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Items: 1 to 50 of 429

1.

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T.

Nat Neurosci. 2020 Jan 20. doi: 10.1038/s41593-019-0566-1. [Epub ahead of print]

PMID:
31959936
2.

Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action.

Bule P, Chuzel L, Blagova E, Wu L, Gray MA, Henrissat B, Rapp E, Bertozzi CR, Taron CH, Davies GJ.

Nat Commun. 2019 Oct 23;10(1):4816. doi: 10.1038/s41467-019-12684-7.

3.

CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity.

Tsui CK, Barfield RM, Fischer CR, Morgens DW, Li A, Smith BAH, Gray MA, Bertozzi CR, Rabuka D, Bassik MC.

Nat Chem Biol. 2019 Oct;15(10):949-958. doi: 10.1038/s41589-019-0342-2. Epub 2019 Aug 26.

PMID:
31451760
4.

Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae.

Lim HC, Sher JW, Rodriguez-Rivera FP, Fumeaux C, Bertozzi CR, Bernhardt TG.

PLoS Genet. 2019 Aug 22;15(8):e1008284. doi: 10.1371/journal.pgen.1008284. eCollection 2019 Aug.

5.

Toxoplasma gondii in cetaceans of Brazil: a histopathological and immunohistochemical survey.

Costa-Silva S, Sacristán C, Gonzales-Viera O, Díaz-Delgado J, Sánchez-Sarmiento AM, Marigo J, Groch KR, Carvalho VL, Ewbank AC, Colosio AC, Marcondes MCC, Meirelles ACO, Bertozzi CP, Lailson-Brito J, Azevedo AF, Ruoppolo V, Oliveira L, Ott PH, Catão-Dias JL.

Rev Bras Parasitol Vet. 2019 Aug 12;28(3):395-402. doi: 10.1590/S1984-29612019051.

6.

An RNA-centric dissection of host complexes controlling flavivirus infection.

Ooi YS, Majzoub K, Flynn RA, Mata MA, Diep J, Li JK, van Buuren N, Rumachik N, Johnson AG, Puschnik AS, Marceau CD, Mlera L, Grabowski JM, Kirkegaard K, Bloom ME, Sarnow P, Bertozzi CR, Carette JE.

Nat Microbiol. 2019 Dec;4(12):2369-2382. doi: 10.1038/s41564-019-0518-2. Epub 2019 Aug 5.

PMID:
31384002
7.

Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs.

Choi J, Wagner LJS, Timmermans SBPE, Malaker SA, Schumann B, Gray MA, Debets MF, Takashima M, Gehring J, Bertozzi CR.

J Am Chem Soc. 2019 Aug 28;141(34):13442-13453. doi: 10.1021/jacs.9b04695. Epub 2019 Aug 16.

PMID:
31373799
8.

Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx.

Möckl L, Pedram K, Roy AR, Krishnan V, Gustavsson AK, Dorigo O, Bertozzi CR, Moerner WE.

Dev Cell. 2019 Jul 1;50(1):57-72.e6. doi: 10.1016/j.devcel.2019.04.035. Epub 2019 May 16.

PMID:
31105009
9.

Physical Principles of Membrane Shape Regulation by the Glycocalyx.

Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O'Donnell JP, Yin R, Pedram K, Möckl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ.

Cell. 2019 Jun 13;177(7):1757-1770.e21. doi: 10.1016/j.cell.2019.04.017. Epub 2019 May 2.

PMID:
31056282
10.

A Sugar Cloak of Invisibility.

Waldman AJ, Bertozzi CR.

Biochemistry. 2019 May 14;58(19):2385-2386. doi: 10.1021/acs.biochem.9b00170. Epub 2019 May 1. No abstract available.

PMID:
31041861
11.

Molecular, serological, pathological, immunohistochemical and microbiological investigation of Brucella spp. in marine mammals of Brazil reveals new cetacean hosts.

Sánchez-Sarmiento AM, Carvalho VL, Díaz-Delgado J, Ressio RA, Fernandes NCCA, Guerra JM, Sacristán C, Groch KR, Silvestre-Perez N, Ferreira-Machado E, Costa-Silva S, Navas-Suárez P, Meirelles ACO, Favero C, Marigo J, Bertozzi CP, Colosio AC, Marcondes MCC, Cremer MJ, Dos Santos Silva N, Ferreira Neto JS, Keid LB, Soares R, Sierra E, Fernández A, Catão-Dias JL.

Transbound Emerg Dis. 2019 Jul;66(4):1674-1692. doi: 10.1111/tbed.13203. Epub 2019 May 20.

PMID:
30980699
12.

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.

Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T.

Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3.

13.

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.

Malaker SA, Pedram K, Ferracane MJ, Bensing BA, Krishnan V, Pett C, Yu J, Woods EC, Kramer JR, Westerlind U, Dorigo O, Bertozzi CR.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7278-7287. doi: 10.1073/pnas.1813020116. Epub 2019 Mar 25.

14.

Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation.

Appel MJ, Meier KK, Lafrance-Vanasse J, Lim H, Tsai CL, Hedman B, Hodgson KO, Tainer JA, Solomon EI, Bertozzi CR.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5370-5375. doi: 10.1073/pnas.1818274116. Epub 2019 Mar 1.

15.

Incidence of gadolinium or fluid signal within surgically proven glenoid labral tears at MR arthrography.

Nacey NC, Fox MG, Bertozzi CJ, Pierce JL, Said N, Diduch DR.

Skeletal Radiol. 2019 Aug;48(8):1185-1191. doi: 10.1007/s00256-018-3143-x. Epub 2019 Jan 25.

PMID:
30683975
16.

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum.

Zhou X, Rodriguez-Rivera FP, Lim HC, Bell JC, Bernhardt TG, Bertozzi CR, Theriot JA.

Nat Chem Biol. 2019 Mar;15(3):221-231. doi: 10.1038/s41589-018-0206-1. Epub 2019 Jan 21.

PMID:
30664686
17.

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.

Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G.

iScience. 2019 Jan 25;11:160-177. doi: 10.1016/j.isci.2018.12.015. Epub 2018 Dec 20.

18.

Is the Nobel Prize in Chemistry Having a Boston Red Sox Moment?

Bertozzi CR.

ACS Cent Sci. 2018 Oct 24;4(10):1291. doi: 10.1021/acscentsci.8b00740. No abstract available.

19.

A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia.

Spiciarich DR, Oh ST, Foley A, Hughes SB, Mauro MJ, Abdel-Wahab O, Press RD, Viner R, Thompson SL, Chen Q, Azadi P, Bertozzi CR, Maxson JE.

Cancer Res. 2018 Dec 15;78(24):6762-6770. doi: 10.1158/0008-5472.CAN-18-1638. Epub 2018 Oct 22.

20.

Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling.

Walton EM, Cronan MR, Cambier CJ, Rossi A, Marass M, Foglia MD, Brewer WJ, Poss KD, Stainier DYR, Bertozzi CR, Tobin DM.

Cell Host Microbe. 2018 Oct 10;24(4):514-525.e6. doi: 10.1016/j.chom.2018.09.004.

21.

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM.

Nat Cell Biol. 2018 Oct;20(10):1203-1214. doi: 10.1038/s41556-018-0183-3. Epub 2018 Sep 10.

22.

IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea.

Wan SJ, Sullivan AB, Shieh P, Metruccio MME, Evans DJ, Bertozzi CR, Fleiszig SMJ.

Front Microbiol. 2018 May 29;9:1117. doi: 10.3389/fmicb.2018.01117. eCollection 2018.

23.

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.

Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T.

J Am Chem Soc. 2018 Jun 13;140(23):7046-7051. doi: 10.1021/jacs.8b03074. Epub 2018 May 30.

24.

Computation-Guided Rational Design of a Peptide Motif That Reacts with Cyanobenzothiazoles via Internal Cysteine-Lysine Relay.

Keyser SGL, Utz A, Bertozzi CR.

J Org Chem. 2018 Jul 20;83(14):7467-7479. doi: 10.1021/acs.joc.8b00625. Epub 2018 May 30.

25.

Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct.

Tomlin FM, Gordon CG, Han Y, Wu TS, Sletten EM, Bertozzi CR.

Bioorg Med Chem. 2018 Oct 15;26(19):5280-5290. doi: 10.1016/j.bmc.2018.04.009. Epub 2018 Apr 4.

26.

Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe.

Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Babu Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD, Bertozzi CR.

Sci Transl Med. 2018 Feb 28;10(430). pii: eaam6310. doi: 10.1126/scitranslmed.aam6310.

27.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

28.

Acute Modulation of Mycobacterial Cell Envelope Biogenesis by Front-Line Tuberculosis Drugs.

Rodriguez-Rivera FP, Zhou X, Theriot JA, Bertozzi CR.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5267-5272. doi: 10.1002/anie.201712020. Epub 2018 Apr 14.

29.

N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2.

Zhou MN, Delaveris CS, Kramer JR, Kenkel JA, Engleman EG, Bertozzi CR.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3137-3142. doi: 10.1002/anie.201713075. Epub 2018 Feb 21.

30.

Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis.

Tsai CT, Robinson PV, Cortez FJ, Elma MLB, Seftel D, Pourmandi N, Pandori MW, Bertozzi CR.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1250-1255. doi: 10.1073/pnas.1711004115. Epub 2018 Jan 22.

31.

Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).

Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ.

Mol Cell Proteomics. 2018 Apr;17(4):764-775. doi: 10.1074/mcp.RA117.000261. Epub 2018 Jan 19.

32.

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement.

Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi CR, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S.

Cell. 2018 Jan 11;172(1-2):305-317.e10. doi: 10.1016/j.cell.2017.12.023.

33.

Imaging Mycobacterial Trehalose Glycolipids.

Kamariza M, Shieh P, Bertozzi CR.

Methods Enzymol. 2018;598:355-369. doi: 10.1016/bs.mie.2017.09.002. Epub 2017 Nov 21.

34.

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.

Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR.

Elife. 2017 Dec 21;6. pii: e25752. doi: 10.7554/eLife.25752.

35.

Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.

Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ.

J Allergy Clin Immunol. 2018 May;141(5):1901-1904.e15. doi: 10.1016/j.jaci.2017.11.021. Epub 2017 Dec 14. No abstract available.

36.

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.

ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.

37.

A Model for Accelerating Patient-to-Bench Research.

Bertozzi C.

ACS Cent Sci. 2017 Nov 22;3(11):1129-1130. doi: 10.1021/acscentsci.7b00540. No abstract available.

38.

Genetic evaluation for birth and conformation traits in dual-purpose Belgian Blue cattle using a mixed inheritance model.

Mota RR, Mayeres P, Bastin C, Glorieux G, Bertozzi C, Vanderick S, Hammami H, Colinet FG, Gengler N.

J Anim Sci. 2017 Oct;95(10):4288-4299. doi: 10.2527/jas2017.1748.

PMID:
29108034
39.

Atoms out of Blobs: CryoEM Takes the Nobel Prize in Chemistry.

Bertozzi C.

ACS Cent Sci. 2017 Oct 25;3(10):1056. doi: 10.1021/acscentsci.7b00494. No abstract available.

40.

Bayesian single-step genomic evaluations combining local and foreign information in Walloon Holsteins.

Colinet FG, Vandenplas J, Vanderick S, Hammami H, Mota RR, Gillon A, Hubin X, Bertozzi C, Gengler N.

Animal. 2018 May;12(5):898-905. doi: 10.1017/S1751731117002324. Epub 2017 Oct 16.

PMID:
29032781
41.

Chemical Tools for Inhibiting Glycosylation.

Esko JD, Bertozzi C, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 55.
2017.

42.

Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics.

Spiciarich DR, Nolley R, Maund SL, Purcell SC, Herschel J, Iavarone AT, Peehl DM, Bertozzi CR.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8992-8997. doi: 10.1002/anie.201701424. Epub 2017 Jun 26.

43.

Werner Reutter: A Visionary Pioneer in Molecular Glycobiology.

Hinderlich S, Tauber R, Bertozzi CR, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1141-1145. doi: 10.1002/cbic.201700277. Epub 2017 Jun 16.

PMID:
28621497
44.

Miraculous Chemistry on the Han River.

Bertozzi C.

ACS Cent Sci. 2017 May 24;3(5):360-361. doi: 10.1021/acscentsci.7b00204. No abstract available.

45.

Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation.

Andres LM, Blong IW, Evans AC, Rumachik NG, Yamaguchi T, Pham ND, Thompson P, Kohler JJ, Bertozzi CR.

ACS Chem Biol. 2017 Aug 18;12(8):2030-2039. doi: 10.1021/acschembio.7b00232. Epub 2017 Jun 19.

46.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Med Chem Lett. 2017 Feb 28;8(4):379-382. doi: 10.1021/acsmedchemlett.7b00056. eCollection 2017 Apr 13. No abstract available.

47.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Cent Sci. 2017 Mar 22;3(3):143-147. doi: 10.1021/acscentsci.7b00069. Epub 2017 Feb 28. No abstract available.

48.

Development of IsoTaG, a Chemical Glycoproteomics Technique for Profiling Intact N- and O-Glycopeptides from Whole Cell Proteomes.

Woo CM, Felix A, Byrd WE, Zuegel DK, Ishihara M, Azadi P, Iavarone AT, Pitteri SJ, Bertozzi CR.

J Proteome Res. 2017 Apr 7;16(4):1706-1718. doi: 10.1021/acs.jproteome.6b01053. Epub 2017 Feb 28.

49.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

J Med Chem. 2017 Mar 23;60(6):2165-2168. doi: 10.1021/acs.jmedchem.7b00229. Epub 2017 Feb 28. No abstract available.

PMID:
28244745
50.

The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

J Chem Inf Model. 2017 Mar 27;57(3):387-390. doi: 10.1021/acs.jcim.7b00105. Epub 2017 Feb 28. No abstract available.

PMID:
28244743

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