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Items: 33

1.

The immune cell landscape in kidneys of patients with lupus nephritis.

Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF 3rd, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B; Accelerating Medicines Partnership in SLE network.

Nat Immunol. 2019 Jul;20(7):902-914. doi: 10.1038/s41590-019-0398-x. Epub 2019 Jun 17.

PMID:
31209404
2.

The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.

Billi AC, Gharaee-Kermani M, Fullmer J, Tsoi LC, Hill BD, Gruszka D, Ludwig J, Xing X, Estadt S, Wolf SJ, Rizvi SM, Berthier CC, Hodgin JB, Beamer MA, Sarkar MK, Liang Y, Uppala R, Shao S, Zeng C, Harms PW, Verhaegen ME, Voorhees JJ, Wen F, Ward NL, Dlugosz AA, Kahlenberg JM, Gudjonsson JE.

JCI Insight. 2019 Apr 18;4(8). pii: 127291. doi: 10.1172/jci.insight.127291. eCollection 2019 Apr 18.

3.

Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.

Tsoi LC, Hile GA, Berthier CC, Sarkar MK, Reed TJ, Liu J, Uppala R, Patrick M, Raja K, Xing X, Xing E, He K, Gudjonsson JE, Kahlenberg JM.

J Immunol. 2019 Apr 1;202(7):2121-2130. doi: 10.4049/jimmunol.1800650. Epub 2019 Feb 11.

PMID:
30745462
4.

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM.

Ann Rheum Dis. 2018 Nov;77(11):1653-1664. doi: 10.1136/annrheumdis-2018-213197. Epub 2018 Jul 18.

PMID:
30021804
5.

Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.

McCoy SS, Reed TJ, Berthier CC, Tsou PS, Liu J, Gudjonsson JE, Khanna D, Kahlenberg JM.

Rheumatology (Oxford). 2017 Nov 1;56(11):1970-1981. doi: 10.1093/rheumatology/kex280.

6.

ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation.

Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC 3rd, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW.

Am J Pathol. 2017 Dec;187(12):2799-2810. doi: 10.1016/j.ajpath.2017.08.018. Epub 2017 Sep 19.

7.

Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy.

Liu P, Lassén E, Nair V, Berthier CC, Suguro M, Sihlbom C, Kretzler M, Betsholtz C, Haraldsson B, Ju W, Ebefors K, Nyström J.

J Am Soc Nephrol. 2017 Oct;28(10):2961-2972. doi: 10.1681/ASN.2016101103. Epub 2017 Jun 23.

8.

Enhanced Inflammasome Activity in Systemic Lupus Erythematosus Is Mediated via Type I Interferon-Induced Up-Regulation of Interferon Regulatory Factor 1.

Liu J, Berthier CC, Kahlenberg JM.

Arthritis Rheumatol. 2017 Sep;69(9):1840-1849. doi: 10.1002/art.40166. Epub 2017 Aug 8.

9.

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases.

Liang Y, Tsoi LC, Xing X, Beamer MA, Swindell WR, Sarkar MK, Berthier CC, Stuart PE, Harms PW, Nair RP, Elder JT, Voorhees JJ, Kahlenberg JM, Gudjonsson JE.

Nat Immunol. 2017 Feb;18(2):152-160. doi: 10.1038/ni.3643. Epub 2016 Dec 19.

10.

A systems approach to renal inflammation in SLE.

Berthier CC, Kretzler M, Davidson A.

Clin Immunol. 2017 Dec;185:109-118. doi: 10.1016/j.clim.2016.08.015. Epub 2016 Aug 14. Review.

11.

Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.

Ju W, Nair V, Smith S, Zhu L, Shedden K, Song PXK, Mariani LH, Eichinger FH, Berthier CC, Randolph A, Lai JY, Zhou Y, Hawkins JJ, Bitzer M, Sampson MG, Thier M, Solier C, Duran-Pacheco GC, Duchateau-Nguyen G, Essioux L, Schott B, Formentini I, Magnone MC, Bobadilla M, Cohen CD, Bagnasco SM, Barisoni L, Lv J, Zhang H, Wang HY, Brosius FC, Gadegbeku CA, Kretzler M; ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium.

Sci Transl Med. 2015 Dec 2;7(316):316ra193. doi: 10.1126/scitranslmed.aac7071.

12.

The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.

Hodgin JB, Berthier CC, John R, Grone E, Porubsky S, Gröne HJ, Herzenberg AM, Scholey JW, Hladunewich M, Cattran DC, Kretzler M, Reich HN.

PLoS One. 2014 Aug 18;9(8):e103413. doi: 10.1371/journal.pone.0103413. eCollection 2014.

13.

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.

Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD; International Consortium for Systemic Lupus Erythematosus Genetics.

J Am Soc Nephrol. 2014 Dec;25(12):2859-70. doi: 10.1681/ASN.2013050446. Epub 2014 Jun 12.

14.

Identification of stage-specific genes associated with lupus nephritis and response to remission induction in (NZB × NZW)F1 and NZM2410 mice.

Bethunaickan R, Berthier CC, Zhang W, Eksi R, Li HD, Guan Y, Kretzler M, Davidson A.

Arthritis Rheumatol. 2014 Aug;66(8):2246-2258. doi: 10.1002/art.38679.

15.

Comparative transcriptional profiling of 3 murine models of SLE nephritis reveals both unique and shared regulatory networks.

Bethunaickan R, Berthier CC, Zhang W, Kretzler M, Davidson A.

PLoS One. 2013 Oct 22;8(10):e77489. doi: 10.1371/journal.pone.0077489. eCollection 2013.

16.

The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus.

Zhao W, Berthier CC, Lewis EE, McCune WJ, Kretzler M, Kaplan MJ.

Clin Immunol. 2013 Oct;149(1):119-32. doi: 10.1016/j.clim.2013.07.002. Epub 2013 Jul 20.

17.

From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine.

Berthier CC, Kretzler M, Davidson A.

J Data Mining Genomics Proteomics. 2012 Mar 27;3(3). pii: 1000123.

18.

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Berthier CC, Bethunaickan R, Gonzalez-Rivera T, Nair V, Ramanujam M, Zhang W, Bottinger EP, Segerer S, Lindenmeyer M, Cohen CD, Davidson A, Kretzler M.

J Immunol. 2012 Jul 15;189(2):988-1001. doi: 10.4049/jimmunol.1103031. Epub 2012 Jun 20.

19.

Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus.

Kahlenberg JM, Thacker SG, Berthier CC, Cohen CD, Kretzler M, Kaplan MJ.

J Immunol. 2011 Dec 1;187(11):6143-56. doi: 10.4049/jimmunol.1101284. Epub 2011 Nov 4.

20.

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, Rubin CJ, Zhao W, Olsen SH, Klinker M, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT, Kaplan MJ.

J Immunol. 2011 Jul 1;187(1):538-52. doi: 10.4049/jimmunol.1100450. Epub 2011 May 25.

21.

A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis.

Bethunaickan R, Berthier CC, Ramanujam M, Sahu R, Zhang W, Sun Y, Bottinger EP, Ivashkiv L, Kretzler M, Davidson A.

J Immunol. 2011 Apr 15;186(8):4994-5003. doi: 10.4049/jimmunol.1003010. Epub 2011 Mar 16.

22.

A molecular signature of proteinuria in glomerulonephritis.

Reich HN, Tritchler D, Cattran DC, Herzenberg AM, Eichinger F, Boucherot A, Henger A, Berthier CC, Nair V, Cohen CD, Scholey JW, Kretzler M.

PLoS One. 2010 Oct 18;5(10):e13451. doi: 10.1371/journal.pone.0013451.

23.

A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue.

Hodgin JB, Borczuk AC, Nasr SH, Markowitz GS, Nair V, Martini S, Eichinger F, Vining C, Berthier CC, Kretzler M, D'Agati VD.

Am J Pathol. 2010 Oct;177(4):1674-86. doi: 10.2353/ajpath.2010.090746. Epub 2010 Sep 16.

24.

The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.

Thacker SG, Berthier CC, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ.

J Immunol. 2010 Oct 1;185(7):4457-69. doi: 10.4049/jimmunol.1001782. Epub 2010 Aug 30.

25.

Renal gene and protein expression signatures for prediction of kidney disease progression.

Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier CC, Shedden K, Cohen CD, Henger A, Krick S, Kopp JB, Stoeckert CJ Jr, Dikman S, Schröppel B, Thomas DB, Schlondorff D, Kretzler M, Böttinger EP.

Am J Pathol. 2009 Jun;174(6):2073-85. doi: 10.2353/ajpath.2009.080888. Erratum in: Am J Pathol. 2009 Sep;175(3):1349.

26.

Experimental heart transplantation: effect of cyclosporine on expression and activity of metzincins.

Berthier CC, Pally C, Weckbecker G, Raulf F, Rehrauer H, Wagner U, Le Hir M, Marti HP.

Swiss Med Wkly. 2009 Apr 18;139(15-16):233-40. doi: smw-12524.

27.

Renal allografts with IF/TA display distinct expression profiles of metzincins and related genes.

Rödder S, Scherer A, Raulf F, Berthier CC, Hertig A, Couzi L, Durrbach A, Rondeau E, Marti HP.

Am J Transplant. 2009 Mar;9(3):517-26. doi: 10.1111/j.1600-6143.2008.02512.x. Epub 2009 Feb 3.

28.

Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy.

Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, Boucherot A, Neusser MA, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC, Kretzler M.

Diabetes. 2009 Feb;58(2):469-77. doi: 10.2337/db08-1328. Epub 2008 Nov 18.

29.

Analysis of independent microarray datasets of renal biopsies identifies a robust transcript signature of acute allograft rejection.

Saint-Mezard P, Berthier CC, Zhang H, Hertig A, Kaiser S, Schumacher M, Wieczorek G, Bigaud M, Kehren J, Rondeau E, Raulf F, Marti HP.

Transpl Int. 2009 Mar;22(3):293-302. doi: 10.1111/j.1432-2277.2008.00790.x. Epub 2008 Nov 6.

30.

The death ligand TRAIL in diabetic nephropathy.

Lorz C, Benito-Martín A, Boucherot A, Ucero AC, Rastaldi MP, Henger A, Armelloni S, Santamaría B, Berthier CC, Kretzler M, Egido J, Ortiz A.

J Am Soc Nephrol. 2008 May;19(5):904-14. doi: 10.1681/ASN.2007050581. Epub 2008 Feb 20.

31.

Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease.

Berthier CC, Wahl PR, Le Hir M, Marti HP, Wagner U, Rehrauer H, Wüthrich RP, Serra AL.

Nephrol Dial Transplant. 2008 Mar;23(3):880-9. Epub 2007 Nov 27.

32.

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy.

Walsh DW, Roxburgh SA, McGettigan P, Berthier CC, Higgins DG, Kretzler M, Cohen CD, Mezzano S, Brazil DP, Martin F.

Biochim Biophys Acta. 2008 Jan;1782(1):10-21. Epub 2007 Oct 11.

33.

Differential regulation of metzincins in experimental chronic renal allograft rejection: potential markers and novel therapeutic targets.

Berthier CC, Lods N, Joosten SA, van Kooten C, Leppert D, Lindberg RL, Kappeler A, Raulf F, Sterchi EE, Lottaz D, Marti HP.

Kidney Int. 2006 Jan;69(2):358-68.

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