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Items: 1 to 50 of 432

1.

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma.

Melo AM, O'Brien AM, Phelan JJ, Kennedy SA, Wood NAW, Veerapen N, Besra GS, Clarke NE, Foley EK, Ravi A, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, Conroy MJ, Hogan AE, O'Sullivan J, Dunne MR.

Front Immunol. 2019 Jul 10;10:1580. doi: 10.3389/fimmu.2019.01580. eCollection 2019.

2.

The hydrolase LpqI primes mycobacterial peptidoglycan recycling.

Moynihan PJ, Cadby IT, Veerapen N, Jankute M, Crosatti M, Mukamolova GV, Lovering AL, Besra GS.

Nat Commun. 2019 Jun 14;10(1):2647. doi: 10.1038/s41467-019-10586-2.

3.

Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.

Smith DG, Martinelli R, Besra GS, Illarionov PA, Szatmari I, Brazda P, Allen MA, Xu W, Wang X, Nagy L, Dowell RD, Rook GAW, Rosa Brunet L, Lowry CA.

Psychopharmacology (Berl). 2019 May;236(5):1653-1670. doi: 10.1007/s00213-019-05253-9. Epub 2019 May 22.

4.

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.

O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE.

J Immunol. 2019 Jun 15;202(12):3404-3411. doi: 10.4049/jimmunol.1801600. Epub 2019 May 10.

PMID:
31076528
5.

Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy.

Wang Y, Sedimbi SK, Löfbom L, Besra GS, Porcelli SA, Cardell SL.

Front Immunol. 2019 Mar 1;10:352. doi: 10.3389/fimmu.2019.00352. eCollection 2019.

6.

Crystal structure of the TreS:Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria.

Kermani AA, Roy R, Gopalasingam C, Kocurek KI, Patel TR, Alderwick LJ, Besra GS, Fütterer K.

J Biol Chem. 2019 May 3;294(18):7348-7359. doi: 10.1074/jbc.RA118.004297. Epub 2019 Mar 15.

7.

Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria.

Kanvatirth P, Jeeves RE, Bacon J, Besra GS, Alderwick LJ.

PLoS One. 2019 Mar 12;14(3):e0213713. doi: 10.1371/journal.pone.0213713. eCollection 2019.

8.

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation.

Cox JAG, Taylor RC, Brown AK, Attoe S, Besra GS, Fütterer K.

Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):101-108. doi: 10.1107/S2059798318017242. Epub 2019 Jan 8.

9.

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2.

Decout A, Silva-Gomes S, Drocourt D, Blattes E, Rivière M, Prandi J, Larrouy-Maumus G, Caminade AM, Hamasur B, Källenius G, Kaur D, Dobos KM, Lucas M, Sutcliffe IC, Besra GS, Appelmelk BJ, Gilleron M, Jackson M, Vercellone A, Tiraby G, Nigou J.

Sci Rep. 2018 Nov 15;8(1):16840. doi: 10.1038/s41598-018-35393-5.

10.

Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones.

Li P, Wang B, Zhang X, Batt SM, Besra GS, Zhang T, Ma C, Zhang D, Lin Z, Li G, Huang H, Lu Y.

Eur J Med Chem. 2018 Dec 5;160:157-170. doi: 10.1016/j.ejmech.2018.09.042. Epub 2018 Sep 17.

PMID:
30336450
11.

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.

Soto R, Perez-Herran E, Rodriguez B, Duma BM, Cacho-Izquierdo M, Mendoza-Losana A, Lelievre J, Aguirre DB, Ballell L, Cox LR, Alderwick LJ, Besra GS.

Sci Rep. 2018 Aug 23;8(1):12664. doi: 10.1038/s41598-018-31157-3.

12.

Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.

Veerapen N, Kharkwal SS, Jervis P, Bhowruth V, Besra AK, North SJ, Haslam SM, Dell A, Hobrath J, Quaid PJ, Moynihan PJ, Cox LR, Kharkwal H, Zauderer M, Besra GS, Porcelli SA.

Bioconjug Chem. 2018 Sep 19;29(9):3161-3173. doi: 10.1021/acs.bioconjchem.8b00484. Epub 2018 Aug 23.

13.

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis.

Jankute M, Alderwick LJ, Moorey AR, Joe M, Gurcha SS, Eggeling L, Lowary TL, Dell A, Pang PC, Yang T, Haslam S, Besra GS.

Cell Surf. 2018 Jun;2:38-53. doi: 10.1016/j.tcsw.2018.06.003.

14.

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2018 Jul 13;9:16227. doi: 10.1038/ncomms16227.

15.

AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.

Alderwick LJ, Birch HL, Krumbach K, Bott M, Eggeling L, Besra GS.

Cell Surf. 2018 Mar;1:2-14. doi: 10.1016/j.tcsw.2017.10.001.

16.

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

Trofimov V, Kicka S, Mucaria S, Hanna N, Ramon-Olayo F, Del Peral LV, Lelièvre J, Ballell L, Scapozza L, Besra GS, Cox JAG, Soldati T.

Sci Rep. 2018 Mar 2;8(1):3939. doi: 10.1038/s41598-018-22228-6.

17.

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.

Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. doi: 10.1073/pnas.1716669115. Epub 2018 Jan 19.

18.

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

Howson LJ, Napolitani G, Shepherd D, Ghadbane H, Kurupati P, Preciado-Llanes L, Rei M, Dobinson HC, Gibani MM, Teng KWW, Newell EW, Veerapen N, Besra GS, Pollard AJ, Cerundolo V.

Nat Commun. 2018 Jan 17;9(1):253. doi: 10.1038/s41467-017-02540-x.

19.

Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery.

Moynihan PJ, Besra GS.

Microbiology. 2017 Oct;163(10):1385-1388. doi: 10.1099/mic.0.000522. Epub 2017 Sep 12.

PMID:
28893361
20.

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.

Salio M, Gasser O, Gonzalez-Lopez C, Martens A, Veerapen N, Gileadi U, Verter JG, Napolitani G, Anderson R, Painter G, Besra GS, Hermans IF, Cerundolo V.

J Immunol. 2017 Oct 15;199(8):2631-2638. doi: 10.4049/jimmunol.1700615. Epub 2017 Sep 6.

21.

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

Abrahams KA, Cox JAG, Fütterer K, Rullas J, Ortega-Muro F, Loman NJ, Moynihan PJ, Pérez-Herrán E, Jiménez E, Esquivias J, Barros D, Ballell L, Alemparte C, Besra GS.

Sci Rep. 2017 Aug 25;7(1):9430. doi: 10.1038/s41598-017-09642-y.

22.

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.

Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C, Gan F, Wang C, Franzblau SG, Jacobs WR Jr, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Fütterer K, Wang F.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13011-13015. doi: 10.1002/anie.201707324. Epub 2017 Sep 7.

23.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

24.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Toh MF, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G.

Nat Commun. 2017 Jul 17;8:16081. doi: 10.1038/ncomms16081. Erratum in: Nat Commun. 2018 Jul 13;9:16227.

25.

The role of hydrophobicity in tuberculosis evolution and pathogenicity.

Jankute M, Nataraj V, Lee OY, Wu HHT, Ridell M, Garton NJ, Barer MR, Minnikin DE, Bhatt A, Besra GS.

Sci Rep. 2017 May 2;7(1):1315. doi: 10.1038/s41598-017-01501-0.

26.

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M.

Nat Immunol. 2017 Jun;18(6):683-693. doi: 10.1038/ni.3724. Epub 2017 Apr 10.

27.

Modular Synthesis of Diverse Natural Product-Like Macrocycles: Discovery of Hits with Antimycobacterial Activity.

Dow M, Marchetti F, Abrahams KA, Vaz L, Besra GS, Warriner S, Nelson A.

Chemistry. 2017 May 29;23(30):7207-7211. doi: 10.1002/chem.201701150. Epub 2017 May 2.

28.

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.

Jankute M, Alderwick LJ, Noack S, Veerapen N, Nigou J, Besra GS.

ACS Chem Biol. 2017 Jan 20;12(1):183-190. doi: 10.1021/acschembio.6b00898. Epub 2016 Dec 5.

29.

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.

Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2.

30.

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.

Cox JA, Mugumbate G, Del Peral LV, Jankute M, Abrahams KA, Jervis P, Jackenkroll S, Perez A, Alemparte C, Esquivias J, Lelièvre J, Ramon F, Barros D, Ballell L, Besra GS.

Sci Rep. 2016 Dec 16;6:38986. doi: 10.1038/srep38986.

31.

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target.

Abrahams KA, Besra GS.

Parasitology. 2018 Feb;145(2):116-133. doi: 10.1017/S0031182016002377. Epub 2016 Dec 15. Review.

32.

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes.

Ivanova IM, Nepogodiev SA, Saalbach G, O'Neill EC, Urbaniak MD, Ferguson MA, Gurcha SS, Besra GS, Field RA.

Carbohydr Res. 2017 Jan 13;438:26-38. doi: 10.1016/j.carres.2016.11.017. Epub 2016 Nov 30.

33.

CD1d-mediated activation of group 3 innate lymphoid cells drives IL-22 production.

Saez de Guinoa J, Jimeno R, Farhadi N, Jervis PJ, Cox LR, Besra GS, Barral P.

EMBO Rep. 2017 Jan;18(1):39-47. doi: 10.15252/embr.201642412. Epub 2016 Oct 31.

34.

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.

Singh A, Varela C, Bhatt K, Veerapen N, Lee OY, Wu HH, Besra GS, Minnikin DE, Fujiwara N, Teramoto K, Bhatt A.

PLoS One. 2016 Oct 14;11(10):e0164253. doi: 10.1371/journal.pone.0164253. eCollection 2016.

35.

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.

Batt SM, Cacho Izquierdo M, Castro Pichel J, Stubbs CJ, Vela-Glez Del Peral L, Pérez-Herrán E, Dhar N, Mouzon B, Rees M, Hutchinson JP, Young RJ, McKinney JD, Barros Aguirre D, Ballell L, Besra GS, Argyrou A.

ACS Infect Dis. 2015 Dec 11;1(12):615-26. doi: 10.1021/acsinfecdis.5b00065. Epub 2015 Aug 25.

PMID:
27623058
36.

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH.

Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581.

37.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.

Cox JA, Abrahams KA, Alemparte C, Ghidelli-Disse S, Rullas J, Angulo-Barturen I, Singh A, Gurcha SS, Nataraj V, Bethell S, Remuiñán MJ, Encinas L, Jervis PJ, Cammack NC, Bhatt A, Kruse U, Bantscheff M, Fütterer K, Barros D, Ballell L, Drewes G, Besra GS.

Nat Microbiol. 2016 Jan 18;1:15006. doi: 10.1038/nmicrobiol.2015.6.

PMID:
27571973
38.

Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.

Harrison J, Lloyd G, Joe M, Lowary TL, Reynolds E, Walters-Morgan H, Bhatt A, Lovering A, Besra GS, Alderwick LJ.

MBio. 2016 Aug 2;7(4). pii: e00972-16. doi: 10.1128/mBio.00972-16.

39.

Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.

Fullam E, Prokes I, Fütterer K, Besra GS.

Open Biol. 2016 Jun;6(6). pii: 160105. doi: 10.1098/rsob.160105.

40.

Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.

Usha V, Lloyd AJ, Roper DI, Dowson CG, Kozlov G, Gehring K, Chauhan S, Imam HT, Blindauer CA, Besra GS.

Sci Rep. 2016 Mar 15;6:23191. doi: 10.1038/srep23191.

41.

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.

Le Nours J, Praveena T, Pellicci DG, Gherardin NA, Ross FJ, Lim RT, Besra GS, Keshipeddy S, Richardson SK, Howell AR, Gras S, Godfrey DI, Rossjohn J, Uldrich AP.

Nat Commun. 2016 Feb 15;7:10570. doi: 10.1038/ncomms10570.

42.

Non-glycosidic compounds can stimulate both human and mouse iNKT cells.

Jukes JP, Gileadi U, Ghadbane H, Yu TF, Shepherd D, Cox LR, Besra GS, Cerundolo V.

Eur J Immunol. 2016 May;46(5):1224-34. doi: 10.1002/eji.201546114. Epub 2016 Mar 1.

43.

The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.

Torreno-Pina JA, Manzo C, Salio M, Aichinger MC, Oddone A, Lakadamyali M, Shepherd D, Besra GS, Cerundolo V, Garcia-Parajo MF.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E772-81. doi: 10.1073/pnas.1514530113. Epub 2016 Jan 21.

44.

Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

45.

Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.

Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD.

Eur J Immunol. 2016 Feb;46(2):381-9. doi: 10.1002/eji.201545858. Epub 2015 Dec 8.

46.

"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes".

Arora P, Kharkwal SS, Ng TW, Kunnath-Velayudhan S, Saini NK, Johndrow CT, Chang YT, Besra GS, Porcelli SA.

Chem Phys Lipids. 2016 Jan;194:49-57. doi: 10.1016/j.chemphyslip.2015.10.006. Epub 2015 Nov 6.

PMID:
26496152
47.

Assembly of the Mycobacterial Cell Wall.

Jankute M, Cox JA, Harrison J, Besra GS.

Annu Rev Microbiol. 2015;69:405-23. doi: 10.1146/annurev-micro-091014-104121. Review.

PMID:
26488279
48.

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

Cameron G, Pellicci DG, Uldrich AP, Besra GS, Illarionov P, Williams SJ, La Gruta NL, Rossjohn J, Godfrey DI.

J Immunol. 2015 Nov 15;195(10):4604-14. doi: 10.4049/jimmunol.1501222. Epub 2015 Sep 30.

49.

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.

Vomhof-DeKrey EE, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, Besra GS, Karlsson MC, Leadbetter EA.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12474-9. doi: 10.1073/pnas.1504790112. Epub 2015 Sep 21.

50.

Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes.

Arora P, Kharkwal SS, Ng TW, Kunnath-Velayudhan S, Saini NK, Johndrow CT, Chang YT, Besra GS, Porcelli SA.

Chem Phys Lipids. 2015 Oct;191:75-83. doi: 10.1016/j.chemphyslip.2015.08.010. Epub 2015 Aug 22.

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