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Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ.

Mol Psychiatry. 2018 Aug 16. doi: 10.1038/s41380-018-0214-2. [Epub ahead of print]


Wide Range of Clinical Outcomes in Patients with Gliomatosis Cerebri Growth Pattern: A Clinical, Radiographic, and Histopathologic Study.

Ly KI, Oakley DH, Pine AB, Frosch MP, Chiou SH, Betensky RA, Pomerantz SR, Hochberg FH, Batchelor TT, Cahill DP, Dietrich J.

Oncologist. 2018 Aug 10. pii: theoncologist.2018-0086. doi: 10.1634/theoncologist.2018-0086. [Epub ahead of print]


Multi-crossover randomized controlled trial designs in Alzheimer's disease.

Arnold SE, Betensky RA.

Ann Neurol. 2018 Jul 16. doi: 10.1002/ana.25280. [Epub ahead of print]


Threshold regression to accommodate a censored covariate.

Qian J, Chiou SH, Maye JE, Atem F, Johnson KA, Betensky RA.

Biometrics. 2018 Jun 22. doi: 10.1111/biom.12922. [Epub ahead of print]


The Prognostic Value of Histopathologic Lesions in Native Kidney Biopsy Specimens: Results from the Boston Kidney Biopsy Cohort Study.

Srivastava A, Palsson R, Kaze AD, Chen ME, Palacios P, Sabbisetti V, Betensky RA, Steinman TI, Thadhani RI, McMahon GM, Stillman IE, Rennke HG, Waikar SS.

J Am Soc Nephrol. 2018 Aug;29(8):2213-2224. doi: 10.1681/ASN.2017121260. Epub 2018 Jun 4.


Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.

Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, Clark TW, Betensky RA, Hyman BT, Hudry E.

J Neurochem. 2018 May 28. doi: 10.1111/jnc.14469. [Epub ahead of print]


PET staging of amyloidosis using striatum.

Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA; Alzheimer's Disease Neuroimaging Initiative; Harvard Aging Brain Study.

Alzheimers Dement. 2018 May 21. pii: S1552-5260(18)30133-X. doi: 10.1016/j.jalz.2018.04.011. [Epub ahead of print]


rBPI21 (Opebacan) Promotes Rapid Trilineage Hematopoietic Recovery in a Murine Model of High-Dose Total Body Irradiation.

Janec KJ, Yuan H, Norton JE, Kelner RH, Hirt CK, Betensky RA, Guinan EC.

Am J Hematol. 2018 May 11. doi: 10.1002/ajh.25136. [Epub ahead of print]


Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results.

Schwamm LH, Wu O, Song SS, Latour LL, Ford AL, Hsia AW, Muzikansky A, Betensky RA, Yoo AJ, Lev MH, Boulouis G, Lauer A, Cougo P, Copen WA, Harris GJ, Warach S; MR WITNESS Investigators.

Ann Neurol. 2018 May;83(5):980-993. doi: 10.1002/ana.25235. Epub 2018 Apr 27.


Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts.

Kim IY, O'Reilly ÉJ, Hughes KC, Gao X, Schwarzschild MA, Hannan MT, Betensky RA, Ascherio A.

Neurology. 2018 May 8;90(19):e1646-e1653. doi: 10.1212/WNL.0000000000005473. Epub 2018 Apr 11.


Reader response: Systematic review and statistical analysis of the integrity of 33 randomized controlled trials.

Betensky RA, Chiou SH.

Neurology. 2018 Mar 20;90(12):578. doi: 10.1212/WNL.0000000000005157. No abstract available.


Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.

Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1289-E1298. doi: 10.1073/pnas.1710329115. Epub 2018 Jan 22.


Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk.

Kim IY, O'Reilly ÉJ, Hughes KC, Gao X, Schwarzschild MA, McCullough ML, Hannan MT, Betensky RA, Ascherio A.

Mov Disord. 2018 Mar;33(3):414-420. doi: 10.1002/mds.27279. Epub 2018 Jan 10.


Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease.

Lee C, Betensky RA; Alzheimer's Disease Neuroimaging Initiative.

Stat Med. 2018 Mar 15;37(6):914-932. doi: 10.1002/sim.7547. Epub 2017 Dec 20.


Inverse probability weighted Cox regression for doubly truncated data.

Mandel M, de Uña-Álvarez J, Simon DK, Betensky RA.

Biometrics. 2018 Jun;74(2):481-487. doi: 10.1111/biom.12771. Epub 2017 Sep 8.


Correlation among baseline variables yields non-uniformity of p-values.

Betensky RA, Chiou SH.

PLoS One. 2017 Sep 8;12(9):e0184531. doi: 10.1371/journal.pone.0184531. eCollection 2017.


Association of cancer and Alzheimer's disease risk in a national cohort of veterans.

Frain L, Swanson D, Cho K, Gagnon D, Lu KP, Betensky RA, Driver J.

Alzheimers Dement. 2017 Dec;13(12):1364-1370. doi: 10.1016/j.jalz.2017.04.012. Epub 2017 Jul 12.


Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.

Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ.

Mol Neurodegener. 2017 Mar 21;12(1):27. doi: 10.1186/s13024-017-0169-9.


APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.

Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D.

PLoS Med. 2017 Mar 21;14(3):e1002254. doi: 10.1371/journal.pmed.1002254. eCollection 2017 Mar.


Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA.

Ann Neurol. 2017 Apr;81(4):583-596. doi: 10.1002/ana.24910. Epub 2017 Apr 6.


Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study.

Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA.

J R Stat Soc Ser C Appl Stat. 2017;66(2):313-328. doi: 10.1111/rssc.12164. Epub 2016 Jun 27.


Biomarker validation with an imperfect reference: Issues and bounds.

Emerson SC, Waikar SS, Fuentes C, Bonventre JV, Betensky RA.

Stat Methods Med Res. 2017 Jan 1:962280216689806. doi: 10.1177/0962280216689806. [Epub ahead of print]


Is this significant?

Betensky RA.

Ann Neurol. 2017 Mar;81(3):344-347. doi: 10.1002/ana.24868. No abstract available.


A Concept-Wide Association Study of Clinical Notes to Discover New Predictors of Kidney Failure.

Singh K, Betensky RA, Wright A, Curhan GC, Bates DW, Waikar SS.

Clin J Am Soc Nephrol. 2016 Dec 7;11(12):2150-2158. Epub 2016 Oct 10.


An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.

Matsouaka RA, Singhal AB, Betensky RA.

Stat Methods Med Res. 2018 Aug;27(8):2384-2400. doi: 10.1177/0962280216680524. Epub 2016 Dec 29.


Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance.

Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA.

Brain Imaging Behav. 2017 Apr;11(2):383-390. doi: 10.1007/s11682-016-9640-4.


Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis.

Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA.

J Appl Stat. 2016;43(15):2886-2896. Epub 2016 Mar 16.


Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly.

Dhilla Albers A, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW.

Ann Neurol. 2016 Dec;80(6):846-857. doi: 10.1002/ana.24792. Epub 2016 Nov 23.


Comparison of Urine Output among Patients Treated with More Intensive Versus Less Intensive RRT: Results from the Acute Renal Failure Trial Network Study.

Mc Causland FR, Asafu-Adjei J, Betensky RA, Palevsky PM, Waikar SS.

Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1335-42. doi: 10.2215/CJN.10991015. Epub 2016 Jul 22.


Decreased hippocampal metabolism in high-amyloid mild cognitive impairment.

Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA.

Alzheimers Dement. 2016 Dec;12(12):1288-1296. doi: 10.1016/j.jalz.2016.06.2357. Epub 2016 Jul 13.


Optimization of Signal Decomposition Matched Filtering (SDMF) for Improved Detection of Copy-Number Variations.

Stamoulis C, Betensky RA.

IEEE/ACM Trans Comput Biol Bioinform. 2016 May-Jun;13(3):584-91. doi: 10.1109/TCBB.2015.2448077.


Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.

Okada K, LeClair KB, Zhang Y, Li Y, Ozdemir C, Krisko TI, Hagen SJ, Betensky RA, Banks AS, Cohen DE.

Mol Metab. 2016 Feb 23;5(5):340-351. doi: 10.1016/j.molmet.2016.02.002. eCollection 2016 May.


Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.

Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT.

J Neuropathol Exp Neurol. 2016 Jun;75(6):516-26. doi: 10.1093/jnen/nlw026. Epub 2016 Apr 22.


A Pairwise Naïve Bayes Approach to Bayesian Classification.

Asafu-Adjei JK, Betensky RA.

Intern J Pattern Recognit Artif Intell. 2015 Oct 1;29(7). pii: 1550023. Epub 2015 Jul 28.


Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring.

Maye JE, Betensky RA, Gidicsin CM, Locascio J, Becker JA, Pepin L, Carmasin J, Rentz DM, Marshall GA, Blacker D, Sperling RA, Johnson KA.

Neurobiol Aging. 2016 Apr;40:61-67. doi: 10.1016/j.neurobiolaging.2015.12.013. Epub 2015 Dec 28.


Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.

Serrano-Pozo A, Betensky RA, Frosch MP, Hyman BT.

Am J Pathol. 2016 Feb;186(2):375-84. doi: 10.1016/j.ajpath.2015.10.010. Epub 2015 Dec 11.


Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV.

Grishchuk Y, Stember KG, Matsunaga A, Olivares AM, Cruz NM, King VE, Humphrey DM, Wang SL, Muzikansky A, Betensky RA, Thoreson WB, Haider N, Slaugenhaupt SA.

Am J Pathol. 2016 Jan;186(1):199-209. doi: 10.1016/j.ajpath.2015.09.017. Epub 2015 Nov 20.


Tau positron emission tomographic imaging in aging and early Alzheimer disease.

Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R.

Ann Neurol. 2016 Jan;79(1):110-9. doi: 10.1002/ana.24546. Epub 2015 Dec 15.


Recognizing the problem of delayed entry in time-to-event studies: Better late than never for clinical neuroscientists.

Betensky RA, Mandel M.

Ann Neurol. 2015 Dec;78(6):839-44. doi: 10.1002/ana.24538. Epub 2015 Nov 13.


Research participant compensation: A matter of statistical inference as well as ethics.

Swanson DM, Betensky RA.

Contemp Clin Trials. 2015 Nov;45(Pt B):265-269. doi: 10.1016/j.cct.2015.08.014. Epub 2015 Aug 31.


Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy.

Zhao L, Arbel-Ornath M, Wang X, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ.

Neurobiol Aging. 2015 Nov;36(11):2963-2971. doi: 10.1016/j.neurobiolaging.2015.07.016. Epub 2015 Jul 16.


Measures of follow-up in time-to-event studies: Why provide them and what should they be?

Betensky RA.

Clin Trials. 2015 Aug;12(4):403-8. doi: 10.1177/1740774515586176. Epub 2015 May 29. Review.


Computationally simple analysis of matched, outcome-based studies of ordinal disease states.

Betensky RA, Szymonifka J, Lee EQ, Nutt CL, Batchelor TT.

Stat Med. 2015 Jul 30;34(17):2514-27. doi: 10.1002/sim.6503. Epub 2015 Apr 22.


APOEε2 is associated with milder clinical and pathological Alzheimer disease.

Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT.

Ann Neurol. 2015 Jun;77(6):917-29. doi: 10.1002/ana.24369.


Reductions in red blood cell 2,3-diphosphoglycerate concentration during continuous renal replacment therapy.

Sharma S, Brugnara C, Betensky RA, Waikar SS.

Clin J Am Soc Nephrol. 2015 Jan 7;10(1):74-9. doi: 10.2215/CJN.02160214. Epub 2014 Dec 23.


Vandetanib plus sirolimus in adults with recurrent glioblastoma: results of a phase I and dose expansion cohort study.

Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden AD, Gerstner ER, Betensky RA, Batchelor TT.

J Neurooncol. 2015 Feb;121(3):627-34. doi: 10.1007/s11060-014-1680-2. Epub 2014 Dec 13.


The effect of hospital care on early survival after penetrating trauma.

Clark DE, Doolittle PC, Winchell RJ, Betensky RA.

Inj Epidemiol. 2014 Dec;1(1):24. Epub 2014 Sep 17.


Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma.

Taylor JW, Dietrich J, Gerstner ER, Norden AD, Rinne ML, Cahill DP, Stemmer-Rachamimov A, Wen PY, Betensky RA, Giorgio DH, Snodgrass K, Randall AE, Batchelor TT, Chi AS.

J Neurooncol. 2015 Feb;121(3):557-63. doi: 10.1007/s11060-014-1667-z. Epub 2014 Nov 20.


Power and sample size calculations for the Wilcoxon-Mann-Whitney test in the presence of death-censored observations.

Matsouaka RA, Betensky RA.

Stat Med. 2015 Feb 10;34(3):406-31. doi: 10.1002/sim.6355. Epub 2014 Nov 13.

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