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Complementary approaches to study NKT cells in cancer.

Berzofsky JA, Olkhanud PB, Terabe M.

Methods Enzymol. 2020;631:371-389. doi: 10.1016/bs.mie.2019.08.010. Epub 2019 Oct 18.


Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d.

Clark K, Yau J, Bloom A, Wang J, Venzon DJ, Suzuki M, Pasquet L, Compton BJ, Cardell SL, Porcelli SA, Painter GF, Zajonc DM, Berzofsky JA, Terabe M.

Front Immunol. 2019 Oct 9;10:2355. doi: 10.3389/fimmu.2019.02355. eCollection 2019.


Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory.

Bloom AC, Bender LH, Tiwary S, Pasquet L, Clark K, Jiang T, Xia Z, Morales-Kastresana A, Jones JC, Walters I, Terabe M, Berzofsky JA.

Oncoimmunology. 2019 Jul 16;8(10):e1625687. doi: 10.1080/2162402X.2019.1625687. eCollection 2019.


Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity.

Tiwary S, Berzofsky JA, Terabe M.

Front Immunol. 2019 Sep 18;10:2187. doi: 10.3389/fimmu.2019.02187. eCollection 2019. Review.


High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.

Morales-Kastresana A, Musich TA, Welsh JA, Telford W, Demberg T, Wood JCS, Bigos M, Ross CD, Kachynski A, Dean A, Felton EJ, Van Dyke J, Tigges J, Toxavidis V, Parks DR, Overton WR, Kesarwala AH, Freeman GJ, Rosner A, Perfetto SP, Pasquet L, Terabe M, McKinnon K, Kapoor V, Trepel JB, Puri A, Kobayashi H, Yung B, Chen X, Guion P, Choyke P, Knox SJ, Ghiran I, Robert-Guroff M, Berzofsky JA, Jones JC.

J Extracell Vesicles. 2019 Jun 19;8(1):1597603. doi: 10.1080/20013078.2019.1597603. eCollection 2019.


Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate.

Vaccari M, Fourati S, Brown DR, Silva de Castro I, Bissa M, Schifanella L, Doster MN, Foulds KE, Roederer M, Koup RA, Sui Y, Berzofsky JA, Sekaly RP, Franchini G.

Front Immunol. 2019 May 14;10:1072. doi: 10.3389/fimmu.2019.01072. eCollection 2019.


Strategies for developing and optimizing cancer vaccines.

Maeng HM, Berzofsky JA.

F1000Res. 2019 May 13;8. pii: F1000 Faculty Rev-654. doi: 10.12688/f1000research.18693.1. eCollection 2019. Review.


Interleukin 21 collaborates with interferon-γ for the optimal expression of interferon-stimulated genes and enhances protection against enteric microbial infection.

Solaymani-Mohammadi S, Berzofsky JA.

PLoS Pathog. 2019 Feb 28;15(2):e1007614. doi: 10.1371/journal.ppat.1007614. eCollection 2019 Feb.


Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.

Sui Y, Lewis GK, Wang Y, Berckmueller K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters RC, Talton J, Klinman D, Clements J, Tomaras GD, Franchini G, Robert-Guroff M, Trinchieri G, Gallo RC, Berzofsky JA.

J Clin Invest. 2019 Mar 1;129(3):1314-1328. doi: 10.1172/JCI122110. Epub 2019 Feb 18.


The effect of antigen dose on T cell-targeting vaccine outcome.

Billeskov R, Beikzadeh B, Berzofsky JA.

Hum Vaccin Immunother. 2019;15(2):407-411. doi: 10.1080/21645515.2018.1527496. Epub 2018 Oct 25.


Tissue-Specific Roles of NKT Cells in Tumor Immunity.

Terabe M, Berzofsky JA.

Front Immunol. 2018 Aug 15;9:1838. doi: 10.3389/fimmu.2018.01838. eCollection 2018. Review.


Prospective Use of High-Refractive Index Materials for Single Molecule Detection in Flow Cytometry.

Welsh JA, Kepley J, Rosner A, Horak P, Berzofsky JA, Jones JC.

Sensors (Basel). 2018 Aug 1;18(8). pii: E2461. doi: 10.3390/s18082461.


Differential Regulation of T-cell mediated anti-tumor memory and cross-protection against the same tumor in lungs versus skin.

O'Konek JJ, Ambrosino E, Bloom AC, Pasquet L, Massilamany C, Xia Z, Terabe M, Berzofsky JA.

Oncoimmunology. 2018 Apr 9;7(7):e1439305. doi: 10.1080/2162402X.2018.1439305. eCollection 2018.


Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques.

Sui Y, Dzutsev A, Venzon D, Frey B, Thovarai V, Trinchieri G, Berzofsky JA.

Mucosal Immunol. 2018 Jul;11(4):1219-1229. doi: 10.1038/s41385-018-0029-0. Epub 2018 Jun 1.


Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.

Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, Ritz T, Longerich T, Theriot CM, McCulloch JA, Roy S, Yuan W, Thovarai V, Sen SK, Ruchirawat M, Korangy F, Wang XW, Trinchieri G, Greten TF.

Science. 2018 May 25;360(6391). pii: eaan5931. doi: 10.1126/science.aan5931.


IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF+ innate T cells in the human liver.

Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK.

Eur J Immunol. 2018 Aug;48(8):1329-1335. doi: 10.1002/eji.201747334. Epub 2018 May 25.


Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells.

Jin P, Chen W, Ren J, Chen S, Wood L, Zhao Y, Remaley A, Pham C, Lian S, Liu S, Liu H, Highfill S, Berzofsky JA, Stroncek DF.

Cytotherapy. 2018 May;20(5):728-739. doi: 10.1016/j.jcyt.2018.03.001. Epub 2018 Apr 11.


Cancer vaccines: translation from mice to human clinical trials.

Maeng H, Terabe M, Berzofsky JA.

Curr Opin Immunol. 2018 Apr;51:111-122. doi: 10.1016/j.coi.2018.03.001. Epub 2018 Mar 16. Review.


Possible Therapeutic Application of Targeting Type II Natural Killer T Cell-Mediated Suppression of Tumor Immunity.

Kato S, Berzofsky JA, Terabe M.

Front Immunol. 2018 Feb 22;9:314. doi: 10.3389/fimmu.2018.00314. eCollection 2018. Review.


Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity.

Frey BF, Jiang J, Sui Y, Boyd LF, Yu B, Tatsuno G, Billeskov R, Solaymani-Mohammadi S, Berman PW, Margulies DH, Berzofsky JA.

J Immunol. 2018 Mar 1;200(5):1853-1864. doi: 10.4049/jimmunol.1701523. Epub 2018 Jan 26.


Cancer vaccine strategies: translation from mice to human clinical trials.

Berzofsky JA, Terabe M, Trepel JB, Pastan I, Stroncek DF, Morris JC, Wood LV.

Cancer Immunol Immunother. 2018 Dec;67(12):1863-1869. doi: 10.1007/s00262-017-2084-x. Epub 2017 Nov 15. Review.


Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins.

Speir M, Authier-Hall A, Brooks CR, Farrand KJ, Compton BJ, Anderson RJ, Heiser A, Osmond TL, Tang CW, Berzofsky JA, Terabe M, Painter GF, Hermans IF, Weinkove R.

Sci Rep. 2017 Oct 27;7(1):14273. doi: 10.1038/s41598-017-14690-5.


Differential T cell homing to colon vs. small intestine is imprinted by local CD11c+ APCs that determine homing receptors.

Dzutsev A, Hogg A, Sui Y, Solaymani-Mohammadi S, Yu H, Frey B, Wang Y, Berzofsky JA.

J Leukoc Biol. 2017 Dec;102(6):1381-1388. doi: 10.1189/jlb.1A1116-463RR. Epub 2017 Sep 26.


Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice.

Hogg A, Sui Y, Ben-Sasson SZ, Paul WE, Berzofsky JA.

Eur J Immunol. 2017 Dec;47(12):2059-2069. doi: 10.1002/eji.201747091. Epub 2017 Aug 28.


Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity.

Leshem Y, O'Brien J, Liu X, Bera TK, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Tai CH, Reiter Y, Pastan I.

Cancer Immunol Res. 2017 Aug;5(8):685-694. doi: 10.1158/2326-6066.CIR-16-0330. Epub 2017 Jul 3.


Immunotherapy biomarkers 2016: overcoming the barriers.

Gulley JL, Berzofsky JA, Butler MO, Cesano A, Fox BA, Gnjatic S, Janetzki S, Kalavar S, Karanikas V, Khleif SN, Kirsch I, Lee PP, Maccalli C, Maecker H, Schlom J, Seliger B, Siebert J, Stroncek DF, Thurin M, Yuan J, Butterfield LH.

J Immunother Cancer. 2017 Mar 21;5(1):29. doi: 10.1186/s40425-017-0225-6.


Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy.

Terabe M, Robertson FC, Clark K, De Ravin E, Bloom A, Venzon DJ, Kato S, Mirza A, Berzofsky JA.

Oncoimmunology. 2017 Mar 31;6(5):e1308616. doi: 10.1080/2162402X.2017.1308616. eCollection 2017.


Labeling Extracellular Vesicles for Nanoscale Flow Cytometry.

Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, Jones JC.

Sci Rep. 2017 May 12;7(1):1878. doi: 10.1038/s41598-017-01731-2.


Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques.

Sui Y, Frey B, Wang Y, Billeskov R, Kulkarni S, McKinnon K, Rourke T, Fritts L, Miller CJ, Berzofsky JA.

PLoS Pathog. 2017 May 12;13(5):e1006395. doi: 10.1371/journal.ppat.1006395. eCollection 2017 May.


Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.

Billeskov R, Wang Y, Solaymani-Mohammadi S, Frey B, Kulkarni S, Andersen P, Agger EM, Sui Y, Berzofsky JA.

J Immunol. 2017 May 1;198(9):3494-3506. doi: 10.4049/jimmunol.1600965. Epub 2017 Mar 27.


Expression of CD14, IL10, and Tolerogenic Signature in Dendritic Cells Inversely Correlate with Clinical and Immunologic Response to TARP Vaccination in Prostate Cancer Patients.

Castiello L, Sabatino M, Ren J, Terabe M, Khuu H, Wood LV, Berzofsky JA, Stroncek DF.

Clin Cancer Res. 2017 Jul 1;23(13):3352-3364. doi: 10.1158/1078-0432.CCR-16-2199. Epub 2017 Jan 10.


Immuno-pharmacodynamics for evaluating mechanism of action and developing immunotherapy combinations.

Parchment RE, Voth AR, Doroshow JH, Berzofsky JA.

Semin Oncol. 2016 Aug;43(4):501-13. doi: 10.1053/j.seminoncol.2016.06.008. Epub 2016 Jun 16. Review.


TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer.

Wood LV, Fojo A, Roberson BD, Hughes MS, Dahut W, Gulley JL, Madan RA, Arlen PM, Sabatino M, Stroncek DF, Castiello L, Trepel JB, Lee MJ, Parnes HL, Steinberg SM, Terabe M, Wilkerson J, Pastan I, Berzofsky JA.

Oncoimmunology. 2016 Jul 1;5(8):e1197459. doi: 10.1080/2162402X.2016.1197459. eCollection 2016 Aug.


Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells.

Zdanov S, Mandapathil M, Abu Eid R, Adamson-Fadeyi S, Wilson W, Qian J, Carnie A, Tarasova N, Mkrtichyan M, Berzofsky JA, Whiteside TL, Khleif SN.

Cancer Immunol Res. 2016 Apr;4(4):354-65. doi: 10.1158/2326-6066.CIR-15-0241. Epub 2016 Feb 15.


Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.

Yu H, Sui Y, Wang Y, Sato N, Frey B, Xia Z, Waldmann TA, Berzofsky J.

PLoS One. 2015 Nov 23;10(11):e0143001. doi: 10.1371/journal.pone.0143001. eCollection 2015.


Early SIV Dissemination After Intrarectal SIVmac251 Challenge Was Associated With Proliferating Virus-Susceptible Cells in the Colorectum.

Sui Y, Lee EM, Wang Y, Hogg A, Frey B, Venzon D, Pal R, Berzofsky JA.

J Acquir Immune Defic Syndr. 2016 Apr 1;71(4):353-8. doi: 10.1097/QAI.0000000000000890.


Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules.

Solaymani-Mohammadi S, Lakhdari O, Minev I, Shenouda S, Frey BF, Billeskov R, Singer SM, Berzofsky JA, Eckmann L, Kagnoff MF.

J Leukoc Biol. 2016 Mar;99(3):475-82. doi: 10.1189/jlb.4A0115-003RR. Epub 2015 Oct 14.


Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.

Wang J, Shirota Y, Bayik D, Shirota H, Tross D, Gulley JL, Wood LV, Berzofsky JA, Klinman DM.

J Immunol. 2015 May 1;194(9):4215-21. doi: 10.4049/jimmunol.1402004. Epub 2015 Mar 30.


Tumor-induced CD11b(+) Gr-1(+) myeloid-derived suppressor cells exacerbate immune-mediated hepatitis in mice in a CD40-dependent manner.

Kapanadze T, Medina-Echeverz J, Gamrekelashvili J, Weiss JM, Wiltrout RH, Kapoor V, Hawk N, Terabe M, Berzofsky JA, Manns MP, Wang E, Marincola FM, Korangy F, Greten TF.

Eur J Immunol. 2015 Apr;45(4):1148-58. doi: 10.1002/eji.201445093. Epub 2015 Feb 23.


Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.

Wang Y, Sui Y, Kato S, Hogg AE, Steel JC, Morris JC, Berzofsky JA.

Nat Commun. 2015 Jan 20;6:6100. doi: 10.1038/ncomms7100.


Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008).

Lacouture ME, Morris JC, Lawrence DP, Tan AR, Olencki TE, Shapiro GI, Dezube BJ, Berzofsky JA, Hsu FJ, Guitart J.

Cancer Immunol Immunother. 2015 Apr;64(4):437-46. doi: 10.1007/s00262-015-1653-0. Epub 2015 Jan 13.


Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer.

Rahma OE, Herrin VE, Ibrahim RA, Toubaji A, Bernstein S, Dakheel O, Steinberg SM, Abu Eid R, Mkrtichyan M, Berzofsky JA, Khleif SN.

J Transl Med. 2014 Dec 16;12:353. doi: 10.1186/s12967-014-0353-4.


NKT cell networks in the regulation of tumor immunity.

Robertson FC, Berzofsky JA, Terabe M.

Front Immunol. 2014 Oct 28;5:543. doi: 10.3389/fimmu.2014.00543. eCollection 2014. Review.


CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.

Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, Wink DA, Berzofsky JA, Roberts DD.

Cancer Res. 2014 Dec 1;74(23):6771-83. doi: 10.1158/0008-5472.CAN-14-0037-T. Epub 2014 Oct 8.


Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques.

Valentin A, McKinnon K, Li J, Rosati M, Kulkarni V, Pilkington GR, Bear J, Alicea C, Vargas-Inchaustegui DA, Jean Patterson L, Pegu P, Liyanage NP, Gordon SN, Vaccari M, Wang Y, Hogg AE, Frey B, Sui Y, Reed SG, Sardesai NY, Berzofsky JA, Franchini G, Robert-Guroff M, Felber BK, Pavlakis GN.

Clin Immunol. 2014 Nov;155(1):91-107. doi: 10.1016/j.clim.2014.09.005. Epub 2014 Sep 16.


Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway.

Abu-Eid R, Samara RN, Ozbun L, Abdalla MY, Berzofsky JA, Friedman KM, Mkrtichyan M, Khleif SN.

Cancer Immunol Res. 2014 Nov;2(11):1080-9. doi: 10.1158/2326-6066.CIR-14-0095. Epub 2014 Jul 30.


Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.

Vargas-Inchaustegui DA, Tuero I, Mohanram V, Musich T, Pegu P, Valentin A, Sui Y, Rosati M, Bear J, Venzon DJ, Kulkarni V, Alicea C, Pilkington GR, Liyanage NP, Demberg T, Gordon SN, Wang Y, Hogg AE, Frey B, Patterson LJ, DiPasquale J, Montefiori DC, Sardesai NY, Reed SG, Berzofsky JA, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M.

Clin Immunol. 2014 Aug;153(2):308-22. doi: 10.1016/j.clim.2014.05.008. Epub 2014 Jun 4.


Episomal expression of truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4+FoxP3- and CD8+ T cells.

Chen Z, Ozbun L, Chong N, Wallecha A, Berzofsky JA, Khleif SN.

Cancer Immunol Res. 2014 Sep;2(9):911-22. doi: 10.1158/2326-6066.CIR-13-0197. Epub 2014 May 28.


Vaccine-induced myeloid cell population dampens protective immunity to SIV.

Sui Y, Hogg A, Wang Y, Frey B, Yu H, Xia Z, Venzon D, McKinnon K, Smedley J, Gathuka M, Klinman D, Keele BF, Langermann S, Liu L, Franchini G, Berzofsky JA.

J Clin Invest. 2014 Jun;124(6):2538-49. doi: 10.1172/JCI73518. Epub 2014 May 16.


Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.

Morris JC, Tan AR, Olencki TE, Shapiro GI, Dezube BJ, Reiss M, Hsu FJ, Berzofsky JA, Lawrence DP.

PLoS One. 2014 Mar 11;9(3):e90353. doi: 10.1371/journal.pone.0090353. eCollection 2014.

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