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Items: 9

1.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.

Cox JA, Abrahams KA, Alemparte C, Ghidelli-Disse S, Rullas J, Angulo-Barturen I, Singh A, Gurcha SS, Nataraj V, Bethell S, Remuiñán MJ, Encinas L, Jervis PJ, Cammack NC, Bhatt A, Kruse U, Bantscheff M, Fütterer K, Barros D, Ballell L, Drewes G, Besra GS.

Nat Microbiol. 2016 Jan 18;1:15006. doi: 10.1038/nmicrobiol.2015.6.

PMID:
27571973
2.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT.

Mol Cancer Ther. 2011 Sep;10(9):1542-52. doi: 10.1158/1535-7163.MCT-11-0426. Epub 2011 Jul 15.

3.

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Andrews DM, Baker G, Bethell SS, Carey S, Chaignot H, Clarke B, Coomber B, Ellis M, Good A, Gray N, Hardy G, Jones P, Mills G, Robinson E.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3359-62.

PMID:
12419361
4.

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains.

England BP, Balasubramanian P, Uings I, Bethell S, Chen MJ, Schatz PJ, Yin Q, Chen YF, Whitehorn EA, Tsavaler A, Martens CL, Barrett RW, McKinnon M.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6862-7.

5.

Kinetic properties of human dopamine sulfotransferase (SULT1A3) expressed in prokaryotic and eukaryotic systems: comparison with the recombinant enzyme purified from Escherichia coli.

Dajani R, Sharp S, Graham S, Bethell SS, Cooke RM, Jamieson DJ, Coughtrie MW.

Protein Expr Purif. 1999 Jun;16(1):11-8.

PMID:
10336855
6.

Single amino acid substitutions disrupt tetramer formation in the dihydroneopterin aldolase enzyme of Pneumocystis carinii.

Thomas MC, Ballantine SP, Bethell SS, Bains S, Kellam P, Delves CJ.

Biochemistry. 1998 Aug 18;37(33):11629-36.

PMID:
9709001
7.

Purification and biochemical properties of soluble recombinant human Bax.

Lewis S, Bethell SS, Patel S, Martinou JC, Antonsson B.

Protein Expr Purif. 1998 Jun;13(1):120-6.

PMID:
9631524
8.

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.

Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.

Biochemistry. 1998 May 12;37(19):6645-57.

PMID:
9578548
9.

Evidence for a double-helical structure for modular polyketide synthases.

Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF.

Nat Struct Biol. 1996 Feb;3(2):188-92.

PMID:
8564546

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