2018 Mar 6;6:e4466. doi: 10.7717/peerj.4466. eCollection 2018.

13.

A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Nature. 2018 Feb 22;554(7693):475-480. doi: 10.1038/nature25739. Epub 2018 Feb 14. Erratum in: Nature. 2018 Aug;560(7716):E3.

PMID:
29443965
14.

Cell-cell signaling in blood vessel development and function.

Betsholtz C.

EMBO Mol Med. 2018 Mar;10(3). pii: e8610. doi: 10.15252/emmm.201708610.

15.

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.

Loganathan K, Salem Said E, Winterrowd E, Orebrand M, He L, Vanlandewijck M, Betsholtz C, Quaggin SE, Jeansson M.

PLoS One. 2018 Jan 2;13(1):e0189433. doi: 10.1371/journal.pone.0189433. eCollection 2018.

16.

Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension.

Tannenberg P, Chang YT, Muhl L, Laviña B, Gladh H, Genové G, Betsholtz C, Folestad E, Tran-Lundmark K.

Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L593-L605. doi: 10.1152/ajplung.00054.2017. Epub 2017 Dec 6.

PMID:
29212800
17.

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.

Wang Y, Jin Y, Mäe MA, Zhang Y, Ortsäter H, Betsholtz C, Mäkinen T, Jakobsson L.

Development. 2017 Oct 1;144(19):3590-3601. doi: 10.1242/dev.147967. Epub 2017 Aug 29.

18.

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

De La Fuente AG, Lange S, Silva ME, Gonzalez GA, Tempfer H, van Wijngaarden P, Zhao C, Di Canio L, Trost A, Bieler L, Zaunmair P, Rotheneichner P, O'Sullivan A, Couillard-Despres S, Errea O, Mäe MA, Andrae J, He L, Keller A, Bátiz LF, Betsholtz C, Aigner L, Franklin RJM, Rivera FJ.

Cell Rep. 2017 Aug 22;20(8):1755-1764. doi: 10.1016/j.celrep.2017.08.007.

19.

Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy.

Liu P, Lassén E, Nair V, Berthier CC, Suguro M, Sihlbom C, Kretzler M, Betsholtz C, Haraldsson B, Ju W, Ebefors K, Nyström J.

J Am Soc Nephrol. 2017 Oct;28(10):2961-2972. doi: 10.1681/ASN.2016101103. Epub 2017 Jun 23.

20.

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

Jin Y, Muhl L, Burmakin M, Wang Y, Duchez AC, Betsholtz C, Arthur HM, Jakobsson L.

Nat Cell Biol. 2017 Jun;19(6):639-652. doi: 10.1038/ncb3534. Epub 2017 May 22.

21.

Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung.

Gouveia L, Betsholtz C, Andrae J.

Physiol Rep. 2017 Mar;5(6). pii: e13092. doi: 10.14814/phy2.13092.

22.

Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice.

Jung B, Arnold TD, Raschperger E, Gaengel K, Betsholtz C.

J Cereb Blood Flow Metab. 2018 Mar;38(3):456-468. doi: 10.1177/0271678X17697720. Epub 2017 Mar 9.

PMID:
28276839
23.

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M; Wellcome Trust Case Control Consortium, Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J; MORGAM Investigators, Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ, Schunkert H, Deloukas P, Kathiresan S; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators.

J Am Coll Cardiol. 2017 Feb 21;69(7):823-836. doi: 10.1016/j.jacc.2016.11.056.

24.

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, Strauss E, Van't Hof FN, Webb TR, Erdman R, Ritchie MD, Elmore JR, Verma A, Pendergrass S, Kullo IJ, Ye Z, Peissig PL, Gottesman O, Verma SS, Malinowski J, Rasmussen-Torvik LJ, Borthwick KM, Smelser DT, Crosslin DR, de Andrade M, Ryer EJ, McCarty CA, Böttinger EP, Pacheco JA, Crawford DC, Carrell DS, Gerhard GS, Franklin DP, Carey DJ, Phillips VL, Williams MJ, Wei W, Blair R, Hill AA, Vasudevan TM, Lewis DR, Thomson IA, Krysa J, Hill GB, Roake J, Merriman TR, Oszkinis G, Galora S, Saracini C, Abbate R, Pulli R, Pratesi C, Saratzis A, Verissimo AR, Bumpstead S, Badger SA, Clough RE, Cockerill G, Hafez H, Scott DJ, Futers TS, Romaine SP, Bridge K, Griffin KJ, Bailey MA, Smith A, Thompson MM, van Bockxmeer FM, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JA, Wijmenga C, de Graaf J, Kiemeney LA, Lindholt JS, Hughes A, Bradley DT, Stirrups K, Golledge J, Norman PE, Powell JT, Humphries SE, Hamby SE, Goodall AH, Nelson CP, Sakalihasan N, Courtois A, Ferrell RE, Eriksson P, Folkersen L, Franco-Cereceda A, Eicher JD, Johnson AD, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Lipovich L, Drolet AM, Verhoeven EL, Zeebregts CJ, Geelkerken RH, van Sambeek MR, van Sterkenburg SM, de Vries JP, Stefansson K, Thompson JR, de Bakker PI, Deloukas P, Sayers RD, Harrison SC, van Rij AM, Samani NJ, Bown MJ.

Circ Res. 2017 Jan 20;120(2):341-353. doi: 10.1161/CIRCRESAHA.116.308765. Epub 2016 Nov 29.

25.

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice.

Gallini R, Lindblom P, Bondjers C, Betsholtz C, Andrae J.

Exp Cell Res. 2016 Dec 10;349(2):282-290. doi: 10.1016/j.yexcr.2016.10.022. Epub 2016 Nov 2.

26.

Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH.

Nature. 2016 Nov 10;539(7628):314. doi: 10.1038/nature19782. Epub 2016 Sep 14. No abstract available.

PMID:
27626373
27.

Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.

Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V.

Cell Stem Cell. 2016 Dec 1;19(6):738-751. doi: 10.1016/j.stem.2016.09.002. Epub 2016 Oct 13.

28.

Analysis of the brain mural cell transcriptome.

He L, Vanlandewijck M, Raschperger E, Andaloussi Mäe M, Jung B, Lebouvier T, Ando K, Hofmann J, Keller A, Betsholtz C.

Sci Rep. 2016 Oct 11;6:35108. doi: 10.1038/srep35108.

29.

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JL.

Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126/science.aad6970.

30.

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart.

Gallini R, Huusko J, Ylä-Herttuala S, Betsholtz C, Andrae J.

PLoS One. 2016 Aug 11;11(8):e0160930. doi: 10.1371/journal.pone.0160930. eCollection 2016.

31.

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.

Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, Assimes TL, Montgomery SB, Schadt EE, Björkegren JL, Quertermous T.

Nat Commun. 2016 Jul 8;7:12092. doi: 10.1038/ncomms12092.

32.

A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K.

Sci Rep. 2016 May 16;6:25955. doi: 10.1038/srep25955.

33.

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.

Villaseñor R, Ozmen L, Messaddeq N, Grüninger F, Loetscher H, Keller A, Betsholtz C, Freskgård PO, Collin L.

Sci Rep. 2016 May 6;6:25658. doi: 10.1038/srep25658.

34.

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH.

Nature. 2016 Apr 21;532(7599):380-4. doi: 10.1038/nature17638. Epub 2016 Apr 13. Erratum in: Nature. 2016 Nov 10;539(7628):314.

35.

Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype.

Gladh H, Folestad EB, Muhl L, Ehnman M, Tannenberg P, Lawrence AL, Betsholtz C, Eriksson U.

PLoS One. 2016 Mar 31;11(3):e0152276. doi: 10.1371/journal.pone.0152276. eCollection 2016.

36.

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L.

Nat Commun. 2016 Mar 23;7:11017. doi: 10.1038/ncomms11017.

37.

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex.

Andrae J, Gouveia L, Gallini R, He L, Fredriksson L, Nilsson I, Johansson BR, Eriksson U, Betsholtz C.

Biol Open. 2016 Apr 15;5(4):461-74. doi: 10.1242/bio.017368.

38.

NEURODEVELOPMENT. Oligodendrocytes follow blood vessel trails in the brain.

Dejana E, Betsholtz C.

Science. 2016 Jan 22;351(6271):341-2. doi: 10.1126/science.aaf1139. No abstract available.

PMID:
26798001
39.

An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors.

Tobin NP, Wennmalm K, Lindström LS, Foukakis T, He L, Genové G, Östman A, Landberg G, Betsholtz C, Bergh J.

Clin Cancer Res. 2016 May 15;22(10):2417-26. doi: 10.1158/1078-0432.CCR-15-1691. Epub 2016 Jan 14.

40.

Vascular biology: Transcriptional control of endothelial energy.

Betsholtz C.

Nature. 2016 Jan 14;529(7585):160-1. doi: 10.1038/nature16866. Epub 2016 Jan 6. No abstract available.

PMID:
26735011
41.

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.

Vanlandewijck M, Lebouvier T, Andaloussi Mäe M, Nahar K, Hornemann S, Kenkel D, Cunha SI, Lennartsson J, Boss A, Heldin CH, Keller A, Betsholtz C.

PLoS One. 2015 Nov 23;10(11):e0143407. doi: 10.1371/journal.pone.0143407. eCollection 2015.

42.

Establishment and Dysfunction of the Blood-Brain Barrier.

Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV.

Cell. 2015 Nov 19;163(5):1064-1078. doi: 10.1016/j.cell.2015.10.067. Review.

43.

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium.

Niaudet C, Hofmann JJ, Mäe MA, Jung B, Gaengel K, Vanlandewijck M, Ekvärn E, Salvado MD, Mehlem A, Al Sayegh S, He L, Lebouvier T, Castro-Freire M, Katayama K, Hultenby K, Moessinger C, Tannenberg P, Cunha S, Pietras K, Laviña B, Hong J, Berg T, Betsholtz C.

PLoS One. 2015 Sep 22;10(9):e0137949. doi: 10.1371/journal.pone.0137949. eCollection 2015.

44.

Knockdown of Tmem234 in zebrafish results in proteinuria.

Rodriguez PQ, Oddsson A, Ebarasi L, He B, Hultenby K, Wernerson A, Betsholtz C, Tryggvason K, Patrakka J.

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F955-66. doi: 10.1152/ajprenal.00525.2014. Epub 2015 Sep 16.

45.

Lipid transport and human brain development.

Betsholtz C.

Nat Genet. 2015 Jul;47(7):699-701. doi: 10.1038/ng.3348.

PMID:
26111510
46.

Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 May 12;10(5):e0126079. doi: 10.1371/journal.pone.0126079. eCollection 2015. No abstract available.

47.

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.

Pang MF, Georgoudaki AM, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander JS, Nelson CM, Jakobsson L, Betsholtz C, Sund M, Karlsson MC, Fuxe J.

Oncogene. 2016 Feb 11;35(6):748-60. doi: 10.1038/onc.2015.133. Epub 2015 May 11.

48.

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 Mar 25;10(3):e0122067. doi: 10.1371/journal.pone.0122067. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126079.

49.

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T.

Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00172-2. doi: 10.1016/j.celrep.2015.02.026. [Epub ahead of print]

50.

Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.

Zeisel A, Muñoz-Manchado AB, Codeluppi S, Lönnerberg P, La Manno G, Juréus A, Marques S, Munguba H, He L, Betsholtz C, Rolny C, Castelo-Branco G, Hjerling-Leffler J, Linnarsson S.

Science. 2015 Mar 6;347(6226):1138-42. doi: 10.1126/science.aaa1934. Epub 2015 Feb 19.

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