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A Phase II Trial of 5-Day Neoadjuvant Radiotherapy for Patients with High-Risk Primary Soft Tissue Sarcoma.

Kalbasi A, Kamrava M, Chu FI, Telesca D, Van Dams R, Yang Y, Ruan D, Nelson SD, Dry SM, Hernandez J, Chmielowski B, Singh AS, Bukata SV, Bernthal NM, Steinberg ML, Weidhaas JB, Eilber FC.

Clin Cancer Res. 2020 Feb 13. doi: 10.1158/1078-0432.CCR-19-3524. [Epub ahead of print]


Novel in vivo mouse model of shoulder implant infection.

Sheppard WL, Mosich GM, Smith RA, Hamad CD, Park HY, Zoller SD, Trikha R, McCoy TK, Borthwell R, Hoang J, Truong N, Cevallos N, Clarkson S, Hori KR, van Dijl JM, Francis KP, Petrigliano FA, Bernthal NM.

J Shoulder Elbow Surg. 2020 Jan 31. pii: S1058-2746(19)30803-1. doi: 10.1016/j.jse.2019.10.032. [Epub ahead of print]


Long-term follow-up of all-polyethylene tibial components when used for oncological endoprosthetic reconstruction.

Bernthal NM, Burke ZDC, Hegde V, Upfill-Brown A, Chen CJ, Hwang R, Eckardt JJ.

Bone Joint J. 2020 Feb;102-B(2):170-176. doi: 10.1302/0301-620X.102B2.BJJ-2019-0535.R1.


Preoperative Vitamin D Repletion in Total Knee Arthroplasty: A Cost-Effectiveness Model.

Arshi A, Shieh A, Adams JS, Bernthal NM, Zeegen EN, Sassoon AA.

J Arthroplasty. 2019 Dec 27. pii: S0883-5403(19)31186-6. doi: 10.1016/j.arth.2019.12.037. [Epub ahead of print]


Controlled Release of Vancomycin and Tigecycline from an Orthopaedic Implant Coating Prevents Staphylococcus aureus Infection in an Open Fracture Animal Model.

Stavrakis AI, Zhu S, Loftin AH, Weixian X, Niska J, Hegde V, Segura T, Bernthal NM.

Biomed Res Int. 2019 Dec 12;2019:1638508. doi: 10.1155/2019/1638508. eCollection 2019.


Current Trends in Orthopaedic Surgery Residency Applications and Match Rates.

Trikha R, Keswani A, Ishmael CR, Greig D, Kelley BV, Bernthal NM.

J Bone Joint Surg Am. 2020 Mar 18;102(6):e24. doi: 10.2106/JBJS.19.00930.


An Early Look at Operative Orthopaedic Injuries Associated with Electric Scooter Accidents: Bringing High-Energy Trauma to a Wider Audience.

Ishmael CR, Hsiue PP, Zoller SD, Wang P, Hori KR, Gatto JD, Li R, Jeffcoat DM, Johnson EE, Bernthal NM.

J Bone Joint Surg Am. 2020 Mar 4;102(5):e18. doi: 10.2106/JBJS.19.00390.


Progress not panacea: vancomycin powder efficacy and dose evaluated in an in vivo mouse model of spine implant infection.

Park HY, Hegde V, Zoller SD, Sheppard W, Hamad C, Smith RA, Sprague MM, Proal JD, Hoang J, Loftin A, Blumstein G, Burke Z, Cevallos N, Scaduto AA, Bernthal NM.

Spine J. 2019 Dec 19. pii: S1529-9430(19)31145-3. doi: 10.1016/j.spinee.2019.12.007. [Epub ahead of print]


The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma.

Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, Houdek MT, Lin PP, Bishop AJ, Hornicek FJ, Chen YL, Lozano-Calderon S, Holt GE, Han I, Biau D, Niu X, Bernthal NM, Ferguson PC, Wunder JS; Japanese Musculoskeletal Oncology Group (JMOG); Soft Tissue Osteosarcoma International Collaborative (STOIC).

Eur J Cancer. 2020 Jan;125:130-141. doi: 10.1016/j.ejca.2019.07.029. Epub 2019 Dec 2.


Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections.

Miller RJ, Crosby HA, Schilcher K, Wang Y, Ortines RV, Mazhar M, Dikeman DA, Pinsker BL, Brown ID, Joyce DP, Zhang J, Archer NK, Liu H, Alphonse MP, Czupryna J, Anderson WR, Bernthal NM, Fortuno-Miranda L, Bulte JWM, Francis KP, Horswill AR, Miller LS.

Sci Rep. 2019 Nov 13;9(1):16663. doi: 10.1038/s41598-019-52982-0.


Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases.

Upfill-Brown A, Bukata S, Bernthal NM, Felsenfeld AL, Nelson SD, Singh A, Wesseling-Perry K, Eilber FC, Federman NC.

JBMR Plus. 2019 Aug 22;3(10):e10210. doi: 10.1002/jbm4.10210. eCollection 2019 Oct.


The Use of a Novel Antimicrobial Implant Coating In Vivo to Prevent Spinal Implant Infection.

Hegde V, Park HY, Dworsky E, Zoller SD, Xi W, Johansen DO, Loftin AH, Hamad CD, Segura T, Bernthal NM.

Spine (Phila Pa 1976). 2020 Mar 15;45(6):E305-E311. doi: 10.1097/BRS.0000000000003279.


Oncologic Accuracy of Image-guided Percutaneous Core-Needle Biopsy of Peripheral Nerve Sheath Tumors at a High-volume Sarcoma Center.

Graham DS, Russell TA, Eckardt MA, Motamedi K, Seeger LL, Singh AS, Bernthal NM, Kalbasi A, Dry SM, Nelson SD, Elashoff D, Levine BD, Eilber FC.

Am J Clin Oncol. 2019 Oct;42(10):739-743. doi: 10.1097/COC.0000000000000591.


Long-term follow-up of custom cross-pin fixation of 56 tumour endoprosthesis stems: a single-institution experience.

Bernthal NM, Upfill-Brown A, Burke ZDC, Ishmael CR, Hsiue P, Hori K, Hornicek F, Eckardt JJ.

Bone Joint J. 2019 Jun;101-B(6):724-731. doi: 10.1302/0301-620X.101B6.BJJ-2018-0993.R1.


Implant Engineering in the Age of Biologics.

Bernthal NM, Park HY, Zoller SD, Petrigliano FA.

J Am Acad Orthop Surg. 2019 Aug 1;27(15):e685-e690. doi: 10.5435/JAAOS-D-17-00503. Review.


Pathologic Response to Neoadjuvant Therapy is Associated With Improved Long-term Survival in High-risk Primary Localized Malignant Peripheral Nerve Sheath Tumors.

Shurell-Linehan E, DiPardo BJ, Elliott IA, Graham DS, Eckardt MA, Dry SM, Nelson SD, Singh AS, Kalbasi A, Federman N, Bernthal NM, Eilber FC.

Am J Clin Oncol. 2019 May;42(5):426-431. doi: 10.1097/COC.0000000000000536.


Multimodal imaging guides surgical management in a preclinical spinal implant infection model.

Zoller SD, Park HY, Olafsen T, Zamilpa C, Burke ZD, Blumstein G, Sheppard WL, Hamad CD, Hori KR, Tseng JC, Czupryna J, McMannus C, Lee JT, Bispo M, Romero Pastrana F, Raineri EJ, Miller JF, Miller LS, van Dijl JM, Francis KP, Bernthal NM.

JCI Insight. 2019 Feb 7;4(3). pii: 124813. doi: 10.1172/jci.insight.124813. [Epub ahead of print]


Reconstructive Science in Orthopedic Oncology.

Burke ZDC, Blumstein GW, Zoller SD, Park HY, Bernthal NM.

Tech Orthop. 2018 Sep;33(3):175-182. doi: 10.1097/BTO.0000000000000282.


Partnership in Ethiopia: University of Utah's and UCLA's Departments of Orthopaedics Collaboration With Soddo Christian Hospital in Ethiopia.

Anderson LA, Bernthal NM, Haller JM, Higgins TF, Elliott IS, Anderson DR.

J Orthop Trauma. 2018 Oct;32 Suppl 7:S12-S15. doi: 10.1097/BOT.0000000000001295.


Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.

Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D.

Nat Commun. 2018 Sep 7;9(1):3634. doi: 10.1038/s41467-018-05573-y.


Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6.


Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature.

Giustini N, Bernthal NM, Bukata SV, Singh AS.

Clin Sarcoma Res. 2018 Jul 10;8:14. doi: 10.1186/s13569-018-0101-2. eCollection 2018.


A Comparison of Defense and Plaintiff Expert Witnesses in Orthopaedic Surgery Malpractice Litigation.

Park HY, Zoller SD, Sheppard WL, Hegde V, Smith RA, Borthwell RM, Clarkson SJ, Hamad CD, Proal JD, Bernthal NM.

J Bone Joint Surg Am. 2018 Jun 6;100(11):e78. doi: 10.2106/JBJS.17.01146.


The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.

Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB.

Cancer Cell. 2018 May 14;33(5):905-921.e5. doi: 10.1016/j.ccell.2018.04.002.


Academic Influence and Its Relationship to Industry Payments in Orthopaedic Surgery.

Buerba RA, Sheppard WL, Herndon KE, Gajewski N, Patel AD, Leong NL, Bernthal NM, SooHoo NF.

J Bone Joint Surg Am. 2018 May 2;100(9):e59. doi: 10.2106/JBJS.17.00838.


Preoperative Vitamin D Deficiency Is Associated With Higher Postoperative Complication Rates in Total Knee Arthroplasty.

Hegde V, Arshi A, Wang C, Buser Z, Wang JC, Jensen AR, Adams JS, Zeegen EN, Bernthal NM.

Orthopedics. 2018 Jul 1;41(4):e489-e495. doi: 10.3928/01477447-20180424-04. Epub 2018 Apr 30.


Long-term Outcomes With Ifosfamide-based Hypofractionated Preoperative Chemoradiotherapy for Extremity Soft Tissue Sarcomas.

Pennington JD, Eilber FC, Eilber FR, Singh AS, Reed JP, Chmielowski B, Eckardt JJ, Bukata SV, Bernthal NM, Federman N, Nelson SD, Dry SM, Wang PC, Luu M, Selch MT, Steinberg ML, Kalbasi A, Kamrava M.

Am J Clin Oncol. 2018 Dec;41(12):1154-1161. doi: 10.1097/COC.0000000000000443.


Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors?

Hegde V, Burke ZDC, Park HY, Zoller SD, Johansen D, Kelley BV, Levine B, Motamedi K, Federman NC, Seeger LL, Nelson SD, Bernthal NM.

Clin Orthop Relat Res. 2018 Mar;476(3):568-577. doi: 10.1007/s11999.0000000000000062.


CORR Insights®: Quantitative Primary Tumor Indocyanine Green Measurements Predict Osteosarcoma Metastatic Lung Burden in a Mouse Model.

Bernthal NM.

Clin Orthop Relat Res. 2018 Mar;476(3):488-489. doi: 10.1007/s11999.0000000000000136. No abstract available.


Local Control of Soft Tissue and Bone Sarcomas.

Crompton JG, Ogura K, Bernthal NM, Kawai A, Eilber FC.

J Clin Oncol. 2018 Jan 10;36(2):111-117. doi: 10.1200/JCO.2017.75.2717. Epub 2017 Dec 8. Review.


Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.

Romero Pastrana F, Thompson JM, Heuker M, Hoekstra H, Dillen CA, Ortines RV, Ashbaugh AG, Pickett JE, Linssen MD, Bernthal NM, Francis KP, Buist G, van Oosten M, van Dam GM, Thorek DLJ, Miller LS, van Dijl JM.

Virulence. 2018 Jan 1;9(1):262-272. doi: 10.1080/21505594.2017.1403004. Epub 2017 Dec 26.


Long-term outcomes of cement in cement technique for revision endoprosthesis surgery.

Bernthal NM, Hegde V, Zoller SD, Park HY, Ghodasra JH, Johansen D, Eilber F, Eilber FC, Chandhanayingyong C, Eckardt JJ.

J Surg Oncol. 2018 Mar;117(3):443-450. doi: 10.1002/jso.24862. Epub 2017 Oct 29.


Single-Dose, Preoperative Vitamin-D Supplementation Decreases Infection in a Mouse Model of Periprosthetic Joint Infection.

Hegde V, Dworsky EM, Stavrakis AI, Loftin AH, Zoller SD, Park HY, Richman S, Johansen D, Hu Y, Taylor JA, Hamad CD, Chun RF, Xi W, Adams JS, Bernthal NM.

J Bone Joint Surg Am. 2017 Oct 18;99(20):1737-1744. doi: 10.2106/JBJS.16.01598.


Current Perspective on the Use of Opioids in Perioperative Medicine: An Evidence-Based Literature Review, National Survey of 70,000 Physicians, and Multidisciplinary Clinical Appraisal.

Jahr JS, Bergese SD, Sheth KR, Bernthal NM, Ho HS, Stoicea N, Apfel CC.

Pain Med. 2018 Sep 1;19(9):1710-1719. doi: 10.1093/pm/pnx191. Review.


The Relationship Between OREF Grants and Future NIH Funding Success.

Hegde V, Johansen D, Park HY, Zoller SD, Hamad C, Bernthal NM.

J Bone Joint Surg Am. 2017 Aug 16;99(16):e87. doi: 10.2106/JBJS.16.01278.


Chondrosarcoma of the Osseous Spine: An Analysis of Epidemiology, Patient Outcomes, and Prognostic Factors Using the SEER Registry From 1973 to 2012.

Arshi A, Sharim J, Park DY, Park HY, Bernthal NM, Yazdanshenas H, Shamie AN.

Spine (Phila Pa 1976). 2017 May 1;42(9):644-652. doi: 10.1097/BRS.0000000000001870.


Combinatory antibiotic therapy increases rate of bacterial kill but not final outcome in a novel mouse model of Staphylococcus aureus spinal implant infection.

Hu Y, Hegde V, Johansen D, Loftin AH, Dworsky E, Zoller SD, Park HY, Hamad CD, Nelson GE, Francis KP, Scaduto A, Bernthal NM.

PLoS One. 2017 Feb 28;12(2):e0173019. doi: 10.1371/journal.pone.0173019. eCollection 2017.


Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection.

Wang Y, Thompson JM, Ashbaugh AG, Khodakivskyi P, Budin G, Sinisi R, Heinmiller A, van Oosten M, van Dijl JM, van Dam GM, Francis KP, Bernthal NM, Dubikovskaya EA, Miller LS.

J Am Acad Orthop Surg. 2017 Feb;25 Suppl 1:S7-S12. doi: 10.5435/JAAOS-D-16-00630.


Prognostic determinants and treatment outcomes analysis of osteosarcoma and Ewing sarcoma of the spine.

Arshi A, Sharim J, Park DY, Park HY, Yazdanshenas H, Bernthal NM, Shamie AN.

Spine J. 2017 May;17(5):645-655. doi: 10.1016/j.spinee.2016.11.002. Epub 2016 Nov 14.


Current management of aneurysmal bone cysts.

Park HY, Yang SK, Sheppard WL, Hegde V, Zoller SD, Nelson SD, Federman N, Bernthal NM.

Curr Rev Musculoskelet Med. 2016 Dec;9(4):435-444. Review.


In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating.

Stavrakis AI, Zhu S, Hegde V, Loftin AH, Ashbaugh AG, Niska JA, Miller LS, Segura T, Bernthal NM.

J Bone Joint Surg Am. 2016 Jul 20;98(14):1183-9. doi: 10.2106/JBJS.15.01273.


Novel in vivo mouse model of implant related spine infection.

Dworsky EM, Hegde V, Loftin AH, Richman S, Hu Y, Lord E, Francis KP, Miller LS, Wang JC, Scaduto A, Bernthal NM.

J Orthop Res. 2017 Jan;35(1):193-199. doi: 10.1002/jor.23273. Epub 2016 May 8.


Ewing Sarcoma in a Patient With Cowden Syndrome.

Chandhanayingyong MC, Bernthal NM, Ungarreevittaya P, Nelson SD, Chawla SP, Singh AS.

J Natl Compr Canc Netw. 2015 Nov;13(11):1310-4.


Current Animal Models of Postoperative Spine Infection and Potential Future Advances.

Stavrakis AI, Loftin AH, Lord EL, Hu Y, Manegold JE, Dworsky EM, Scaduto AA, Bernthal NM.

Front Med (Lausanne). 2015 May 26;2:34. doi: 10.3389/fmed.2015.00034. eCollection 2015. Review.


Variation in practice habits in the treatment of pediatric distal radius fractures.

Bernthal NM, Mitchell S, Bales JG, Benhaim P, Silva M.

J Pediatr Orthop B. 2015 Sep;24(5):400-7. doi: 10.1097/BPB.0000000000000204.


The role of chairman and research director in influencing scholarly productivity and research funding in academic orthopaedic surgery.

Stavrakis AI, Patel AD, Burke ZD, Loftin AH, Dworsky EM, Silva M, Bernthal NM.

J Orthop Res. 2015 Oct;33(10):1407-11. doi: 10.1002/jor.22919. Epub 2015 May 20.


Erratum to: Outcomes of Modified Harrington Reconstructions for Nonprimary Periacetabular Tumors: An Effective and Inexpensive Technique.

Bernthal NM, Price SL, Monument MJ, Wilkinson B, Jones KB, Randall RL.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1612. doi: 10.1245/s10434-015-4543-y. No abstract available.


Outcomes of Modified Harrington Reconstructions for Nonprimary Periacetabular Tumors: An Effective and Inexpensive Technique.

Bernthal NM, Price SL, Monument MJ, Wilkinson B, Jones KB, Randall RL.

Ann Surg Oncol. 2015 Nov;22(12):3921-8. doi: 10.1245/s10434-015-4507-2. Epub 2015 Mar 17. Erratum in: Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1612.


Rotationplasty: Beauty is in the Eye of the Beholder.

Bernthal NM, Monument MJ, Randall RL, Jones KB.

Oper Tech Orthop. 2014 Jun 1;24(2):103-110.


Combined in vivo optical and µCT imaging to monitor infection, inflammation, and bone anatomy in an orthopaedic implant infection in mice.

Bernthal NM, Taylor BN, Meganck JA, Wang Y, Shahbazian JH, Niska JA, Francis KP, Miller LS.

J Vis Exp. 2014 Oct 16;(92):e51612. doi: 10.3791/51612.

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