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Items: 13


Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.

Garner KL, Betin VMS, Pinto V, Graham M, Abgueguen E, Barnes M, Bedford DC, McArdle CA, Coward RJM.

Sci Rep. 2018 Mar 2;8(1):3902. doi: 10.1038/s41598-018-22233-9.


Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Østergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM.

Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29.


Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.

Betin VM, Singleton BK, Parsons SF, Anstee DJ, Lane JD.

Autophagy. 2013 Jun 1;9(6):881-93. doi: 10.4161/auto.24172. Epub 2013 Mar 18.


The ins and outs of human reticulocyte maturation: autophagy and the endosome/exosome pathway.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VM, Trakarnsanga K, Massey EJ, Parsons SF, Anstee DJ, Lane JD.

Autophagy. 2012 Jul 1;8(7):1150-1. doi: 10.4161/auto.20648. Epub 2012 Jun 4.


Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VM, Trakarnsanga K, Massey EJ, Lane JD, Parsons SF, Anstee DJ.

Blood. 2012 Jun 28;119(26):6296-306. doi: 10.1182/blood-2011-09-376475. Epub 2012 Apr 6.


A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress.

Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD.

Autophagy. 2012 Apr;8(4):664-76. doi: 10.4161/auto.19227. Epub 2012 Apr 1.


Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis.

Cheng JP, Betin VM, Weir H, Shelmani GM, Moss DK, Lane JD.

Cell Death Dis. 2010 Oct 7;1:e82. doi: 10.1038/cddis.2010.59.


Atg4D at the interface between autophagy and apoptosis.

Betin VM, Lane JD.

Autophagy. 2009 Oct;5(7):1057-9. Epub 2009 Oct 27.


Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.

Betin VM, Lane JD.

J Cell Sci. 2009 Jul 15;122(Pt 14):2554-66. doi: 10.1242/jcs.046250. Epub 2009 Jun 23.


The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase.

Betin VM, Lane JD.

SEB Exp Biol Ser. 2008;59:267-89. No abstract available.


A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation.

Moss DK, Betin VM, Malesinski SD, Lane JD.

J Cell Sci. 2006 Jun 1;119(Pt 11):2362-74.


Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

Gillespie KM, Nolsøe R, Betin VM, Kristiansen OP, Bingley PJ, Mandrup-Poulsen T, Gale EA.

Diabetes. 2005 Apr;54(4):1245-8.


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