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Items: 34


HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.

Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner-Gruenberger R, Wolfson MR, Houser SR.

Sci Transl Med. 2020 Jan 8;12(525). pii: eaay7205. doi: 10.1126/scitranslmed.aay7205.


Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction.

Hobby ARH, Sharp TE 3rd, Berretta RM, Borghetti G, Feldsott E, Mohsin S, Houser SR.

Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H820-H829. doi: 10.1152/ajpheart.00144.2019. Epub 2019 Aug 23.


Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.

Sharp TE 3rd, Kubo H, Berretta RM, Starosta T, Wallner M, Schena GJ, Hobby AR, Yu D, Trappanese DM, George JC, Molkentin JD, Houser SR.

JACC Basic Transl Sci. 2017 Dec 25;2(6):669-683. doi: 10.1016/j.jacbts.2017.06.007. eCollection 2017 Dec.


A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function.

Wallner M, Eaton DM, Berretta RM, Borghetti G, Wu J, Baker ST, Feldsott EA, Sharp TE 3rd, Mohsin S, Oyama MA, von Lewinski D, Post H, Wolfson MR, Houser SR.

Sci Rep. 2017 Nov 29;7(1):16587. doi: 10.1038/s41598-017-15851-2.


Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.

Sharp TE 3rd, Schena GJ, Hobby AR, Starosta T, Berretta RM, Wallner M, Borghetti G, Gross P, Yu D, Johnson J, Feldsott E, Trappanese DM, Toib A, Rabinowitz JE, George JC, Kubo H, Mohsin S, Houser SR.

Circ Res. 2017 Nov 10;121(11):1263-1278. doi: 10.1161/CIRCRESAHA.117.311174. Epub 2017 Sep 14.


Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

Toib A, Zhang C, Borghetti G, Zhang X, Wallner M, Yang Y, Troupes CD, Kubo H, Sharp TE, Feldsott E, Berretta RM, Zalavadia N, Trappanese DM, Harper S, Gross P, Chen X, Mohsin S, Houser SR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H620-H630. doi: 10.1152/ajpheart.00167.2017. Epub 2017 Jun 23.


Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction.

Troupes CD, Wallner M, Borghetti G, Zhang C, Mohsin S, von Lewinski D, Berretta RM, Kubo H, Chen X, Soboloff J, Houser S.

Circ Res. 2017 Jul 7;121(2):125-136. doi: 10.1161/CIRCRESAHA.117.311094. Epub 2017 Jun 7.


Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Correll RN, Makarewich CA, Zhang H, Zhang C, Sargent MA, York AJ, Berretta RM, Chen X, Houser SR, Molkentin JD.

Cardiovasc Res. 2017 Jun 1;113(7):749-759. doi: 10.1093/cvr/cvx046.


Acute right heart failure after hemorrhagic shock and trauma pneumonectomy-a management approach: A blinded randomized controlled animal trial using inhaled nitric oxide.

Lubitz AL, Sjoholm LO, Goldberg A, Pathak A, Santora T, Sharp TE 3rd, Wallner M, Berretta RM, Poole LA, Wu J, Wolfson MR.

J Trauma Acute Care Surg. 2017 Feb;82(2):243-251. doi: 10.1097/TA.0000000000001325.


Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

Wallner M, Duran JM, Mohsin S, Troupes CD, Vanhoutte D, Borghetti G, Vagnozzi RJ, Gross P, Yu D, Trappanese DM, Kubo H, Toib A, Sharp TE 3rd, Harper SC, Volkert MA, Starosta T, Feldsott EA, Berretta RM, Wang T, Barbe MF, Molkentin JD, Houser SR.

Circ Res. 2016 Sep 16;119(7):865-79. doi: 10.1161/CIRCRESAHA.116.308687. Epub 2016 Jul 26.


Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

Mohsin S, Troupes CD, Starosta T, Sharp TE, Agra EJ, Smith S, Duran JM, Zalavadia N, Zhou Y, Kubo H, Berretta RM, Houser SR.

Circ Res. 2015 Dec 4;117(12):1024-33. doi: 10.1161/CIRCRESAHA.115.307362. Epub 2015 Oct 15.


Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.

Taghavi S, Sharp TE 3rd, Duran JM, Makarewich CA, Berretta RM, Starosta T, Kubo H, Barbe M, Houser SR.

Clin Transl Sci. 2015 Oct;8(5):425-31. doi: 10.1111/cts.12251. Epub 2015 Feb 11.


Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction.

Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR.

Circ Res. 2014 Aug 29;115(6):567-580. doi: 10.1161/CIRCRESAHA.115.303831. Epub 2014 Jul 21.


Imatinib activates pathological hypertrophy by altering myocyte calcium regulation.

Barr LA, Makarewich CA, Berretta RM, Gao H, Troupes CD, Woitek F, Recchia F, Kubo H, Force T, Houser SR.

Clin Transl Sci. 2014 Oct;7(5):360-7. doi: 10.1111/cts.12173. Epub 2014 Jun 16.


Sorafenib cardiotoxicity increases mortality after myocardial infarction.

Duran JM, Makarewich CA, Trappanese D, Gross P, Husain S, Dunn J, Lal H, Sharp TE, Starosta T, Vagnozzi RJ, Berretta RM, Barbe M, Yu D, Gao E, Kubo H, Force T, Houser SR.

Circ Res. 2014 May 23;114(11):1700-1712. doi: 10.1161/CIRCRESAHA.114.303200. Epub 2014 Apr 9.


Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms.

Duran JM, Makarewich CA, Sharp TE, Starosta T, Zhu F, Hoffman NE, Chiba Y, Madesh M, Berretta RM, Kubo H, Houser SR.

Circ Res. 2013 Aug 16;113(5):539-52. doi: 10.1161/CIRCRESAHA.113.301202. Epub 2013 Jun 25.


A characterization and targeting of the infarct border zone in a swine model of myocardial infarction.

Duran JM, Taghavi S, Berretta RM, Makarewich CA, Sharp Iii T, Starosta T, Udeshi F, George JC, Kubo H, Houser SR.

Clin Transl Sci. 2012 Oct;5(5):416-21. doi: 10.1111/j.1752-8062.2012.00432.x. Epub 2012 Jun 26.


Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling.

Gao H, Wang F, Wang W, Makarewich CA, Zhang H, Kubo H, Berretta RM, Barr LA, Molkentin JD, Houser SR.

J Mol Cell Cardiol. 2012 Nov;53(5):657-67. doi: 10.1016/j.yjmcc.2012.08.005. Epub 2012 Aug 21.


Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice.

Zhang D, Fang P, Jiang X, Nelson J, Moore JK, Kruger WD, Berretta RM, Houser SR, Yang X, Wang H.

Circ Res. 2012 Jun 22;111(1):37-49. doi: 10.1161/CIRCRESAHA.112.269472. Epub 2012 May 24.


Validation of transcatheter left ventricular electromechanical mapping for assessment of cardiac function and targeted transendocardial injection in a porcine ischemia-reperfusion model.

Taghavi S, Duran JM, Berretta RM, Makarewich CA, Udeshi F, Sharp TE, Kubo H, Houser SR, George JC.

Am J Transl Res. 2012;4(2):240-6. Epub 2012 Apr 18.


A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility.

Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR.

Circ Res. 2012 Mar 2;110(5):669-74. doi: 10.1161/CIRCRESAHA.111.264028. Epub 2012 Feb 2.


Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.

Zhang H, Makarewich CA, Kubo H, Wang W, Duran JM, Li Y, Berretta RM, Koch WJ, Chen X, Gao E, Valdivia HH, Houser SR.

Circ Res. 2012 Mar 16;110(6):831-40. doi: 10.1161/CIRCRESAHA.111.255158. Epub 2012 Feb 2.


Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells.

Angert D, Berretta RM, Kubo H, Zhang H, Chen X, Wang W, Ogorek B, Barbe M, Houser SR.

Circ Res. 2011 May 13;108(10):1226-37. doi: 10.1161/CIRCRESAHA.110.239046. Epub 2011 Mar 31.


Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.

Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR.

J Mol Cell Cardiol. 2011 Mar;50(3):460-70. doi: 10.1016/j.yjmcc.2010.11.012. Epub 2010 Nov 25.


{beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways.

Wang W, Zhang H, Gao H, Kubo H, Berretta RM, Chen X, Houser SR.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H322-31. doi: 10.1152/ajpheart.00392.2010. Epub 2010 May 21.


c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes.

Kubo H, Berretta RM, Jaleel N, Angert D, Houser SR.

Clin Transl Sci. 2009 Feb;2(1):26-32. doi: 10.1111/j.1752-8062.2008.00089.x.


Increased cardiac myocyte progenitors in failing human hearts.

Kubo H, Jaleel N, Kumarapeli A, Berretta RM, Bratinov G, Shan X, Wang H, Houser SR, Margulies KB.

Circulation. 2008 Aug 5;118(6):649-57. doi: 10.1161/CIRCULATIONAHA.107.761031. Epub 2008 Jul 21.


Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.

Chen X, Zhang X, Harris DM, Piacentino V 3rd, Berretta RM, Margulies KB, Houser SR.

Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2257-67. doi: 10.1152/ajpheart.01335.2007. Epub 2008 Mar 21.


Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.

Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB.

J Mol Cell Cardiol. 2007 Nov;43(5):552-63. Epub 2007 Sep 6.


Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction.

McGinley JC, Berretta RM, Chaudhary K, Rossman E, Bratinov GD, Gaughan JP, Houser S, Margulies KB.

Eur J Heart Fail. 2007 Sep;9(9):857-64. Epub 2007 Jun 26.


Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties.

Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, Kajstura J, Anversa P, Houser SR.

Circ Res. 2007 Mar 2;100(4):536-44. Epub 2007 Feb 1.


Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy.

Mills GD, Kubo H, Harris DM, Berretta RM, Piacentino V 3rd, Houser SR.

Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H61-70.


Subvalvular alterations promote increased mitral valve regurgitation in progressive dilated cardiomyopathy.

McGinley JC, Berretta RM, Bratinov GD, Dhar S, Gaughan JP, Margulies KB.

J Card Fail. 2005 Jun;11(5):343-50.


Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release.

Harris DM, Mills GD, Chen X, Kubo H, Berretta RM, Votaw VS, Santana LF, Houser SR.

Circ Res. 2005 Mar 18;96(5):543-50. Epub 2005 Feb 10.


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