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Items: 7


A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel.

Argudo D, Capponi S, Bethel NP, Grabe M.

J Gen Physiol. 2019 Feb 6. pii: jgp.201812266. doi: 10.1085/jgp.201812266. [Epub ahead of print]


Chemically induced vesiculation as a platform for studying TMEM16F activity.

Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1309-1318. doi: 10.1073/pnas.1817498116. Epub 2019 Jan 8.


The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY.

Neuron. 2018 Mar 7;97(5):1063-1077.e4. doi: 10.1016/j.neuron.2018.01.048. Epub 2018 Feb 22.


Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates.

Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL.

Mol Biol Cell. 2017 Jul 15;28(15):2076-2090. doi: 10.1091/mbc.E17-03-0184. Epub 2017 May 24.


New Continuum Approaches for Determining Protein-Induced Membrane Deformations.

Argudo D, Bethel NP, Marcoline FV, Wolgemuth CW, Grabe M.

Biophys J. 2017 May 23;112(10):2159-2172. doi: 10.1016/j.bpj.2017.03.040.


Atomistic insight into lipid translocation by a TMEM16 scramblase.

Bethel NP, Grabe M.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14049-14054. Epub 2016 Nov 21.


Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models.

Argudo D, Bethel NP, Marcoline FV, Grabe M.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1619-34. doi: 10.1016/j.bbamem.2016.02.003. Epub 2016 Feb 4. Review.

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