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Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.

Esposito R, Spaziano G, Giannattasio D, Ferrigno F, Liparulo A, Rossi A, Roviezzo F, Sessa M, Falciani M, Berrino L, Polverino M, Polverino F, D'Agostino B.

Front Pharmacol. 2019 Sep 24;10:1094. doi: 10.3389/fphar.2019.01094. eCollection 2019.


The European clinical trials regulation (No 536/2014): changes and challenges.

Scavone C, di Mauro G, Pietropaolo M, Alfano R, Berrino L, Rossi F, Tomino C, Capuano A.

Expert Rev Clin Pharmacol. 2019 Nov;12(11):1027-1032. doi: 10.1080/17512433.2019.1680282. Epub 2019 Oct 21. Review.


Angiotensin II and angiotensin 1-7: which is their role in atrial fibrillation?

Mascolo A, Urbanek K, De Angelis A, Sessa M, Scavone C, Berrino L, Rosano GMC, Capuano A, Rossi F.

Heart Fail Rev. 2019 Aug 2. doi: 10.1007/s10741-019-09837-7. [Epub ahead of print] Review.


Corrigendum to "Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib".

Gorini S, De Angelis A, Berrino L, Malara N, Rosano G, Ferraro E.

Oxid Med Cell Longev. 2019 Jun 26;2019:9601435. doi: 10.1155/2019/9601435. eCollection 2019.


The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs.

Scavone C, di Mauro G, Mascolo A, Berrino L, Rossi F, Capuano A.

Front Pharmacol. 2019 Feb 13;10:111. doi: 10.3389/fphar.2019.00111. eCollection 2019. Review.


Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension.

Cappetta D, Ciuffreda LP, Cozzolino A, Esposito G, Scavone C, Sapio L, Naviglio S, D'Amario D, Crea F, Rossi F, Berrino L, De Angelis A, Urbanek K.

Oxid Med Cell Longev. 2019 Jan 10;2019:8912768. doi: 10.1155/2019/8912768. eCollection 2019.


Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66Shc.

Costantino S, Paneni F, Mitchell K, Mohammed SA, Hussain S, Gkolfos C, Berrino L, Volpe M, Schwarzwald C, Lüscher TF, Cosentino F.

Int J Cardiol. 2018 Oct 1;268:179-186. doi: 10.1016/j.ijcard.2018.04.082. Epub 2018 Jun 30.


Neuropsychiatric clinical manifestations in elderly patients treated with hydroxychloroquine: a review article.

Mascolo A, Berrino PM, Gareri P, Castagna A, Capuano A, Manzo C, Berrino L.

Inflammopharmacology. 2018 Oct;26(5):1141-1149. doi: 10.1007/s10787-018-0498-5. Epub 2018 Jun 9. Review.


Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib.

Gorini S, De Angelis A, Berrino L, Malara N, Rosano G, Ferraro E.

Oxid Med Cell Longev. 2018 Mar 18;2018:7582730. doi: 10.1155/2018/7582730. eCollection 2018. Review. Erratum in: Oxid Med Cell Longev. 2019 Jun 26;2019:9601435.


Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema.

Cappetta D, De Angelis A, Spaziano G, Tartaglione G, Piegari E, Esposito G, Ciuffreda LP, Liparulo A, Sgambato M, Russo TP, Rossi F, Berrino L, Urbanek K, D'Agostino B.

Stem Cells Int. 2018 Mar 14;2018:9492038. doi: 10.1155/2018/9492038. eCollection 2018.


Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation.

Chianese R, Viggiano A, Urbanek K, Cappetta D, Troisi J, Scafuro M, Guida M, Esposito G, Ciuffreda LP, Rossi F, Berrino L, Fasano S, Pierantoni R, De Angelis A, Meccariello R.

Sci Rep. 2018 Feb 13;8(1):2961. doi: 10.1038/s41598-018-21076-8.


Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity.

Cappetta D, De Angelis A, Sapio L, Prezioso L, Illiano M, Quaini F, Rossi F, Berrino L, Naviglio S, Urbanek K.

Oxid Med Cell Longev. 2017;2017:1521020. doi: 10.1155/2017/1521020. Epub 2017 Oct 18. Review.


Strengths, weaknesses and future challenges of biosimilars' development. An opinion on how to improve the knowledge and use of biosimilars in clinical practice.

Scavone C, Rafaniello C, Berrino L, Rossi F, Capuano A.

Pharmacol Res. 2017 Dec;126:138-142. doi: 10.1016/j.phrs.2017.11.002. Epub 2017 Nov 4. Review.


Imatinib mesylate-induced cardiomyopathy involves resident cardiac progenitors.

Savi M, Frati C, Cavalli S, Graiani G, Galati S, Buschini A, Madeddu D, Falco A, Prezioso L, Mazzaschi G, Galaverna F, Lagrasta CAM, Corradini E, De Angelis A, Cappetta D, Berrino L, Aversa F, Quaini F, Urbanek K.

Pharmacol Res. 2018 Jan;127:15-25. doi: 10.1016/j.phrs.2017.09.020. Epub 2017 Sep 28.


Safety Profile of Anticancer and Immune-Modulating Biotech Drugs Used in a Real World Setting in Campania Region (Italy): BIO-Cam Observational Study.

Scavone C, Sportiello L, Sullo MG, Ferrajolo C, Ruggiero R, Sessa M, Berrino PM, di Mauro G, Berrino L, Rossi F, Rafaniello C, Capuano A; BIO-Cam Group.

Front Pharmacol. 2017 Sep 6;8:607. doi: 10.3389/fphar.2017.00607. eCollection 2017.


Results of the safety run-in part of the METAL (METformin in Advanced Lung cancer) study: a multicentre, open-label phase I-II study of metformin with erlotinib in second-line therapy of patients with stage IV non-small-cell lung cancer.

Morgillo F, Fasano M, Della Corte CM, Sasso FC, Papaccio F, Viscardi G, Esposito G, Di Liello R, Normanno N, Capuano A, Berrino L, Vicidomini G, Fiorelli A, Santini M, Ciardiello F.

ESMO Open. 2017 May 2;2(2):e000132. doi: 10.1136/esmoopen-2016-000132. eCollection 2017.


Doxorubicin targets multiple players: A new view of an old problem.

Cappetta D, Rossi F, Piegari E, Quaini F, Berrino L, Urbanek K, De Angelis A.

Pharmacol Res. 2018 Jan;127:4-14. doi: 10.1016/j.phrs.2017.03.016. Epub 2017 Mar 20. Review.


Effects of ranolazine in a model of doxorubicin-induced left ventricle diastolic dysfunction.

Cappetta D, Esposito G, Coppini R, Piegari E, Russo R, Ciuffreda LP, Rivellino A, Santini L, Rafaniello C, Scavone C, Rossi F, Berrino L, Urbanek K, De Angelis A.

Br J Pharmacol. 2017 Nov;174(21):3696-3712. doi: 10.1111/bph.13791. Epub 2017 May 16.


Upregulation of TH/IL-17 Pathway-Related Genes in Human Coronary Endothelial Cells Stimulated with Serum of Patients with Acute Coronary Syndromes.

Cimmino G, Ciuffreda LP, Ciccarelli G, Calabrò P, Ferraiolo FA, Rivellino A, De Palma R, Golino P, Rossi F, Cirillo P, Berrino L.

Front Cardiovasc Med. 2017 Feb 7;4:1. doi: 10.3389/fcvm.2017.00001. eCollection 2017.


Biosimilars in the European Union from comparability exercise to real world experience: What we achieved and what we still need to achieve.

Scavone C, Sportiello L, Berrino L, Rossi F, Capuano A.

Pharmacol Res. 2017 May;119:265-271. doi: 10.1016/j.phrs.2017.02.006. Epub 2017 Feb 16. No abstract available.


Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction.

Esposito G, Cappetta D, Russo R, Rivellino A, Ciuffreda LP, Roviezzo F, Piegari E, Berrino L, Rossi F, De Angelis A, Urbanek K.

Br J Pharmacol. 2017 Nov;174(22):4070-4086. doi: 10.1111/bph.13686. Epub 2017 Mar 21. Erratum in: Br J Pharmacol. 2018 May;175(10 ):1781.


Campania Region (Italy) spontaneous reporting system and preventability assessment through a case-by-case approach: a pilot study on psychotropic drugs.

Sessa M, Rafaniello C, Sportiello L, Mascolo A, Scavone C, Maccariello A, Iannaccone T, Fabrazzo M, Berrino L, Rossi F, Capuano A.

Expert Opin Drug Saf. 2016 Dec;15(sup2):9-15.


New and old roles of the peripheral and brain renin-angiotensin-aldosterone system (RAAS): Focus on cardiovascular and neurological diseases.

Mascolo A, Sessa M, Scavone C, De Angelis A, Vitale C, Berrino L, Rossi F, Rosano G, Capuano A.

Int J Cardiol. 2017 Jan 15;227:734-742. doi: 10.1016/j.ijcard.2016.10.069. Epub 2016 Oct 27. Review.


Disclosing negative trial results - procedure.

Scavone C, Rafaniello C, Sportiello L, Berrino L, Capuano A.

Expert Rev Clin Pharmacol. 2016 Dec;9(12):1517-1519. Epub 2016 Nov 2. No abstract available.


MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat.

Piegari E, Russo R, Cappetta D, Esposito G, Urbanek K, Dell'Aversana C, Altucci L, Berrino L, Rossi F, De Angelis A.

Oncotarget. 2016 Sep 20;7(38):62312-62326. doi: 10.18632/oncotarget.11468.


Long-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction.

De Angelis A, Cappetta D, Piegari E, Rinaldi B, Ciuffreda LP, Esposito G, Ferraiolo FA, Rivellino A, Russo R, Donniacuo M, Rossi F, Urbanek K, Berrino L.

Int J Cardiol. 2016 Aug 15;217:69-79. doi: 10.1016/j.ijcard.2016.04.168. Epub 2016 May 12.


SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.

Cappetta D, Esposito G, Piegari E, Russo R, Ciuffreda LP, Rivellino A, Berrino L, Rossi F, De Angelis A, Urbanek K.

Int J Cardiol. 2016 Feb 15;205:99-110. doi: 10.1016/j.ijcard.2015.12.008. Epub 2015 Dec 15.


Atenolol vs enalapril in young hypertensive patients after successful repair of aortic coarctation.

Di Salvo G, Castaldi B, Gala S, Baldini L, Del Gaizo F, D'Aiello FA, Mormile A, Rea A, Scognamiglio G, Pacileo G, Keating S, Fadel BM, Berrino L, Perna A, Russo MG, Calabrò R.

J Hum Hypertens. 2016 Jun;30(6):363-7. doi: 10.1038/jhh.2015.87. Epub 2015 Aug 20.


AXL is an oncotarget in human colorectal cancer.

Martinelli E, Martini G, Cardone C, Troiani T, Liguori G, Vitagliano D, Napolitano S, Morgillo F, Rinaldi B, Melillo RM, Liotti F, Nappi A, Bianco R, Berrino L, Ciuffreda LP, Ciardiello D, Iaffaioli V, Botti G, Ferraiolo F, Ciardiello F.

Oncotarget. 2015 Sep 15;6(27):23281-96.


SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells.

De Angelis A, Piegari E, Cappetta D, Russo R, Esposito G, Ciuffreda LP, Ferraiolo FA, Frati C, Fagnoni F, Berrino L, Quaini F, Rossi F, Urbanek K.

Int J Cardiol. 2015;189:30-44. doi: 10.1016/j.ijcard.2015.03.438. Epub 2015 Apr 2.


Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab.

Napolitano S, Martini G, Rinaldi B, Martinelli E, Donniacuo M, Berrino L, Vitagliano D, Morgillo F, Barra G, De Palma R, Merolla F, Ciardiello F, Troiani T.

Clin Cancer Res. 2015 Jul 1;21(13):2975-83. doi: 10.1158/1078-0432.CCR-15-0020. Epub 2015 Apr 2.


A multicenter, open-label phase II study of metformin with erlotinib in second-line therapy of stage IV non-small-cell lung cancer patients: treatment rationale and protocol dynamics of the METAL trial.

Fasano M, Della Corte CM, Capuano A, Sasso FC, Papaccio F, Berrino L, Ciardiello F, Morgillo F.

Clin Lung Cancer. 2015 Jan;16(1):57-9. doi: 10.1016/j.cllc.2014.06.010. Epub 2014 Aug 17.


Novel potential targets for prevention of arterial restenosis: insights from the pre-clinical research.

Forte A, Rinaldi B, Berrino L, Rossi F, Galderisi U, Cipollaro M.

Clin Sci (Lond). 2014 Dec;127(11):615-34. doi: 10.1042/CS20140131. Review.


Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells.

Troiani T, Martinelli E, Napolitano S, Vitagliano D, Ciuffreda LP, Costantino S, Morgillo F, Capasso A, Sforza V, Nappi A, De Palma R, D'Aiuto E, Berrino L, Bianco R, Ciardiello F.

Clin Cancer Res. 2013 Dec 15;19(24):6751-65. doi: 10.1158/1078-0432.CCR-13-0423. Epub 2013 Oct 11.


Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.

Rinaldi B, Donniacuo M, Sodano L, Gritti G, Signoriello S, Parretta E, Berrino L, Urbanek K, Capuano A, Rossi F.

PLoS One. 2013 Jul 29;8(7):e69954. doi: 10.1371/journal.pone.0069954. Print 2013.


Glutamate-induced ATP synthesis: relationship between plasma membrane Na+/Ca2+ exchanger and excitatory amino acid transporters in brain and heart cell models.

Magi S, Arcangeli S, Castaldo P, Nasti AA, Berrino L, Piegari E, Bernardini R, Amoroso S, Lariccia V.

Mol Pharmacol. 2013 Oct;84(4):603-14. doi: 10.1124/mol.113.087775. Epub 2013 Aug 2.


Local inhibition of ornithine decarboxylase reduces vascular stenosis in a murine model of carotid injury.

Forte A, Grossi M, Turczynska KM, Svedberg K, Rinaldi B, Donniacuo M, Holm A, Baldetorp B, Vicchio M, De Feo M, Santè P, Galderisi U, Berrino L, Rossi F, Hellstrand P, Nilsson BO, Cipollaro M.

Int J Cardiol. 2013 Oct 9;168(4):3370-80. doi: 10.1016/j.ijcard.2013.04.153. Epub 2013 May 13.


Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.

Martinelli E, Troiani T, D'Aiuto E, Morgillo F, Vitagliano D, Capasso A, Costantino S, Ciuffreda LP, Merolla F, Vecchione L, De Vriendt V, Tejpar S, Nappi A, Sforza V, Martini G, Berrino L, De Palma R, Ciardiello F.

Int J Cancer. 2013 Nov;133(9):2089-101. doi: 10.1002/ijc.28236. Epub 2013 May 29.


Doxorubicin induces senescence and impairs function of human cardiac progenitor cells.

Piegari E, De Angelis A, Cappetta D, Russo R, Esposito G, Costantino S, Graiani G, Frati C, Prezioso L, Berrino L, Urbanek K, Quaini F, Rossi F.

Basic Res Cardiol. 2013 Mar;108(2):334. doi: 10.1007/s00395-013-0334-4. Epub 2013 Feb 15.


Commercially available lipid formulations of amphotericin b: are they bioequivalent and therapeutically equivalent?

Cifani C, Costantino S, Massi M, Berrino L.

Acta Biomed. 2012 Aug;83(2):154-63. Review.


Cytokines and VEGF induction in orthodontic movement in animal models.

Di Domenico M, D'apuzzo F, Feola A, Cito L, Monsurrò A, Pierantoni GM, Berrino L, De Rosa A, Polimeni A, Perillo L.

J Biomed Biotechnol. 2012;2012:201689. doi: 10.1155/2012/201689. Epub 2012 May 14. Review.


Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.

Troiani T, Vecchione L, Martinelli E, Capasso A, Costantino S, Ciuffreda LP, Morgillo F, Vitagliano D, D'Aiuto E, De Palma R, Tejpar S, Van Cutsem E, De Lorenzi M, Caraglia M, Berrino L, Ciardiello F.

Br J Cancer. 2012 May 8;106(10):1648-59. doi: 10.1038/bjc.2012.129.


Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities.

Scaglione F, Berrino L.

Int J Antimicrob Agents. 2012 Jun;39(6):458-63. doi: 10.1016/j.ijantimicag.2011.11.013. Epub 2012 Jan 23.


Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells.

Forte A, Rinaldi B, Sodano L, Berrino L, Rossi F, Finicelli M, Grossi M, Cobellis G, Botti C, De Feo M, Santè P, Galderisi U, Cipollaro M.

Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8.


Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors.

Morgillo F, Cascone T, D'Aiuto E, Martinelli E, Troiani T, Saintigny P, De Palma R, Heymach JV, Berrino L, Tuccillo C, Ciardiello F.

Br J Cancer. 2011 Jul 26;105(3):382-92. doi: 10.1038/bjc.2011.244. Epub 2011 Jul 12.


Datura stramonium intake: a report on three cases.

Stella L, Vitelli MR, Palazzo E, Oliva P, De Novellis V, Capuano A, Scafuro MA, Berrino L, Rossi F, Maione S.

J Psychoactive Drugs. 2010 Dec;42(4):507-12.


Moving towards supraspinal TRPV1 receptors for chronic pain relief.

Palazzo E, Luongo L, de Novellis V, Berrino L, Rossi F, Maione S.

Mol Pain. 2010 Oct 11;6:66. doi: 10.1186/1744-8069-6-66. Review.


Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells.

Martinelli E, Troiani T, Morgillo F, Rodolico G, Vitagliano D, Morelli MP, Tuccillo C, Vecchione L, Capasso A, Orditura M, De Vita F, Eckhardt SG, Santoro M, Berrino L, Ciardiello F.

Clin Cancer Res. 2010 Oct 15;16(20):4990-5001. doi: 10.1158/1078-0432.CCR-10-0923. Epub 2010 Sep 1.


Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function.

De Angelis A, Piegari E, Cappetta D, Marino L, Filippelli A, Berrino L, Ferreira-Martins J, Zheng H, Hosoda T, Rota M, Urbanek K, Kajstura J, Leri A, Rossi F, Anversa P.

Circulation. 2010 Jan 19;121(2):276-92. doi: 10.1161/CIRCULATIONAHA.109.895771. Epub 2009 Dec 28.


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