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Items: 45


Helicobacter pylori elicits B7H3 expression on gastric epithelial cells: Implications in local T cell regulation and subset development during infection.

Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE.

Clin Oncol Res. 2019;2(5). doi: 10.31487/j.cor.2019.05.05. Epub 2019 Oct 10.


Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn's disease and regulate Th1/Th17 cell responses.

Aguirre JE, Beswick EJ, Grim C, Uribe G, Tafoya M, Chacon Palma G, Samedi V, McKee R, Villeger R, Fofanov Y, Cong Y, Yochum G, Koltun W, Powell D, Pinchuk IV.

Int Immunol. 2020 Jan 9;32(1):57-68. doi: 10.1093/intimm/dxz060.


G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis.

Jacenik D, Beswick EJ, Krajewska WM, Prossnitz ER.

World J Gastroenterol. 2019 Aug 14;25(30):4092-4104. doi: 10.3748/wjg.v25.i30.4092. Review.


MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma.

Berggren KL, Restrepo Cruz S, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN.

Oncogene. 2019 Nov;38(48):7329-7341. doi: 10.1038/s41388-019-0945-9. Epub 2019 Aug 15.


MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth.

Phinney BB, Ray AL, Peretti AS, Jerman SJ, Grim C, Pinchuk IV, Beswick EJ.

Front Immunol. 2018 Sep 21;9:1857. doi: 10.3389/fimmu.2018.01857. eCollection 2018.


Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn's Disease and Determines Their Capacity to Suppress Th1 Cells.

Beswick EJ, Grim C, Singh A, Aguirre JE, Tafoya M, Qiu S, Rogler G, McKee R, Samedi V, Ma TY, Reyes VE, Powell DW, Pinchuk IV.

Front Immunol. 2018 May 30;9:1125. doi: 10.3389/fimmu.2018.01125. eCollection 2018.


Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth.

Ray AL, Berggren KL, Restrepo Cruz S, Gan GN, Beswick EJ.

Int J Cancer. 2018 Apr 15;142(8):1702-1711. doi: 10.1002/ijc.31191. Epub 2017 Dec 12.


MK2: an unrecognized regulator of tumor promoting macrophages in colorectal cancer?

Castillo EF, Ray AL, Beswick EJ.

Macrophage (Houst). 2016;3. pii: e1166. Epub 2016 Feb 1.


Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens.

Johnson P, Beswick EJ, Chao C, Powell DW, Hellmich MR, Pinchuk IV.

J Vis Exp. 2016 Jan 31;(107):e53691. doi: 10.3791/53691.


CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer.

Huynh PT, Beswick EJ, Coronado YA, Johnson P, O'Connell MR, Watts T, Singh P, Qiu S, Morris K, Powell DW, Pinchuk IV.

Int J Cancer. 2016 Apr 15;138(8):1971-81. doi: 10.1002/ijc.29939. Epub 2015 Dec 10.


Blockade of MK2 is protective in inflammation-associated colorectal cancer development.

Ray AL, Castillo EF, Morris KT, Nofchissey RA, Weston LL, Samedi VG, Hanson JA, Gaestel M, Pinchuk IV, Beswick EJ.

Int J Cancer. 2016 Feb 1;138(3):770-5. doi: 10.1002/ijc.29716. Epub 2015 Aug 21.


Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses.

Morris KT, Castillo EF, Ray AL, Weston LL, Nofchissey RA, Hanson JA, Samedi VG, Pinchuk IV, Hudson LG, Beswick EJ.

Oncotarget. 2015 Sep 8;6(26):22338-47.


Effect of Helicobacter pylori on gastric epithelial cells.

Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE.

World J Gastroenterol. 2014 Sep 28;20(36):12767-80. doi: 10.3748/wjg.v20.i36.12767. Review.


Immune evasion strategies used by Helicobacter pylori.

Lina TT, Alzahrani S, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE.

World J Gastroenterol. 2014 Sep 28;20(36):12753-66. doi: 10.3748/wjg.v20.i36.12753. Review.


Differential susceptibility of human peripheral blood T cells to suppression by environmental levels of sodium arsenite and monomethylarsonous acid.

Burchiel SW, Lauer FT, Beswick EJ, Gandolfi AJ, Parvez F, Liu KJ, Hudson LG.

PLoS One. 2014 Oct 1;9(10):e109192. doi: 10.1371/journal.pone.0109192. eCollection 2014.


TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.

Beswick EJ, Johnson JR, Saada JI, Humen M, House J, Dann S, Qiu S, Brasier AR, Powell DW, Reyes VE, Pinchuk IV.

J Immunol. 2014 Sep 1;193(5):2218-29. doi: 10.4049/jimmunol.1203441. Epub 2014 Jul 28.


Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers.

Morris KT, Nofchissey RA, Pinchuk IV, Beswick EJ.

PLoS One. 2014 Jun 2;9(6):e98656. doi: 10.1371/journal.pone.0098656. eCollection 2014.


G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration.

Morris KT, Khan H, Ahmad A, Weston LL, Nofchissey RA, Pinchuk IV, Beswick EJ.

Br J Cancer. 2014 Mar 4;110(5):1211-20. doi: 10.1038/bjc.2013.822. Epub 2014 Jan 21.


CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection.

Lina TT, Pinchuk IV, House J, Yamaoka Y, Graham DY, Beswick EJ, Reyes VE.

J Immunol. 2013 Oct 1;191(7):3838-46. doi: 10.4049/jimmunol.1300524. Epub 2013 Aug 30.


Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment.

Pinchuk IV, Morris KT, Nofchissey RA, Earley RB, Wu JY, Ma TY, Beswick EJ.

PLoS One. 2013;8(1):e53798. doi: 10.1371/journal.pone.0053798. Epub 2013 Jan 24.


Inflammation, immunity, and vaccines for Helicobacter pylori infection.

Ihan A, Pinchuk IV, Beswick EJ.

Helicobacter. 2012 Sep;17 Suppl 1:16-21. doi: 10.1111/j.1523-5378.2012.00977.x. Review.


Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection.

Beswick EJ, Pinchuk IV, Earley RB, Schmitt DA, Reyes VE.

Infect Immun. 2011 Jul;79(7):2737-45. doi: 10.1128/IAI.01146-10. Epub 2011 Apr 11.


Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.

Pinchuk IV, Beswick EJ, Saada JI, Boya G, Schmitt D, Raju GS, Brenmoehl J, Rogler G, Reyes VE, Powell DW.

Gastroenterology. 2011 Jun;140(7):2019-30. doi: 10.1053/j.gastro.2011.02.059. Epub 2011 Mar 2.


Staphylococcal enterotoxins.

Pinchuk IV, Beswick EJ, Reyes VE.

Toxins (Basel). 2010 Aug;2(8):2177-97. doi: 10.3390/toxins2082177. Epub 2010 Aug 18. Review.


CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

Beswick EJ, Reyes VE.

World J Gastroenterol. 2009 Jun 21;15(23):2855-61. Review.


PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.

Pinchuk IV, Saada JI, Beswick EJ, Boya G, Qiu SM, Mifflin RC, Raju GS, Reyes VE, Powell DW.

Gastroenterology. 2008 Oct;135(4):1228-1237, 1237.e1-2. doi: 10.1053/j.gastro.2008.07.016. Epub 2008 Jul 17.


Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin a: relevance to staphylococcal enterotoxigenic disease.

Pinchuk IV, Beswick EJ, Saada JI, Suarez G, Winston J, Mifflin RC, Di Mari JF, Powell DW, Reyes VE.

J Immunol. 2007 Jun 15;178(12):8097-106.


Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains.

Lu H, Wu JY, Beswick EJ, Ohno T, Odenbreit S, Haas R, Reyes VE, Kita M, Graham DY, Yamaoka Y.

J Biol Chem. 2007 Mar 2;282(9):6242-54. Epub 2007 Jan 3.


H pylori and host interactions that influence pathogenesis.

Beswick EJ, Suarez G, Reyes VE.

World J Gastroenterol. 2006 Sep 21;12(35):5599-605. Review.


Immune response to H. pylori.

Suarez G, Reyes VE, Beswick EJ.

World J Gastroenterol. 2006 Sep 21;12(35):5593-8. Review.


H. pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response.

Bland DA, Suarez G, Beswick EJ, Sierra JC, Reyes VE.

World J Gastroenterol. 2006 Sep 7;12(33):5306-10.


H pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response.

Bland DA, Suarez G, Beswick EJ, Sierra JC, Reyes VE.

World J Gastroenterol. 2006 Aug 7;12(29):4689-93.


Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection.

Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE.

J Immunol. 2006 Mar 1;176(5):3000-9.


The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production.

Beswick EJ, Pinchuk IV, Minch K, Suarez G, Sierra JC, Yamaoka Y, Reyes VE.

Infect Immun. 2006 Feb;74(2):1148-55.


Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression.

Beswick EJ, Das S, Pinchuk IV, Adegboyega P, Suarez G, Yamaoka Y, Reyes VE.

J Immunol. 2005 Jul 1;175(1):171-6.


Polarized expression of CD74 by gastric epithelial cells.

Barrera CA, Beswick EJ, Sierra JC, Bland D, Espejo R, Mifflin R, Adegboyega P, Crowe SE, Ernst PB, Reyes VE.

J Histochem Cytochem. 2005 Dec;53(12):1481-9. Epub 2005 May 27.


Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production.

Beswick EJ, Bland DA, Suarez G, Barrera CA, Fan X, Reyes VE.

Infect Immun. 2005 May;73(5):2736-43.


Comparative studies of glycosaminoglycan involvement in Chlamydia pneumoniae and C. trachomatis invasion of host cells.

Beswick EJ, Travelstead A, Cooper MD.

J Infect Dis. 2003 Apr 15;187(8):1291-300. Epub 2003 Apr 2.


The relationship of clinical and laboratory measurements to radiological change in ankylosing spondylitis.

Taylor HG, Wardle T, Beswick EJ, Dawes PT.

Br J Rheumatol. 1991 Oct;30(5):330-5.


Sulphasalazine in ankylosing spondylitis. A radiological, clinical and laboratory assessment.

Taylor HG, Beswick EJ, Dawes PT.

Clin Rheumatol. 1991 Mar;10(1):43-8.


Quantitative radio-isotope scanning in ankylosing spondylitis: a clinical, laboratory and computerised tomographic study.

Taylor HG, Gadd R, Beswick EJ, Venkateswaran M, Dawes PT.

Scand J Rheumatol. 1991;20(4):274-9.


Enthesopathy index in ankylosing spondylitis.

Dawes PT, Sheeran TP, Beswick EJ, Hothersall TE.

Ann Rheum Dis. 1987 Sep;46(9):717. No abstract available.

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