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Items: 34


IRF2 transcriptionally induces GSDMD expression for pyroptosis.

Kayagaki N, Lee BL, Stowe IB, Kornfeld OS, O'Rourke K, Mirrashidi KM, Haley B, Watanabe C, Roose-Girma M, Modrusan Z, Kummerfeld S, Reja R, Zhang Y, Cho V, Andrews TD, Morris LX, Goodnow CC, Bertram EM, Dixit VM.

Sci Signal. 2019 May 21;12(582). pii: eaax4917. doi: 10.1126/scisignal.aax4917.


Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.

Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16.


Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5189-98. doi: 10.1073/pnas.1511585112. Epub 2015 Aug 12.


Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.

Enders A, Short A, Miosge LA, Bergmann H, Sontani Y, Bertram EM, Whittle B, Balakishnan B, Yoshida K, Sjollema G, Field MA, Andrews TD, Hagiwara H, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4513-8. doi: 10.1073/pnas.1402739111. Epub 2014 Mar 10.


The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.

Cho V, Mei Y, Sanny A, Chan S, Enders A, Bertram EM, Tan A, Goodnow CC, Andrews TD.

Genome Biol. 2014 Jan 29;15(1):R26. doi: 10.1186/gb-2014-15-1-r26.


Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.


LIGHT (TNFSF14/CD258) is a decisive factor for recovery from experimental autoimmune encephalomyelitis.

Maña P, Liñares D, Silva DG, Fordham S, Scheu S, Pfeffer K, Staykova M, Bertram EM.

J Immunol. 2013 Jul 1;191(1):154-63. doi: 10.4049/jimmunol.1203016. Epub 2013 May 29.


Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation.

Teh CE, Horikawa K, Arnold CN, Beutler B, Kucharska EM, Vinuesa CG, Bertram EM, Goodnow CC, Enders A.

Genes Immun. 2013 Jun;14(4):223-33. doi: 10.1038/gene.2013.11. Epub 2013 Apr 4.


Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ.

PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31.


B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

Bergmann H, Yabas M, Short A, Miosge L, Barthel N, Teh CE, Roots CM, Bull KR, Jeelall Y, Horikawa K, Whittle B, Balakishnan B, Sjollema G, Bertram EM, Mackay F, Rimmer AJ, Cornall RJ, Field MA, Andrews TD, Goodnow CC, Enders A.

J Exp Med. 2013 Jan 14;210(1):31-40. doi: 10.1084/jem.20121076. Epub 2012 Dec 24.


Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.

Chang PP, Lee SK, Hu X, Davey G, Duan G, Cho JH, Karupiah G, Sprent J, Heath WR, Bertram EM, Vinuesa CG.

J Immunol. 2012 Jul 15;189(2):701-10. doi: 10.4049/jimmunol.1102432. Epub 2012 Jun 8.


DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

Randall KL, Chan SS, Ma CS, Fung I, Mei Y, Yabas M, Tan A, Arkwright PD, Al Suwairi W, Lugo Reyes SO, Yamazaki-Nakashimada MA, Garcia-Cruz Mde L, Smart JM, Picard C, Okada S, Jouanguy E, Casanova JL, Lambe T, Cornall RJ, Russell S, Oliaro J, Tangye SG, Bertram EM, Goodnow CC.

J Exp Med. 2011 Oct 24;208(11):2305-20. doi: 10.1084/jem.20110345. Epub 2011 Oct 17.


Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.

Altin JA, Tian L, Liston A, Bertram EM, Goodnow CC, Cook MC.

J Allergy Clin Immunol. 2011 May;127(5):1277-85.e5. doi: 10.1016/j.jaci.2010.12.1081. Epub 2011 Feb 12.


T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.

Watts TH, Bertram EM, Bukczynski J, Wen T.

Can J Infect Dis. 2003 Jul;14(4):221-9.


Exploiting 4-1BB costimulation for enhancing antiviral vaccination.

Harrison JM, Bertram EM, Ramshaw IA.

Viral Immunol. 2006 Winter;19(4):593-601. Review.


4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine.

Harrison JM, Bertram EM, Boyle DB, Coupar BE, Ranasinghe C, Ramshaw IA.

Vaccine. 2006 Nov 17;24(47-48):6867-74. Epub 2006 Jun 22.


4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

Dawicki W, Bertram EM, Sharpe AH, Watts TH.

J Immunol. 2004 Nov 15;173(10):5944-51.


Role of T cell costimulation in anti-viral immunity.

Bertram EM, Dawicki W, Watts TH.

Semin Immunol. 2004 Jun;16(3):185-96. Review.


Studying host immune responses against duck hepatitis B virus infection.

Miller DS, Bertram EM, Scougall CA, Kotlarski I, Jilbert AR.

Methods Mol Med. 2004;96:3-25. No abstract available.


A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.

Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH.

J Immunol. 2004 Jan 15;172(2):981-8.


The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.

Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW.

Nat Immunol. 2003 Sep;4(9):899-906. Epub 2003 Aug 17.


A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B.

Ewen C, Kane KP, Shostak I, Griebel PJ, Bertram EM, Watts TH, Bleackley RC, McElhaney JE.

J Immunol Methods. 2003 May 1;276(1-2):89-101.


Role of ICOS versus CD28 in antiviral immunity.

Bertram EM, Tafuri A, Shahinian A, Chan VS, Hunziker L, Recher M, Ohashi PS, Mak TW, Watts TH.

Eur J Immunol. 2002 Dec;32(12):3376-85.


4-1BBL enhances anti-tumor responses in the presence or absence of CD28 but CD28 is required for protective immunity against parental tumors.

Guinn BA, Bertram EM, DeBenedette MA, Berinstein NL, Watts TH.

Cell Immunol. 2001 May 25;210(1):56-65.


Characterisation of duck thrombocytes.

Bertram EM, Jilbert AR, Kotlarski I.

Res Vet Sci. 1998 May-Jun;64(3):267-70.


Characterization of age- and dose-related outcomes of duck hepatitis B virus infection.

Jilbert AR, Botten JA, Miller DS, Bertram EM, Hall PM, Kotlarski J, Burrell CJ.

Virology. 1998 May 10;244(2):273-82.


An homologous in vitro assay to detect lymphokines released by PHA-activated duck peripheral blood lymphocytes and spleen cells.

Bertram EM, Jilbert AR, Kotlarski I.

Vet Immunol Immunopathol. 1997 May;56(1-2):163-74.


Identification of duck T lymphocytes using an anti-human T cell (CD3) antiserum.

Bertram EM, Wilkinson RG, Lee BA, Jilbert AR, Kotlarski I.

Vet Immunol Immunopathol. 1996 Jun 1;51(3-4):353-63.


Immunogenicity of the Escherichia coli fimbrial antigen K99 when expressed by Salmonella enteritidis 11RX.

Bertram EM, Attridge SR, Kotlarski I.

Vaccine. 1994 Nov;12(15):1372-8.


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