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Pilot Study Experiences With Hyperpolarized [1-13 C]pyruvate MRI in Pancreatic Cancer Patients.

Stødkilde-Jørgensen H, Laustsen C, Hansen ESS, Schulte R, Ardenkjaer-Larsen JH, Comment A, Frøkiaer J, Ringgaard S, Bertelsen LB, Ladekarl M, Weber B.

J Magn Reson Imaging. 2019 Aug 1. doi: 10.1002/jmri.26888. [Epub ahead of print] No abstract available.


High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.

Laustsen C, Lipsø K, Østergaard JA, Nielsen PM, Bertelsen LB, Flyvbjerg A, Pedersen M, Palm F, Ardenkjær-Larsen JH.

Tomography. 2019 Jun;5(2):239-247. doi: 10.18383/j.tom.2019.00003.


A woman in her forties with pelvic pain and unclear MRI findings.

Brattås MK, Gjelberg HK, Dizdar V, Vetti N, Bertelsen LT, Reikvam H.

Tidsskr Nor Laegeforen. 2019 Apr 24;139(8). doi: 10.4045/tidsskr.18.0541. Print 2019 May 7. Norwegian. No abstract available.


Impact of Multiple Myocardial Scars Detected by CMR in Patients Following STEMI.

Ekström K, Nepper-Christensen L, Ahtarovski KA, Kyhl K, Göransson C, Bertelsen L, Ghotbi AA, Kelbæk H, Helqvist S, Høfsten DE, Køber L, Schoos MM, Vejlstrup N, Lønborg J, Engstrøm T.

JACC Cardiovasc Imaging. 2019 Apr 10. pii: S1936-878X(19)30241-4. doi: 10.1016/j.jcmg.2019.01.032. [Epub ahead of print]


Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3-PRIMULTI Cardiac Magnetic Resonance Substudy.

Kyhl K, Ahtarovski KA, Nepper-Christensen L, Ekström K, Ghotbi AA, Schoos M, Göransson C, Bertelsen L, Helqvist S, Holmvang L, Jørgensen E, Pedersen F, Saunamäki K, Clemmensen P, De Backer O, Høfsten DE, Køber L, Kelbæk H, Vejlstrup N, Lønborg J, Engstrøm T.

JACC Cardiovasc Interv. 2019 Apr 22;12(8):721-730. doi: 10.1016/j.jcin.2019.01.248.


Music Therapy as Treatment of Negative Symptoms for Adult Patients Diagnosed with Schizophrenia-Study Protocol for a Randomized, Controlled and Blinded Study.

Pedersen IN, Bonde LO, Hannibal NJ, Nielsen J, Aagaard J, Bertelsen LR, Jensen SB, Nielsen RE.

Medicines (Basel). 2019 Apr 1;6(2). pii: E46. doi: 10.3390/medicines6020046.


Metabolic consequences of lactate dehydrogenase inhibition by oxamate in hyperglycemic proximal tubular cells.

Wang Z, Nielsen PM, Laustsen C, Bertelsen LB.

Exp Cell Res. 2019 May 1;378(1):51-56. doi: 10.1016/j.yexcr.2019.03.001. Epub 2019 Mar 2.


Hyperpolarized [1-13 C] pyruvate as a possible diagnostic tool in liver disease.

Kjaergaard U, Laustsen C, Nørlinger T, Tougaard RS, Mikkelsen E, Qi H, Bertelsen LB, Jessen N, Stødkilde-Jørgensen H.

Physiol Rep. 2018 Dec;6(23):e13943. doi: 10.14814/phy2.13943.


Hyperpolarized [1-13 C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model.

Tougaard RS, Szocska Hansen ES, Laustsen C, Nørlinger TS, Mikkelsen E, Lindhardt J, Nielsen PM, Bertelsen LB, Schroeder M, Bøtker HE, Kim WY, Wiggers H, Stødkilde-Jørgensen H.

Magn Reson Med. 2019 Apr;81(4):2655-2665. doi: 10.1002/mrm.27560. Epub 2018 Nov 2.


Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-13C]Pyruvate MRI.

Bertelsen LB, Nielsen PM, Qi H, Mariager CØ, Lindhardt J, Laustsen C.

Tomography. 2018 Sep;4(3):105-109. doi: 10.18383/j.tom.2018.00022.


Importance of elevated heart rate in the very early phase of ST-segment elevation myocardial infarction: Results from the DANAMI-3 trial.

Nepper-Christensen L, Lønborg J, Ahtarovski KA, Høfsten DE, Kyhl K, Schoos MM, Göransson C, Laursen PN, Sadjadieh G, Ghotbi AA, Bertelsen L, Køber L, Helqvist S, Pedersen F, Jørgensen E, Kelbæk H, Vejlstrup N, Holmvang L, Engstrøm T.

Eur Heart J Acute Cardiovasc Care. 2019 Jun;8(4):318-328. doi: 10.1177/2048872618795515. Epub 2018 Aug 23.


Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging-a DANAMI3 substudy.

Göransson C, Ahtarovski KA, Kyhl K, Lønborg J, Nepper-Christensen L, Bertelsen L, Ghotbi AA, Schoos MM, Køber L, Høfsten D, Helqvist S, Kelbæk H, Engstrøm T, Vejlstrup N.

Eur Heart J Cardiovasc Imaging. 2019 Mar 1;20(3):361-366. doi: 10.1093/ehjci/jey106.


Can Hyperpolarized 13C-Urea be Used to Assess Glomerular Filtration Rate? A Retrospective Study.

Østergaard Mariager C, Nielsen PM, Qi H, Schroeder M, Bertelsen LB, Laustsen C.

Tomography. 2017 Sep;3(3):146-152. doi: 10.18383/j.tom.2017.00010.


Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke.

Xu Y, Ringgaard S, Mariager CØ, Bertelsen LB, Schroeder M, Qi H, Laustsen C, Stødkilde-Jørgensen H.

Tomography. 2017 Jun;3(2):67-73. doi: 10.18383/j.tom.2017.00106.


Danegaptide for primary percutaneous coronary intervention in acute myocardial infarction patients: a phase 2 randomised clinical trial.

Engstrøm T, Nepper-Christensen L, Helqvist S, Kløvgaard L, Holmvang L, Jørgensen E, Pedersen F, Saunamaki K, Tilsted HH, Steensberg A, Fabricius S, Mouritzen U, Vejlstrup N, Ahtarovski KA, Göransson C, Bertelsen L, Kyhl K, Olivecrona G, Kelbæk H, Lassen JF, Køber L, Lønborg J.

Heart. 2018 Oct;104(19):1593-1599. doi: 10.1136/heartjnl-2017-312774. Epub 2018 Mar 30.


Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats.

Qi H, Nielsen PM, Schroeder M, Bertelsen LB, Palm F, Laustsen C.

Diabetologia. 2018 Feb;61(2):445-454. doi: 10.1007/s00125-017-4445-6. Epub 2017 Sep 21.


The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents.

Iversen AB, Busk M, Bertelsen LB, Laustsen C, Munk OL, Nielsen T, Wittenborn TR, Bussink J, Lok J, Stødkilde-Jørgensen H, Horsman MR.

Acta Oncol. 2017 Nov;56(11):1626-1633. doi: 10.1080/0284186X.2017.1351622. Epub 2017 Aug 25.


Myocardial Damage in Patients With Deferred Stenting After STEMI: A DANAMI-3-DEFER Substudy.

Lønborg J, Engstrøm T, Ahtarovski KA, Nepper-Christensen L, Helqvist S, Vejlstrup N, Kyhl K, Schoos MM, Ghotbi A, Göransson C, Bertelsen L, Holmvang L, Pedersen F, Jørgensen E, Saunamäki K, Clemmensen P, De Backer O, Kløvgaard L, Høfsten DE, Køber L, Kelbæk H; DANAMI-3 Investigators.

J Am Coll Cardiol. 2017 Jun 13;69(23):2794-2804. doi: 10.1016/j.jacc.2017.03.601.


Association Between Early Q Waves and Reperfusion Success in Patients With ST-Segment-Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: A Cardiac Magnetic Resonance Imaging Study.

Topal DG, Lønborg J, Ahtarovski KA, Nepper-Christensen L, Helqvist S, Holmvang L, Pedersen F, Clemmensen P, Saünamaki K, Jørgensen E, Kyhl K, Ghotbi A, Schoos MM, Göransson C, Bertelsen L, Høfsten D, Køber L, Kelbæk H, Vejlstrup N, Engstrøm T.

Circ Cardiovasc Interv. 2017 Mar;10(3). pii: e004467. doi: 10.1161/CIRCINTERVENTIONS.116.004467.


Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1-13 C]pyruvate study.

Hansen ESS, Tougaard RS, Nørlinger TS, Mikkelsen E, Nielsen PM, Bertelsen LB, Bøtker HE, Jørgensen HS, Laustsen C.

NMR Biomed. 2017 Jun;30(6). doi: 10.1002/nbm.3702. Epub 2017 Feb 10.


Fumarase activity: an in vivo and in vitro biomarker for acute kidney injury.

Nielsen PM, Eldirdiri A, Bertelsen LB, Jørgensen HS, Ardenkjaer-Larsen JH, Laustsen C.

Sci Rep. 2017 Jan 17;7:40812. doi: 10.1038/srep40812.


Antioxidant treatment attenuates lactate production in diabetic nephropathy.

Laustsen C, Nielsen PM, Nørlinger TS, Qi H, Pedersen UK, Bertelsen LB, Østergaard JA, Flyvbjerg A, Ardenkjær-Larsen JH, Palm F, Stødkilde-Jørgensen H.

Am J Physiol Renal Physiol. 2017 Jan 1;312(1):F192-F199. doi: 10.1152/ajprenal.00148.2016. Epub 2016 Nov 9.


Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Nepper-Christensen L, Lønborg J, Ahtarovski KA, Høfsten DE, Kyhl K, Ghotbi AA, Schoos MM, Göransson C, Bertelsen L, Køber L, Helqvist S, Pedersen F, Saünamaki K, Jørgensen E, Kelbæk H, Holmvang L, Vejlstrup N, Engstrøm T.

J Am Heart Assoc. 2017 Jan 9;6(1). pii: e004823. doi: 10.1161/JAHA.116.004823.


Establishment and characterization of porcine focal cerebral ischemic model induced by endothelin-1.

Zhang R, Bertelsen LB, Flø C, Wang Y, Stødkilde-Jørgensen H.

Neurosci Lett. 2016 Dec 2;635:1-7. doi: 10.1016/j.neulet.2016.10.036. Epub 2016 Oct 20.


Safety of magnetic resonance scanning without monitoring of patients with pacemakers.

Bertelsen L, Petersen HH, Philbert BT, Svendsen JH, Thomsen C, Vejlstrup N.

Europace. 2017 May 1;19(5):818-823. doi: 10.1093/europace/euw066.


Multimodality Cardiac Imaging for the Assessment of Left Atrial Function and the Association With Atrial Arrhythmias.

Olsen FJ, Bertelsen L, de Knegt MC, Christensen TE, Vejlstrup N, Svendsen JH, Jensen JS, Biering-Sørensen T.

Circ Cardiovasc Imaging. 2016 Oct;9(10). pii: e004947. Review.


13C dynamic nuclear polarization for measuring metabolic flux in endothelial progenitor cells.

Nielsen N, Laustsen C, Bertelsen LB.

Exp Cell Res. 2016 Nov 15;349(1):95-100. doi: 10.1016/j.yexcr.2016.10.002. Epub 2016 Oct 5.


In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?

Nielsen PM, Laustsen C, Bertelsen LB, Qi H, Mikkelsen E, Kristensen ML, Nørregaard R, Stødkilde-Jørgensen H.

Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F465-F473. doi: 10.1152/ajprenal.00561.2015. Epub 2016 Sep 21.


Flow measurement at the aortic root - impact of location of through-plane phase contrast velocity mapping.

Bertelsen L, Svendsen JH, Køber L, Haugan K, Højberg S, Thomsen C, Vejlstrup N.

J Cardiovasc Magn Reson. 2016 Sep 7;18(1):55. doi: 10.1186/s12968-016-0277-7.


Ex vivo hyperpolarized MR spectroscopy on isolated renal tubular cells: A novel technique for cell energy phenotyping.

Juul T, Palm F, Nielsen PM, Bertelsen LB, Laustsen C.

Magn Reson Med. 2017 Aug;78(2):457-461. doi: 10.1002/mrm.26379. Epub 2016 Aug 16.


Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13 C,15 N-Urea.

Bertelsen LB, Nielsen PM, Qi H, Nørlinger TS, Zhang X, Stødkilde-Jørgensen H, Laustsen C.

Magn Reson Med. 2017 Apr;77(4):1650-1655. doi: 10.1002/mrm.26256. Epub 2016 May 12.


Early diabetic kidney maintains the corticomedullary urea and sodium gradient.

Qi H, Nørlinger TS, Nielsen PM, Bertelsen LB, Mikkelsen E, Xu Y, Stødkilde Jørgensen H, Laustsen C.

Physiol Rep. 2016 Mar;4(5). pii: e12714. doi: 10.14814/phy2.12714. Erratum in: Physiol Rep. 2016 May;4(9). pii: e12797. doi: 10.14814/phy2.12797.


Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia.

Jensen VF, Mølck AM, Heydenreich A, Jensen KJ, Bertelsen LO, Alifrangis L, Andersen L, Søeborg H, Chapman M, Lykkesfeldt J, Bøgh IB.

J Toxicol Pathol. 2016 Jan;29(1):17-30. doi: 10.1293/tox.2015-0041. Epub 2015 Oct 29.


Acute porcine renal metabolic effect of endogastric soft drink administration assessed with hyperpolarized [1-(13)C]pyruvate.

Laustsen C, Hansen ES, Kjaergaard U, Bertelsen LB, Ringgaard S, Stødkilde-Jørgensen H.

Magn Reson Med. 2015 Aug;74(2):558-63. doi: 10.1002/mrm.25692. Epub 2015 May 27.


Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model.

Bertelsen LB, Bohn AB, Shen YY, Falborg L, Stødkilde-Jørgensen H, Horsman MR.

BMC Cancer. 2014 Dec 2;14:903. doi: 10.1186/1471-2407-14-903.


A combretastatin-mediated decrease in neutrophil concentration in peripheral blood and the impact on the anti-tumor activity of this drug in two different murine tumor models.

Bohn AB, Wittenborn T, Brems-Eskildsen AS, Laurberg T, Bertelsen LB, Nielsen T, Stødkilde-Jørgensen H, Møller BK, Horsman MR.

PLoS One. 2014 Oct 9;9(10):e110091. doi: 10.1371/journal.pone.0110091. eCollection 2014.


In vivo bio-distribution and homing of endothelial outgrowth cells in a tumour model.

Bertelsen LB, Hagensen M, Busk M, Zhang R, Knudsen AS, Nielsen N, Falborg L, Møller BK, Horsman MR, Stødkilde-Jørgensen H.

Nucl Med Biol. 2014 Nov-Dec;41(10):848-55. doi: 10.1016/j.nucmedbio.2014.07.007. Epub 2014 Aug 1.


Are endothelial outgrowth cells a potential source for future re-vascularization therapy?

Bertelsen LB, Bohn AB, Smith M, Mølgaard B, Møller B, Stødkilde-Jørgensen H, Kristensen P.

Exp Gerontol. 2014 Oct;58:132-8. doi: 10.1016/j.exger.2014.07.021. Epub 2014 Aug 1.


Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature.

Gunnarsson R, Andreassen AK, Molberg Ø, Lexberg ÅS, Time K, Dhainaut AS, Bertelsen LT, Palm Ø, Irgens K, Becker-Merok A, Nordeide JL, Johnsen V, Pedersen S, Prøven A, Garabet LS, Garen T, Aaløkken TM, Gilboe IM, Gran JT.

Rheumatology (Oxford). 2013 Jul;52(7):1208-13. doi: 10.1093/rheumatology/kes430. Epub 2013 Feb 12. Review.


Treatment with the vascular disrupting agent combretastatin is associated with impaired AQP2 trafficking and increased urine output.

Bohn AB, Nørregaard R, Stødkilde L, Wang Y, Bertelsen LB, Fenton RA, Matchkov VV, Bouzinova EV, Horsman MR, Frøkiær J, Stødkilde-Jørgensen H.

Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15;303(2):R186-98. doi: 10.1152/ajpregu.00572.2011. Epub 2012 May 23.


Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study.

Gunnarsson R, Aaløkken TM, Molberg Ø, Lund MB, Mynarek GK, Lexberg AS, Time K, Dhainaut AS, Bertelsen LT, Palm O, Irgens K, Becker-Merok A, Nordeide JL, Johnsen V, Pedersen S, Prøven A, Garabet LS, Gran JT.

Ann Rheum Dis. 2012 Dec;71(12):1966-72. doi: 10.1136/annrheumdis-2011-201253. Epub 2012 May 1.


Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

Bertelsen LB, Shen YY, Nielsen T, Stødkilde-Jørgensen H, Lloyd GK, Siemann DW, Horsman MR.

Int J Radiat Biol. 2011 Nov;87(11):1126-34. doi: 10.3109/09553002.2011.605418.


Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors.

Toumi F, Frankson M, Ward JB, Kelly OB, Mroz MS, Bertelsen LS, Keely SJ.

Neurogastroenterol Motil. 2011 Feb;23(2):178-86, e43. doi: 10.1111/j.1365-2982.2010.01610.x. Epub 2010 Oct 5.


Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL-12p70 production in dendritic cells.

Bertelsen LB, Petersen CC, Kofod-Olsen E, Oster B, Höllsberg P, Agger R, Hokland M.

Scand J Immunol. 2010 Jun;71(6):431-9. doi: 10.1111/j.1365-3083.2010.02389.x.


The protease inhibitors ritonavir and saquinavir influence lipid metabolism: a pig model for the rapid evaluation of new drugs.

Petersen E, Mu H, Porsgaard T, Bertelsen LS.

Antivir Ther. 2010;15(2):243-51. doi: 10.3851/IMP1509.


Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer.

Reding KW, Bernstein JL, Langholz BM, Bernstein L, Haile RW, Begg CB, Lynch CF, Concannon P, Borg A, Teraoka SN, Törngren T, Diep A, Xue S, Bertelsen L, Liang X, Reiner AS, Capanu M, Malone KE; WECARE Collaborative Study Group.

Breast Cancer Res Treat. 2010 Sep;123(2):491-8. doi: 10.1007/s10549-010-0769-3. Epub 2010 Feb 5.


Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study.

Figueiredo JC, Haile RW, Bernstein L, Malone KE, Largent J, Langholz B, Lynch CF, Bertelsen L, Capanu M, Concannon P, Borg A, Børresen-Dale AL, Diep A, Teraoka S, Torngren T, Xue S, Bernstein JL.

Breast Cancer Res Treat. 2010 Feb;120(1):175-83. doi: 10.1007/s10549-009-0455-5. Epub 2009 Jul 14.


Role of mitogen-activated protein kinases, nuclear factor-kappaB, and interferon regulatory factor 3 in Toll-like receptor 4-mediated activation of HIV long terminal repeat.

Berg RS, Aggerholm A, Bertelsen LS, Østergaard L, Paludan SR.

APMIS. 2009 Feb;117(2):124-32. doi: 10.1111/j.1600-0463.2008.00024.x.


Age-specific incidence of breast cancer in breast cancer survivors and their first-degree relatives.

Bertelsen L, Mellemkjaer L, Christensen J, Rawal R, Olsen JH.

Epidemiology. 2009 Mar;20(2):175-80. doi: 10.1097/EDE.0b013e318190eee6.


Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis.

Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE.

Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1839-45. doi: 10.1152/ajpregu.00412.2007. Epub 2008 Oct 1.

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