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Items: 1 to 50 of 447

1.

Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries.

Verma N, Liu M, Ly H, Loria A, Campbell KS, Bush H, Kern PA, Jose PA, Taegtmeyer H, Bers DM, Despa S, Goldstein LB, Murray AJ, Despa F.

Kidney Int. 2019 Sep 5. pii: S0085-2538(19)30844-0. doi: 10.1016/j.kint.2019.07.028. [Epub ahead of print]

PMID:
31739987
2.

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.

Tiscione SA, Vivas O, Ginsburg KS, Bers DM, Ory DS, Santana LF, Dixon RE, Dickson EJ.

J Cell Biol. 2019 Oct 10. pii: jcb.201903018. doi: 10.1083/jcb.201903018. [Epub ahead of print]

PMID:
31601621
3.

Intrafibrillar and perinuclear mitochondrial heterogeneity in adult cardiac myocytes.

Lu X, Thai PN, Lu S, Pu J, Bers DM.

J Mol Cell Cardiol. 2019 Nov;136:72-84. doi: 10.1016/j.yjmcc.2019.08.013. Epub 2019 Sep 3.

PMID:
31491377
4.

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.

Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC.

Eur Heart J. 2019 Jun 20. pii: ehz326. doi: 10.1093/eurheartj/ehz326. [Epub ahead of print]

PMID:
31219556
5.

Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts.

Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM.

J Physiol. 2019 Aug;597(15):3867-3883. doi: 10.1113/JP278016. Epub 2019 Jul 11.

PMID:
31215643
6.

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters.

Bers DM, Xiang YK, Zaccolo M.

Physiology (Bethesda). 2019 Jul 1;34(4):240-249. doi: 10.1152/physiol.00002.2019.

PMID:
31165682
7.

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides.

Thai PN, Seidlmayer LK, Miller C, Ferrero M, Dorn GW II, Schaefer S, Bers DM, Dedkova EN.

Front Physiol. 2019 Apr 10;10:382. doi: 10.3389/fphys.2019.00382. eCollection 2019.

8.

Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes.

Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM.

Circ Arrhythm Electrophysiol. 2019 Mar;12(3):e007061. doi: 10.1161/CIRCEP.118.007061.

PMID:
30879336
9.

Cardiotoxicity of environmental contaminant tributyltin involves myocyte oxidative stress and abnormal Ca2+ handling.

Pereira CLV, Ximenes CF, Merlo E, Sciortino AS, Monteiro JS, Moreira A, Jacobsen BB, Graceli JB, Ginsburg KS, Ribeiro Junior RF, Bers DM, Stefanon I.

Environ Pollut. 2019 Apr;247:371-382. doi: 10.1016/j.envpol.2019.01.053. Epub 2019 Jan 16.

PMID:
30690233
10.

Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.

Xie Y, Yang Y, Galice S, Bers DM, Sato D.

Biophys J. 2019 Feb 5;116(3):530-539. doi: 10.1016/j.bpj.2018.12.017. Epub 2019 Jan 3.

PMID:
30686487
11.

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.

Hegyi B, Bers DM, Bossuyt J.

J Mol Cell Cardiol. 2019 Feb;127:246-259. doi: 10.1016/j.yjmcc.2019.01.001. Epub 2019 Jan 8. Review.

PMID:
30633874
12.

Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation.

Seidlmayer LK, Gomez-Garcia MR, Shiba T, Porter GA Jr, Pavlov EV, Bers DM, Dedkova EN.

Arch Biochem Biophys. 2019 Feb 15;662:177-189. doi: 10.1016/j.abb.2018.12.019. Epub 2018 Dec 17.

PMID:
30571965
13.

The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.

Kwong JQ, Huo J, Bround MJ, Boyer JG, Schwanekamp JA, Ghazal N, Maxwell JT, Jang YC, Khuchua Z, Shi K, Bers DM, Davis J, Molkentin JD.

JCI Insight. 2018 Nov 15;3(22). pii: 121689. doi: 10.1172/jci.insight.121689.

14.

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Thai PN, Daugherty DJ, Frederich BJ, Lu X, Deng W, Bers DM, Dedkova EN, Schaefer S.

Sci Rep. 2018 Nov 1;8(1):16213. doi: 10.1038/s41598-018-34451-2.

15.

Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.

Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M.

J Mol Cell Cardiol. 2018 Dec;125:87-97. doi: 10.1016/j.yjmcc.2018.10.011. Epub 2018 Oct 22.

PMID:
30359562
16.

Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets.

Wood BM, Simon M, Galice S, Alim CC, Ferrero M, Pinna NN, Bers DM, Bossuyt J.

J Mol Cell Cardiol. 2018 Dec;125:18-28. doi: 10.1016/j.yjmcc.2018.10.010. Epub 2018 Oct 12.

PMID:
30321537
17.

Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats.

Morra EA, Rodrigues PL, Jesus ICG, Do Val Lima PR, Ávila RA, Zanardo TÉC, Nogueira BV, Bers DM, Guatimosim S, Stefanon I, Ribeiro Júnior RF.

Free Radic Biol Med. 2019 Jan;130:174-188. doi: 10.1016/j.freeradbiomed.2018.10.406. Epub 2018 Oct 10.

PMID:
30315935
18.

β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII.

Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y.

J Mol Cell Cardiol. 2018 Oct;123:168-179. doi: 10.1016/j.yjmcc.2018.09.006. Epub 2018 Sep 18.

19.

Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release.

Galice S, Xie Y, Yang Y, Sato D, Bers DM.

J Am Heart Assoc. 2018 Jun 21;7(13). pii: e008724. doi: 10.1161/JAHA.118.008724.

20.

Complex electrophysiological remodeling in postinfarction ischemic heart failure.

Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3036-E3044. doi: 10.1073/pnas.1718211115. Epub 2018 Mar 12.

21.

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.

Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J.

Elife. 2018 Feb 22;7. pii: e31019. doi: 10.7554/eLife.31019.

22.

Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents.

Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM.

Circ Arrhythm Electrophysiol. 2018 Feb;11(2):e005852. doi: 10.1161/CIRCEP.117.005852.

23.

Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.

Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X.

Circ Res. 2018 Mar 16;122(6):821-835. doi: 10.1161/CIRCRESAHA.117.312536. Epub 2018 Jan 19.

24.

Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium.

Liu M, Hoskins A, Verma N, Bers DM, Despa S, Despa F.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1923-1930. doi: 10.1016/j.bbadis.2017.10.024. Epub 2017 Oct 21.

25.

Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart.

Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM.

Circ Res. 2017 Dec 8;121(12):1379-1391. doi: 10.1161/CIRCRESAHA.117.312050. Epub 2017 Oct 2.

26.

Dynamics of sodium current mediated early afterdepolarizations.

Sato D, Clancy CE, Bers DM.

Heliyon. 2017 Sep 6;3(9):e00388. doi: 10.1016/j.heliyon.2017.e00388. eCollection 2017 Sep.

27.

MarkoLAB: A simulator to study ionic channel's stochastic behavior.

da Silva RR, Goroso DG, Bers DM, Puglisi JL.

Comput Biol Med. 2017 Aug 1;87:258-270. doi: 10.1016/j.compbiomed.2017.05.032. Epub 2017 Jun 12.

PMID:
28618338
28.

Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.

Yuen GK, Galice S, Bers DM.

J Mol Cell Cardiol. 2017 Jul;108:158-169. doi: 10.1016/j.yjmcc.2017.05.013. Epub 2017 Jun 3.

29.

β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.

Pereira L, Bare DJ, Galice S, Shannon TR, Bers DM.

J Mol Cell Cardiol. 2017 Jul;108:8-16. doi: 10.1016/j.yjmcc.2017.04.005. Epub 2017 May 2.

30.

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M.

Nat Commun. 2017 Apr 20;8:15031. doi: 10.1038/ncomms15031.

31.

K+ channels and cardiac electrophysiology.

Bers DM, Chen-Izu Y.

J Physiol. 2017 Apr 1;595(7):2205-2207. doi: 10.1113/JP274181. No abstract available.

32.

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction.

De Jesus NM, Wang L, Lai J, Rigor RR, Francis Stuart SD, Bers DM, Lindsey ML, Ripplinger CM.

Heart Rhythm. 2017 May;14(5):727-736. doi: 10.1016/j.hrthm.2017.01.027. Epub 2017 Jan 19.

33.

CALMing Down Arrhythmogenic Calmodulinopathies via a Precision Medicine Approach.

Bers DM.

Circ Res. 2017 Jan 6;120(1):3-4. doi: 10.1161/CIRCRESAHA.116.310216. No abstract available.

34.

Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes.

Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM.

J Physiol. 2017 Apr 1;595(7):2253-2268. doi: 10.1113/JP273676. Epub 2017 Mar 28.

35.

Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans.

Kennedy M, Bers DM, Chiamvimonvat N, Sato D.

J Physiol. 2017 Apr 1;595(7):2285-2297. doi: 10.1113/JP273626. Epub 2017 Jan 24.

36.

Potassium channels in the heart: structure, function and regulation.

Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V.

J Physiol. 2017 Apr 1;595(7):2209-2228. doi: 10.1113/JP272864. Epub 2016 Nov 13. Review.

37.

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.

J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. doi: 10.1016/j.jacc.2016.07.779.

38.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM.

J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review.

39.

Stabilizing ryanodine receptor gating quiets arrhythmogenic events in human heart failure and atrial fibrillation.

Bers DM.

Heart Rhythm. 2017 Mar;14(3):420-421. doi: 10.1016/j.hrthm.2016.10.005. Epub 2016 Oct 7. No abstract available.

PMID:
27725286
40.

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels.

Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL.

SLAS Discov. 2017 Feb;22(2):176-186. doi: 10.1177/1087057116674312. Epub 2016 Oct 22.

41.

L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes.

Himes RD, Smolin N, Kukol A, Bossuyt J, Bers DM, Robia SL.

Biochemistry. 2016 Nov 8;55(44):6196-6204. Epub 2016 Oct 25.

42.

Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction.

Galice S, Bers DM, Sato D.

Biophys J. 2016 Jun 21;110(12):2671-2677. doi: 10.1016/j.bpj.2016.05.026.

43.

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.

Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM.

J Mol Cell Cardiol. 2016 Sep;98:62-72. doi: 10.1016/j.yjmcc.2016.06.007. Epub 2016 Jun 16.

44.

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.

Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.

J Biol Chem. 2016 Jul 22;291(30):15896-907. doi: 10.1074/jbc.M115.713107. Epub 2016 May 19.

45.

Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.

Sato D, Shannon TR, Bers DM.

Biophys J. 2016 Jan 19;110(2):382-390. doi: 10.1016/j.bpj.2015.12.009.

46.

Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings.

Lu X, Kwong JQ, Molkentin JD, Bers DM.

Circ Res. 2016 Mar 4;118(5):834-41. doi: 10.1161/CIRCRESAHA.115.308093. Epub 2015 Dec 28.

47.

Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.

Hoeker GS, Hanafy MA, Oster RA, Bers DM, Pogwizd SM.

J Cardiovasc Pharmacol. 2016 Mar;67(3):260-5. doi: 10.1097/FJC.0000000000000343.

48.

Adrenergic Fight-or-Flight: S-NO Falls on PKA Targets.

Bers DM.

Circ Res. 2015 Oct 9;117(9):747-9. doi: 10.1161/CIRCRESAHA.115.307397. No abstract available.

49.

Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM.

Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1472-80. doi: 10.1161/CIRCEP.115.003085. Epub 2015 Sep 25.

50.

Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment.

Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers DM, Sussman MA, Poizat C.

J Biol Chem. 2015 Oct 16;290(42):25411-26. doi: 10.1074/jbc.M115.657775. Epub 2015 Aug 31.

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