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Items: 20


Heterocellular Contact Can Dictate Arterial Function.

Shu X, Ruddiman CA, Keller TCS 4th, Keller AS, Yang Y, Good ME, Best AK, Columbus L, Isakson BE.

Circ Res. 2019 May 10;124(10):1473-1481. doi: 10.1161/CIRCRESAHA.118.313926.


Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane.

DeLalio LJ, Billaud M, Ruddiman CA, Johnstone SR, Butcher JT, Wolpe AG, Jin X, Keller TCS 4th, Keller AS, Rivière T, Good ME, Best AK, Lohman AW, Swayne LA, Penuela S, Thompson RJ, Lampe PD, Yeager M, Isakson BE.

J Biol Chem. 2019 Apr 26;294(17):6940-6956. doi: 10.1074/jbc.RA118.006982. Epub 2019 Feb 27.


Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.

DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. doi: 10.1161/ATVBAHA.118.311290.


Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Keller TC 4th, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE.

Hypertension. 2016 Dec;68(6):1494-1503. Epub 2016 Oct 31.


Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.

Lohman AW, Leskov IL, Butcher JT, Johnstone SR, Stokes TA, Begandt D, DeLalio LJ, Best AK, Penuela S, Leitinger N, Ravichandran KS, Stokes KY, Isakson BE.

Nat Commun. 2015 Aug 5;6:7965. doi: 10.1038/ncomms8965.


A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE.

Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824.


Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2.


Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.

Straub AC, Lohman AW, Billaud M, Johnstone SR, Dwyer ST, Lee MY, Bortz PS, Best AK, Columbus L, Gaston B, Isakson BE.

Nature. 2012 Nov 15;491(7424):473-7. doi: 10.1038/nature11626. Epub 2012 Oct 31.


Expression of pannexin isoforms in the systemic murine arterial network.

Lohman AW, Billaud M, Straub AC, Johnstone SR, Best AK, Lee M, Barr K, Penuela S, Laird DW, Isakson BE.

J Vasc Res. 2012;49(5):405-16. doi: 10.1159/000338758. Epub 2012 Jun 26.


MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.

Johnstone SR, Kroncke BM, Straub AC, Best AK, Dunn CA, Mitchell LA, Peskova Y, Nakamoto RK, Koval M, Lo CW, Lampe PD, Columbus L, Isakson BE.

Circ Res. 2012 Jul 6;111(2):201-11. doi: 10.1161/CIRCRESAHA.112.272302. Epub 2012 May 31.


A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction.

Heberlein KR, Han J, Straub AC, Best AK, Kaun C, Wojta J, Isakson BE.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1271-9. doi: 10.1161/ATVBAHA.112.246371. Epub 2012 Mar 1.


Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction.

Billaud M, Lohman AW, Straub AC, Looft-Wilson R, Johnstone SR, Araj CA, Best AK, Chekeni FB, Ravichandran KS, Penuela S, Laird DW, Isakson BE.

Circ Res. 2011 Jun 24;109(1):80-5. doi: 10.1161/CIRCRESAHA.110.237594. Epub 2011 May 5.


A new method for in vivo visualization of vessel remodeling using a near-infrared dye.

Billaud M, Ross JA, Greyson MA, Bruce AC, Seaman SA, Heberlein KR, Han J, Best AK, Peirce SM, Isakson BE.

Microcirculation. 2011 Apr;18(3):163-71. doi: 10.1111/j.1549-8719.2011.00085.x.


Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.

Straub AC, Billaud M, Johnstone SR, Best AK, Yemen S, Dwyer ST, Looft-Wilson R, Lysiak JJ, Gaston B, Palmer L, Isakson BE.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):399-407. doi: 10.1161/ATVBAHA.110.215939. Epub 2010 Nov 11.


Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function.

Johnstone SR, Best AK, Wright CS, Isakson BE, Errington RJ, Martin PE.

J Cell Biochem. 2010 Jun 1;110(3):772-82. doi: 10.1002/jcb.22590.


Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.

Heberlein KR, Straub AC, Best AK, Greyson MA, Looft-Wilson RC, Sharma PR, Meher A, Leitinger N, Isakson BE.

Circ Res. 2010 Apr 2;106(6):1092-102. doi: 10.1161/CIRCRESAHA.109.215723. Epub 2010 Feb 4.


Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium.

Straub AC, Johnstone SR, Heberlein KR, Rizzo MJ, Best AK, Boitano S, Isakson BE.

J Vasc Res. 2010;47(4):277-86. doi: 10.1159/000265562. Epub 2009 Dec 16.


Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation.

Isakson BE, Best AK, Duling BR.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2898-904. doi: 10.1152/ajpheart.91488.2007. Epub 2008 Apr 11.


Best cases from the AFIP: cardiac angiosarcoma.

Best AK, Dobson RL, Ahmad AR.

Radiographics. 2003 Oct;23 Spec No:S141-5. No abstract available.


Salvage after severe lower-extremity trauma: are the outcomes worth the means?

Dagum AB, Best AK, Schemitsch EH, Mahoney JL, Mahomed MN, Blight KR.

Plast Reconstr Surg. 1999 Apr;103(4):1212-20.


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