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Items: 17


The Sleep-Immune Crosstalk in Health and Disease.

Besedovsky L, Lange T, Haack M.

Physiol Rev. 2019 Jul 1;99(3):1325-1380. doi: 10.1152/physrev.00010.2018. Review.


s-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells.

Dimitrov S, Lange T, Gouttefangeas C, Jensen ATR, Szczepanski M, Lehnnolz J, Soekadar S, Rammensee HG, Born J, Besedovsky L.

J Exp Med. 2019 Mar 4;216(3):517-526. doi: 10.1084/jem.20181169. Epub 2019 Feb 12.


Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation.

Dimitrov S, Gouttefangeas C, Besedovsky L, Jensen ATR, Chandran PA, Rusch E, Businger R, Schindler M, Lange T, Born J, Rammensee HG.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5536-E5545. doi: 10.1073/pnas.1720714115. Epub 2018 May 29.


Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function.

Besedovsky L, Ngo HV, Dimitrov S, Gassenmaier C, Lehmann R, Born J.

Nat Commun. 2017 Dec 7;8(1):1984. doi: 10.1038/s41467-017-02170-3.


Nocturnal sleep uniformly reduces numbers of different T-cell subsets in the blood of healthy men.

Besedovsky L, Dimitrov S, Born J, Lange T.

Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R637-R642. doi: 10.1152/ajpregu.00149.2016. Epub 2016 Jul 27.


Signs of enhanced sleep and sleep-associated memory processing following the anti-inflammatory antibiotic minocycline in men.

Besedovsky L, Schmidt EM, Linz B, Diekelmann S, Lange T, Born J.

J Psychopharmacol. 2017 Feb;31(2):204-210. doi: 10.1177/0269881116658991. Epub 2016 Jul 19.


Sleep, Don't Sneeze: Longer Sleep Reduces the Risk of Catching a Cold.

Besedovsky L, Born J.

Sleep. 2015 Sep 1;38(9):1341-2. doi: 10.5665/sleep.4958. No abstract available.


Emotional memory can be persistently weakened by suppressing cortisol during retrieval.

Rimmele U, Besedovsky L, Lange T, Born J.

Neurobiol Learn Mem. 2015 Mar;119:102-7. doi: 10.1016/j.nlm.2015.01.010. Epub 2015 Feb 11.


Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes.

Schmidt EM, Linz B, Diekelmann S, Besedovsky L, Lange T, Born J.

Brain Behav Immun. 2015 Jul;47:178-85. doi: 10.1016/j.bbi.2014.11.012. Epub 2014 Dec 20.


Differential acute effects of sleep on spontaneous and stimulated production of tumor necrosis factor in men.

Dimitrov S, Besedovsky L, Born J, Lange T.

Brain Behav Immun. 2015 Jul;47:201-10. doi: 10.1016/j.bbi.2014.11.017. Epub 2014 Dec 10.


Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans.

Besedovsky L, Linz B, Dimitrov S, Groch S, Born J, Lange T.

Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1322-9. doi: 10.1152/ajpendo.00678.2013. Epub 2014 Apr 22.


Dopamine D2-like receptor activation wipes out preferential consolidation of high over low reward memories during human sleep.

Feld GB, Besedovsky L, Kaida K, Münte TF, Born J.

J Cogn Neurosci. 2014 Oct;26(10):2310-20. doi: 10.1162/jocn_a_00629. Epub 2014 Mar 26.


Mineralocorticoid receptor signaling reduces numbers of circulating human naïve T cells and increases their CD62L, CCR7, and CXCR4 expression.

Besedovsky L, Linz B, Born J, Lange T.

Eur J Immunol. 2014 Jun;44(6):1759-69. doi: 10.1002/eji.201344265. Epub 2014 Apr 10.


Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4.

Besedovsky L, Born J, Lange T.

FASEB J. 2014 Jan;28(1):67-75. doi: 10.1096/fj.13-237958. Epub 2013 Sep 19.


Blocking mineralocorticoid receptors impairs, blocking glucocorticoid receptors enhances memory retrieval in humans.

Rimmele U, Besedovsky L, Lange T, Born J.

Neuropsychopharmacology. 2013 Apr;38(5):884-94. doi: 10.1038/npp.2012.254. Epub 2012 Dec 6.


Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans.

Besedovsky L, Born J, Lange T.

Brain Behav Immun. 2012 Oct;26(7):1116-21. doi: 10.1016/j.bbi.2012.07.016. Epub 2012 Aug 3.


Sleep and immune function.

Besedovsky L, Lange T, Born J.

Pflugers Arch. 2012 Jan;463(1):121-37. doi: 10.1007/s00424-011-1044-0. Epub 2011 Nov 10. Review.

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