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Items: 1 to 50 of 180

1.

Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection.

Cheng Y, Zhu YO, Becht E, Aw P, Chen J, Poidinger M, de Sessions PF, Hibberd ML, Bertoletti A, Lim SG, Newell EW.

Sci Immunol. 2019 Feb 8;4(32). pii: eaau6905. doi: 10.1126/sciimmunol.aau6905.

PMID:
30737354
2.

Use of Expression Profiles of HBV DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

Tan AT, Yang N, Krishnamoorthy TL, Oei V, Chua A, Xinyuan Z, Si TH, Chia A, Le Bert N, Low D, Tan HK, Kumar R, Irani FG, Zong HZ, Zhang Q, Guccione E, Lu-En W, Koh S, Hwang W, Chow WC, Bertoletti A.

Gastroenterology. 2019 Jan 31. pii: S0016-5085(19)30348-8. doi: 10.1053/j.gastro.2019.01.251. [Epub ahead of print]

3.

HBV antiviral immunity: not all CD8 T cells are born equal.

Bertoletti A, Kennedy PTF.

Gut. 2019 Jan 30. pii: gutjnl-2018-317959. doi: 10.1136/gutjnl-2018-317959. [Epub ahead of print] No abstract available.

PMID:
30700541
4.

Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection.

Khakpoor A, Ni Y, Chen A, Ho ZZ, Oei V, Yang N, Giri R, Chow JX, Tan AT, Kennedy PT, Maini M, Urban S, Bertoletti A.

J Virol. 2019 Feb 5;93(4). pii: e01457-18. doi: 10.1128/JVI.01457-18. Print 2019 Feb 15.

5.

Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Lim MQ, Kumaran EAP, Tan HC, Lye DC, Leo YS, Ooi EE, MacAry PA, Bertoletti A, Rivino L.

Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.

6.

Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver.

Otano I, Escors D, Schurich A, Singh H, Robertson F, Davidson BR, Fusai G, Vargas FA, Tan ZMD, Aw JYJ, Hansi N, Kennedy PTF, Xue SA, Stauss HJ, Bertoletti A, Pavesi A, Maini MK.

Mol Ther. 2018 Nov 7;26(11):2553-2566. doi: 10.1016/j.ymthe.2018.08.013. Epub 2018 Aug 16.

7.

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.

Salimzadeh L, Le Bert N, Dutertre CA, Gill US, Newell EW, Frey C, Hung M, Novikov N, Fletcher S, Kennedy PT, Bertoletti A.

J Clin Invest. 2018 Oct 1;128(10):4573-4587. doi: 10.1172/JCI121957. Epub 2018 Aug 7.

8.

Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.

Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.

Front Immunol. 2018 Jul 24;9:1719. doi: 10.3389/fimmu.2018.01719. eCollection 2018.

9.

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Zhao X, Sankaran S, Yap J, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti A, MacAry PA, Brzostek J, Gascoigne NRJ.

Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.

10.

Editorial overview: Antiviral strategies: Virological and immunological basis for HBV cure.

Urban S, Bertoletti A.

Curr Opin Virol. 2018 Jun;30:iv-vi. doi: 10.1016/j.coviro.2018.05.001. No abstract available.

PMID:
29866361
11.

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.

Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.

Front Immunol. 2018 Mar 6;9:416. doi: 10.3389/fimmu.2018.00416. eCollection 2018. Erratum in: Front Immunol. 2018 Jul 24;9:1719.

12.

Nonlytic Lymphocytes Engineered to Express Virus-Specific T-Cell Receptors Limit HBV Infection by Activating APOBEC3.

Koh S, Kah J, Tham CYL, Yang N, Ceccarello E, Chia A, Chen M, Khakpoor A, Pavesi A, Tan AT, Dandri M, Bertoletti A.

Gastroenterology. 2018 Jul;155(1):180-193.e6. doi: 10.1053/j.gastro.2018.03.027. Epub 2018 Mar 14.

PMID:
29550589
13.

CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype.

Dharmadhikari B, Nickles E, Harfuddin Z, Ishak NDB, Zeng Q, Bertoletti A, Schwarz H.

Cancer Immunol Immunother. 2018 Jun;67(6):893-905. doi: 10.1007/s00262-018-2144-x. Epub 2018 Mar 5.

PMID:
29508025
14.

Immunotherapy for Chronic Hepatitis B Virus Infection.

Bertoletti A, Le Bert N.

Gut Liver. 2018 Sep 15;12(5):497-507. doi: 10.5009/gnl17233. Review.

15.

Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.

Rivino L, Le Bert N, Gill US, Kunasegaran K, Cheng Y, Tan DZ, Becht E, Hansi NK, Foster GR, Su TH, Tseng TC, Lim SG, Kao JH, Newell EW, Kennedy PT, Bertoletti A.

J Clin Invest. 2018 Feb 1;128(2):668-681. doi: 10.1172/JCI92812. Epub 2018 Jan 8.

16.

HBV infection and HCC: the 'dangerous liaisons'.

Bertoletti A, Kennedy PTF, Durantel D.

Gut. 2018 May;67(5):787-788. doi: 10.1136/gutjnl-2017-315528. Epub 2017 Dec 1. No abstract available.

PMID:
29196438
17.

T-cell therapy for chronic viral hepatitis.

Bertoletti A, Tan AT, Koh S.

Cytotherapy. 2017 Nov;19(11):1317-1324. doi: 10.1016/j.jcyt.2017.07.011. Epub 2017 Aug 25. Review.

PMID:
28847469
18.

Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B.

Nat Commun. 2017 Aug 18;8:16141. doi: 10.1038/ncomms16141.

19.

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection.

Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lütgehetmann M, Bertoletti A, Dandri M.

J Clin Invest. 2017 Aug 1;127(8):3177-3188. doi: 10.1172/JCI93024. Epub 2017 Jul 24.

20.

Tolerance and immunity to pathogens in early life: insights from HBV infection.

Hong M, Bertoletti A.

Semin Immunopathol. 2017 Nov;39(6):643-652. doi: 10.1007/s00281-017-0641-1. Epub 2017 Jul 6. Review.

21.

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B.

Nat Commun. 2017 Jun 28;8:15865. doi: 10.1038/ncomms15865. Erratum in: Nat Commun. 2017 Aug 18;8:16141.

22.

A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.

Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A.

JCI Insight. 2017 Jun 15;2(12). pii: 89762. doi: 10.1172/jci.insight.89762. [Epub ahead of print]

23.

Clinical Trial Design for Immune-Based Therapy of Hepatitis B Virus.

Gill US, Bertoletti A.

Semin Liver Dis. 2017 May;37(2):85-94. doi: 10.1055/s-0037-1600522. Epub 2017 May 31. Review.

PMID:
28564718
24.

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease.

Tan-Garcia A, Wai LE, Zheng D, Ceccarello E, Jo J, Banu N, Khakpoor A, Chia A, Tham CYL, Tan AT, Hong M, Keng CT, Rivino L, Tan KC, Lee KH, Lim SG, Newell EW, Pavelka N, Chen J, Ginhoux F, Chen Q, Bertoletti A, Dutertre CA.

J Hepatol. 2017 Sep;67(3):490-500. doi: 10.1016/j.jhep.2017.04.023. Epub 2017 May 5.

PMID:
28483682
25.

Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks.

Kennedy PTF, Litwin S, Dolman GE, Bertoletti A, Mason WS.

Viruses. 2017 Apr 29;9(5). pii: E96. doi: 10.3390/v9050096. Review.

26.

Corrigendum: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.

Yeap WH, Wong KL, Shimasaki N, Teo EC, Quek JK, Yong HX, Diong CP, Bertoletti A, Linn YC, Wong SC.

Sci Rep. 2017 Apr 7;7:46202. doi: 10.1038/srep46202. No abstract available.

27.

Reply.

Kennedy PTF, Bertoletti A, Mason WS.

Gastroenterology. 2017 Apr;152(5):1246-1247. doi: 10.1053/j.gastro.2017.03.002. Epub 2017 Mar 6. No abstract available.

PMID:
28273438
28.

Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.

Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, Lohmann V, Koh S, Bertoletti A, Chen M.

J Virol. 2017 Apr 13;91(9). pii: e00010-17. doi: 10.1128/JVI.00010-17. Print 2017 May 1.

29.

An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers.

Wijaya L, Tham CYL, Chan YFZ, Wong AWL, Li LT, Wang LF, Bertoletti A, Low JG.

Vaccine. 2017 Feb 22;35(8):1175-1183. doi: 10.1016/j.vaccine.2016.12.031. Epub 2017 Jan 22.

PMID:
28118938
30.

HBV in 2016: Global and immunotherapeutic insights into hepatitis B.

Maini MK, Bertoletti A.

Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):71-72. doi: 10.1038/nrgastro.2016.196. Epub 2017 Jan 5. Review. No abstract available.

PMID:
28053337
31.

CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.

Yeap WH, Wong KL, Shimasaki N, Teo EC, Quek JK, Yong HX, Diong CP, Bertoletti A, Linn YC, Wong SC.

Sci Rep. 2016 Sep 27;6:34310. doi: 10.1038/srep34310. Erratum in: Sci Rep. 2017 Apr 07;7:46202.

32.

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

Wong MT, Ong DE, Lim FS, Teng KW, McGovern N, Narayanan S, Ho WQ, Cerny D, Tan HK, Anicete R, Tan BK, Lim TK, Chan CY, Cheow PC, Lee SY, Takano A, Tan EH, Tam JK, Tan EY, Chan JK, Fink K, Bertoletti A, Ginhoux F, Curotto de Lafaille MA, Newell EW.

Immunity. 2016 Aug 16;45(2):442-56. doi: 10.1016/j.immuni.2016.07.007. Epub 2016 Aug 9.

33.

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant.

Mason WS, Gill US, Litwin S, Zhou Y, Peri S, Pop O, Hong ML, Naik S, Quaglia A, Bertoletti A, Kennedy PT.

Gastroenterology. 2016 Nov;151(5):986-998.e4. doi: 10.1053/j.gastro.2016.07.012. Epub 2016 Jul 22.

PMID:
27453547
34.

Advanced Design of Dumbbell-shaped Genetic Minimal Vectors Improves Non-coding and Coding RNA Expression.

Jiang X, Yu H, Teo CR, Tan GS, Goh SC, Patel P, Chua YK, Hameed NB, Bertoletti A, Patzel V.

Mol Ther. 2016 Sep;24(9):1581-91. doi: 10.1038/mt.2016.138. Epub 2016 Jun 30.

35.

Redirecting T Cell Specificity Using T Cell Receptor Messenger RNA Electroporation.

Koh S, Shimasaki N, Bertoletti A.

Methods Mol Biol. 2016;1428:285-96. doi: 10.1007/978-1-4939-3625-0_19.

PMID:
27236807
36.

Microfluidic models for adoptive cell-mediated cancer immunotherapies.

Adriani G, Pavesi A, Tan AT, Bertoletti A, Thiery JP, Kamm RD.

Drug Discov Today. 2016 Sep;21(9):1472-1478. doi: 10.1016/j.drudis.2016.05.006. Epub 2016 May 13. Review.

37.

Adaptive immunity in HBV infection.

Bertoletti A, Ferrari C.

J Hepatol. 2016 Apr;64(1 Suppl):S71-S83. doi: 10.1016/j.jhep.2016.01.026. Review.

PMID:
27084039
38.

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.

Ng OW, Chia A, Tan AT, Jadi RS, Leong HN, Bertoletti A, Tan YJ.

Vaccine. 2016 Apr 12;34(17):2008-14. doi: 10.1016/j.vaccine.2016.02.063. Epub 2016 Mar 5.

PMID:
26954467
39.

T cell fitness in the liver: How can T cells keep it up?

Bertoletti A.

J Hepatol. 2016 Jun;64(6):1208-10. doi: 10.1016/j.jhep.2016.02.035. Epub 2016 Mar 2. No abstract available.

PMID:
26943972
40.

Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future.

Koh S, Tan AT, Li L, Bertoletti A.

Diseases. 2016 Feb 15;4(1). pii: E10. doi: 10.3390/diseases4010010. Review.

41.

Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies.

Pavesi A, Tan AT, Chen MB, Adriani G, Bertoletti A, Kamm RD.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:1853-6. doi: 10.1109/EMBC.2015.7318742.

PMID:
26736642
42.

Advances in therapeutics for chronic hepatitis B.

Yang N, Bertoletti A.

Hepatol Int. 2016 Mar;10(2):277-85. doi: 10.1007/s12072-015-9661-x. Epub 2015 Sep 12. Review.

PMID:
26363922
43.

Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways.

Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M, Hong M, Bertoletti A, Bicciato S, Invernizzi P, Lugli E, Torzilli G, Gershwin ME, Mavilio D.

J Autoimmun. 2016 Jan;66:40-50. doi: 10.1016/j.jaut.2015.08.011. Epub 2015 Aug 30.

44.

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

Fergusson JR, Hühn MH, Swadling L, Walker LJ, Kurioka A, Llibre A, Bertoletti A, Holländer G, Newell EW, Davis MM, Sverremark-Ekström E, Powrie F, Capone S, Folgori A, Barnes E, Willberg CB, Ussher JE, Klenerman P.

Mucosal Immunol. 2016 Mar;9(2):401-13. doi: 10.1038/mi.2015.69. Epub 2015 Jul 29.

45.

T cell receptor-therapy in HBV-related hepatocellularcarcinoma.

Bertoletti A, Brunetto M, Maini MK, Bonino F, Qasim W, Stauss H.

Oncoimmunology. 2015 Mar 19;4(6):e1008354. eCollection 2015 Jun.

46.

Immune Response in Hepatitis B Virus Infection.

Tan A, Koh S, Bertoletti A.

Cold Spring Harb Perspect Med. 2015 Jul 1;5(8):a021428. doi: 10.1101/cshperspect.a021428. Review.

47.

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.

Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK.

Nat Med. 2015 Jun;21(6):591-600. doi: 10.1038/nm.3856. Epub 2015 May 11.

48.

Overview of the special issue on HBV immunity.

Bertoletti A, Wang FS.

Cell Mol Immunol. 2015 May;12(3):253-4. doi: 10.1038/cmi.2015.24. Epub 2015 Apr 13. No abstract available.

49.

Trained immunity in newborn infants of HBV-infected mothers.

Hong M, Sandalova E, Low D, Gehring AJ, Fieni S, Amadei B, Urbani S, Chong YS, Guccione E, Bertoletti A.

Nat Commun. 2015 Mar 25;6:6588. doi: 10.1038/ncomms7588.

50.

Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.

PMID:
25761891

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